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2W1B
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BU of 2w1b by Molmil
The structure of the efflux pump AcrB in complex with bile acid
Descriptor: (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, ACRIFLAVIN RESISTANCE PROTEIN B
Authors:Drew, D, Klepsch, M.M, Newstead, S, Flaig, R, De Gier, J.W, Iwata, S, Beis, K.
Deposit date:2008-10-17
Release date:2008-12-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.85 Å)
Cite:The Structure of the Efflux Pump Acrb in Complex with Bile Acid.
Mol.Membr.Biol., 25, 2008
7S24
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BU of 7s24 by Molmil
Crystal structure of the Na+/H+ antiporter NhaA at pH 6.5
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Na(+)/H(+) antiporter NhaA, PENTAETHYLENE GLYCOL
Authors:Drew, D, Brock, J, Uzdavinys, P, Matsuoka, R.
Deposit date:2021-09-03
Release date:2022-08-10
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the Na + /H + antiporter NhaA at active pH reveals the mechanistic basis for pH sensing.
Nat Commun, 13, 2022
4ATV
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BU of 4atv by Molmil
STRUCTURE OF A TRIPLE MUTANT OF THE NHAA DIMER, CRYSTALLISED AT LOW PH
Descriptor: DODECYL-ALPHA-D-MALTOSIDE, NA(+)/H(+) ANTIPORTER NHAA, SULFATE ION
Authors:Drew, D, Lee, C, Iwata, S, Cameron, A.D.
Deposit date:2012-05-10
Release date:2013-07-10
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of the sodium-proton antiporter NhaA dimer and new mechanistic insights.
J. Gen. Physiol., 144, 2014
4AU5
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BU of 4au5 by Molmil
Structure of the NhaA dimer, crystallised at low pH
Descriptor: DODECYL-ALPHA-D-MALTOSIDE, NA(+)/H(+) ANTIPORTER NHAA, SULFATE ION
Authors:Drew, D, Lee, C, Iwata, S, Cameron, A.D.
Deposit date:2012-05-14
Release date:2013-07-10
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.696 Å)
Cite:Crystal structure of the sodium-proton antiporter NhaA dimer and new mechanistic insights.
J. Gen. Physiol., 144, 2014
6Z3Y
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BU of 6z3y by Molmil
CryoEM structure of horse sodium/proton exchanger NHE9 in an inward-facing conformation
Descriptor: Sodium/hydrogen exchanger
Authors:Winkelmannm, I, Matsuoka, R, Meier, P, Drew, D.
Deposit date:2020-05-22
Release date:2020-11-04
Last modified:2025-07-09
Method:ELECTRON MICROSCOPY (3.51 Å)
Cite:Structure and elevator mechanism of the mammalian sodium/proton exchanger NHE9.
Embo J., 39, 2020
8PVR
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BU of 8pvr by Molmil
Cryo-EM structure of horse Nhe9 bound to PI(3,5)P2
Descriptor: (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, Sodium/hydrogen exchanger 9
Authors:Kokane, S, Meier, P, Gulati, A, Delemotte, L, Drew, D.
Deposit date:2023-07-18
Release date:2024-07-24
Last modified:2025-04-09
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:PIP 2 -mediated oligomerization of the endosomal sodium/proton exchanger NHE9.
Nat Commun, 16, 2025
8PXB
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BU of 8pxb by Molmil
Cryo-EM structure of horse NHE9 with a extracellular loop
Descriptor: Sodium/hydrogen exchanger 9
Authors:Kokane, S, Meier, P, Matsuoka, R, Drew, D.
Deposit date:2023-07-23
Release date:2024-08-07
Last modified:2025-07-09
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:PIP 2 -mediated oligomerization of the endosomal sodium/proton exchanger NHE9.
Nat Commun, 16, 2025
7P1K
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BU of 7p1k by Molmil
Cryo EM structure of bison NHA2 in nano disc structure
Descriptor: CHOLESTEROL HEMISUCCINATE, Phosphatidylinositol, mitochondrial sodium/hydrogen exchanger 9B2
Authors:Matsuoka, R, Fudim, R, Jung, S, Drew, D.
Deposit date:2021-07-01
Release date:2022-01-26
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3.64 Å)
Cite:Structure, mechanism and lipid-mediated remodeling of the mammalian Na + /H + exchanger NHA2.
Nat.Struct.Mol.Biol., 29, 2022
7P1J
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BU of 7p1j by Molmil
Cryo EM structure of bison NHA2 in detergent structure
Descriptor: mitochondrial sodium/hydrogen exchanger 9B2
Authors:Matsuoka, R, Fudim, R, Jung, S, Drew, D.
