Author results

2XGT
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ASPARAGINYL-TRNA SYNTHETASE FROM BRUGIA MALAYI COMPLEXED WITH THE SULPHAMOYL ANALOGUE OF ASPARAGINYL-ADENYLATE
Descriptor:ASPARAGINYL-TRNA SYNTHETASE, CYTOPLASMIC, GLYCEROL, ...
Authors:Crepin, T., Haertlein, M., Kron, M., Cusack, S.
Deposit date:2010-06-07
Release date:2010-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A Hybrid Structural Model of the Complete Brugia Malayi Cytoplasmic Asparaginyl-tRNA Synthetase.
J.Mol.Biol., 405, 2011
2XTI
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ASPARAGINYL-TRNA SYNTHETASE FROM BRUGIA MALAYI COMPLEXED WITH ATP:MG AND L-ASP-BETA-NOH ADENYLATE:PPI:MG
Descriptor:ASPARAGINYL-TRNA SYNTHETASE\, CYTOPLASMIC\, PUTATIVE, ...
Authors:Crepin, T., Haertlein, M., Kron, M., Cusack, S.
Deposit date:2010-10-10
Release date:2010-12-15
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A Hybrid Structural Model of the Complete Brugia Malayi Cytoplasmic Asparaginyl-tRNA Synthetase.
J.Mol.Biol., 405, 2011
1MKH
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C-TERMINAL DOMAIN OF METHIONYL-TRNA SYNTHETASE FROM PYROCOCCUS ABYSSI
Descriptor:C-terminal domain of Methionyl-tRNA synthetase
Authors:Crepin, T., Schmitt, E., Blanquet, S., Mechulam, Y.
Deposit date:2002-08-29
Release date:2003-02-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structure and function of the C-terminal domain of methionyl-tRNA synthetase
Biochemistry, 41, 2002
1P7P
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METHIONYL-TRNA SYNTHETASE FROM ESCHERICHIA COLI COMPLEXED WITH METHIONINE PHOSPHONATE
Descriptor:Methionyl-tRNA synthetase, ZINC ION, (1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHONIC ACID
Authors:Crepin, T., Schmitt, E., Mechulam, Y., Sampson, P.B., Vaughan, M.D., Honek, J.F., Blanquet, S.
Deposit date:2003-05-05
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Use of analogues of methionine and methionyl adenylate to sample conformational changes during catalysis in Escherichia coli methionyl-tRNA synthetase.
J.Mol.Biol., 332, 2003
1PFU
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METHIONYL-TRNA SYNTHETASE FROM ESCHERICHIA COLI COMPLEXED WITH METHIONINE PHOSPHINATE
Descriptor:Methionyl-tRNA synthetase, ZINC ION, (1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHINIC ACID
Authors:Crepin, T., Schmitt, E., Mechulam, Y., Sampson, P.B., Vaughan, M.D., Honek, J.F., Blanquet, S.
Deposit date:2003-05-27
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Use of analogues of methionine and methionyl adenylate to sample conformational changes during catalysis in Escherichia coli methionyl-tRNA synthetase.
J.Mol.Biol., 332, 2003
1PFV
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METHIONYL-TRNA SYNTHETASE FROM ESCHERICHIA COLI COMPLEXED WITH DIFLUOROMETHIONINE
Descriptor:Methionyl-tRNA synthetase, ZINC ION, S-(DIFLUOROMETHYL)HOMOCYSTEINE
Authors:Crepin, T., Schmitt, E., Mechulam, Y., Sampson, P.B., Vaughan, M.D., Honek, J.F., Blanquet, S.
Deposit date:2003-05-27
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Use of analogues of methionine and methionyl adenylate to sample conformational changes during catalysis in Escherichia coli methionyl-tRNA synthetase.
J.Mol.Biol., 332, 2003
1PFW
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METHIONYL-TRNA SYNTHETASE FROM ESCHERICHIA COLI COMPLEXED WITH TRIFLUOROMETHIONINE
Descriptor:Methionyl-tRNA synthetase, ZINC ION, 2-AMINO-4-TRIFLUOROMETHYLSULFANYL-BUTYRIC ACID
Authors:Crepin, T., Schmitt, E., Mechulam, Y., Sampson, P.B., Vaughan, M.D., Honek, J.F., Blanquet, S.
Deposit date:2003-05-27
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Use of analogues of methionine and methionyl adenylate to sample conformational changes during catalysis in Escherichia coli methionyl-tRNA synthetase.
J.Mol.Biol., 332, 2003
1PFY
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METHIONYL-TRNA SYNTHETASE FROM ESCHERICHIA COLI COMPLEXED WITH METHIONYL SULPHAMOYL ADENOSINE
Descriptor:Methionyl-tRNA synthetase, ZINC ION, 5'-O-[(L-METHIONYL)-SULPHAMOYL]ADENOSINE
Authors:Crepin, T., Schmitt, E., Mechulam, Y., Sampson, P.B., Vaughan, M.D., Honek, J.F., Blanquet, S.
