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1FRO
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BU of 1fro by Molmil
HUMAN GLYOXALASE I WITH BENZYL-GLUTATHIONE INHIBITOR
Descriptor: LACTOYLGLUTATHIONE LYASE, S-BENZYL-GLUTATHIONE, ZINC ION
Authors:Cameron, A.D, Jones, T.A.
Deposit date:1997-02-25
Release date:1997-06-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping.
EMBO J., 16, 1997
1GSE
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BU of 1gse by Molmil
GLUTATHIONE TRANSFERASE A1-1 COMPLEXED WITH AN ETHACRYNIC ACID GLUTATHIONE CONJUGATE (MUTANT R15K)
Descriptor: BETA-MERCAPTOETHANOL, ETHACRYNIC ACID, GLUTATHIONE, ...
Authors:Cameron, A.D, Jones, T.A.
Deposit date:1995-06-09
Release date:1995-09-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.
Structure, 3, 1995
1YCB
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BU of 1ycb by Molmil
DISTAL POCKET POLARITY IN LIGAND BINDING TO MYOGLOBIN: DEOXY AND CARBONMONOXY FORMS OF A THREONINE68 (E11) MUTANT INVESTIGATED BY X-RAY CRYSTALLOGRAPHY AND INFRARED SPECTROSCOPY
Descriptor: MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE
Authors:Cameron, A.D, Smerdon, S.J, Wilkinson, A.J, Habash, J, Helliwell, J.R.
Deposit date:1993-08-10
Release date:1994-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Distal pocket polarity in ligand binding to myoglobin: deoxy and carbonmonoxy forms of a threonine68(E11) mutant investigated by X-ray crystallography and infrared spectroscopy.
Biochemistry, 32, 1993
1YCA
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BU of 1yca by Molmil
DISTAL POCKET POLARITY IN LIGAND BINDING TO MYOGLOBIN: DEOXY AND CARBONMONOXY FORMS OF A THREONINE68 (E11) MUTANT INVESTIGATED BY X-RAY CRYSTALLOGRAPHY AND INFRARED SPECTROSCOPY
Descriptor: CARBON MONOXIDE, MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE
Authors:Cameron, A.D, Smerdon, S.J, Wilkinson, A.J, Habash, J, Helliwell, J.R.
Deposit date:1993-08-10
Release date:1994-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Distal pocket polarity in ligand binding to myoglobin: deoxy and carbonmonoxy forms of a threonine68(E11) mutant investigated by X-ray crystallography and infrared spectroscopy.
Biochemistry, 32, 1993
1QIP
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BU of 1qip by Molmil
HUMAN GLYOXALASE I COMPLEXED WITH S-P-NITROBENZYLOXYCARBONYLGLUTATHIONE
Descriptor: BETA-MERCAPTOETHANOL, PROTEIN (LACTOYLGLUTATHIONE LYASE), S-P-NITROBENZYLOXYCARBONYLGLUTATHIONE, ...
Authors:Cameron, A.D, Ridderstrom, M, Olin, B, Mannervik, B.
Deposit date:1999-06-14
Release date:1999-11-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue.
Biochemistry, 38, 1999
1QIN
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BU of 1qin by Molmil
HUMAN GLYOXALASE I COMPLEXED WITH S-(N-HYDROXY-N-P-IODOPHENYLCARBAMOYL) GLUTATHIONE
Descriptor: PROTEIN (LACTOYLGLUTATHIONE LYASE), S-(N-HYDROXY-N-IODOPHENYLCARBAMOYL)GLUTATHIONE, ZINC ION
Authors:Cameron, A.D, Ridderstrom, M, Olin, B, Mannervik, B.
Deposit date:1999-06-14
Release date:1999-11-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue.
Biochemistry, 38, 1999
1QH5
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BU of 1qh5 by Molmil
HUMAN GLYOXALASE II WITH S-(N-HYDROXY-N-BROMOPHENYLCARBAMOYL)GLUTATHIONE
Descriptor: GLUTATHIONE, PROTEIN (HYDROXYACYLGLUTATHIONE HYDROLASE), S-(N-HYDROXY-N-BROMOPHENYLCARBAMOYL)GLUTATHIONE, ...
Authors:Cameron, A.D, Ridderstrom, M, Olin, B, Mannervik, B.
Deposit date:1999-05-11
Release date:1999-09-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue.
