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2V5Z
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STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR SAFINAMIDE
Descriptor:AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE, (S)-(+)-2-[4-(FLUOROBENZYLOXY-BENZYLAMINO)PROPIONAMIDE]
Authors:Binda, C., Wang, J., Pisani, L., Caccia, C., Carotti, A., Salvati, P., Edmondson, D.E., Mattevi, A.
Deposit date:2007-07-12
Release date:2007-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs.
J.Med.Chem., 50, 2007
2V60
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STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR 7-(3- CHLOROBENZYLOXY)-4-CARBOXALDEHYDE-COUMARIN
Descriptor:AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE, 7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE
Authors:Binda, C., Wang, J., Pisani, L., Caccia, C., Carotti, A., Salvati, P., Edmondson, D.E., Mattevi, A.
Deposit date:2007-07-12
Release date:2007-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs.
J.Med.Chem., 50, 2007
2V61
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STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR 7-(3- CHLOROBENZYLOXY)-4-(METHYLAMINO)METHYL-COUMARIN
Descriptor:AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE, 7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE
Authors:Binda, C., Wang, J., Pisani, L., Caccia, C., Carotti, A., Salvati, P., Edmondson, D.E., Mattevi, A.
Deposit date:2007-07-13
Release date:2007-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs.
J.Med.Chem., 50, 2007
1A70
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SPINACH FERREDOXIN
Descriptor:FERREDOXIN, FE2/S2 (INORGANIC) CLUSTER
Authors:Binda, C., Coda, A., Mattevi, A., Aliverti, A., Zanetti, G.
Deposit date:1998-03-19
Release date:1998-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the mutant E92K of [2Fe-2S] ferredoxin I from Spinacia oleracea at 1.7 A resolution.
Acta Crystallogr.,Sect.D, 54, 1998
1B37
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A 30 ANGSTROM U-SHAPED CATALYTIC TUNNEL IN THE CRYSTAL STRUCTURE OF POLYAMINE OXIDASE
Descriptor:PROTEIN (POLYAMINE OXIDASE), N-ACETYL-D-GLUCOSAMINE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Binda, C., Coda, A., Angelini, R., Federico, R., Ascenzi, P., Mattevi, A.
Deposit date:1998-12-17
Release date:1999-12-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A 30-angstrom-long U-shaped catalytic tunnel in the crystal structure of polyamine oxidase.
Structure Fold.Des., 7, 1999
1B5Q
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A 30 ANGSTROM U-SHAPED CATALYTIC TUNNEL IN THE CRYSTAL STRUCTURE OF POLYAMINE OXIDASE
Descriptor:PROTEIN (POLYAMINE OXIDASE), N-ACETYL-D-GLUCOSAMINE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Binda, C., Coda, A., Angelini, R., Federico, R., Ascenzi, P., Mattevi, A.
Deposit date:1999-01-07
Release date:2000-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A 30-angstrom-long U-shaped catalytic tunnel in the crystal structure of polyamine oxidase.
Structure Fold.Des., 7, 1999
1EA0
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ALPHA SUBUNIT OF A. BRASILENSE GLUTAMATE SYNTHASE
Descriptor:GLUTAMATE SYNTHASE [NADPH] LARGE CHAIN, S-DIOXYMETHIONINE, FLAVIN MONONUCLEOTIDE, ...
Authors:Binda, C., Bossi, R.T., Vanoni, M.A., Mattevi, A.
Deposit date:2000-11-02
Release date:2001-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Cross-Talk and Ammonia Channeling between Active Centers in the Unexpected Domain Arrangement of Glutamate Synthase
Structure, 8, 2000
1GOS
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HUMAN MONOAMINE OXIDASE B
Descriptor:MONOAMINE OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, N-[(E)-METHYL](PHENYL)-N-[(E)-2-PROPENYLIDENE]METHANAMINIUM
Authors:Binda, C., Newton-Vinson, P., Hubalek, F., Edmondson, D.E., Mattevi, A.
Deposit date:2001-10-26
Release date:2001-11-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of Human Monoamine Oxidase B, a Drug Target for the Treatment of Neurological Disorders
Nat.Struct.Biol., 9, 2001
1H81
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STRUCTURE OF POLYAMINE OXIDASE IN THE REDUCED STATE
Descriptor:POLYAMINE OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Binda, C., Coda, A., Angelini, R., Federico, R., Ascenzi, P., Mattevi, A.
