Author results

1BH5
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HUMAN GLYOXALASE I Q33E, E172Q DOUBLE MUTANT
Descriptor:LACTOYLGLUTATHIONE LYASE, ZINC ION, S-HEXYLGLUTATHIONE
Authors:Cameron, A.D., Jones, T.A.
Deposit date:1998-06-13
Release date:1998-11-04
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Involvement of an active-site Zn2+ ligand in the catalytic mechanism of human glyoxalase I.
J.Biol.Chem., 273, 1998
1BYL
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BLEOMYCIN RESISTANCE PROTEIN FROM STREPTOALLOTEICHUS HINDUSTANUS
Descriptor:PROTEIN (BLEOMYCIN RESISTANCE PROTEIN)
Authors:Dumas, P., Bergdoll, M., Cagnon, C., Masson, J.M.
Deposit date:1998-10-17
Release date:1999-10-21
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure and site-directed mutagenesis of a bleomycin resistance protein and their significance for drug sequestering.
EMBO J., 13, 1994
1FRO
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HUMAN GLYOXALASE I WITH BENZYL-GLUTATHIONE INHIBITOR
Descriptor:LACTOYLGLUTATHIONE LYASE, ZINC ION, S-BENZYL-GLUTATHIONE
Authors:Cameron, A.D., Jones, T.A.
Deposit date:1997-02-25
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping.
EMBO J., 16, 1997
1GQT
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ACTIVATION OF RIBOKINASE BY MONOVALENT CATIONS
Descriptor:RIBOKINASE, CESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:Andersson, C.E., Mowbray, S.L.
Deposit date:2001-12-05
Release date:2002-01-28
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Activation of Ribokinase by Monovalent Cations.
J.Mol.Biol., 315, 2002
1GSD
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GLUTATHIONE TRANSFERASE A1-1 IN UNLIGANDED FORM
Descriptor:GLUTATHIONE TRANSFERASE A1-1
Authors:L'Hermite, G., Sinning, I., Cameron, A.D., Jones, T.A.
Deposit date:1995-06-09
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.
Structure, 3, 1995
1GSE
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GLUTATHIONE TRANSFERASE A1-1 COMPLEXED WITH AN ETHACRYNIC ACID GLUTATHIONE CONJUGATE (MUTANT R15K)
Descriptor:GLUTATHIONE TRANSFERASE, GLUTATHIONE, ETHACRYNIC ACID, ...
Authors:Cameron, A.D., Jones, T.A.
Deposit date:1995-06-09
Release date:1995-09-15
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.
Structure, 3, 1995
1GSF
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GLUTATHIONE TRANSFERASE A1-1 COMPLEXED WITH ETHACRYNIC ACID
Descriptor:GLUTATHIONE TRANSFERASE A1-1, ETHACRYNIC ACID
Authors:L'Hermite, G., Sinning, I., Cameron, A.D., Jones, T.A.
Deposit date:1995-06-09
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.
Structure, 3, 1995
1H8V
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THE X-RAY CRYSTAL STRUCTURE OF THE TRICHODERMA REESEI FAMILY 12 ENDOGLUCANASE 3, CEL12A, AT 1.9 A RESOLUTION
Descriptor:ENDO-BETA-1,4-GLUCANASE, N-ACETYL-D-GLUCOSAMINE
Authors:Sandgren, M., Shaw, A., Ropp, T.H., Wu, S., Bott, R., Cameron, A.D., Stahlberg, J., Mitchinson, C., Jones, T.A.
Deposit date:2001-02-16
Release date:2001-04-24
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The X-Ray Crystal Structure of the Trichoderma Reesei Family 12 Endoglucanase 3, Cel12A, at 1.9 A Resolution
J.Mol.Biol., 308, 2001
1MNH
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INTERACTIONS AMONG RESIDUES CD3, E7, E10 AND E11 IN MYOGLOBINS: ATTEMPTS TO SIMULATE THE O2 AND CO BINDING PROPERTIES OF APLYSIA MYOGLOBIN
Descriptor:MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE
Authors:Davies, G.J., Wilkinson, A.J.
Deposit date:1995-01-11
Release date:1995-05-08
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Interactions among residues CD3, E7, E10, and E11 in myoglobins: attempts to simulate the ligand-binding properties of Aplysia myoglobin.
Biochemistry, 34, 1995
1MNI
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ALTERATION OF AXIAL COORDINATION BY PROTEIN ENGINEERING IN MYOGLOBIN. BIS-IMIDAZOLE LIGATION IN THE HIS64-->VAL(SLASH)VAL68-->HIS DOUBLE MUTANT
Descriptor:MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE
Authors:Krzywda, S., Wilkinson, A.J.