Structure Fold.Des., 7, 1999
1QH3
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BU of 1qh3 by Molmil
HUMAN GLYOXALASE II WITH CACODYLATE AND ACETATE IONS PRESENT IN THE ACTIVE SITE
Descriptor: ACETATE ION, CACODYLATE ION, CHLORIDE ION, ...
Authors:Cameron, A.D, Ridderstrom, M, Olin, B, Mannervik, B.
Deposit date:1999-05-10
Release date:1999-09-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue.
Structure Fold.Des., 7, 1999
6H7B
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BU of 6h7b by Molmil
Structure of Leishmania PABP1 (domain J) complexed with a peptide containing the PAM2 motif of eIF4E4.
Descriptor: HIS-HIS-MET-ASN-PRO-ASN-ALA-THR-GLU-PHE-MET-PRO, Polyadenylate-binding protein
Authors:Cameron, A.D, Firczuk, H, dos Santos Rodrigues, F.H, McCarthy, J.E.G.
Deposit date:2018-07-31
Release date:2018-12-12
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:The Leishmania PABP1-eIF4E4 interface: a novel 5'-3' interaction architecture for trans-spliced mRNAs.
Nucleic Acids Res., 47, 2019
6H7A
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BU of 6h7a by Molmil
Structure of Leishmania PABP1 (domain J).
Descriptor: PABP1 domain J
Authors:Cameron, A.D, Firczuk, H, dos Santos Rodrigues, F.H, McCarthy, J.E.G.
Deposit date:2018-07-31
Release date:2018-12-12
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:The Leishmania PABP1-eIF4E4 interface: a novel 5'-3' interaction architecture for trans-spliced mRNAs.
Nucleic Acids Res., 47, 2019
1BH5
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BU of 1bh5 by Molmil
HUMAN GLYOXALASE I Q33E, E172Q DOUBLE MUTANT
Descriptor: LACTOYLGLUTATHIONE LYASE, S-HEXYLGLUTATHIONE, ZINC ION
Authors:Cameron, A.D, Jones, T.A.
Deposit date:1998-06-13
Release date:1998-11-04
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Involvement of an active-site Zn2+ ligand in the catalytic mechanism of human glyoxalase I.
J.Biol.Chem., 273, 1998
2JGB
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BU of 2jgb by Molmil
Structure of human eIF4E homologous protein 4EHP with m7GTP
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 2, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
Authors:Cameron, A.D, Rosettani, P, Knapp, S, Vismara, M.G, Rusconi, L.
Deposit date:2007-02-12
Release date:2007-02-27
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.
J. Mol. Biol., 368, 2007
2JGC
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BU of 2jgc by Molmil
Structure of the human eIF4E homologous protein, 4EHP without ligand bound
Descriptor: EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 2, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
Authors:Cameron, A.D, Rosettani, P, Knapp, S, Vismara, M.G, Rusconi, L.
Deposit date:2007-02-12
Release date:2007-02-27
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.
J. Mol. Biol., 368, 2007
2J50
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BU of 2j50 by Molmil
Structure of Aurora-2 in complex with PHA-739358
Descriptor: N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE, SERINE/THREONINE-PROTEIN KINASE 6, SULFATE ION
Authors:Cameron, A.D, Izzo, G, Storici, P, Rusconi, L, Fancelli, D, Varasi, M, Berta, D, Bindi, S, Forte, B, Severino, D, Tonani, R, Vianello, P.
Deposit date:2006-09-08
Release date:2006-11-06
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:1,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrazoles: Identification of a Potent Aurora Kinase Inhibitor with a Favorable Antitumor Kinase Inhibition Profile.
J.Med.Chem., 49, 2006
1GSF
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BU of 1gsf by Molmil
GLUTATHIONE TRANSFERASE A1-1 COMPLEXED WITH ETHACRYNIC ACID
Descriptor: ETHACRYNIC ACID, GLUTATHIONE TRANSFERASE A1-1
Authors:L'Hermite, G, Sinning, I, Cameron, A.D, Jones, T.A.
Deposit date:1995-06-09
Release date:1995-09-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.
Structure, 3, 1995
1GSD
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BU of 1gsd by Molmil
GLUTATHIONE TRANSFERASE A1-1 IN UNLIGANDED FORM
Descriptor: GLUTATHIONE TRANSFERASE A1-1
Authors:L'Hermite, G, Sinning, I, Cameron, A.D, Jones, T.A.
