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4UYP
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HIGH RESOLUTION STRUCTURE OF THE THIRD COHESIN SCAC IN COMPLEX WITH THE SCAB DOCKERIN WITH A MUTATION IN THE N-TERMINAL HELIX (IN TO SI) FROM ACETIVIBRIO CELLULOLYTICUS DISPLAYING A TYPE I INTERACTION.
Descriptor:Cellulosomal scaffoldin anchoring protein C, Cellulosomal scaffoldin adaptor protein B, SULFATE ION, ...
Authors:Cameron, K., Alves, V.D., Bule, P., Ferreira, L.M.A., Fontes, C.M.G.A., Najmudin, S.
Deposit date:2014-09-02
Release date:2015-04-15
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Cell-surface Attachment of Bacterial Multienzyme Complexes Involves Highly Dynamic Protein-Protein Anchors.
J. Biol. Chem., 290, 2015
4UYQ
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HIGH RESOLUTION STRUCTURE OF THE THIRD COHESIN SCAC IN COMPLEX WITH THE SCAB DOCKERIN WITH A MUTATION IN THE C-TERMINAL HELIX (IN TO SI) FROM ACETIVIBRIO CELLULOLYTICUS DISPLAYING A TYPE I INTERACTION.
Descriptor:Cellulosomal scaffoldin anchoring protein C, Cellulosomal scaffoldin adaptor protein B, CALCIUM ION
Authors:Cameron, K., Fontes, C.M.G.A., Najmudin, S.
Deposit date:2014-09-02
Release date:2015-04-15
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Cell-surface Attachment of Bacterial Multienzyme Complexes Involves Highly Dynamic Protein-Protein Anchors.
J. Biol. Chem., 290, 2015
4UMS
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THE CRYSTAL STRUCTURE OF THE SEVENTH SCAB TYPE I COHESIN FROM PSEUDOBACTEROIDES CELLULOSOLVENS
Descriptor:CELLULOSOMAL ANCHORING SCAFFOLDIN B
Authors:Cameron, K., Alves, V.D., Ferreira, L.M.A., Fontes, C.M.G.A., Najmudin, S.
Deposit date:2014-05-20
Release date:2015-05-06
Last modified:2015-07-08
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Combined Crystal Structure of a Type-I Cohesin, Mutation and Affinity-Binding Studies Reveal Structural Determinants of Cohesin-Dockerin Specificity
J.Biol.Chem., 290, 2015
3ZNI
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STRUCTURE OF PHOSPHOTYR363-CBL-B - UBCH5B-UB - ZAP-70 PEPTIDE COMPLEX
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE CBL-B, TYROSINE-PROTEIN KINASE ZAP-70, UBIQUITIN-CONJUGATING ENZYME E2 D2, ...
Authors:Dou, H., Buetow, L., Sibbet, G.J., Cameron, K., Huang, D.T.
Deposit date:2013-02-14
Release date:2013-07-10
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Essentiality of a Non-Ring Element in Priming Donor Ubiquitin for Catalysis by a Monomeric E3.
Nat.Struct.Mol.Biol., 20, 2013
4AUQ
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STRUCTURE OF BIRC7-UBCH5B-UB COMPLEX.
Descriptor:UBIQUITIN-CONJUGATING ENZYME E2 D2, BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 7, POLYUBIQUITIN-C, ...
Authors:Dou, H., Buetow, L., Sibbet, G.J., Cameron, K., Huang, D.T.
Deposit date:2012-05-21
Release date:2012-08-15
Last modified:2012-09-26
Method:X-RAY DIFFRACTION (2.176 Å)
Cite:Birc7-E2 Ubiquitin Conjugate Structure Reveals the Mechanism of Ubiquitin Transfer by a Ring Dimer.