Deposit date:1995-01-11
Release date:1995-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Alteration of axial coordination by protein engineering in myoglobin. Bisimidazole ligation in the His64-->Val/Val68-->His double mutant.
J.Biol.Chem., 270, 1995
1MNJ
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INTERACTIONS AMONG RESIDUES CD3, E7, E10 AND E11 IN MYOGLOBINS: ATTEMPTS TO SIMULATE THE O2 AND CO BINDING PROPERTIES OF APLYSIA MYOGLOBIN
Descriptor:MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE
Authors:Krzywda, S., Wilkinson, A.J.
Deposit date:1995-01-11
Release date:1995-04-20
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Interactions among residues CD3, E7, E10, and E11 in myoglobins: attempts to simulate the ligand-binding properties of Aplysia myoglobin.
Biochemistry, 34, 1995
1MNK
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INTERACTIONS AMONG RESIDUES CD3, E7, E10 AND E11 IN MYOGLOBINS: ATTEMPTS TO SIMULATE THE O2 AND CO BINDING PROPERTIES OF APLYSIA MYOGLOBIN
Descriptor:MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE
Authors:Krzywda, S., Wilkinson, A.J.
Deposit date:1995-01-11
Release date:1995-04-20
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Interactions among residues CD3, E7, E10, and E11 in myoglobins: attempts to simulate the ligand-binding properties of Aplysia myoglobin.
Biochemistry, 34, 1995
1QH3
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HUMAN GLYOXALASE II WITH CACODYLATE AND ACETATE IONS PRESENT IN THE ACTIVE SITE
Descriptor:PROTEIN (HYDROXYACYLGLUTATHIONE HYDROLASE), ZINC ION, CACODYLATE ION, ...
Authors:Cameron, A.D., Ridderstrom, M., Olin, B., Mannervik, B.
Deposit date:1999-05-10
Release date:1999-09-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue.
Structure Fold.Des., 7, 1999
1QH5
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HUMAN GLYOXALASE II WITH S-(N-HYDROXY-N-BROMOPHENYLCARBAMOYL)GLUTATHIONE
Descriptor:PROTEIN (HYDROXYACYLGLUTATHIONE HYDROLASE), ZINC ION, GLUTATHIONE, ...
Authors:Cameron, A.D., Ridderstrom, M., Olin, B., Mannervik, B.
Deposit date:1999-05-11
Release date:1999-09-24
Last modified:2011-12-14
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue.
Structure Fold.Des., 7, 1999
1QIN
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HUMAN GLYOXALASE I COMPLEXED WITH S-(N-HYDROXY-N-P-IODOPHENYLCARBAMOYL) GLUTATHIONE
Descriptor:PROTEIN (LACTOYLGLUTATHIONE LYASE), ZINC ION, S-(N-HYDROXY-N-IODOPHENYLCARBAMOYL)GLUTATHIONE
Authors:Cameron, A.D., Ridderstrom, M., Olin, B., Mannervik, B.
Deposit date:1999-06-14
Release date:1999-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue.
Biochemistry, 38, 1999
1QIP
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HUMAN GLYOXALASE I COMPLEXED WITH S-P-NITROBENZYLOXYCARBONYLGLUTATHIONE
Descriptor:PROTEIN (LACTOYLGLUTATHIONE LYASE), ZINC ION, S-P-NITROBENZYLOXYCARBONYLGLUTATHIONE, ...
Authors:Cameron, A.D., Ridderstrom, M., Olin, B., Mannervik, B.
Deposit date:1999-06-14
Release date:1999-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue.
Biochemistry, 38, 1999
1RK2
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E. COLI RIBOKINASE COMPLEXED WITH RIBOSE AND ADP, SOLVED IN SPACE GROUP P212121
Descriptor:RIBOKINASE, RIBOSE, TETRAFLUOROALUMINATE ION, ...
Authors:Sigrell, J.A., Cameron, A.D., Mowbray, S.L.
Deposit date:1999-05-20
Release date:1999-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Induced fit on sugar binding activates ribokinase.
J.Mol.Biol., 290, 1999
1RKA
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THE APO FORM OF E. COLI RIBOKINASE
Descriptor:PROTEIN (RIBOKINASE)
Authors:Sigrell, J.A., Cameron, A.D., Mowbray, S.L.
Deposit date:1999-03-22
Release date:1999-08-31
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Induced fit on sugar binding activates ribokinase.
