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3MHU
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CRYSTAL STRUCTURE OF DIHYDROOROTATE DEHYDROGENASE FROM LEISHMANIA MAJOR IN COMPLEX WITH 5-NITROOROTIC ACID
Descriptor:Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, 5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, ...
Authors:Pinheiro, M.P., Rocha, J.R., Cheleski, J., Montanari, C.A., Nonato, M.C.
Deposit date:2010-04-08
Release date:2011-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery.
Eur.J.Med.Chem., 45, 2010
3MJY
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CRYSTAL STRUCTURE OF DIHYDROOROTATE DEHYDROGENASE FROM LEISHMANIA MAJOR IN COMPLEX WITH 5-AMINOOROTIC ACID
Descriptor:Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, 5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, ...
Authors:Pinheiro, M.P., Rocha, J.R., Cheleski, J., Montanari, C.A., Nonato, M.C.
Deposit date:2010-04-13
Release date:2011-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery.
Eur.J.Med.Chem., 45, 2010
5E8C
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PSEUDORABIES VIRUS NUCLEAR EGRESS COMPLEX, PUL31, PUL34
Descriptor:UL31, UL34 protein, ZINC ION, ...
Authors:Zeev-Ben-Mordehai, T., Cheleski, J., Whittle, C., El Omari, K., Harlos, K., Hagen, C., Klupp, B., Mettenleiter, T.C., Gruenewald, K.
Deposit date:2015-10-14
Release date:2015-12-23
Last modified:2016-01-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of the Herpesvirus Nuclear Egress Complex Provides Insights into Inner Nuclear Membrane Remodeling.
Cell Rep, 13, 2015
5E93
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CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH NEQ0071
Descriptor:Dihydroorotate dehydrogenase (fumarate), 5-[(E)-3-(furan-2-yl)prop-2-enylidene]-1,3-diazinane-2,4,6-trione, GLYCEROL, ...
Authors:Rocha, J.R., Inaoka, D.K., Cheleski, J., Shiba, T., Harada, S., Montanari, C.A., Kita, K.
Deposit date:2015-10-14
Release date:2016-10-19
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Exploring Trypanosoma cruzi Dihydroorotate Dehydrogenase Active Site Plasticity for the Discovery of Potent and Selective Inhibitors with Trypanocidal Activity
To be Published
5EA9
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CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH NEQ0130
Descriptor:Dihydroorotate dehydrogenase (fumarate), 5-[(E)-3-thiophen-2-ylprop-2-enylidene]-1,3-diazinane-2,4,6-trione, GLYCEROL, ...
Authors:Rocha, J.R., Inaoka, D.K., Cheleski, J., Shiba, T., Harada, S., Montanari, C.A., Kita, K.
Deposit date:2015-10-15
Release date:2016-10-19
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Exploring Trypanosoma cruzi Dihydroorotate Dehydrogenase Active Site Plasticity for the Discovery of Potent and Selective Inhibitors with Trypanocidal Activity
To be Published
3VCO
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SCHISTOSOMA MANSONI DIHYDROFOLATE REDUCTASE
Descriptor:Dihydrofolate reductase, SULFATE ION
Authors:Serrao, V.H.B., Romanello, L., Cassago, A., DeMarco, R., Pereira, H.M.
Deposit date:2012-01-04
Release date:2013-03-06
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (1.946 Å)
Cite:Structure and kinetics assays of recombinant Schistosoma mansoni dihydrofolate reductase.
Acta Trop., 170, 2017
4KLB
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CRYSTAL STRUCTURE OF CRUZAIN IN COMPLEX WITH THE NON-COVALENT INHIBITOR NEQUIMED176
Descriptor:Cruzipain, 2-{[(1H-1,2,4-triazol-5-ylsulfanyl)acetyl]amino}thiophene-3-carboxamide
Authors:Fernandes, W.B., Montanari, C.A., Mckerrow, J.H.
Deposit date:2013-05-07
Release date:2013-09-18
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Non-peptidic Cruzain Inhibitors with Trypanocidal Activity Discovered by Virtual Screening and In Vitro Assay.
Plos Negl Trop Dis, 7, 2013
5FKI
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PSEUDORABIES VIRUS (PRV) NUCLEAR EGRESS COMPLEX PROTEINS FITTED AS A HEXAMERIC LATTICE INTO A SUB-TOMOGRAM AVERAGE DERIVED FROM FOCUSED- ION BEAM MILLED LAMELLAE ELECTRON CRYO-MICROSCOPIC DATA
Descriptor:UL31, UL34 protein, ZINC ION, ...
Authors:Hagen, C., Dent, K.C., Zeev Ben Mordehai, T., Vasishtan, D., Antonin, W., Mettenleiter, T.C., Gruenewald, K.
Deposit date:2015-10-16
Release date:2016-03-16
Last modified:2018-11-21
Method:ELECTRON MICROSCOPY (35 Å)
Cite:Crystal Structure of the Herpesvirus Nuclear Egress Complex Provides Insights Into Inner Nuclear Membrane Remodelling
Cell Rep., 13, 2015