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1OKM
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CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKM INHIBITOR 4-SULFONAMIDE-[1-(4-AMINOBUTANE)]BENZAMIDE
Descriptor:CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION, ...
Authors:Elbaum, D., Nair, S.K., Patchan, M.W., Thompson, R.B., Christianson, D.W.
Deposit date:1996-06-25
Release date:1997-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-based design of a sulfonamide probe for fluorescence anisotropy detection of zinc with a carbonic anhydrase-based biosensor.
J.Am.Chem.Soc., 118, 1996
1OKN
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CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKN INHIBITOR 4-SULFONAMIDE-[1-(4-N-(5-FLUORESCEIN THIOUREA)BUTANE)]
Descriptor:CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION, ...
Authors:Elbaum, D., Nair, S.K., Patchan, M.W., Thompson, R.B., Christianson, D.W.
Deposit date:1996-06-25
Release date:1997-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-based design of a sulfonamide probe for fluorescence anisotropy detection of zinc with a carbonic anhydrase-based biosensor.
J.Am.Chem.Soc., 118, 1996
1OKL
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CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKL INHIBITOR 5-DIMETHYLAMINO-NAPHTHALENE-1-SULFONAMIDE
Descriptor:CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION, ...
Authors:Nair, S.K., Elbaum, D., Christianson, D.W.
Deposit date:1996-06-25
Release date:1997-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Unexpected binding mode of the sulfonamide fluorophore 5-dimethylamino-1-naphthalene sulfonamide to human carbonic anhydrase II. Implications for the development of a zinc biosensor.
J.Biol.Chem., 271, 1996
2OFU
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X-RAY CRYSTAL STRUCTURE OF 2-AMINOPYRIMIDINE CARBAMATE 43 BOUND TO LCK
Descriptor:Proto-oncogene tyrosine-protein kinase LCK, SULFATE ION, 2,6-DIMETHYLPHENYL 2-(3,5-DIMETHOXY-4-(3-(4-METHYLPIPERAZIN-1-YL)PROPOXY)PHENYLAMINO)PYRIMIDIN- 4-YL(2,4-DIMETHOXYPHENYL)CARBAMATE
Authors:Huang, X.
Deposit date:2007-01-04
Release date:2007-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Novel 2-Aminopyrimidine Carbamates as Potent and Orally Active Inhibitors of Lck: Synthesis, SAR, and in Vivo Antiinflammatory Activity
J.Med.Chem., 49, 2006
2QU5
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CRYSTAL STRUCTURE OF THE VEGFR2 KINASE DOMAIN IN COMPLEX WITH A BENZIMIDAZOLE INHIBITOR
Descriptor:Vascular endothelial growth factor receptor 2, 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide
Authors:Whittington, D.A., Kim, J.L., Long, A.M., Rose, P., Gu, Y., Zhao, H.
Deposit date:2007-08-03
Release date:2007-09-25
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Design, Synthesis, and Evaluation of Orally Active Benzimidazoles and Benzoxazoles as Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase Inhibitors.
J.Med.Chem., 50, 2007
2QU6
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CRYSTAL STRUCTURE OF THE VEGFR2 KINASE DOMAIN IN COMPLEX WITH A BENZOXAZOLE INHIBITOR
Descriptor:Vascular endothelial growth factor receptor 2, SULFATE ION, 4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}phenyl)amino]-1,3-benzoxazol-5-yl}oxy)-N-methylpyridine-2-carboxamide
Authors:Whittington, D.A., Kim, J.L., Long, A.M., Rose, P., Gu, Y., Zhao, H.
Deposit date:2007-08-03
Release date:2007-09-25
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Design, Synthesis, and Evaluation of Orally Active Benzimidazoles and Benzoxazoles as Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase Inhibitors.
J.Med.Chem., 50, 2007