2C4H | | TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH 500MM ACETYLTHIOCHOLINE | | Descriptor: | ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, TRIETHYLENE GLYCOL, ... | | Authors: | Colletier, J.P., Fournier, D., Greenblatt, H.M., Sussman, J.L., Zaccai, G., Silman, I., Weik, M. | | Deposit date: | 2005-10-19 | | Release date: | 2006-06-14 | | Last modified: | 2019-04-03 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural insights into substrate traffic and inhibition in acetylcholinesterase.
EMBO J., 25, 2006
|
|
2C58 | | TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH 20MM ACETYLTHIOCHOLINE | | Descriptor: | ACETYLCHOLINESTERASE, 2-(TRIMETHYLAMMONIUM)ETHYL THIOL, ACETYLTHIOCHOLINE, ... | | Authors: | Colletier, J.P., Fournier, D., Greenblatt, H.M., Sussman, J.L., Zaccai, G., Silman, I., Weik, M. | | Deposit date: | 2005-10-26 | | Release date: | 2006-06-14 | | Last modified: | 2019-05-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Insights Into Substrate Traffic and Inhibition in Acetylcholinesterase.
Embo J., 25, 2006
|
|
2C5F | | TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A NON HYDROLYSABLE SUBSTRATE ANALOGUE, 4-OXO-N,N,N-TRIMETHYLPENTANAMINIUM | | Descriptor: | ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, TRIETHYLENE GLYCOL, ... | | Authors: | Colletier, J.P., Fournier, D., Greenblatt, H.M., Sussman, J.L., Zaccai, G., Silman, I., Weik, M. | | Deposit date: | 2005-10-27 | | Release date: | 2006-06-14 | | Last modified: | 2019-04-03 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural Insights Into Substrate Traffic and Inhibition in Acetylcholinesterase.
Embo J., 25, 2006
|
|
2C5G | | TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH 20MM THIOCHOLINE | | Descriptor: | ACETYLCHOLINESTERASE, 2-(TRIMETHYLAMMONIUM)ETHYL THIOL, CHLORIDE ION, ... | | Authors: | Colletier, J.P., Fournier, D., Greenblatt, H.M., Sussman, J.L., Zaccai, G., Silman, I., Weik, M. | | Deposit date: | 2005-10-27 | | Release date: | 2006-06-14 | | Last modified: | 2019-04-03 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural Insights Into Substrate Traffic and Inhibition in Acetylcholinesterase.
Embo J., 25, 2006
|
|
2VJA | | TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A NON HYDROLYSABLE SUBSTRATE ANALOGUE, 4-OXO-N,N,N- TRIMETHYLPENTANAMINIUM - ORTHORHOMBIC SPACE GROUP - DATASET A AT 100K | | Descriptor: | ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ... | | Authors: | Colletier, J.P., Bourgeois, D., Fournier, D., Silman, I., Sussman, J.L., Weik, M. | | Deposit date: | 2007-12-09 | | Release date: | 2008-07-22 | | Last modified: | 2019-04-03 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Shoot-and-Trap: Use of Specific X-Ray Damage to Study Structural Protein Dynamics by Temperature-Controlled Cryo-Crystallography.
Proc.Natl.Acad.Sci.USA, 105, 2008
|
|
2VJB | | TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A NON HYDROLYSABLE SUBSTRATE ANALOGUE, 4-OXO-N,N,N- TRIMETHYLPENTANAMINIUM - ORTHORHOMBIC SPACE GROUP - DATASET D AT 100K | | Descriptor: | ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ... | | Authors: | Colletier, J.P., Bourgeois, D., Fournier, D., Silman, I., Sussman, J.L., Weik, M. | | Deposit date: | 2007-12-09 | | Release date: | 2008-07-22 | | Last modified: | 2019-04-03 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | Shoot-and-Trap: Use of Specific X-Ray Damage to Study Structural Protein Dynamics by Temperature-Controlled Cryo-Crystallography.
Proc.Natl.Acad.Sci.USA, 105, 2008
|
|
2VJC | | TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A NON HYDROLYSABLE SUBSTRATE ANALOGUE, 4-OXO-N,N,N- TRIMETHYLPENTANAMINIUM - ORTHORHOMBIC SPACE GROUP - DATASET A AT 150K | | Descriptor: | ACETYLCHOLINESTERASE, CHLORIDE ION, (4R)-4-HYDROXY-N,N,N-TRIMETHYLPENTAN-1-AMINIUM, ... | | Authors: | Colletier, J.P., Bourgeois, D., Fournier, D., Silman, I., Sussman, J.L., Weik, M. | | Deposit date: | 2007-12-09 | | Release date: | 2008-07-22 | | Last modified: | 2019-04-03 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Shoot-and-Trap: Use of Specific X-Ray Damage to Study Structural Protein Dynamics by Temperature-Controlled Cryo-Crystallography.
