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6HVH
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HUMAN PFKFB3 IN COMPLEX WITH A N-ARYL 6-AMINOQUINOXALINE INHIBITOR 1
Descriptor:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, 3-[[8-(1-methylindol-6-yl)quinoxalin-6-yl]amino]-~{N}-(oxan-4-yl)pyridine-4-carboxamide, PYROPHOSPHATE 2-, ...
Authors:Banaszak, K., Jakubiec, K., Bialas, A., Fabritius, C.H., Nowak, M.
Deposit date:2018-10-11
Release date:2018-11-14
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Discovery and Structure-Activity Relationships of N-Aryl 6-Aminoquinoxalines as Potent PFKFB3 Kinase Inhibitors.
ChemMedChem, 14, 2019
6HVJ
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HUMAN PFKFB3 IN COMPLEX WITH A N-ARYL 6-AMINOQUINOXALINE INHIBITOR 3
Descriptor:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, 8-(3-methyl-1-benzofuran-5-yl)-~{N}-(4-methylsulfonylpyridin-3-yl)quinoxalin-6-amine, FRUCTOSE-6-PHOSPHATE, ...
Authors:Banaszak, K., Pawlik, H., Bialas, A., Fabritius, C.H., Nowak, M.
Deposit date:2018-10-11
Release date:2018-11-14
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Discovery and Structure-Activity Relationships of N-Aryl 6-Aminoquinoxalines as Potent PFKFB3 Kinase Inhibitors.
ChemMedChem, 14, 2019
6IBX
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HUMAN PFKFB3 IN COMPLEX WITH A N-ARYL 6-AMINOQUINOXALINE INHIBITOR 5
Descriptor:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, 3-[[8-(1-methylindol-6-yl)quinoxalin-6-yl]amino]-~{N}-[(3~{S})-1-methylpiperidin-3-yl]pyridine-4-carboxamide, PYROPHOSPHATE 2-, ...
Authors:Banaszak, K., Pawlik, H., Bialas, A., Fabritius, C.H., Nowak, M.
Deposit date:2018-12-01
Release date:2019-01-23
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties.
Bioorg. Med. Chem. Lett., 29, 2019
6IBY
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HUMAN PFKFB3 IN COMPLEX WITH A N-ARYL 6-AMINOQUINOXALINE INHIBITOR 6
Descriptor:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, 3-[[8-(1-methylindol-6-yl)quinoxalin-6-yl]amino]-~{N}-[(3~{S})-1-methylpyrrolidin-3-yl]pyridine-4-carboxamide, PYROPHOSPHATE 2-, ...
Authors:Banaszak, K., Pawlik, H., Bialas, A., Fabritius, C.H., Nowak, M.
Deposit date:2018-12-01
Release date:2019-01-23
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties.
Bioorg. Med. Chem. Lett., 29, 2019
6IC0
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HUMAN PFKFB3 IN COMPLEX WITH A N-ARYL 6-AMINOQUINOXALINE INHIBITOR 4
Descriptor:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, 3-[[8-(1-methylindol-6-yl)quinoxalin-6-yl]amino]-~{N}-pyrimidin-5-yl-pyridine-4-carboxamide, PYROPHOSPHATE 2-, ...
Authors:Banaszak, K., Pawlik, H., Bialas, A., Fabritius, C.H., Nowak, M.
Deposit date:2018-12-01
Release date:2019-01-23
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties.
Bioorg. Med. Chem. Lett., 29, 2019
6HVI
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HUMAN PFKFB3 IN COMPLEX WITH A N-ARYL 6-AMINOQUINOXALINE INHIBITOR 2
Descriptor:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, 8-[3-(dimethylamino)phenyl]-~{N}-(4-methylsulfonylpyridin-3-yl)quinoxalin-6-amine, PYROPHOSPHATE 2-, ...
Authors:Banaszak, K., Sowinska, M., Gondela, A., Fabritius, C.H., Nowak, M.
Deposit date:2018-10-11
Release date:2018-11-14
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Discovery and Structure-Activity Relationships of N-Aryl 6-Aminoquinoxalines as Potent PFKFB3 Kinase Inhibitors.
ChemMedChem, 14, 2019
6IBZ
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HUMAN PFKFB3 IN COMPLEX WITH A N-ARYL 6-AMINOQUINOXALINE INHIBITOR 7
Descriptor:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, PHOSPHATE ION, CITRATE ANION, ...
Authors:Banaszak, K., Tomczyk, M., Guzik, P., Fabritius, C.H., Nowak, M.
Deposit date:2018-12-01
Release date:2019-01-23
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties.
Bioorg. Med. Chem. Lett., 29, 2019