Deposit date:2003-05-27
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Use of analogues of methionine and methionyl adenylate to sample conformational changes during catalysis in Escherichia coli methionyl-tRNA synthetase.
J.Mol.Biol., 332, 2003
1PG0
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METHIONYL-TRNA SYNTHETASE FROM ESCHERICHIA COLI COMPLEXED WITH METHIONINYL ADENYLATE
Descriptor:Methionyl-tRNA synthetase, L-METHIONYL ADENYLATE
Authors:Crepin, T., Schmitt, E., Mechulam, Y., Sampson, P.B., Vaughan, M.D., Honek, J.F., Blanquet, S.
Deposit date:2003-05-27
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Use of analogues of methionine and methionyl adenylate to sample conformational changes during catalysis in Escherichia coli methionyl-tRNA synthetase.
J.Mol.Biol., 332, 2003
1PG2
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METHIONYL-TRNA SYNTHETASE FROM ESCHERICHIA COLI COMPLEXED WITH METHIONINE AND ADENOSINE
Descriptor:Methionyl-tRNA synthetase, ADENOSINE, METHIONINE
Authors:Crepin, T., Schmitt, E., Mechulam, Y., Sampson, P.B., Vaughan, M.D., Honek, J.F., Blanquet, S.
Deposit date:2003-05-27
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Use of analogues of methionine and methionyl adenylate to sample conformational changes during catalysis in Escherichia coli methionyl-tRNA synthetase.
J.Mol.Biol., 332, 2003
1RQG
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METHIONYL-TRNA SYNTHETASE FROM PYROCOCCUS ABYSSI
Descriptor:Methionyl-tRNA synthetase, ZINC ION
Authors:Crepin, T., Schmitt, E., Blanquet, S., Mechulam, Y.
Deposit date:2003-12-05
Release date:2004-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Three-dimensional structure of methionyl-tRNA synthetase from Pyrococcus abyssi.
Biochemistry, 43, 2004
2I4L
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RHODOPSEUDOMONAS PALUSTRIS PROLYL-TRNA SYNTHETASE
Descriptor:Proline-tRNA ligase
Authors:Crepin, T., Yaremchuk, A., Tukalo, M., Cusack, S.
Deposit date:2006-08-22
Release date:2006-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of Two Bacterial Prolyl-tRNA Synthetases with and without a cis-Editing Domain.
Structure, 14, 2006
2I4M
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RHODOPSEUDOMONAS PALUSTRIS PROLYL-TRNA SYNTHETASE IN COMPLEX WITH PROAMS
Descriptor:Proline-tRNA ligase, 5'-O-[N-(PROLYL)-SULFAMOYL]ADENOSINE
Authors:Crepin, T., Yaremchuk, A., Tukalo, M., Cusack, S.
Deposit date:2006-08-22
Release date:2006-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of Two Bacterial Prolyl-tRNA Synthetases with and without a cis-Editing Domain.
Structure, 14, 2006
2I4N
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RHODOPSEUDOMONAS PALUSTRIS PROLYL-TRNA SYNTHETASE IN COMPLEX WITH CYSAMS
Descriptor:Proline-tRNA ligase, 5'-O-(N-(L-CYSTEINYL)-SULFAMOYL)ADENOSINE
Authors:Crepin, T., Yaremchuk, A., Tukalo, M., Cusack, S.
Deposit date:2006-08-22
Release date:2006-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structures of Two Bacterial Prolyl-tRNA Synthetases with and without a cis-Editing Domain.
Structure, 14, 2006
2I4O
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RHODOPSEUDOMONAS PALUSTRIS PROLYL-TRNA SYNTHETASE IN COMPLEX WITH ATP
Descriptor:Proline-tRNA ligase, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Crepin, T., Yaremchuk, A., Tukalo, M., Cusack, S.
Deposit date:2006-08-22
Release date:2006-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of Two Bacterial Prolyl-tRNA Synthetases with and without a cis-Editing Domain.
Structure, 14, 2006
2J3L
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PROLYL-TRNA SYNTHETASE FROM ENTEROCOCCUS FAECALIS COMPLEXED WITH A PROLYL-ADENYLATE ANALOGUE ('5'-O-(N-(L-PROLYL)-SULFAMOYL)ADENOSINE)
Descriptor:PROLYL-TRNA SYNTHETASE, SULFATE ION, '5'-O-(N-(L-PROLYL)-SULFAMOYL)ADENOSINE
Authors:Crepin, T., Yaremchuk, A., Tukalo, M., Cusack, S.
Deposit date:2006-08-22
Release date:2006-10-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of Two Bacterial Prolyl-tRNA Synthetases with and without a Cis-Editing Domain.