Proc.Natl.Acad.Sci.USA, 105, 2008
|
|
2VJD | | TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A NON HYDROLYSABLE SUBSTRATE ANALOGUE, 4-OXO-N,N,N- TRIMETHYLPENTANAMINIUM - ORTHORHOMBIC SPACE GROUP - DATASET C AT 150K | | Descriptor: | ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ... | | Authors: | Colletier, J.P., Bourgeois, D., Fournier, D., Silman, I., Sussman, J.L., Weik, M. | | Deposit date: | 2007-12-09 | | Release date: | 2008-07-22 | | Last modified: | 2019-04-03 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Shoot-and-Trap: Use of Specific X-Ray Damage to Study Structural Protein Dynamics by Temperature-Controlled Cryo-Crystallography.
Proc.Natl.Acad.Sci.USA, 105, 2008
|
|
2VT6 | | NATIVE TORPEDO CALIFORNICA ACETYLCHOLINESTERASE COLLECTED WITH A CUMULATED DOSE OF 9400000 GY | | Descriptor: | ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ... | | Authors: | Colletier, J.P., Bourgeois, D., Sanson, B., Fournier, D., Sussman, J.L., Silman, I., Weik, M. | | Deposit date: | 2008-05-09 | | Release date: | 2008-07-22 | | Last modified: | 2019-05-08 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Shoot-and-Trap: Use of Specific X-Ray Damage to Study Structural Protein Dynamics by Temperature-Controlled Cryo-Crystallography.
Proc.Natl.Acad.Sci.USA, 105, 2008
|
|
2VT7 | | NATIVE TORPEDO CALIFORNICA ACETYLCHOLINESTERASE COLLECTED WITH A CUMULATED DOSE OF 800000 GY | | Descriptor: | ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ... | | Authors: | Colletier, J.P., Bourgeois, D., Sanson, B., Fournier, D., Sussman, J.L., Silman, I., Weik, M. | | Deposit date: | 2008-05-09 | | Release date: | 2008-07-22 | | Last modified: | 2019-05-08 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Shoot-and-Trap: Use of Specific X-Ray Damage to Study Structural Protein Dynamics by Temperature-Controlled Cryo-Crystallography.
Proc.Natl.Acad.Sci.USA, 105, 2008
|
|
3ZZN | | 5-MUTANT (R79W, R151A, E279A, E299A,E313A) LACTATE-DEHYDROGENASE FROM THERMUS THERMOPHILLUS | | Descriptor: | LACTATE DEHYDROGENASE, ADENOSINE-5'-DIPHOSPHATE | | Authors: | Colletier, J.P., Mraihi, S., Madern, D. | | Deposit date: | 2011-09-02 | | Release date: | 2012-02-08 | | Last modified: | 2019-05-29 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Sampling the conformational energy landscape of a hyperthermophilic protein by engineering key substitutions.
Mol. Biol. Evol., 29, 2012
|
|
2CEK | | CONFORMATIONAL FLEXIBILITY IN THE PERIPHERAL SITE OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE REVEALED BY THE COMPLEX STRUCTURE WITH A BIFUNCTIONAL INHIBITOR | | Descriptor: | ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, N-[8-(1,2,3,4-TETRAHYDROACRIDIN-9-YLTHIO)OCTYL]-1,2,3,4-TETRAHYDROACRIDIN-9-AMINE, ... | | Authors: | Sanson, B., Colletier, J.P., Nachon, F., Gabellieri, E., Fattorusso, C., Campiani, G., Weik, M. | | Deposit date: | 2006-02-08 | | Release date: | 2006-04-10 | | Last modified: | 2019-05-08 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Conformational flexibility in the peripheral site of Torpedo californica acetylcholinesterase revealed by the complex structure with a bifunctional inhibitor.
J. Am. Chem. Soc., 128, 2006
|
|
5N9I | |
5NXR | |
5NXU | |
4D64 | |
4D65 | |
2WFZ | | NON-AGED CONJUGATE OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE WITH SOMAN | | Descriptor: | ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ... | | Authors: | Sanson, B., Nachon, F., Colletier, J.P., Froment, M.T., Toker, L., Greenblatt, H.M., Sussman, J.L., Ashani, Y., Masson, P., Silman, I., Weik, M. | | Deposit date: | 2009-04-15 | | Release date: | 2009-08-11 | | Last modified: | 2019-04-03 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystallographic Snapshots of Nonaged and Aged Conjugates of Soman with Acetylcholinesterase, and of a Ternary Complex of the Aged Conjugate with Pralidoxime.
