Author results

1TYA
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STRUCTURAL ANALYSIS OF A SERIES OF MUTANTS OF TYROSYL-TRNA SYNTHETASE: ENHANCEMENT OF CATALYSIS BY HYDROPHOBIC INTERACTIONS
Descriptor:TYROSYL-tRNA SYNTHETASE, TYROSINE
Authors:Brown, K.A., De Meester, P., Blow, D.M.
Deposit date:1992-07-06
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Analysis of a Series of Mutants of Tyrosyl-tRNA Synthetase: Enhancement of Catalysis by Hydrophobic Interactions
To be Published
1TYB
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STRUCTURAL ANALYSIS OF A SERIES OF MUTANTS OF TYROSYL-TRNA SYNTHETASE: ENHANCEMENT OF CATALYSIS BY HYDROPHOBIC INTERACTIONS
Descriptor:TYROSYL-tRNA SYNTHETASE, TYROSINE
Authors:Brown, K.A., De Meester, P., Blow, D.M.
Deposit date:1992-07-06
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Analysis of a Series of Mutants of Tyrosyl-tRNA Synthetase: Enhancement of Catalysis by Hydrophobic Interactions
To be Published
1TYC
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STRUCTURAL ANALYSIS OF A SERIES OF MUTANTS OF TYROSYL-TRNA SYNTHETASE: ENHANCEMENT OF CATALYSIS BY HYDROPHOBIC INTERACTIONS
Descriptor:TYROSYL-tRNA SYNTHETASE
Authors:Brown, K.A., Brick, P., De Meester, P., Blow, D.M.
Deposit date:1992-07-06
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Analysis of a Series of Mutants of Tyrosyl-tRNA Synthetase: Enhancement of Catalysis by Hydrophobic Interactions
To be Published
1TYD
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STRUCTURE OF TYROSYL-TRNA SYNTHETASE REFINED AT 2.3 ANGSTROMS RESOLUTION. INTERACTION OF THE ENZYME WITH THE TYROSYL ADENYLATE INTERMEDIATE
Descriptor:TYROSYL-tRNA SYNTHETASE, TYROSINE
Authors:Brown, K.A., De Meester, P., Blow, D.M.
Deposit date:1992-07-06
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of tyrosyl-tRNA synthetase refined at 2.3 A resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate.
J.Mol.Biol., 208, 1989
4CHA
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STRUCTURE OF ALPHA-*CHYMOTRYPSIN REFINED AT 1.68 ANGSTROMS RESOLUTION
Descriptor:ALPHA-CHYMOTRYPSIN A
Authors:Tsukada, H., Blow, D.M.
Deposit date:1984-11-26
Release date:1985-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structure of alpha-chymotrypsin refined at 1.68 A resolution.
J.Mol.Biol., 184, 1985
2CHA
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THE STRUCTURE OF CRYSTALLINE ALPHA-CHYMOTRYPSIN, $V.THE ATOMIC STRUCTURE OF TOSYL-ALPHA-CHYMOTRYPSIN AT 2 ANGSTROMS RESOLUTION
Descriptor:ALPHA-CHYMOTRYPSIN A, PARA-TOLUENE SULFONATE
Authors:Birktoft, J.J., Blow, D.M.
Deposit date:1975-01-01
Release date:1977-01-18
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of crystalline -chymotrypsin. V. The atomic structure of tosyl- -chymotrypsin at 2 A resolution.
J.Mol.Biol., 68, 1972
2TS1
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STRUCTURE OF TYROSYL-T/RNA SYNTHETASE REFINED AT 2.3 ANGSTROMS RESOLUTION. INTERACTION OF THE ENZYME WITH THE TYROSYL ADENYLATE INTERMEDIATE
Descriptor:TYROSYL-TRNA SYNTHETASE
Authors:Brick, P., Bhat, T.N., Blow, D.M.
Deposit date:1989-06-29
Release date:1989-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of tyrosyl-tRNA synthetase refined at 2.3 A resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate.