Deposit date:2001-01-24
Release date:2001-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Bases for Inhibitor Binding and Catalysis in Polyamine Oxidase
Biochemistry, 40, 2001
1H82
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STRUCTURE OF POLYAMINE OXIDASE IN COMPLEX WITH GUAZATINE
Descriptor:POLYAMINE OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, N-{8-[(8-{[(E)-AMINO(IMINO)METHYL]AMINO}OCTYL)AMINO]OCTYL}GUANIDINE, ...
Authors:Binda, C., Coda, A., Angelini, R., Federico, R., Ascenzi, P., Mattevi, A.
Deposit date:2001-01-24
Release date:2001-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Bases for Inhibitor Binding and Catalysis in Polyamine Oxidase
Biochemistry, 40, 2001
1H83
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STRUCTURE OF POLYAMINE OXIDASE IN COMPLEX WITH 1,8-DIAMINOOCTANE
Descriptor:POLYAMINE OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, OCTANE 1,8-DIAMINE, ...
Authors:Binda, C., Coda, A., Angelini, R., Federico, R., Ascenzi, P., Mattevi, A.
Deposit date:2001-01-24
Release date:2001-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Bases for Inhibitor Binding and Catalysis in Polyamine Oxidase
Biochemistry, 40, 2001
1H84
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COVALENT ADDUCT BETWEEN POLYAMINE OXIDASE AND N1ETHYLN11((CYCLOHEPTYL)METHYL)4,8DIAZAUNDECANE AT PH 4.6
Descriptor:POLYAMINE OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, 3-[(3-{[3-(METHYLAMINO)PROPYL]AMINO}PROPYL)AMINO]PROPANE-1,1-DIOL, ...
Authors:Binda, C., Coda, A., Angelini, R., Federico, R., Ascenzi, P., Mattevi, A.
Deposit date:2001-01-24
Release date:2001-01-31
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Bases for Inhibitor Binding and Catalysis in Polyamine Oxidase
Biochemistry, 40, 2001
1H86
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COVALENT ADDUCT BETWEEN POLYAMINE OXIDASE AND N1ETHYLN11((CYCLOHEPTYL)METHYL)4,8DIAZAUNDECANE AT PH 7.0
Descriptor:POLYAMINE OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, 3-[(3-{[3-(METHYLAMINO)PROPYL]AMINO}PROPYL)AMINO]PROPANE-1,1-DIOL, ...
Authors:Binda, C., Coda, A., Angelini, R., Federico, R., Ascenzi, P., Mattevi, A.
Deposit date:2001-01-24
Release date:2001-01-31
Last modified:2012-01-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Bases for Inhibitor Binding and Catalysis in Polyamine Oxidase
Biochemistry, 40, 2001
1OJ9
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HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH 1,4-DIPHENYL-2-BUTENE
Descriptor:AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, 1,4-DIPHENYL-2-BUTENE
Authors:Binda, C., Edmondson, D.E., Mattevi, A.
Deposit date:2003-07-08
Release date:2003-08-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insights Into the Mode of Inhibition of Human Mitochondrial Monoamine Oxidase B from High-Resolution Crystal Structures
Proc.Natl.Acad.Sci.USA, 100, 2003
1OJA
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HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH ISATIN
Descriptor:AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, ISATIN
Authors:Binda, C., Edmondson, D.E., Mattevi, A.
Deposit date:2003-07-08
Release date:2003-08-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Insights Into the Mode of Inhibition of Human Mitochondrial Monoamine Oxidase B from High-Resolution Crystal Structures
Proc.Natl.Acad.Sci.USA, 100, 2003
1OJC
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HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH N-(2-AMINOETHYL)-P-CHLOROBENZAMIDE
Descriptor:AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, N-(2-AMINOETHYL)-P-CHLOROBENZAMIDE
Authors:Binda, C., Edmondson, D.E., Mattevi, A.
Deposit date:2003-07-08
Release date:2003-08-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Insights Into the Mode of Inhibition of Human Mitochondrial Monoamine Oxidase B from High-Resolution Crystal Structures
Proc.Natl.Acad.Sci.USA, 100, 2003
1OJD
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HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH LAURYLDIMETHYLAMINE-N-OXIDE (LDAO)
Descriptor:AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, LAURYL DIMETHYLAMINE-N-OXIDE
Authors:Binda, C., Edmondson, D.E., Mattevi, A.
Deposit date:2003-07-08
Release date:2003-08-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Insights Into the Mode of Inhibition of Human Mitochondrial Monoamine Oxidase B from High-Resolution Crystal Structures
Proc.Natl.Acad.Sci.USA, 100, 2003
1S2Q
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CRYSTAL STRUCTURE OF MAOB IN COMPLEX WITH N-PROPARGYL-1(R)-AMINOINDAN (RASAGILINE)
Descriptor:Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, (1R)-N-(prop-2-en-1-yl)-2,3-dihydro-1H-inden-1-amine
Authors:Binda, C., Hubalek, F., Li, M., Herzig, Y., Sterling, J., Edmondson, D.E., Mattevi, A.
