Author results

1YU9
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GPPNHP-BOUND RAB4A
Descriptor:GTP-binding protein, MAGNESIUM ION, SULFATE ION, ...
Authors:Eathiraj, S., Pan, X., Ritacco, C., Lambright, D.G.
Deposit date:2005-02-13
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1YVD
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GPPNHP-BOUND RAB22 GTPASE
Descriptor:Ras-related protein Rab-22A, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Eathiraj, S., Pan, X., Ritacco, C., Lambright, D.G.
Deposit date:2005-02-15
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1YZK
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GPPNHP BOUND RAB11 GTPASE
Descriptor:Ras-related protein Rab-11A, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Eathiraj, S., Pan, X., Ritacco, C., Lambright, D.G.
Deposit date:2005-02-28
Release date:2005-07-26
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1YZL
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GPPNHP-BOUND RAB9 GTPASE
Descriptor:Ras-related protein Rab-9A, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Eathiraj, S., Pan, X., Ritacco, C., Lambright, D.G.
Deposit date:2005-02-28
Release date:2005-07-26
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1YZM
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STRUCTURE OF RABENOSYN (458-503), RAB4 BINDING DOMAIN
Descriptor:FYVE-finger-containing Rab5 effector protein rabenosyn-5
Authors:Eathiraj, S., Pan, X., Ritacco, C., Lambright, D.G.
Deposit date:2005-02-28
Release date:2005-07-26
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1YZN
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GPPNHP-BOUND YPT1P GTPASE
Descriptor:GTP-binding protein YPT1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Eathiraj, S., Pan, X., Ritacco, C., Lambright, D.G.
Deposit date:2005-02-28
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1YZQ
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GPPNHP-BOUND RAB6 GTPASE
Descriptor:small GTP binding protein RAB6 isoform, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Eathiraj, S., Pan, X., Ritacco, C., Lambright, D.G.
Deposit date:2005-02-28
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1YZT
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GPPNHP-BOUND RAB21 GTPASE AT 2.05 A RESOLUTION
Descriptor:Ras-related protein Rab-21, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Eathiraj, S., Pan, X., Ritacco, C., Lambright, D.G.
Deposit date:2005-02-28
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1YZU
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GPPNHP-BOUND RAB21 GTPASE AT 2.50 A RESOLUTION
Descriptor:Ras-related protein Rab-21, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Eathiraj, S., Pan, X., Ritacco, C., Lambright, D.G.
Deposit date:2005-02-28
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z06
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GPPNHP-BOUND RAB33 GTPASE
Descriptor:Ras-related protein Rab-33B, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Eathiraj, S., Pan, X., Ritacco, C., Lambright, D.G.
Deposit date:2005-03-01
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z07
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GPPNHP-BOUND RAB5C G55Q MUTANT GTPASE
Descriptor:Ras-related protein Rab-5C, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Eathiraj, S., Pan, X., Ritacco, C., Lambright, D.G.
Deposit date:2005-03-01
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z08
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GPPNHP-BOUND RAB21 Q53G MUTANT GTPASE
Descriptor:Ras-related protein Rab-21, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Eathiraj, S., Pan, X., Ritacco, C., Lambright, D.G.
Deposit date:2005-03-01
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z0A
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GDP-BOUND RAB2A GTPASE
Descriptor:Ras-related protein Rab-2A, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Eathiraj, S., Pan, X., Ritacco, C., Lambright, D.G.
Deposit date:2005-03-01
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z0D
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GDP-BOUND RAB5C GTPASE
Descriptor:Ras-related protein Rab-5C, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Eathiraj, S., Pan, X., Ritacco, C., Lambright, D.G.
Deposit date:2005-03-01
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z0F
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GDP-BOUND RAB14 GTPASE
Descriptor:RAB14, member RAS oncogene family, MAGNESIUM ION, ...
Authors:Eathiraj, S., Pan, X., Ritacco, C., Lambright, D.G.
Deposit date:2005-03-01
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z0I
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GDP-BOUND RAB21 GTPASE
Descriptor:Ras-related protein Rab-21, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Eathiraj, S., Pan, X., Ritacco, C., Lambright, D.G.
Deposit date:2005-03-01
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z0J
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STRUCTURE OF GTP-BOUND RAB22Q64L GTPASE IN COMPLEX WITH THE MINIMAL RAB BINDING DOMAIN OF RABENOSYN-5
Descriptor:Ras-related protein Rab-22A, FYVE-finger-containing Rab5 effector protein rabenosyn-5, MAGNESIUM ION, ...
