Author results

2UAG
  • Download 2uag
  • View 2uag
Molmil generated image of 2uag
UDP-N-ACETYLMURAMOYL-L-ALANINE:D-GLUTAMATE LIGASE
分子名称:PROTEIN (UDP-N-ACETYLMURAMOYL-L-ALANINE:D-GLUTAMATE LIGASE), MAGNESIUM ION, URIDINE-5'-DIPHOSPHATE-N-ACETYLMURAMOYL-L-ALANINE, ...
著者Bertrand, J., Fanchon, E., Dideberg, O.
登録日1999-02-23
公開日2000-02-25
最終更新日2018-04-11
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Determination of the MurD mechanism through crystallographic analysis of enzyme complexes.
J.Mol.Biol., 289, 1999
4UAG
  • Download 4uag
  • View 4uag
Molmil generated image of 4uag
UDP-N-ACETYLMURAMOYL-L-ALANINE:D-GLUTAMATE LIGASE
分子名称:UDP-N-ACETYLMURAMOYL-L-ALANINE:D-GLUTAMATE LIGASE, SULFATE ION, URIDINE-5'-DIPHOSPHATE-N-ACETYLMURAMOYL-L-ALANINE-D-GLUTAMATE, ...
著者Bertrand, J., Auger, G., Martin, L., Fanchon, E., Blanot, D., Le Beller, D., Van Heijenoort, J., Dideberg, O.
登録日1999-03-09
公開日2000-03-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Determination of the MurD mechanism through crystallographic analysis of enzyme complexes.
J.Mol.Biol., 289, 1999
1E0D
  • Download 1e0d
  • View 1e0d
Molmil generated image of 1e0d
UDP-N-ACETYLMURAMOYL-L-ALANINE:D-GLUTAMATE LIGASE
分子名称:UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE, SULFATE ION
著者Fanchon, E., Bertrand, J., Chantalat, L., Dideberg, O.
登録日2000-03-24
公開日2000-06-09
最終更新日2018-06-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献"Open" Structures of Murd: Domain Movements and Structural Similarities with Folylpolyglutamate Synthetase.
J.Mol.Biol., 301, 2000
4D0W
  • Download 4d0w
  • View 4d0w
Molmil generated image of 4d0w
PYRROLE-3-CARBOXAMIDES AS POTENT AND SELECTIVE JAK2 INHIBITORS
分子名称:TYROSINE-PROTEIN KINASE JAK2, GLYCEROL, 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-1H-pyrrole-3-carboxamide
著者Bertrand, J., Canevari, G., Fasolini, M., Brasca, M.G., Nesi, M., Avanzi, N., Ballinari, D., Bandiera, T., Bindi, S., Carenzi, D., Casero, D., Ceriani, L., Ciomei, M., Cirla, A., Colombo, M., Cribioli, S., Cristiani, C., Della Vedova, F., Fachin, G., Felder, E.R., Galvani, A., Isacchi, A., Mirizzi, D., Motto, I., Panzeri, A., Pesenti, E., Vianello, P., Gnocchi, P., Donati, D.
登録日2014-04-30
公開日2014-07-23
最終更新日2019-04-24
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Pyrrole-3-Carboxamides as Potent and Selective Jak2 Inhibitors.
Bioorg.Med.Chem., 22, 2014
4D1S
  • Download 4d1s
  • View 4d1s
Molmil generated image of 4d1s
PYRROLE-3-CARBOXAMIDES AS POTENT AND SELECTIVE JAK2 INHIBITORS
分子名称:TYROSINE-PROTEIN KINASE JAK2, 2-(5-chloro-2-methylphenyl)-1-methyl-5-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1H-pyrrole-3-carboxamide
著者Bertrand, J., Canevari, G., Fasolini, M., Brasca, M.G., Nesi, M., Avanzi, N., Ballinari, D., Bandiera, T., Bindi, S., Carenzi, D., Casero, D., Ceriani, L., Ciomei, M., Cirla, A., Colombo, M., Cribioli, S., Cristiani, C., Della Vedova, F., Fachin, G., Felder, E.R., Galvani, A., Isacchi, A., Mirizzi, D., Motto, I., Panzeri, A., Pesenti, E., Vianello, P., Gnocchi, P., Donati, D.
登録日2014-05-05
公開日2014-07-23
最終更新日2019-04-24
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Pyrrole-3-Carboxamides as Potent and Selective Jak2 Inhibitors.
Bioorg.Med.Chem., 22, 2014
2GFS
  • Download 2gfs
  • View 2gfs
Molmil generated image of 2gfs
P38 KINASE CRYSTAL STRUCTURE IN COMPLEX WITH RO3201195
分子名称:Mitogen-Activated Protein Kinase 14, [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE
著者Harris, S.F., Bertrand, J., Villasenor, A.
