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4ZWY
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HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A GLUCOSYL SULFAMATE INHIBITOR
分子名称:Carbonic anhydrase 2, ZINC ION, (6S)-1,3,4,5-tetra-O-acetyl-2,6-anhydro-6-{[5-(sulfamoyloxy)pentyl]sulfamoyl}-L-altritol, ...
著者Mahon, B.P., Lomelino, C.L., Driscoll, J.M., McKenna, R.
登録日2015-05-19
公開日2015-08-05
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates.
J.Med.Chem., 58, 2015
4ZWZ
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ENGINEERED CARBONIC ANHYDRASE IX MIMIC IN COMPLEX WITH A GLUCOSYL SULFAMATE INHIBITOR
分子名称:Carbonic anhydrase 2, ZINC ION, methyl (2S,4R)-1-[(2S,3R,4R,5S,6S)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]sulfonyl-4-sulfamoyloxy-pyrrolidine-2-carboxylate, ...
著者Mahon, B.P., Lomelino, C.L., Driscoll, J.M., McKenna, R.
登録日2015-05-19
公開日2015-08-05
最終更新日2015-09-09
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates.
J.Med.Chem., 58, 2015
5DVX
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CRYSTAL STRUCTURE OF THE CATALYTIC-DOMAIN OF HUMAN CARBONIC ANHYDRASE IX AT 1.6 ANGSTROM RESOLUTION
分子名称:Carbonic anhydrase 9, ZINC ION, GLYCEROL, ...
著者Mahon, B.P., Socorro, L., Driscoll, J.M., McKenna, R.
登録日2015-09-21
公開日2016-08-03
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (1.598 Å)
主引用文献The Structure of Carbonic Anhydrase IX Is Adapted for Low-pH Catalysis.
Biochemistry, 55, 2016
4RIU
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A CARBONIC ANHYDRASE IX MIMIC IN COMPLEX WITH A SACCHARIN-BASED INHIBITOR
分子名称:Carbonic anhydrase 2, ZINC ION, GLYCEROL, ...
著者Mahon, B.P., McKenna, R.
登録日2014-10-07
公開日2015-02-04
最終更新日2015-02-25
実験手法X-RAY DIFFRACTION (1.651 Å)
主引用文献Saccharin: A lead compound for structure-based drug design of carbonic anhydrase IX inhibitors.
Bioorg.Med.Chem., 23, 2015
4RIV
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A CARBONIC ANHYDRASE IX MIMIC IN COMPLEX WITH SACCHARIN
分子名称:Carbonic anhydrase 2, ZINC ION, 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, ...
著者Mahon, B.P., McKenna, R.
登録日2014-10-07
公開日2015-02-04
最終更新日2015-02-25
実験手法X-RAY DIFFRACTION (1.631 Å)
主引用文献Saccharin: A lead compound for structure-based drug design of carbonic anhydrase IX inhibitors.
Bioorg.Med.Chem., 23, 2015
4ZWI
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SURFACE LYSINE ACETYLATED HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A SULFAMATE-BASED INHIBITOR
分子名称:Carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ...
著者Lomelino, C.L., Mahon, B.P., McKenna, M.
登録日2015-05-19
公開日2015-08-26
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Observed surface lysine acetylation of human carbonic anhydrase II expressed in Escherichia coli.
Protein Sci., 24, 2015
4ZWX
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ENGINEERED CARBONIC ANHYDRASE IX MIMIC IN COMPLEX WITH GLUCOSYL SULFAMATE INHIBITOR
分子名称:Carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ...
著者Mahon, B.P., Lomelino, C.L., Salguero, A.L., McKenna, R.
登録日2015-05-19
公開日2015-10-28
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (1.696 Å)
主引用文献Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates.
J.Med.Chem., 58, 2015
4ZX0
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HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A GLUCOSYL SULFAMATE INHIBITOR
分子名称:Carbonic anhydrase 2, ZINC ION, methyl (2S,4R)-1-[(2S,3R,4R,5S,6S)-6-(acetyloxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]sulfonyl-4-sulfamoyloxy-pyrrolidine-2-carboxylate, ...
著者Mahon, B.P., Lomelino, C.L., Pinard, M.A., McKenna, R.
登録日2015-05-19
公開日2015-10-28
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX using Structure-Activity Relationships of Glucosyl-Based Sulfamates
J. Med. Chem., 58, 2015
4ZX1
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ENGINEERED CARBONIC ANHYDRASE IX MIMIC IN COMPLEX WITH A GLUCOSYL SULFAMATE INHIBITOR
分子名称:Carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ...
著者Mahon, B.P., Lomelino, C.L., Salguero, A.L., McKenna, R.
登録日2015-05-20
公開日2015-10-28
実験手法X-RAY DIFFRACTION (1.501 Å)
主引用文献Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX using Structure-Activity Relationships of Glucosyl-Based Sulfamates
J. Med. Chem., 58, 2015