Deposit date:1995-06-09
Release date:1995-09-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.
Structure, 3, 1995
8OYF
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BU of 8oyf by Molmil
Crystal structure of ASBTNM in lipidic cubic phase without substrate bound
Descriptor: (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, NICKEL (II) ION, PHOSPHATIDYLETHANOLAMINE, ...
Authors:Becker, P, Cameron, A.D.
Deposit date:2023-05-04
Release date:2023-07-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Mechanism of substrate binding and transport in BASS transporters.
Biorxiv, 2023
8OYG
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BU of 8oyg by Molmil
Crystal structure of ASBTNM in complex with pantoate
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CADMIUM ION, PANTOATE, ...
Authors:Becker, P, Cameron, A.D.
Deposit date:2023-05-04
Release date:2023-07-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mechanism of substrate binding and transport in BASS transporters.
Biorxiv, 2023
8QA2
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BU of 8qa2 by Molmil
Cryo-EM structure of Cx26 solubilised in LMNG: classification on subunit A; Nconst-mon conformation
Descriptor: Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE
Authors:Brotherton, D.H, Cameron, A.D.
Deposit date:2023-08-22
Release date:2024-06-12
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO 2.
Elife, 13, 2024
8QA1
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BU of 8qa1 by Molmil
Cryo-EM structure of Cx26 solubilised in LMNG - Hemichannel classification NFlex conformation
Descriptor: Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE
Authors:Brotherton, D.H, Cameron, A.D.
Deposit date:2023-08-22
Release date:2024-06-12
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO 2.
Elife, 13, 2024
8Q9Z
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BU of 8q9z by Molmil
Cryo-EM structure of Cx26 gap junction K125E mutant in bicarbonate buffer (classification on hemichannel)
Descriptor: DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE
Authors:Brotherton, D.H, Cameron, A.D.
Deposit date:2023-08-22
Release date:2024-06-12
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO 2.
Elife, 13, 2024
8QA0
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BU of 8qa0 by Molmil
Cryo-EM structure of Cx26 solubilised in LMNG - hemichannel classification - NConst conformation
Descriptor: Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE
Authors:Brotherton, D.H, Cameron, A.D.
Deposit date:2023-08-22
Release date:2024-06-12
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO 2.
Elife, 13, 2024
8QA3
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BU of 8qa3 by Molmil
Cryo-EM structure of Cx26 solubilised in LMNG: classification on subunit A; NFlex conformation
Descriptor: Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE
Authors:Brotherton, D.H, Cameron, A.D.
Deposit date:2023-08-22
Release date:2024-06-12
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO 2.
Elife, 13, 2024
4D1C
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BU of 4d1c by Molmil
STRUCTURE OF MHP1, A NUCLEOBASE-CATION-SYMPORT-1 FAMILY TRANSPORTER, IN A CLOSED CONFORMATION WITH bromovinylhydantoin bound.
Descriptor: (5Z)-5-[(3-bromophenyl)methylidene]imidazolidine-2,4-dione, HYDANTOIN TRANSPORT PROTEIN, SODIUM ION
Authors:Weyand, S, Brueckner, F, Geng, T, Drew, D, Iwata, S, Henderson, P.J.F, Cameron, A.D.
Deposit date:2014-05-01
Release date:2014-07-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Molecular Mechanism of Ligand Recognition by Membrane Transport Protein, Mhp1.
Embo J., 33, 2014
4D1D
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BU of 4d1d by Molmil
STRUCTURE OF MHP1, A NUCLEOBASE-CATION-SYMPORT-1 FAMILY TRANSPORTER with the inhibitor 5-(2-naphthylmethyl)-L-hydantoin.
Descriptor: 5-(2-NAPHTHYLMETHYL)-D-HYDANTOIN, 5-(2-NAPHTHYLMETHYL)-L-HYDANTOIN, HYDANTOIN TRANSPORT PROTEIN, ...
Authors:Weyand, S, Brueckner, F, Geng, T, Drew, D, Iwata, S, Henderson, P.J.F, Cameron, A.D.
Deposit date:2014-05-01
Release date:2014-07-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Molecular Mechanism of Ligand Recognition by Membrane Transport Protein, Mhp1.
Embo J., 33, 2014

 

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