J.Mol.Biol., 208, 1989
3TS1
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STRUCTURE OF TYROSYL-T/RNA SYNTHETASE REFINED AT 2.3 ANGSTROMS RESOLUTION. INTERACTION OF THE ENZYME WITH THE TYROSYL ADENYLATE INTERMEDIATE
Descriptor:TYROSYL-TRNA SYNTHETASE, PHOSPHORIC ACID 2-AMINO-3-(4-HYDROXY-PHENYL)-PROPYL ESTER ADENOSIN-5'YL ESTER
Authors:Monteilhet, C., Brick, P., Blow, D.M.
Deposit date:1989-06-29
Release date:1989-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of tyrosyl-tRNA synthetase refined at 2.3 A resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate.
J.Mol.Biol., 208, 1989
1XMZ
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CRYSTAL STRUCTURE OF THE DARK STATE OF KINDLING FLUORESCENT PROTEIN KFP FROM ANEMONIA SULCATA
Descriptor:GFP-like chromoprotein FP595, AMINO GROUP, BETA-MERCAPTOETHANOL
Authors:Quillin, M.L., Anstrom, D.M., Shu, X., O'Leary, S., Kallio, K., Chudakov, D.M., Remington, S.J.
Deposit date:2004-10-04
Release date:2005-04-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Kindling Fluorescent Protein from Anemonia sulcata: Dark-State Structure at 1.38 Resolution
Biochemistry, 44, 2005
1EST
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THE ATOMIC STRUCTURE OF CRYSTALLINE PORCINE PANCREATIC ELASTASE AT 2.5 ANGSTROMS RESOLUTION. COMPARISONS WITH THE STRUCTURE OF ALPHA-CHYMOTRYPSIN
Descriptor:PORCINE PANCREATIC ELASTASE, SULFATE ION, PARA-TOLUENE SULFONATE
Authors:Sawyer, L., Shotton, D.M., Watson, H.C.
Deposit date:1976-05-17
Release date:1976-05-27
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The atomic structure of crystalline porcine pancreatic elastase at 2.5 A resolution: comparisons with the structure of alpha-chymotrypsin.
J.Mol.Biol., 118, 1978
1M7Q
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CRYSTAL STRUCTURE OF P38 MAP KINASE IN COMPLEX WITH A DIHYDROQUINAZOLINONE INHIBITOR
Descriptor:Mitogen-activated protein kinase 14, SULFATE ION, 1-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERAZIN-1-YL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE
Authors:Stelmach, J.E., Liu, L., Patel, S.B., Pivnichny, J.V., Scapin, G., Singh, S., Hop, C.E.C.A., Wang, Z., Cameron, P.M., Nichols, E.A., O'Keefe, S.J., O'Neill, E.A., Schmatz, D.M., Schwartz, C.D., Thompson, C.M., Zaller, D.M., Doherty, J.B.
Deposit date:2002-07-22
Release date:2002-12-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase.
Bioorg.Med.Chem.Lett., 13, 2003
1MS6
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DIPEPTIDE NITRILE INHIBITOR BOUND TO CATHEPSIN S.
Descriptor:Cathepsin S, MORPHOLINE-4-CARBOXYLIC ACID [1S-(2-BENZYLOXY-1R-CYANO-ETHYLCARBAMOYL)-3-METHYL-BUTYL]AMIDE
Authors:Ward, Y.D., Thomson, D.S., Frye, L.L., Cywin, C.L., Morwick, T., Emmanuel, M.J., Zindell, R., McNeil, D., Bekkali, Y., Giradot, M., Hrapchak, M., DeTuri, M., Crane, K., White, D., Pav, S., Wang, Y., Hao, M.H., Grygon, C.A., Labadia, M.E., Freeman, D.M., Davidson, W., Hopkins, J.L., Brown, M.L., Spero, D.M.
Deposit date:2002-09-19
Release date:2003-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors
J.Med.Chem., 45, 2002
1W2Z
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PSAO AND XENON
Descriptor:AMINE OXIDASE, COPPER CONTAINING, COPPER (II) ION, ...
Authors:Duff, A.P., Trambaiolo, D.M., Cohen, A.E., Ellis, P.J., Juda, G.A., Shepard, E.M., Langley, D.B., Dooley, D.M., Freeman, H.C., Guss, J.M.
Deposit date:2004-07-11
Release date:2004-11-17
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Using Xenon as a Probe for Dioxygen-Binding Sites in Copper Amine Oxidases.
