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2O5K
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CRYSTAL STRUCTURE OF GSK3BETA IN COMPLEX WITH A BENZOIMIDAZOL INHIBITOR
Descriptor:Glycogen synthase kinase-3 beta, 2-(2,4-DICHLORO-PHENYL)-7-HYDROXY-1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID [2-(4-METHANESULFONYLAMINO-PHENYL)-ETHYL]-AMIDE
Authors:Shin, D., Lee, S.C., Heo, Y.S., Cho, Y.S., Kim, Y.E., Hyun, Y.L., Cho, J.M., Lee, Y.S., Ro, S.
Deposit date:2006-12-06
Release date:2007-10-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Design and synthesis of 7-hydroxy-1H-benzoimidazole derivatives as novel inhibitors of glycogen synthase kinase-3beta
Bioorg.Med.Chem.Lett., 17, 2007
1UDT
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 5 COMPLEXED WITH SILDENAFIL(VIAGRA)
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Sung, B.-J., Lee, J.I., Heo, Y.-S., Kim, J.H., Moon, J., Yoon, J.M., Hyun, Y.-L., Kim, E., Eum, S.J., Lee, T.G., Cho, J.M., Park, S.-Y., Lee, J.-O., Jeon, Y.H., Hwang, K.Y., Ro, S.
Deposit date:2003-05-06
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules
Nature, 425, 2003
1UDU
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 5 COMPLEXED WITH TADALAFIL(CIALIS)
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Sung, B.-J., Lee, J.I., Heo, Y.-S., Kim, J.H., Moon, J., Yoon, J.M., Hyun, Y.-L., Kim, E., Eum, S.J., Lee, T.G., Cho, J.M., Park, S.-Y., Lee, J.-O., Jeon, Y.H., Hwang, K.Y., Ro, S.
Deposit date:2003-05-06
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules
Nature, 425, 2003
1UHO
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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 5 COMPLEXED WITH VARDENAFIL(LEVITRA)
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Sung, B.-J., Lee, J.I., Heo, Y.-S., Kim, J.H., Moon, J., Yoon, J.M., Hyun, Y.-L., Kim, E., Eum, S.J., Lee, T.G., Cho, J.M., Park, S.-Y., Lee, J.-O., Jeon, Y.H., Hwang, K.Y., Ro, S.
Deposit date:2003-07-09
Release date:2004-07-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules
Nature, 425, 2003
1UKH
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STRUCTURAL BASIS FOR THE SELECTIVE INHIBITION OF JNK1 BY THE SCAFFOLDING PROTEIN JIP1 AND SP600125
Descriptor:Mitogen-activated protein kinase 8 isoform 4, 11-mer peptide from C-jun-amino-terminal kinase interacting protein 1
Authors:Heo, Y.-S., Kim, Y.K., Sung, B.-J., Lee, H.S., Lee, J.I., Seo, C.I., Park, S.-Y., Kim, J.H., Hyun, Y.-L., Jeon, Y.H., Ro, S., Lee, T.G., Cho, J.M., Hwang, K.Y., Yang, C.-H.
Deposit date:2003-08-23
Release date:2004-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
Embo J., 23, 2004
1UKI
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STRUCTURAL BASIS FOR THE SELECTIVE INHIBITION OF JNK1 BY THE SCAFFOLDING PROTEIN JIP1 AND SP600125
Descriptor:mitogen-activated protein kinase 8 isoform 4, 11-mer peptide from C-jun-amino-terminal kinase interacting protein 1, 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE
Authors:Heo, Y.-S., Kim, Y.K., Sung, B.-J., Lee, H.S., Lee, J.I., Seo, C.I., Park, S.-Y., Kim, J.H., Hyun, Y.-L., Jeon, Y.H., Ro, S., Lee, T.G., Cho, J.M., Hwang, K.Y., Yang, C.-H.
Deposit date:2003-08-23
Release date:2004-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
Embo J., 23, 2004
1MOL
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TWO CRYSTAL STRUCTURES OF A POTENTLY SWEET PROTEIN: NATURAL MONELLIN AT 2.75 ANGSTROMS RESOLUTION AND SINGLE-CHAIN MONELLIN AT 1.7 ANGSTROMS RESOLUTION
Descriptor:MONELLIN
Authors:Somoza, J.R., Kim, S.-H.
Deposit date:1993-04-27
Release date:1994-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Two crystal structures of a potently sweet protein. Natural monellin at 2.75 A resolution and single-chain monellin at 1.7 A resolution.
J.Mol.Biol., 234, 1993
2HJW
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CRYSTAL STRUCTURE OF THE BC DOMAIN OF ACC2
Descriptor:Acetyl-CoA carboxylase 2
Authors:Cho, Y.S., Lee, J.I., Shin, D., Kim, H.T., Lee, T.G., Heo, Y.S.
Deposit date:2006-07-02
Release date:2007-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the biotin carboxylase domain of human acetyl-CoA carboxylase 2.
