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6E6Z
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STRUCTURE OF WILD TYPE HUMAN TRANSTHYRETIN IN COMPLEX WITH TAFAMIDIS
Descriptor:Transthyretin, 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid
Authors:Chung, K., Saelices, L., Sawaya, M.R., Cascio, D., Eisenberg, D.
Deposit date:2018-07-25
Release date:2019-07-31
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Variants of Transthyretin
To Be Published
6E70
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STRUCTURE OF WILD TYPE HUMAN TRANSTHYRETIN IN COMPLEX WITH DIFLUNISAL
Descriptor:Transthyretin, 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, CALCIUM ION
Authors:Chung, K., Saelices, L., Sawaya, M.R., Cascio, D., Eisenberg, D.
Deposit date:2018-07-25
Release date:2019-07-31
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.992 Å)
Cite:Structural Variants of Transthyretin
To Be Published
6E72
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STRUCTURE OF HUMAN TRANSTHYRETIN VAL30MET MUTANT IN COMPLEX WITH TAFAMIDIS
Descriptor:Transthyretin, 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid
Authors:Chung, K., Saelices, L., Sawaya, M.R., Cascio, D., Eisenberg, D.
Deposit date:2018-07-25
Release date:2019-07-31
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural Variants of Transthyretin
To Be Published
6E73
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STRUCTURE OF HUMAN TRANSTHYRETIN VAL30MET MUTANT IN COMPLEX WITH DIFLUNISAL
Descriptor:Transthyretin, 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, ACETATE ION
Authors:Chung, K., Saelices, L., Sawaya, M.R., Cascio, D., Eisenberg, D.S.
Deposit date:2018-07-25
Release date:2019-07-31
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.797 Å)
Cite:Structural Variants of Transthyretin
to be published
6E75
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STRUCTURE OF HUMAN TRANSTHYRETIN ASP38ALA MUTANT
Descriptor:Transthyretin, ACETATE ION
Authors:Chung, K., Saelices, L., Sawaya, M.R., Cascio, D., Eisenberg, D.
Deposit date:2018-07-25
Release date:2019-07-31
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Variants of Transthyretin
To Be Published
6E78
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STRUCTURE OF HUMAN TRANSTHYRETIN ASP38ALA MUTANT IN COMPLEX WITH DIFLUNISAL
Descriptor:Transthyretin, 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID
Authors:Chung, K., Saelices, L., Sawaya, M.R., Cascio, D., Eisenberg, D.
Deposit date:2018-07-25
Release date:2019-07-31
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.499 Å)
Cite:Structural Variants of Transthyretin
To Be Published
4AUA
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LIGANDED X-RAY CRYSTAL STRUCTURE OF CYCLIN DEPENDENT KINASE 6 (CDK6)
Descriptor:CYCLIN-DEPENDENT KINASE 6, 1H-benzimidazol-2-yl(1H-pyrrol-2-yl)methanone
Authors:Cho, Y.S., Angove, H., Brain, C., Chen, C.H.T., Cheng, R., Chopra, R., Chung, K., Congreve, M., Dagostin, C., Davis, D., Feltell, R., Giraldes, J., Hiscock, S., Kim, S., Kovats, S., Lagu, B., Lewry, K., Loo, A., Lu, Y., Luzzio, M., Maniara, W., Mcmenamin, R., Mortenson, P., Benning, R., O'Reilly, M., Rees, D., Shen, J., Smith, T., Wang, Y., Williams, G., Woolford, A., Wrona, W., Xu, M., Yang, F., Howard, S.
Deposit date:2012-05-15
Release date:2013-02-06
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors.
ACS Med Chem Lett, 3, 2012
6E71
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STRUCTURE OF HUMAN TRANSTHYRETIN VAL30MET/THR119MET MUTANT
Descriptor:Transthyretin, DI(HYDROXYETHYL)ETHER
Authors:Saelices, L., Chung, K., Sawaya, M.R., Cascio, D., Eisenberg, D.
Deposit date:2018-07-25
Release date:2019-07-31
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Variants of Transthyretin
To Be Published
6E74
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STRUCTURE OF HUMAN TRANSTHYRETIN LEU55PRO MUTANT IN COMPLEX WITH TAFAMIDIS
Descriptor:Transthyretin, 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid
Authors:Saelices, L., Chung, K., Sawaya, M.R., Cascio, D., Eisenberg, D.
Deposit date:2018-07-25
Release date:2019-07-31
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Variants of Transthyretin
To Be Published
6E76
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STRUCTURE OF HUMAN TRANSTHYRETIN ASP38ALA/THR119MET MUTANT
Descriptor:Transthyretin, GLYCEROL, SULFATE ION, ...
Authors:Saelices, L., Chung, K., Sawaya, M.R., Cascio, D., Eisenberg, D.
Deposit date:2018-07-25
Release date:2019-07-31
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Variants of Transthyretin
To Be Published
6E77
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STRUCTURE OF HUMAN TRANSTHYRETIN ASP38ALA MUTANT IN COMPLEX WITH TAFAMIDIS
Descriptor:Transthyretin, 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid
Authors:Saelices, L., Chung, K., Sawaya, M.R., Cascio, D., Eisenberg, D.
Deposit date:2018-07-25
Release date:2019-07-31
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Variants of Transthyretin
To Be Published
4EZ5
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CDK6 (MONOMERIC) IN COMPLEX WITH INHIBITOR
Descriptor:Cyclin-dependent kinase 6, {5-[4-(dimethylamino)piperidin-1-yl]-1H-imidazo[4,5-b]pyridin-2-yl}[2-(isoquinolin-4-yl)pyridin-4-yl]methanone
Authors:Chopra, R., Xu, M.
Deposit date:2012-05-02
Release date:2013-02-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors.
ACS Med Chem Lett, 3, 2012
1L3X
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SOLUTION STRUCTURE OF NOVEL DISINTEGRIN SALMOSIN
Descriptor:platelet aggregation inhibitor disintegrin
Authors:Shin, J., Lee, W.
Deposit date:2002-03-01
Release date:2003-12-23
Last modified:2012-11-21
Method:SOLUTION NMR
Cite:Solution structure of a novel disintegrin, salmosin, from Agkistrondon halys venom
Biochemistry, 42, 2003
3NUP
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CDK6 (MONOMERIC) IN COMPLEX WITH INHIBITOR
Descriptor:Cell division protein kinase 6, 4-[3-(1-methylethyl)-1H-pyrazol-4-yl]-N-(1-methylpiperidin-4-yl)pyrimidin-2-amine
Authors:Chopra, R.
Deposit date:2010-07-07
Release date:2010-12-22
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6.
J.Med.Chem., 53, 2010
3NUX
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CDK6 (MONOMERIC) IN COMPLEX WITH INHIBITOR
Descriptor:Cell division protein kinase 6, 4-[5-chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-(5-piperazin-1-ylpyridin-2-yl)pyrimidin-2-amine
Authors:Chopra, R.
Deposit date:2010-07-07
Release date:2010-12-22
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6.
J.Med.Chem., 53, 2010