J.Mol.Biol., 344, 2004
1W4N
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AGAO COVALENT COMPLEX WITH TRANYLCYPROMINE
Descriptor:PHENYLETHYLAMINE OXIDASE, COPPER (II) ION, SODIUM ION, ...
Authors:Duff, A.P., Trambaiolo, D.M., Langley, D.B., Juda, G.A., Shepard, E.M., Dooley, D.M., Freeman, H.C., Guss, J.M.
Deposit date:2004-07-27
Release date:2005-12-08
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Complexes of the Copper-Containing Amine Oxidase from Arthrobacter Globiformis with the Inhibitors Benzylhydrazine and Tranylcypromine.
Acta Crystallogr.,Sect.F, 64, 2008
1W5Z
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AGAO COVALENT COMPLEX WITH BENZYLHYDRAZINE
Descriptor:PHENYLETHYLAMINE OXIDASE, COPPER (II) ION, SODIUM ION, ...
Authors:Duff, A.P., Trambaiolo, D.M., Langley, D.B., Juda, G.A., Shepard, E.M., Dooley, D.M., Freeman, H.C., Guss, J.M.
Deposit date:2004-08-11
Release date:2005-12-08
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Complexes of the Copper-Containing Amine Oxidase from Arthrobacter Globiformis with the Inhibitors Benzylhydrazine and Tranylcypromine.
Acta Crystallogr.,Sect.F, 64, 2008
2R9M
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CATHEPSIN S COMPLEXED WITH COMPOUND 15
Descriptor:Cathepsin S, N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide
Authors:Ward, Y.D., Emmanuel, M.J., Thomson, D.S., Liu, W., Bekkali, Y., Frye, L.L., Girardot, M., Morwick, T., Young, E.R.R., Zindell, R., Hrapchak, M., DeTuri, M., White, A., Crane, K.M., White, D.M., Wang, Y., Hao, M.-H., Grygon, C.A., Labadia, M.E., Wildeson, J., Freeman, D., Nelson, R., Capolino, A., Peterson, J.D., Raymond, E.L., Brown, M.L., Spero, D.M.
Deposit date:2007-09-13
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Design and Synthesis of Reversible Inhibitors of Cathepsin S: alpha,alpha-Disubstitution at the P1 Residue Provides Potent Inhibitors in Cellular Assays and In Vivo Models of Antigen Presentation
To be Published
2R9N
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CATHEPSIN S COMPLEXED WITH COMPOUND 26
Descriptor:Cathepsin S, N-[(1S)-2-{[(3S)-1-benzyl-3-cyanopyrrolidin-3-yl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide
Authors:Ward, Y.D., Emmanuel, M.J., Thomson, D.S., Liu, W., Bekkali, Y., Frye, L.L., Girardot, M., Morwick, T., Young, E.R.R., Zindell, R., Hrapchak, M., DeTuri, M., White, A., Crane, K.M., White, D.M., Wang, Y., Hao, M.-H., Grygon, C.A., Labadia, M.E., Wildeson, J., Freeman, D., Nelson, R., Capolino, A., Peterson, J.D., Raymond, E.L., Brown, M.L., Spero, D.M.
Deposit date:2007-09-13
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design and Synthesis of Reversible Inhibitors of Cathepsin S: alpha,alpha-Disubstitution at the P1 Residue Provides Potent Inhibitors in Cellular Assays and In Vivo Models of Antigen Presentation
to be published
2R9O
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CATHEPSIN S COMPLEXED WITH COMPOUND 8
Descriptor:Cathepsin S, N-[(1S)-2-{[(1R)-2-(benzyloxy)-1-cyano-1-methylethyl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide
Authors:Ward, Y.D., Emmanuel, M.J., Thomson, D.S., Liu, W., Bekkali, Y., Frye, L.L., Girardot, M., Morwick, T., Young, E.R.R., Zindell, R., Hrapchak, M., DeTuri, M., White, A., Crane, K.M., White, D.M., Wang, Y., Hao, M.-H., Grygon, C.A., Labadia, M.E., Wildeson, J., Freeman, D., Nelson, R., Capolino, A., Peterson, J.D., Raymond, E.L., Brown, M.L., Spero, D.M.