J.Mol.Biol., 290, 1999
1RKD
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E. COLI RIBOKINASE COMPLEXED WITH RIBOSE AND ADP
Descriptor:RIBOKINASE, RIBOSE, PHOSPHATE ION, ...
Authors:Sigrell, J.A., Cameron, A.D., Jones, T.A., Mowbray, S.L.
Deposit date:1997-11-29
Release date:1998-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structure of Escherichia coli ribokinase in complex with ribose and dinucleotide determined to 1.8 A resolution: insights into a new family of kinase structures.
Structure, 6, 1998
1RKS
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E. COLI RIBOKINASE IN COMPLEX WITH D-RIBOSE
Descriptor:PROTEIN (RIBOKINASE), RIBOSE, PHOSPHATE ION
Authors:Sigrell, J.A., Cameron, A.D., Mowbray, S.L.
Deposit date:1999-05-17
Release date:1999-08-31
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Induced fit on sugar binding activates ribokinase.
J.Mol.Biol., 290, 1999
1YCA
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DISTAL POCKET POLARITY IN LIGAND BINDING TO MYOGLOBIN: DEOXY AND CARBONMONOXY FORMS OF A THREONINE68 (E11) MUTANT INVESTIGATED BY X-RAY CRYSTALLOGRAPHY AND INFRARED SPECTROSCOPY
Descriptor:MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE
Authors:Cameron, A.D., Smerdon, S.J., Wilkinson, A.J., Habash, J., Helliwell, J.R.
Deposit date:1993-08-10
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Distal pocket polarity in ligand binding to myoglobin: deoxy and carbonmonoxy forms of a threonine68(E11) mutant investigated by X-ray crystallography and infrared spectroscopy.
Biochemistry, 32, 1993
1YCB
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DISTAL POCKET POLARITY IN LIGAND BINDING TO MYOGLOBIN: DEOXY AND CARBONMONOXY FORMS OF A THREONINE68 (E11) MUTANT INVESTIGATED BY X-RAY CRYSTALLOGRAPHY AND INFRARED SPECTROSCOPY
Descriptor:MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE
Authors:Cameron, A.D., Smerdon, S.J., Wilkinson, A.J., Habash, J., Helliwell, J.R.
Deposit date:1993-08-10
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Distal pocket polarity in ligand binding to myoglobin: deoxy and carbonmonoxy forms of a threonine68(E11) mutant investigated by X-ray crystallography and infrared spectroscopy.
Biochemistry, 32, 1993
2BMC
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AURORA-2 T287D T288D COMPLEXED WITH PHA-680632
Descriptor:SERINE THREONINE-PROTEIN KINASE 6, (3E)-N-(2,6-DIETHYLPHENYL)-3-{[4-(4-METHYLPIPERAZIN-1-YL)BENZOYL]IMINO}PYRROLO[3,4-C]PYRAZOLE-5(3H)-CARBOXAMIDE
Authors:Cameron, A.D., Izzo, G., Sagliano, A., Rusconi, L., Storici, P., Fancelli, D., Berta, D., Bindi, S., Catana, C., Forte, B., Giordano, P., Mantegani, S., Meroni, M., Moll, J., Pittala, V., Severino, D., Tonani, R., Varasi, M., Vulpetti, A., Vianello, P.
Deposit date:2005-03-11
Release date:2005-03-17
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Potent and Selective Aurora Inhibitors Identified by the Expansion of a Novel Scaffold for Protein Kinase Inhibition.
J.Med.Chem., 48, 2005
2J4Z
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STRUCTURE OF AURORA-2 IN COMPLEX WITH PHA-680626
Descriptor:SERINE THREONINE-PROTEIN KINASE 6, 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE, ARSENIC
Authors:Cameron, A.D., Izzo, G., Storici, P., Rusconi, L., Fancelli, D., Varasi, M., Berta, D., Bindi, S., Forte, B., Severino, D., Tonani, R., Vianello, P.
Deposit date:2006-09-08
Release date:2006-11-06
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile.
J. Med. Chem., 49, 2006
2J50
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STRUCTURE OF AURORA-2 IN COMPLEX WITH PHA-739358
Descriptor:SERINE/THREONINE-PROTEIN KINASE 6, N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE, SULFATE ION
Authors:Cameron, A.D., Izzo, G., Storici, P., Rusconi, L., Fancelli, D., Varasi, M., Berta, D., Bindi, S., Forte, B., Severino, D., Tonani, R., Vianello, P.
Deposit date:2006-09-08
Release date:2006-11-06
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:1,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrazoles: Identification of a Potent Aurora Kinase Inhibitor with a Favorable Antitumor Kinase Inhibition Profile.
J.Med.Chem., 49, 2006
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