J.Med.Chem., 52, 2009
|
|
2WG0 | | AGED CONJUGATE OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE WITH SOMAN (OBTAINED BY IN CRYSTALLO AGING) | | Descriptor: | ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ... | | Authors: | Sanson, B., Nachon, F., Colletier, J.P., Froment, M.T., Toker, L., Greenblatt, H.M., Sussman, J.L., Ashani, Y., Masson, P., Silman, I., Weik, M. | | Deposit date: | 2009-04-15 | | Release date: | 2009-08-11 | | Last modified: | 2019-04-03 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystallographic Snapshots of Nonaged and Aged Conjugates of Soman with Acetylcholinesterase, and of a Ternary Complex of the Aged Conjugate with Pralidoxime.
J.Med.Chem., 52, 2009
|
|
2WG1 | | TERNARY COMPLEX OF THE AGED CONJUGATE OF TORPEDO CALIFORNICA ACEYLCHOLINESTERASE WITH SOMAN AND 2-PAM | | Descriptor: | ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ... | | Authors: | Sanson, B., Nachon, F., Colletier, J.P., Froment, M.T., Toker, L., Greenblatt, H.M., Sussman, J.L., Ashani, Y., Masson, P., Silman, I., Weik, M. | | Deposit date: | 2009-04-15 | | Release date: | 2009-08-11 | | Last modified: | 2019-04-03 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystallographic Snapshots of Nonaged and Aged Conjugates of Soman with Acetylcholinesterase, and of a Ternary Complex of the Aged Conjugate with Pralidoxime.
J.Med.Chem., 52, 2009
|
|
2WG2 | | NON-AGED CONJUGATE OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE WITH SOMAN (ALTERNATIVE REFINEMENT) | | Descriptor: | ACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ... | | Authors: | Sanson, B., Nachon, F., Colletier, J.P., Froment, M.T., Toker, L., Greenblatt, H.M., Sussman, J.L., Ashani, Y., Masson, P., Silman, I., Weik, M. | | Deposit date: | 2009-04-15 | | Release date: | 2010-04-21 | | Last modified: | 2019-04-03 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystallographic Snapshots of Nonaged and Aged Conjugates of Soman with Acetylcholinesterase, and of a Ternary Complex of the Aged Conjugate with Pralidoxime.
J.Med.Chem., 52, 2009
|
|
2X8B | | CRYSTAL STRUCTURE OF HUMAN ACETYLCHOLINESTERASE INHIBITED BY AGED TABUN AND COMPLEXED WITH FASCICULIN-II | | Descriptor: | ACETHYLCHOLINESTERASE, FASCICULIN-2, CHLORIDE ION, ... | | Authors: | Carletti, E., Colletier, J.P., Nachon, F. | | Deposit date: | 2010-03-08 | | Release date: | 2010-04-28 | | Last modified: | 2018-02-28 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation.
J. Med. Chem., 53, 2010
|
|
2XI4 | | TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH AFLATOXIN B1 (ORTHORHOMBIC SPACE GROUP) | | Descriptor: | ACETYLCHOLINESTERASE, AFLATOXIN B1, CHLORIDE ION, ... | | Authors: | Sanson, B., Colletier, J.P., Xu, Y., Lang, P.T., Jiang, H., Silman, I., Sussman, J.L., Weik, M. | | Deposit date: | 2010-06-28 | | Release date: | 2011-03-23 | | Last modified: | 2019-04-03 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Backdoor Opening Mechanism in Acetylcholinesterase Based on X-Ray Crystallography and Molecular Dynamics Simulations.
Protein Sci., 20, 2011
|
|
2Y1K | | STRUCTURE OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY CBDP (12H SOAK): PHOSPHOSERINE ADDUCT | | Descriptor: | CHOLINESTERASE, SULFATE ION, SODIUM ION, ... | | Authors: | Carletti, E., Colletier, J.P., Nachon, F., Weik, M. | | Deposit date: | 2010-12-08 | | Release date: | 2011-06-29 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Reaction of Cresyl Saligenin Phosphate, the Organophosphorus Agent Implicated in Aerotoxic Syndrome, with Human Cholinesterases: Mechanistic Studies Employing Kinetics, Mass Spectrometry, and X-Ray Structure Analysis.
Chem.Res.Toxicol., 24, 2011
|
|
4TPK | | HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH N-((1-(2,3-DIHYDRO-1H-INDEN-2-YL)PIPERIDIN-3-YL)METHYL)-N-(2-METHOXYETHYL)-2-NAPHTHAMIDE | | Descriptor: | Cholinesterase, N-ACETYL-D-GLUCOSAMINE, BETA-L-FUCOSE, ... | | Authors: | Coquelle, N., Brus, B., Colletier, J.P., Gobec, S. | | Deposit date: | 2014-06-07 | | Release date: | 2014-10-22 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.
J.Med.Chem., 57, 2014
|
|