Deposit date:2007-09-13
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design and Synthesis of Reversible Inhibitors of Cathepsin S: alpha,alpha-Disubstitution at the P1 Residue Provides Potent Inhibitors in Cellular Assays and In Vivo Models of Antigen Presentation
to be published
4TS1
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CRYSTAL STRUCTURE OF A DELETION MUTANT OF A TYROSYL-T/RNA SYNTHETASE COMPLEXED WITH TYROSINE
Descriptor:TYROSYL-tRNA SYNTHETASE, TYROSINE
Authors:Brick, P., Blow, D.M.
Deposit date:1989-06-29
Release date:1989-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a deletion mutant of a tyrosyl-tRNA synthetase complexed with tyrosine.
J.Mol.Biol., 194, 1987
5DO7
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CRYSTAL STRUCTURE OF THE HUMAN STEROL TRANSPORTER ABCG5/ABCG8
Descriptor:ATP-binding cassette sub-family G member 5, ATP-binding cassette sub-family G member 8
Authors:Lee, J.-Y., Kinch, L.N., Borek, D.M., Urbatsch, I.L., Xie, X.-S., Grishin, N.V., Cohen, J.C., Otwinowski, Z., Hobbs, H.H., Rosenbaum, D.M.
Deposit date:2015-09-10
Release date:2016-05-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.93 Å)
Cite:Crystal structure of the human sterol transporter ABCG5/ABCG8.
Nature, 533, 2016
1MWN
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SOLUTION NMR STRUCTURE OF S100B BOUND TO THE HIGH-AFFINITY TARGET PEPTIDE TRTK-12
Descriptor:S-100 protein, beta chain, F-actin capping protein alpha-1 subunit, ...
Authors:Inman, K.G., Yang, R., Rustandi, R.R., Miller, K.E., Baldisseri, D.M., Weber, D.J.
Deposit date:2002-09-30
Release date:2002-12-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12
J.Mol.Biol., 324, 2002
1OKK
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HOMO-HETERODIMERIC COMPLEX OF THE SRP GTPASES
Descriptor:SIGNAL RECOGNITION PARTICLE PROTEIN, CELL DIVISION PROTEIN FTSY, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ...
Authors:Focia, P.J., Freymann, D.M.
Deposit date:2003-07-26
Release date:2004-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Heterodimeric Gtpase Core of the Srp Targeting Complex
Science, 303, 2004
1XLA
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MECHANISM FOR ALDOSE-KETOSE INTERCONVERSION BY D-XYLOSE ISOMERASE INVOLVING RING OPENING FOLLOWED BY A 1,2-HYDRIDE SHIFT
Descriptor:D-XYLOSE ISOMERASE
Authors:Collyer, C.A., Henrick, K., Blow, D.M.
Deposit date:1991-10-09
Release date:1993-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mechanism for aldose-ketose interconversion by D-xylose isomerase involving ring opening followed by a 1,2-hydride shift.
J.Mol.Biol., 212, 1990
1XLB
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MECHANISM FOR ALDOSE-KETOSE INTERCONVERSION BY D-XYLOSE ISOMERASE INVOLVING RING OPENING FOLLOWED BY A 1,2-HYDRIDE SHIFT
Descriptor:D-XYLOSE ISOMERASE, MAGNESIUM ION
Authors:Collyer, C.A., Henrick, K., Blow, D.M.
Deposit date:1991-10-09
Release date:1993-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanism for aldose-ketose interconversion by D-xylose isomerase involving ring opening followed by a 1,2-hydride shift.
J.Mol.Biol., 212, 1990
1XLC
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MECHANISM FOR ALDOSE-KETOSE INTERCONVERSION BY D-XYLOSE ISOMERASE INVOLVING RING OPENING FOLLOWED BY A 1,2-HYDRIDE SHIFT
Descriptor:D-XYLOSE ISOMERASE, D-XYLITOL, MAGNESIUM ION
Authors:Collyer, C.A., Henrick, K., Blow, D.M.
Deposit date:1991-10-09
Release date:1993-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanism for aldose-ketose interconversion by D-xylose isomerase involving ring opening followed by a 1,2-hydride shift.
J.Mol.Biol., 212, 1990