Author results

4GG6
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PROTEIN COMPLEX
Descriptor:HLA class II histocompatibility antigen, DQ alpha 1 chain, DQ beta 1 chain, ...
Authors:Broughton, S.E., Theodossis, A., Petersen, J., Reid, H.H., Rossjohn, J.
Deposit date:2012-08-06
Release date:2012-10-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Biased T Cell Receptor Usage Directed against Human Leukocyte Antigen DQ8-Restricted Gliadin Peptides Is Associated with Celiac Disease
Immunity, 2012
4GG8
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IMMUNE RECEPTOR
Descriptor:T-CELL RECEPTOR, SP3.4 ALPHA CHAIN, SP3.4 BETA CHAIN, ...
Authors:Broughton, S.E., Theodossis, A., Petersen, J., Reid, H.H., Rossjohn, J.
Deposit date:2012-08-06
Release date:2012-10-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Biased T Cell Receptor Usage Directed against Human Leukocyte Antigen DQ8-Restricted Gliadin Peptides Is Associated with Celiac Disease
Immunity, 2012
4JZJ
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CRYSTAL STRUCTURE OF RECEPTOR-FAB COMPLEX
Descriptor:Interleukin-3 receptor subunit alpha, Fab Heavy Chain, Fab Light Chain, ...
Authors:Broughton, S.E., Parker, M.W.
Deposit date:2013-04-03
Release date:2014-04-09
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody
Cell Rep, 8, 2014
4RS1
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CRYSTAL STRUCTURE OF RECEPTOR-CYTOKINE COMPLEX
Descriptor:Granulocyte-macrophage colony-stimulating factor receptor subunit alpha, Granulocyte-macrophage colony-stimulating factor, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Broughton, S.E., Parker, M.W., Dhagat, U.
Deposit date:2014-11-06
Release date:2015-11-11
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
Structure, 24, 2016
5UV8
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INTERLEUKIN-3 RECEPTOR COMPLEX
Descriptor:Interleukin-3 receptor subunit alpha, Interleukin-3, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Broughton, S.E., Parker, M.W.
Deposit date:2017-02-19
Release date:2018-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.
Nat Commun, 9, 2018
5UWC
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CYTOKINE-RECEPTOR COMPLEX
Descriptor:Interleukin-3 receptor subunit alpha, Interleukin-3, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Broughton, S.E., Parker, M.W.
Deposit date:2017-02-21
Release date:2018-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.
Nat Commun, 9, 2018
4NKQ
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STRUCTURE OF A CYTOKINE RECEPTOR COMPLEX
Descriptor:Cytokine receptor common subunit beta, Granulocyte-macrophage colony-stimulating factor, Granulocyte-macrophage colony-stimulating factor receptor subunit alpha, ...
Authors:Parker, M.W., Broughton, S.E.
Deposit date:2013-11-13
Release date:2015-09-23
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (3.301 Å)
Cite:Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
Structure, 24, 2016
6BFQ
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THE MECHANISM OF GM-CSF INHIBITION BY HUMAN GM-CSF AUTO-ANTIBODIES
Descriptor:Fab Heavy chain, Fab Light Chain, Granulocyte-macrophage colony-stimulating factor
Authors:Dhagat, U., Hercus, T.R., Broughton, S.E., Nero, T.L., Lopez, A.F., Parker, M.W.
Deposit date:2017-10-26
Release date:2018-09-12
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.
MAbs, 10, 2018
2B7A
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THE STRUCTURAL BASIS OF JANUS KINASE 2 INHIBITION BY A POTENT AND SPECIFIC PAN-JANUS KINASE INHIBITOR
Descriptor:Tyrosine-protein kinase JAK2, 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE
Authors:Lucet, I.S., Fantino, E., Styles, M., Bamert, R., Patel, O., Broughton, S.E., Walter, M., Burns, C.J., Treutlein, H., Wilks, A.F., Rossjohn, J.
Deposit date:2005-10-04
Release date:2006-01-10
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor.
Blood, 107, 2006
2OGV
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CRYSTAL STRUCTURE OF THE AUTOINHIBITED HUMAN C-FMS KINASE DOMAIN
Descriptor:Macrophage colony-stimulating factor 1 receptor precursor
Authors:Walter, M., Lucet, I.S., Patel, O., Broughton, S.E., Bamert, R., Williams, N.K., Fantino, E., Wilks, A.F., Rossjohn, J.
Deposit date:2007-01-09
Release date:2007-02-06
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The 2.7 A crystal structure of the autoinhibited human c-Fms kinase domain.
J.Mol.Biol., 367, 2007
6BFS
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THE MECHANISM OF GM-CSF INHIBITION BY HUMAN GM-CSF AUTO-ANTIBODIES
Descriptor:Fab light Chain, Fab Heavy Chain, Granulocyte-macrophage colony-stimulating factor
Authors:Dhagat, U., Hercus, T.R., Broughton, S.E., Nero, T.L., Lopez, A.F., Parker, M.W.
Deposit date:2017-10-26
Release date:2018-09-12
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.
MAbs, 10, 2018