Structure, 14, 2006
2J3M
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PROLYL-TRNA SYNTHETASE FROM ENTEROCOCCUS FAECALIS COMPLEXED WITH ATP, MANGANESE AND PROLINOL
Descriptor:PROLYL-TRNA SYNTHETASE, ADENOSINE-5'-TRIPHOSPHATE, PYRROLIDINE-2-CARBALDEHYDE, ...
Authors:Crepin, T., Yaremchuk, A., Tukalo, M., Cusack, S.
Deposit date:2006-08-22
Release date:2006-10-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of Two Bacterial Prolyl-tRNA Synthetases with and without a Cis-Editing Domain.
Structure, 14, 2006
4C0S
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MAMMALIAN TRANSLATION ELONGATION FACTOR EEF1A2
Descriptor:ELONGATION FACTOR 1-ALPHA 2, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Crepin, T., Shalak, V.F., Yaremchuk, A.D., Vlasenko, D.O., McCarthy, A.A., Negrutskii, B.S., Tukalo, M.A., El'skaya, A.V.
Deposit date:2013-08-07
Release date:2014-08-27
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Mammalian Translation Elongation Factor Eef1A2: X-Ray Structure and New Features of Gdp/GTP Exchange Mechanism in Higher Eukaryotes
Nucleic Acids Res., 42, 2014
2V0C
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LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A SULPHAMOYL ANALOGUE OF LEUCYL-ADENYLATE IN THE SYNTHETIC SITE AND AN ADDUCT OF AMP WITH 5-FLUORO-1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE (AN2690) IN THE EDITING SITE
Descriptor:AMINOACYL-TRNA SYNTHETASE, LEUCINE, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDRO-2-FURANYL]METHYL SULFAMATE, ...
Authors:Rock, F., Mao, W., Yaremchuk, A., Tukalo, M., Crepin, T., Zhou, H., Zhang, Y., Hernandez, V., Akama, T., Baker, S., Plattner, J., Shapiro, L., Martinis, S.A., Benkovic, S.J., Cusack, S., Alley, M.R.K.
Deposit date:2007-05-14
Release date:2007-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site.
Science, 316, 2007
2V0G
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LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A TRNA(LEU) TRANSCRIPT WITH 5-FLUORO-1,3-DIHYDRO-1-HYDROXY-2,1- BENZOXABOROLE (AN2690) FORMING AN ADDUCT TO THE RIBOSE OF ADENOSINE- 76 IN THE ENZYME EDITING SITE.
Descriptor:AMINOACYL-TRNA SYNTHETASE, TRNALEU, LEUCINE, ...
Authors:Rock, F., Mao, W., Yaremchuk, A., Tukalo, M., Crepin, T., Zhou, H., Zhang, Y., Hernandez, V., Akama, T., Baker, S., Plattner, J., Shapiro, L., Martinis, S.A., Benkovic, S.J., Cusack, S., Alley, M.R.K.
Deposit date:2007-05-14
Release date:2007-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site.
Science, 316, 2007
3ZJT
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TERNARY COMPLEX OF E.COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU)574 AND THE BENZOXABOROLE AN3017 IN THE EDITING CONFORMATION
Descriptor:LEUCYL-TRNA SYNTHETASE, TRNALEU5 UAA ISOACCEPTOR, MAGNESIUM ION
Authors:Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
Deposit date:2013-01-18
Release date:2013-04-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
3ZJU
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TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3016 IN THE EDITING CONFORMATION
Descriptor:LEUCYL-TRNA SYNTHETASE, TRNALEU5 UAA ISOACCEPTOR, MAGNESIUM ION
Authors:Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
Deposit date:2013-01-18
Release date:2013-04-17
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
3ZJV
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TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3213 IN THE EDITING CONFORMATION
Descriptor:LEUCINE--TRNA LIGASE, TRNALEU5 UAA ISOACCEPTOR
Authors:Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
Deposit date:2013-01-18
Release date:2013-04-17
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
4CGS
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF THE PA SUBUNIT OF DHORI VIRUS POLYMERASE
Descriptor:POLYMERASE SUBUNIT PA, GLYCEROL
Authors:Guilligay, D., Kadlec, J., Crepin, T., Lunardi, T., Bouvier, D., Kochs, G., Ruigrok, R.W.H., Cusack, S.
Deposit date:2013-11-26
Release date:2014-02-05
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Comparative Structural and Functional Analysis of Orthomyxovirus Polymerase CAP-Snatching Domains.
Plos One, 9, 2014
4CGX
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF THE PA SUBUNIT OF THOGOTO VIRUS POLYMERASE (FORM 1)
Descriptor:POLYMERASE ACIDIC PROTEIN
Authors:Guilligay, D., Kadlec, J., Crepin, T., Lunardi, T., Bouvier, D., Kochs, G., Ruigrok, R.W.H., Cusack, S.
Deposit date:2013-11-27
Release date:2014-02-05
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Comparative Structural and Functional Analysis of Orthomyxovirus Polymerase CAP-Snatching Domains.
Plos One, 9, 2014
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