Deposit date:2021-07-01
Release date:2022-01-26
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Structure, mechanism and lipid-mediated remodeling of the mammalian Na + /H + exchanger NHA2.
Nat.Struct.Mol.Biol., 29, 2022
7P1I
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BU of 7p1i by Molmil
Cryo EM structure of bison NHA2 in detergent and N-terminal extension helix
Descriptor: mitochondrial sodium/hydrogen exchanger 9B2
Authors:Matsuoka, R, Fudim, R, Jung, S, Drew, D.
Deposit date:2021-07-01
Release date:2022-01-26
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Structure, mechanism and lipid-mediated remodeling of the mammalian Na + /H + exchanger NHA2.
Nat.Struct.Mol.Biol., 29, 2022
9QUW
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BU of 9quw by Molmil
Cryo-EM structure of the human NHA2-Fab complex bound to phloretin
Descriptor: 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, 3-(4-HYDROXYPHENYL)-1-(2,4,6-TRIHYDROXYPHENYL)PROPAN-1-ONE, Fab heavy chain, ...
Authors:Jung, S, Drew, D.
Deposit date:2025-04-11
Release date:2025-05-14
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure and Inhibition of the Human Na + /H + Exchanger SLC9B2.
Int J Mol Sci, 26, 2025
9QUB
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BU of 9qub by Molmil
Cryo-EM structure of the human NHA2-Fab complex
Descriptor: 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, Fab-heavy chain, Fab-light chain, ...
Authors:Jung, S, Drew, D.
Deposit date:2025-04-10
Release date:2025-05-14
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structure and Inhibition of the Human Na + /H + Exchanger SLC9B2.
Int J Mol Sci, 26, 2025
8PS0
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BU of 8ps0 by Molmil
Cryo-EM structure of Sodium proton exchanger NhaA with bound cardiolipin
Descriptor: CARDIOLIPIN, Na(+)/H(+) antiporter NhaA
Authors:Gulati, A, Meier, P, Kokane, S, Drew, D.
Deposit date:2023-07-13
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (3.37 Å)
Cite:Cryo-EM structure of Sodium proton exchanger NhaA with bound cardiolipin
To Be Published
8OTW
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BU of 8otw by Molmil
Cryo-EM structure of Strongylocentrotus purpuratus SLC9C1 in presence of cAMP
Descriptor: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Sperm-specific sodium proton exchanger
Authors:Yeo, H, Mehta, V, Gulati, A, Drew, D.
Deposit date:2023-04-21
Release date:2023-11-01
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (3.68 Å)
Cite:Structure and electromechanical coupling of a voltage-gated Na + /H + exchanger.
Nature, 623, 2023
4D1C
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BU of 4d1c by Molmil
STRUCTURE OF MHP1, A NUCLEOBASE-CATION-SYMPORT-1 FAMILY TRANSPORTER, IN A CLOSED CONFORMATION WITH bromovinylhydantoin bound.
Descriptor: (5Z)-5-[(3-bromophenyl)methylidene]imidazolidine-2,4-dione, HYDANTOIN TRANSPORT PROTEIN, SODIUM ION
Authors:Weyand, S, Brueckner, F, Geng, T, Drew, D, Iwata, S, Henderson, P.J.F, Cameron, A.D.
Deposit date:2014-05-01
Release date:2014-07-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Molecular Mechanism of Ligand Recognition by Membrane Transport Protein, Mhp1.
Embo J., 33, 2014
4D1D
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BU of 4d1d by Molmil
STRUCTURE OF MHP1, A NUCLEOBASE-CATION-SYMPORT-1 FAMILY TRANSPORTER with the inhibitor 5-(2-naphthylmethyl)-L-hydantoin.
Descriptor: 5-(2-NAPHTHYLMETHYL)-D-HYDANTOIN, 5-(2-NAPHTHYLMETHYL)-L-HYDANTOIN, HYDANTOIN TRANSPORT PROTEIN, ...
Authors:Weyand, S, Brueckner, F, Geng, T, Drew, D, Iwata, S, Henderson, P.J.F, Cameron, A.D.
Deposit date:2014-05-01
Release date:2014-07-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Molecular Mechanism of Ligand Recognition by Membrane Transport Protein, Mhp1.
Embo J., 33, 2014
4D1B
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BU of 4d1b by Molmil
STRUCTURE OF MHP1, A NUCLEOBASE-CATION-SYMPORT-1 FAMILY TRANSPORTER, IN A CLOSED CONFORMATION WITH BENZYL-HYDANTOIN
Descriptor: (5S)-5-benzylimidazolidine-2,4-dione, HYDANTOIN TRANSPORT PROTEIN, SODIUM ION
Authors:Brueckner, F, Geng, T, Weyand, S, Drew, D, Iwata, S, Henderson, P.J.F, Cameron, A.D.