Nat.Struct.Mol.Biol., 19, 2012
4U3S
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CRYSTAL STRUCTURE OF COH3SCAB-XDOC_M1SCAA COMPLEX: A N-TERMINAL INTERFACE MUTANT OF TYPE II COHESIN-X-DOCKERIN COMPLEX FROM ACETIVIBRIO CELLULOLYTICUS
Descriptor:Cellulosomal scaffoldin adaptor protein B, Cellulosomal scaffoldin, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ...
Authors:Alves, V.D., Cameron, K., Najmudin, S.H., Fontes, C.M.G.A.
Deposit date:2014-07-22
Release date:2015-07-29
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Crystal structure of Coh3ScaB-XDoc_M1ScaA complex: A N-terminal interface mutant of type II Cohesin-X-Dockerin complex from Acetivibrio cellulolyticus
To Be Published
4WI0
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CRYSTAL STRUCTURE OF COH3SCAB-XDOC_M2SCAA COMPLEX: A C-TERMINAL INTERFACE MUTANT OF TYPE II COHESIN-X-DOCKERIN COMPLEX FROM ACETIVIBRIO CELLULOLYTICUS
Descriptor:Cellulosomal scaffoldin adaptor protein B, Cellulosomal scaffoldin, CALCIUM ION
Authors:Alves, V.D., Cameron, K., Najmudin, S.H., Fontes, C.M.G.A.
Deposit date:2014-09-24
Release date:2015-10-07
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Crystal structure of Coh3ScaB-XDoc_M1ScaA complex: A C-terminal interface mutant of type II Cohesin-X-Dockerin complex from Acetivibrio cellulolyticus
To Be Published
5G5D
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CRYSTAL STRUCTURE OF THE COHSCAC2-XDOCCIPA TYPE II COMPLEX FROM CLOSTRIDIUM THERMOCELLUM
Descriptor:CELLULOSOME ANCHORING PROTEIN COHESIN REGION, CELLULOSOMAL-SCAFFOLDING PROTEIN A, CALCIUM ION
Authors:Carvalho, A.L., A Bras, J.L., Najmudin, S.H., Pinheiro, B.A., Fontes, C.M.G.A.
Deposit date:2016-05-23
Release date:2017-04-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:Diverse specificity of cellulosome attachment to the bacterial cell surface.
Sci Rep, 6, 2016
5K39
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THE TYPE II COHESIN DOCKERIN COMPLEX FROM CLOSTRIDIUM THERMOCELLUM
Descriptor:Cellulosome anchoring protein cohesin region, Dockerin module from a protein of unknown function, CALCIUM ION
Authors:Viegas, A., Pinheiro, B., Bras, J.L.A., Romao, M.J., Alves, V., Carvalho, A.L., Fontes, C.M.G.A.
Deposit date:2016-05-19
Release date:2017-03-29
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Diverse specificity of cellulosome attachment to the bacterial cell surface.
Sci Rep, 6, 2016
5M0Y
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CRYSTAL STRUCTURE OF THE COHSCAA-XDOCCIPB TYPE II COMPLEX FROM CLOSTRIDIUM THERMOCELLUM AT 1.5ANGSTROM RESOLUTION
Descriptor:Ig domain protein group 2 domain protein, Cellulosome anchoring protein cohesin region, CALCIUM ION, ...
Authors:Pinheiro, B.A., Bras, J.L., Carvalho, A.L., Fontes, C.M.G.A.
Deposit date:2016-10-06
Release date:2017-09-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Diverse specificity of cellulosome attachment to the bacterial cell surface.
Sci Rep, 6, 2016
5NRK
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CRYSTAL STRUCTURE OF THE SIXTH COHESIN FROM ACETIVIBRIO CELLULOLYTICUS' SCAFFOLDIN B IN COMPLEX WITH CEL5 DOCKERIN S15I, I16N MUTANT
Descriptor:Endoglucanase, DocCel5: Type I dockerin repeat domain from A. cellulolyticus family 5 endoglucanase WP_010249057 S15I, I16N mutant, ...