Proteins, 70, 2008
1FUW
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SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF A DOUBLE MUTANT SINGLE-CHAIN MONELLIN(SCM) DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Descriptor:MONELLIN
Authors:Sung, Y.H., Shin, J., Jung, J., Lee, W.
Deposit date:2000-09-18
Release date:2001-06-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure, backbone dynamics, and stability of a double mutant single-chain monellin. structural origin of sweetness.
J.Biol.Chem., 276, 2001
1L8L
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MOLECULAR BASIS FOR THE LOCAL CONFOMATIONAL REARRANGEMENT OF HUMAN PHOSPHOSERINE PHOSPHATASE
Descriptor:L-3-phosphoserine phosphatase, D-2-AMINO-3-PHOSPHONO-PROPIONIC ACID
Authors:Kim, H.Y., Heo, Y.S., Kim, J.H., Park, M.H., Moon, J., Park, S.Y., Lee, T.G., Jeon, Y.H., Ro, S., Hwang, K.Y.
Deposit date:2002-03-21
Release date:2003-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase.
J.Biol.Chem., 277, 2002
1L8O
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MOLECULAR BASIS FOR THE LOCAL CONFORMATIONAL REARRANGEMENT OF HUMAN PHOSPHOSERINE PHOSPHATASE
Descriptor:L-3-phosphoserine phosphatase, PHOSPHATE ION, SERINE
Authors:Kim, H.Y., Heo, Y.S., Kim, J.H., Park, M.H., Moon, J., Park, S.Y., Lee, T.G., Jeon, Y.H., Ro, S., Hwang, K.Y.
Deposit date:2002-03-21
Release date:2003-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase
J.Biol.Chem., 277, 2002
1MNL
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HIGH-RESOLUTION SOLUTION STRUCTURE OF A SWEET PROTEIN SINGLE-CHAIN MONELLIN (SCM) DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND DYNAMICAL SIMULATED ANNEALING CALCULATIONS, 21 STRUCTURES
Descriptor:MONELLIN
Authors:Lee, S.-Y., Lee, J.-H., Chang, H.-J., Jo, J.-M., Jung, J.-W., Lee, W.
Deposit date:1998-08-06
Release date:1999-06-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a sweet protein single-chain monellin determined by nuclear magnetic resonance and dynamical simulated annealing calculations.
Biochemistry, 38, 1999
1V3A
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STRUCTURE OF HUMAN PRL-3, THE PHOSPHATASE ASSOCIATED WITH CANCER METASTASIS
Descriptor:protein tyrosine phosphatase type IVA
Authors:Jeon, Y.H., Cheong, C.
Deposit date:2003-10-30
Release date:2004-10-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of human PRL-3, the phosphatase associated with cancer metastasis
Febs Lett., 565, 2004
3PJD
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STRUCTURE OF ENR G93A MUTANT-NAD+-TRICLOSAN COMPLEX
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN
Authors:Kim, H.T., Shin, D.G., Chang, H.J.
Deposit date:2010-11-10
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of triclosan resistance
J.Struct.Biol., 174, 2011
3PJE
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STRUCTURE OF ENR G93S MUTANT-NAD+-TRICLOSAN COMPLEX
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN
Authors:Kim, H.T., Shin, D.G., Chang, H.J.
Deposit date:2010-11-10
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of triclosan resistance
J.Struct.Biol., 174, 2011
3PJF
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STRUCTURE OF ENR G93V MUTANT-NAD+-TRICLOSAN COMPLEX
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN
Authors:Kim, H.T., Shin, D.G., Chang, H.J.
Deposit date:2010-11-10
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of triclosan resistance
J.Struct.Biol., 174, 2011
5X68
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CRYSTAL STRUCTURE OF HUMAN KMO
Descriptor:Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Kim, H.T., Hwang, K.Y.
Deposit date:2017-02-21
Release date:2018-02-21
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase
Cell Chem Biol, 25, 2018
5X6P
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CRYSTAL STRUCTURE OF PSEUDOMONAS FLUORESCENS KMO
Descriptor:Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Kim, H.T., Hwang, K.Y.
Deposit date:2017-02-22
Release date:2018-02-21
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase
Cell Chem Biol, 25, 2018
5X6Q
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CRYSTAL STRUCTURE OF PSEUDOMONAS FLUORESCENS KMO IN COMPLEX WITH RO 61-8048
Descriptor:Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
Authors:Kim, H.T., Hwang, K.Y.
Deposit date:2017-02-23
Release date:2018-02-21
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (1.897 Å)
Cite:Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase
Cell Chem Biol, 25, 2018
5X6R
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CRYSTAL STRUCTURE OF SACCHAROMYCES CEREVISIAE KMO IN COMPLEX WITH RO 61-8048
Descriptor:Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
Authors:Kim, H.T., Hwang, K.Y.
Deposit date:2017-02-23
Release date:2018-02-21
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (1.911 Å)
Cite:Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase
Cell Chem Biol, 25, 2018