Deposit date:2014-05-01
Release date:2014-07-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Molecular Mechanism of Ligand Recognition by Membrane Transport Protein, Mhp1.
Embo J., 33, 2014
4D1A
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BU of 4d1a by Molmil
STRUCTURE OF MHP1, A NUCLEOBASE-CATION-SYMPORT-1 FAMILY TRANSPORTER, IN A CLOSED CONFORMATION WITH INDOLYLMETHYL-HYDANTOIN
Descriptor: (5S)-5-(1H-indol-3-ylmethyl)imidazolidine-2,4-dione, HYDANTOIN TRANSPORT PROTEIN, SODIUM ION
Authors:Weyand, S, Brueckner, F, Geng, T, Drew, D, Iwata, S, Henderson, P.J.F, Cameron, A.D.
Deposit date:2014-05-01
Release date:2014-07-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Molecular Mechanism of Ligand Recognition by Membrane Transport Protein, Mhp1.
Embo J., 33, 2014
8OTX
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BU of 8otx by Molmil
Cryo-EM structure of Strongylocentrotus purpuratus sperm-specific Na+/H+ exchanger SLC9C1 in nanodisc
Descriptor: 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, Sperm-specific sodium proton exchanger
Authors:Yeo, H, Mehta, V, Gulati, A, Drew, D.
Deposit date:2023-04-21
Release date:2023-11-01
Last modified:2025-07-09
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Structure and electromechanical coupling of a voltage-gated Na + /H + exchanger.
Nature, 623, 2023
8OTQ
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BU of 8otq by Molmil
Cryo-EM structure of Strongylocentrotus purpuratus sperm-specific Na+/H+ exchanger SLC9C1 in GDN
Descriptor: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, PALMITIC ACID, Sperm-specific sodium proton exchanger
Authors:Yeo, H, Mehta, V, Gulati, A, Drew, D.
Deposit date:2023-04-21
Release date:2023-11-01
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:Structure and electromechanical coupling of a voltage-gated Na + /H + exchanger.
Nature, 623, 2023
9EMB
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BU of 9emb by Molmil
Structure of KefC Asp156Asn variant
Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE MONOPHOSPHATE, Glutathione-regulated potassium-efflux system protein KefC
Authors:Gulati, A, Kokane, S, Drew, D.
Deposit date:2024-03-07
Release date:2024-06-05
Last modified:2025-01-29
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Structure and mechanism of the K + /H + exchanger KefC.
Nat Commun, 15, 2024
6Z3Z
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BU of 6z3z by Molmil
CryoEM structure of horse sodium/proton exchanger NHE9 without C-terminal regulatory domain in an inward-facing conformation
Descriptor: Sodium/hydrogen exchanger
Authors:Winkelmann, I, Matsuoka, R, Meier, P, Drew, D.
Deposit date:2020-05-22
Release date:2020-11-04
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3.19 Å)
Cite:Structure and elevator mechanism of the mammalian sodium/proton exchanger NHE9.
Embo J., 39, 2020
9GSL
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BU of 9gsl by Molmil
Cryo-EM structure of human SLC35B1 in inward facing conformation
Descriptor: Fv-MBP, Solute carrier family 35 member B1
Authors:Gulati, A, Ahn, D, Suades, A, Drew, D.
Deposit date:2024-09-16
Release date:2025-05-21
Method:ELECTRON MICROSCOPY (3.37 Å)
Cite:Structure and step-wise nucleotide translocation of the human ATP/ADP exchanger SLC35B1
To Be Published
9GRY
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BU of 9gry by Molmil
Cryo-EM structure of human SLC35B1-Q113F variant with AMP-PNP
Descriptor: Maltodextrin-binding protein, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, human SLC35B1-Q113F
Authors:Gulati, A, Ahn, D, Suades, A, Drew, D.
Deposit date:2024-09-13
Release date:2025-05-21
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure and step-wise nucleotide translocation of the human ATP/ADP exchanger SLC35B1
To Be Published
9I20
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BU of 9i20 by Molmil
Cryo-EM structure of human SLC35B1 with ADP
Descriptor: (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, ADENOSINE-5'-DIPHOSPHATE, Maltodextrin-binding protein, ...
Authors:Gulati, A, Ahn, D, Suades, A, Drew, D.
Deposit date:2025-01-17
Release date:2025-05-21
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Structure and step-wise nucleotide translocation of the human ATP/ADP exchanger SLC35B1
To Be Published

 

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