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3V3M
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BU of 3v3m by Molmil
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease in Complex with N-[(1R)-2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-N-(4-tert-butylphenyl)furan-2-carboxamide inhibitor.
Descriptor: 3C-like proteinase, DIMETHYL SULFOXIDE, N-[(1R)-2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-N-(4-tert-butylphenyl)furan-2-carboxamide
Authors:Jacobs, J, Grum-Tokars, V, Zhou, Y, Turlington, M, Saldanha, S.A, Chase, P, Eggler, A, Dawson, E.S, Baez-Santos, Y.M, Tomar, S, Mielech, A.M, Baker, S.C, Lindsley, C.W, Hodder, P, Mesecar, A, Stauffer, S.R.
Deposit date:2011-12-13
Release date:2013-01-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease.
J.Med.Chem., 56, 2013
7EOD
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BU of 7eod by Molmil
MITF HLHLZ Delta AKE
Descriptor: GLYCEROL, Isoform M1 of Microphthalmia-associated transcription factor
Authors:Li, P, Liu, Z, Fang, P, Wang, J.
Deposit date:2021-04-22
Release date:2022-04-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy.
Cell Res., 33, 2023
7D8T
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BU of 7d8t by Molmil
MITF bHLHLZ complex with M-box DNA
Descriptor: DNA (5'-D(*TP*GP*TP*AP*AP*CP*AP*TP*GP*TP*GP*TP*CP*CP*CP*C)-3'), DNA (5'-D(P*GP*GP*GP*AP*CP*AP*CP*AP*TP*GP*TP*TP*AP*CP*AP*G)-3'), Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit
Authors:Guo, M, Fang, P, Wang, J.
Deposit date:2020-10-09
Release date:2021-10-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.201 Å)
Cite:A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy.
Cell Res., 33, 2023
7D8R
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BU of 7d8r by Molmil
MITF HLHLZ structure
Descriptor: Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit
Authors:Guo, M, Fang, P, Wang, J.
Deposit date:2020-10-09
Release date:2021-10-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy.
Cell Res., 33, 2023
7D8S
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BU of 7d8s by Molmil
MITF bHLHLZ apo structure
Descriptor: Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit, SULFATE ION
Authors:Guo, M, Fang, P, Wang, J.
Deposit date:2020-10-09
Release date:2021-10-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy.
Cell Res., 33, 2023
4MDS
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BU of 4mds by Molmil
Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: identification of ML300 and non-covalent nanomolar inhibitors with an induced-fit binding
Descriptor: 3C-like proteinase, DIMETHYL SULFOXIDE, N-[4-(acetylamino)phenyl]-2-(1H-benzotriazol-1-yl)-N-[(1R)-2-[(2-methylbutan-2-yl)amino]-1-(1-methyl-1H-pyrrol-2-yl)-2-oxoethyl]acetamide
Authors:Mesecar, A.D, Grum-Tokars, V.
Deposit date:2013-08-23
Release date:2013-10-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.598 Å)
Cite:Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding.
Bioorg.Med.Chem.Lett., 23, 2013
8UWY
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BU of 8uwy by Molmil
The structure of the native cardiac thin filament troponin core in Ca2+-free rotated state from the upper strand
Descriptor: Actin, alpha cardiac muscle 1, Tropomyosin alpha-1 chain, ...
Authors:Galkin, V.E, Risi, C.M.
Deposit date:2023-11-08
Release date:2024-03-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Troponin Structural Dynamics in the Native Cardiac Thin Filament Revealed by Cryo Electron Microscopy.
J.Mol.Biol., 436, 2024
8UZX
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BU of 8uzx by Molmil
The structure of the native cardiac thin filament troponin core in Ca2+-bound fully activated state from the upper strand
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ...
Authors:Galkin, V.E, Risi, C.M.
Deposit date:2023-11-16
Release date:2024-03-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.4 Å)
Cite:Troponin Structural Dynamics in the Native Cardiac Thin Filament Revealed by Cryo Electron Microscopy.
J.Mol.Biol., 436, 2024
8UZY
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BU of 8uzy by Molmil
The structure of the native cardiac thin filament troponin core in Ca2+-bound partially activated state from the upper strand
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ...
Authors:Galkin, V.E, Risi, C.M.