Authors:Eathiraj, S., Pan, X., Ritacco, C., Lambright, D.G.
Deposit date:2005-03-01
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z0K
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STRUCTURE OF GTP-BOUND RAB4Q67L GTPASE IN COMPLEX WITH THE CENTRAL RAB BINDING DOMAIN OF RABENOSYN-5
Descriptor:GTP-binding protein, FYVE-finger-containing Rab5 effector protein rabenosyn-5, MAGNESIUM ION, ...
Authors:Eathiraj, S., Pan, X., Ritacco, C., Lambright, D.G.
Deposit date:2005-03-01
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z22
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GDP-BOUND RAB23 GTPASE CRYSTALLIZED IN C222(1) SPACE GROUP
Descriptor:Ras-related protein Rab-23, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Eathiraj, S., Pan, X., Ritacco, C., Lambright, D.G.
Deposit date:2005-03-07
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
1Z2A
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GDP-BOUND RAB23 GTPASE CRYSTALLIZED IN P2(1)2(1)2(1) SPACE GROUP
Descriptor:Ras-related protein Rab-23, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Eathiraj, S., Pan, X., Ritacco, C., Lambright, D.G.
Deposit date:2005-03-07
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature, 436, 2005
2HV8
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CRYSTAL STRUCTURE OF GTP-BOUND RAB11 IN COMPLEX WITH FIP3
Descriptor:Ras-related protein Rab-11A, Rab11 family-interacting protein 3, MAGNESIUM ION, ...
Authors:Eathiraj, S., Mishra, A., Prekeris, R., Lambright, D.G.
Deposit date:2006-07-27
Release date:2006-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structural Basis for Rab11-mediated Recruitment of FIP3 to Recycling Endosomes.
J.Mol.Biol., 364, 2006
3RHK
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF C-MET KINASE IN COMPLEX WITH ARQ 197
Descriptor:Hepatocyte growth factor receptor, 1-[(3R,4R)-4-(1H-indol-3-yl)-2,5-dioxopyrrolidin-3-yl]pyrrolo[3,2,1-ij]quinolinium
Authors:Eathiraj, S., Palma, R., Volckova, E., Hirschi, M., France, D.S., Ashwell, M.A., Chan, T.C.
Deposit date:2011-04-11
Release date:2011-04-27
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197.
J.Biol.Chem., 286, 2011
3RHX
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF FGFR1 KINASE IN COMPLEX WITH ARQ 069
Descriptor:Basic fibroblast growth factor receptor 1, (6S)-6-phenyl-5,6-dihydrobenzo[h]quinazolin-2-amine, SULFATE ION, ...
Authors:Eathiraj, S., Palma, R., Hirschi, M., Volckova, E., Nakuci, E., Castro, J., Chen, C.R., Chan, T.C., France, D.S., Ashwell, M.A.
Deposit date:2011-04-12
Release date:2011-05-04
Last modified:2011-10-19
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor.
J.Biol.Chem., 286, 2011
3RI1
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF FGFR2 KINASE IN COMPLEX WITH ARQ 069
Descriptor:Fibroblast growth factor receptor 2, (6S)-6-phenyl-5,6-dihydrobenzo[h]quinazolin-2-amine, SULFATE ION
Authors:Eathiraj, S., Palma, R., Hirschi, M., Volckova, E., Nakuci, E., Castro, J., Chen, C.R., Chan, T.C., France, D.S., Ashwell, M.A.
Deposit date:2011-04-12
Release date:2011-05-04
Last modified:2011-10-19
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor.
J.Biol.Chem., 286, 2011
4EJN
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CRYSTAL STRUCTURE OF AUTOINHIBITED FORM OF AKT1 IN COMPLEX WITH N-(4-(5-(3-ACETAMIDOPHENYL)-2-(2-AMINOPYRIDIN-3-YL)-3H-IMIDAZO[4,5-B]PYRIDIN-3-YL)BENZYL)-3-FLUOROBENZAMIDE
Descriptor:RAC-alpha serine/threonine-protein kinase, N-(4-{5-[3-(acetylamino)phenyl]-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl}benzyl)-3-fluorobenzamide, 2-BUTANOL, ...
Authors:Eathiraj, S.
Deposit date:2012-04-06
Release date:2012-05-23
Last modified:2013-01-02
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Discovery and optimization of a series of 3-(3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: orally bioavailable, selective, and potent ATP-independent Akt inhibitors.
J.Med.Chem., 55, 2012
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