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1Z3D
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PROTEIN CRYSTAL GROWTH IMPROVEMENT LEADING TO THE 2.5A CRYSTALLOGRAPHIC STRUCTURE OF UBIQUITIN-CONJUGATING ENZYME (UBC-1) FROM CAENORHABDITIS ELEGANS
Descriptor:Ubiquitin-conjugating enzyme E2 1
Authors:Gavira, J.A., DiGiammarino, E., Tempel, W., Toh, D., Liu, Z.J., Wang, B.C., Meehan, E., Ng, J.D., Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2005-03-11
Release date:2005-03-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Protein crystal growth improvement leading to the 2.5A crystallographic structure of ubiquitin-conjugating enzyme (ubc-1) from Caenorhabditis elegans
To be Published
1WMS
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HIGH RESOLUTION CRYSTAL STRUCTURE OF HUMAN RAB9 GTPASE: A NOVEL ANTIVIRAL DRUG TARGET
Descriptor:Ras-related protein Rab-9A, GUANOSINE-5'-DIPHOSPHATE
Authors:Chen, L., DiGiammarino, E., Zhou, X.E., Wang, Y., Toh, D., Hodge, T.W., Meehan, E.J.
Deposit date:2004-07-16
Release date:2004-09-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:High resolution crystal structure of human Rab9 GTPase: A novel antiviral drug target
J.Biol.Chem., 279, 2004
1ZLM
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CRYSTAL STRUCTURE OF THE SH3 DOMAIN OF HUMAN OSTEOCLAST STIMULATING FACTOR
Descriptor:Osteoclast stimulating factor 1
Authors:Chen, L., Wang, Y., Wells, D., Toh, D., Harold, H., Zhou, J., DiGiammarino, E., Meehan, E.J.
Deposit date:2005-05-06
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.07 Å)
Cite:Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution.
Acta Crystallogr.,Sect.F, 62, 2006
4HJJ
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STRUCTURE REVEALS FUNCTION OF THE DUAL VARIABLE DOMAIN IMMUNOGLOBULIN (DVD-IG) MOLECULE
Descriptor:Interleukin-18, Anti-IL12 Anti-IL18 DFab Heavy Chain, Anti-IL12 Anti-IL18 DFab Light Chain, ...
Authors:Jakob, C.G., Edalji, R., Judge, R.A., DiGiammarino, E., Li, Y., Gu, J., Ghayur, T.
Deposit date:2012-10-12
Release date:2013-05-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure reveals function of the dual variable domain immunoglobulin (DVD-Ig[TM]) molecule
MAbs, 5, 2013
6E99
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CRYSTAL STRUCTURE OF PROTEIN KINASE A IN COMPLEX WITH THE PKI PEPTIDE AND AN AMINO-PYRIDINYLBENZAMIDE BASED INHIBITOR.
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, PKI peptide, 2-[(2-aminoethyl)amino]-N-[(1R)-1-(3-methoxyphenyl)ethyl]-4-(pyridin-4-yl)benzamide
Authors:Judge, R.A., Hobson, A.D.
Deposit date:2018-07-31
Release date:2018-11-14
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure Based Drug Design.
J. Med. Chem., 61, 2018
6E9L
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CRYSTAL STRUCTURE OF PROTEIN KINASE A IN COMPLEX WITH THE PKI PEPTIDE AND A PYRIDINYLBENZAMIDE BASED INHIBITOR
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, PKI peptide, N-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamide
Authors:Judge, R.A., Hobson, A.D.
Deposit date:2018-08-01
Release date:2018-11-14
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure Based Drug Design.
J. Med. Chem., 61, 2018
6E9W
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CRYSTAL STRUCTURE OF ROCK1 WITH A PYRIDINYLBENZAMIDE BASED INHIBITOR
Descriptor:Rho-associated protein kinase 1, N-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamide, SULFATE ION
Authors:Judge, R.A., Hobson, A.D.
Deposit date:2018-08-01
Release date:2018-11-14
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure Based Drug Design.
J. Med. Chem., 61, 2018
6ED6
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CRYSTAL STRUCTURE OF ROCK2 WITH A PYRIDINYLBENZAMIDE BASED INHIBITOR
Descriptor:Rho-associated protein kinase 2, N-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamide
Authors:Judge, R.A., Hobson, A.D.
Deposit date:2018-08-08
Release date:2018-11-14
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure Based Drug Design.
J. Med. Chem., 61, 2018
1VIE
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STRUCTURE OF DIHYDROFOLATE REDUCTASE
Descriptor:DIHYDROFOLATE REDUCTASE
Authors:Narayana, N., Matthews, D.A., Howell, E.E., Xuong, N.-H.
Deposit date:1996-10-03
Release date:1997-10-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site.
Nat.Struct.Biol., 2, 1995
1VIF
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STRUCTURE OF DIHYDROFOLATE REDUCTASE
Descriptor:DIHYDROFOLATE REDUCTASE, FOLIC ACID
Authors:Narayana, N., Matthews, D.A., Howell, E.E., Xuong, N.-H.
Deposit date:1996-10-03
Release date:1997-10-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site.
Nat.Struct.Biol., 2, 1995