Deposit date:2023-11-16
Release date:2024-03-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.3 Å)
Cite:Troponin Structural Dynamics in the Native Cardiac Thin Filament Revealed by Cryo Electron Microscopy.
J.Mol.Biol., 436, 2024
8UWW
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BU of 8uww by Molmil
The structure of the native cardiac thin filament troponin core in Ca2+-free state from the upper strand
Descriptor: Actin, alpha cardiac muscle 1, Tropomyosin alpha-1 chain, ...
Authors:Galkin, V.E, Risi, C.M.
Deposit date:2023-11-08
Release date:2024-03-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.1 Å)
Cite:Troponin Structural Dynamics in the Native Cardiac Thin Filament Revealed by Cryo Electron Microscopy.
J.Mol.Biol., 436, 2024
8V01
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BU of 8v01 by Molmil
The structure of the native cardiac thin filament troponin core in Ca2+-bound fully activated state 1 from the lower strand
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ...
Authors:Galkin, V.E, Risi, C.M.
Deposit date:2023-11-16
Release date:2024-03-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Troponin Structural Dynamics in the Native Cardiac Thin Filament Revealed by Cryo Electron Microscopy.
J.Mol.Biol., 436, 2024
8UZ6
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BU of 8uz6 by Molmil
The structure of the native cardiac thin filament troponin core in Ca2+-free tilted state from the lower strand
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ...
Authors:Galkin, V.E, Risi, C.M.
Deposit date:2023-11-14
Release date:2024-03-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:Troponin Structural Dynamics in the Native Cardiac Thin Filament Revealed by Cryo Electron Microscopy.
J.Mol.Biol., 436, 2024
8UWX
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BU of 8uwx by Molmil
The structure of the native cardiac thin filament troponin core in Ca2+-free tilted state from the upper strand
Descriptor: Actin, alpha cardiac muscle 1, Tropomyosin alpha-1 chain, ...
Authors:Galkin, V.E, Risi, C.M.
Deposit date:2023-11-08
Release date:2024-03-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (6 Å)
Cite:Troponin Structural Dynamics in the Native Cardiac Thin Filament Revealed by Cryo Electron Microscopy.
J.Mol.Biol., 436, 2024
8V0I
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BU of 8v0i by Molmil
The structure of the native cardiac thin filament troponin core in Ca2+-bound fully activated state 2 from the lower strand
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ...
Authors:Galkin, V.E, Risi, C.M.
Deposit date:2023-11-17
Release date:2024-03-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Troponin Structural Dynamics in the Native Cardiac Thin Filament Revealed by Cryo Electron Microscopy.
J.Mol.Biol., 436, 2024
8UZ5
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BU of 8uz5 by Molmil
The structure of the native cardiac thin filament troponin core in Ca2+-free rotated state from the lower strand
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ...
Authors:Galkin, V.E, Risi, C.M.
Deposit date:2023-11-14
Release date:2024-03-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:Troponin Structural Dynamics in the Native Cardiac Thin Filament Revealed by Cryo Electron Microscopy.
J.Mol.Biol., 436, 2024
8V0Y
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BU of 8v0y by Molmil
The structure of the native cardiac thin filament troponin core in Ca2+-free state from the upper strand activated by the C1-domain of cardiac myosin binding protein C
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ...
Authors:Galkin, V.E, Risi, C.M.
Deposit date:2023-11-17
Release date:2024-03-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Troponin Structural Dynamics in the Native Cardiac Thin Filament Revealed by Cryo Electron Microscopy.
J.Mol.Biol., 436, 2024
8UYD
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BU of 8uyd by Molmil
The structure of the native cardiac thin filament troponin core in Ca2+-free state from the lower strand
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ...
Authors:Galkin, V.E, Risi, C.M.
Deposit date:2023-11-13
Release date:2024-03-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.3 Å)
Cite:Troponin Structural Dynamics in the Native Cardiac Thin Filament Revealed by Cryo Electron Microscopy.
J.Mol.Biol., 436, 2024
8V0K
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BU of 8v0k by Molmil
The structure of the native cardiac thin filament troponin core in Ca2+-bound partially activated state from the lower strand
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ...
Authors:Galkin, V.E, Risi, C.M.
Deposit date:2023-11-17
Release date:2024-03-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.2 Å)
Cite:Troponin Structural Dynamics in the Native Cardiac Thin Filament Revealed by Cryo Electron Microscopy.
J.Mol.Biol., 436, 2024

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