Authors:Bule, P., Najmudin, S., Fontes, C.M.G.A., Alves, V.D.
Deposit date:2017-04-24
Release date:2018-01-31
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure-function analyses generate novel specificities to assemble the components of multienzyme bacterial cellulosome complexes.
J. Biol. Chem., 293, 2018
5NRM
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CRYSTAL STRUCTURE OF THE SIXTH COHESIN FROM ACETIVIBRIO CELLULOLYTICUS' SCAFFOLDIN B IN COMPLEX WITH CEL5 DOCKERIN S51I, L52N MUTANT
Descriptor:Endoglucanase, DocCel5: Type I dockerin repeat domain from A. cellulolyticus family 5 endoglucanase WP_010249057 S51I, L52N mutant, ...
Authors:Bule, P., Najmudin, S., Fontes, C.M.G.A., Alves, V.D.
Deposit date:2017-04-24
Release date:2018-01-31
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-function analyses generate novel specificities to assemble the components of multienzyme bacterial cellulosome complexes.
J. Biol. Chem., 293, 2018
6I0Z
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CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 1
Descriptor:Fascin, ~{N}-(2,4-dichlorophenyl)-~{N}-methyl-ethanamide
Authors:Schuettelkopf, A.W.
Deposit date:2018-10-27
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg.Med.Chem.Lett., 29, 2019
6I10
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CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 2
Descriptor:Fascin, 1-[(3~{R})-1,1-bis(oxidanylidene)thiolan-3-yl]-5-[(3,4-dichlorophenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one, ACETATE ION, ...
Authors:Schuettelkopf, A.W.
Deposit date:2018-10-27
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg.Med.Chem.Lett., 29, 2019
6I11
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CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 3
Descriptor:Fascin, ACETATE ION, ~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-2-(phenylmethyl)isoquinoline-4-carboxamide
Authors:Schuettelkopf, A.W.
Deposit date:2018-10-27
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg.Med.Chem.Lett., 29, 2019
6I12
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CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 5
Descriptor:Fascin, ACETATE ION, 2-[(4-chlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-isoquinoline-4-carboxamide
Authors:Schuettelkopf, A.W.
Deposit date:2018-10-27
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg.Med.Chem.Lett., 29, 2019
6I13
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CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 7
Descriptor:Fascin, ACETATE ION, 1,2-ETHANEDIOL, ...
Authors:Schuettelkopf, A.W.
Deposit date:2018-10-27
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg.Med.Chem.Lett., 29, 2019
6I14
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CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 9
Descriptor:Fascin, ACETATE ION, 2-[(3,4-dichlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-isoquinoline-4-carboxamide
Authors:Schuettelkopf, A.W.
Deposit date:2018-10-27
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg.Med.Chem.Lett., 29, 2019
6I15
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CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 11
Descriptor:Fascin, 1,2-ETHANEDIOL, ACETATE ION, ...
Authors:Schuettelkopf, A.W.
Deposit date:2018-10-27
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg.Med.Chem.Lett., 29, 2019
6I16
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CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 15
Descriptor:Fascin, ACETATE ION, 6-[(3,4-dichlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-5-oxidanylidene-1,6-naphthyridine-8-carboxamide
Authors:Schuettelkopf, A.W.
Deposit date:2018-10-27
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg.Med.Chem.Lett., 29, 2019
6I17
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CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 24
Descriptor:Fascin, ACETATE ION, 1,2-ETHANEDIOL, ...
Authors:Schuettelkopf, A.W.
Deposit date:2018-10-27
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg.Med.Chem.Lett., 29, 2019
6I18
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CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH BDP-13176
Descriptor:Fascin, ACETATE ION, 1,2-ETHANEDIOL, ...
Authors:Schuettelkopf, A.W.
Deposit date:2018-10-27
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg.Med.Chem.Lett., 29, 2019