Deposit date:2004-01-09
Release date:2004-03-30
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Crystal Structures of Monoamine Oxidase B in Complex with Four Inhibitors of the N-Propargylaminoindan Class.
J.Med.Chem., 47, 2004
1S2Y
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CRYSTAL STRUCTURE OF MAOB IN COMPLEX WITH N-PROPARGYL-1(S)-AMINOINDAN
Descriptor:Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, N-PROPARGYL-1(S)-AMINOINDAN
Authors:Binda, C., Hubalek, F., Li, M., Herzig, Y., Sterling, J., Edmondson, D.E., Mattevi, A.
Deposit date:2004-01-12
Release date:2004-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Crystal Structures of Monoamine Oxidase B in Complex with Four Inhibitors of the N-Propargylaminoindan Class.
J.Med.Chem., 47, 2004
1S3B
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CRYSTAL STRUCTURE OF MAOB IN COMPLEX WITH N-METHYL-N-PROPARGYL-1(R)-AMINOINDAN
Descriptor:Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, N-[(1S)-2,3-DIHYDRO-1H-INDEN-1-YL]-N-METHYL-N-PROP-2-YNYLAMINE
Authors:Binda, C., Hubalek, F., Li, M., Herzig, Y., Sterling, J., Edmondson, D.E., Mattevi, A.
Deposit date:2004-01-13
Release date:2004-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structures of Monoamine Oxidase B in Complex with Four Inhibitors of the N-Propargylaminoindan Class.
J.Med.Chem., 47, 2004
1S3E
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CRYSTAL STRUCTURE OF MAOB IN COMPLEX WITH 6-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN
Descriptor:Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, (3R)-3-(PROP-2-YNYLAMINO)INDAN-5-OL
Authors:Binda, C., Hubalek, F., Li, M., Herzig, Y., Sterling, J., Edmondson, D.E., Mattevi, A.
Deposit date:2004-01-13
Release date:2004-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structures of Monoamine Oxidase B in Complex with Four Inhibitors of the N-Propargylaminoindan Class.
J.Med.Chem., 47, 2004
2C64
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MAO INHIBITION BY RASAGILINE ANALOGUES
Descriptor:AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE, (1R)-6-HYDROXY-N-METHYL-N-[(1Z)-PROP-2-EN-1-YLIDENE]INDAN-1-AMINIUM
Authors:Binda, C., Hubalek, F., Li, M., Herzig, Y., Sterling, J., Edmondson, D.E., Mattevi, A.
Deposit date:2005-11-07
Release date:2006-01-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Binding of Rasagiline-Related Inhibitors to Human Monoamine Oxidases: A Kinetic and Crystallographic Analysis.
J.Med.Chem., 48, 2005
2C65
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MAO INHIBITION BY RASAGILINE ANALOGUES
Descriptor:AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, (1R)-4-({[ETHYL(METHYL)AMINO]CARBONYL}OXY)-N-METHYL-N-[(1E)-PROP-2-EN-1-YLIDENE]INDAN-1-AMINIUM
Authors:Binda, C., Hubalek, F., Li, M., Herzig, Y., Sterling, J., Edmondson, D.E., Mattevi, A.
Deposit date:2005-11-07
Release date:2006-01-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Binding of Rasagiline-Related Inhibitors to Human Monoamine Oxidases: A Kinetic and Crystallographic Analysis.
J.Med.Chem., 48, 2005
2C66
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MAO INHIBITION BY RASAGILINE ANALOGUES
Descriptor:AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE, 4-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN
Authors:Binda, C., Hubalek, F., Li, M., Herzig, Y., Sterling, J., Edmondson, D.E., Mattevi, A.
Deposit date:2005-11-07
Release date:2006-01-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Binding of Rasagiline-Related Inhibitors to Human Monoamine Oxidases: A Kinetic and Crystallographic Analysis.
J.Med.Chem., 48, 2005
2C67
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MAO INHIBITION BY RASAGILINE ANALOGUES
Descriptor:AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE, N-METHYL-1(R)-AMINOINDAN
Authors:Binda, C., Hubalek, F., Li, M., Herzig, Y., Sterling, J., Edmondson, D.E., Mattevi, A.
Deposit date:2005-11-07
Release date:2006-01-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Binding of Rasagiline-Related Inhibitors to Human Monoamine Oxidases: A Kinetic and Crystallographic Analysis.
J.Med.Chem., 48, 2005