登録日2006-03-23
公開日2006-04-18
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.752 Å)
主引用文献Discovery of S-[5-Amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]-methanone (RO3201195), and Orally Bioavailable and Highly Selective Inhibitor of p38 Map Kinase
J.Med.Chem., 49, 2006
4D0X
  • Download 4d0x
  • View 4d0x
Molmil generated image of 4d0x
PYRROLE-3-CARBOXAMIDES AS POTENT AND SELECTIVE JAK2 INHIBITORS
分子名称:TYROSINE-PROTEIN KINASE JAK2, 5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide, GLYCEROL
著者Canevari, G., Fasolini, M., Bertrand, J., Brasca, M.G., Nesi, M., Avanzi, N., Ballinari, D., Bandiera, T., Bindi, S., Carenzi, D., Casero, D., Ceriani, L., Ciomei, M., Cirla, A., Colombo, M., Cribioli, S., Cristiani, C., Della Vedova, F., Fachin, G., Felder, E.R., Galvani, A., Isacchi, A., Mirizzi, D., Motto, I., Panzeri, A., Pesenti, E., Vianello, P., Gnocchi, P., Donati, D.
登録日2014-04-30
公開日2014-07-23
最終更新日2019-04-24
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Pyrrole-3-Carboxamides as Potent and Selective Jak2 Inhibitors.
Bioorg.Med.Chem., 22, 2014
5AEP
  • Download 5aep
  • View 5aep
Molmil generated image of 5aep
NOVEL PYRROLE CARBOXAMIDE INHIBITORS OF JAK2 AS POTENTIAL TREATMENT OF MYELOPROLIFERATIVE DISORDERS
分子名称:TYROSINE-PROTEIN KINASE JAK2, 1-(5-chloro-2-methylphenyl)-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yl)-1H-pyrrole-2-carboxamide
著者Canevari, G., Bertrand, J., Brasca, M.G., Nesi, M., Amboldi, N., Avanzi, N., Bindi, S., Casero, D., Ciomei, M., Colombo, N., Cribioli, S., Fachin, G., Felder, E.R., Galvani, A., Isacchi, A., Motto, I., Panzeri, A., Gnocchi, P., Donati, D.
登録日2015-01-08
公開日2015-04-29
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Novel Pyrrole Carboxamide Inhibitors of Jak2 as Potential Treatment of Myeloproliferative Disorders.
Bioorg.Med.Chem., 23, 2015
1MAX
  • Download 1max
  • View 1max
Molmil generated image of 1max
BETA-TRYPSIN PHOSPHONATE INHIBITED
分子名称:BETA-TRYPSIN, CALCIUM ION, [N-(BENZYLOXYCARBONYL)AMINO](4-AMIDINOPHENYL)METHANE-PHOSPHONATE
著者Bertrand, J., Oleksyszyn, J., Kam, C., Boduszek, B., Presnell, S., Plaskon, R., Suddath, F., Powers, J., Williams, L.
登録日1996-02-06
公開日1996-10-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Inhibition of trypsin and thrombin by amino(4-amidinophenyl)methanephosphonate diphenyl ester derivatives: X-ray structures and molecular models.
Biochemistry, 35, 1996
1MAY
  • Download 1may
  • View 1may
Molmil generated image of 1may
BETA-TRYPSIN PHOSPHONATE INHIBITED
分子名称:BETA-TRYPSIN, CALCIUM ION, [N-(BENZYLOXYCARBONYL)AMINO](4-AMIDINOPHENYL)METHANE-PHOSPHONATE
著者Bertrand, J., Oleksyszyn, J., Kam, C., Boduszek, B., Presnell, S., Plaskon, R., Suddath, F., Powers, J., Williams, L.
登録日1996-02-06
公開日1996-10-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Inhibition of trypsin and thrombin by amino(4-amidinophenyl)methanephosphonate diphenyl ester derivatives: X-ray structures and molecular models.
Biochemistry, 35, 1996
1UAG
  • Download 1uag
  • View 1uag
Molmil generated image of 1uag
UDP-N-ACETYLMURAMOYL-L-ALANINE:D-GLUTAMATE LIGASE
分子名称:UDP-N-ACETYLMURAMOYL-L-ALANINE/:D-GLUTAMATE LIGASE, SULFATE ION, URIDINE-5'-DIPHOSPHATE-N-ACETYLMURAMOYL-L-ALANINE
著者Bertrand, J., Fanchon, E., Dideberg, O.
登録日1997-03-13
公開日1998-03-18
最終更新日2018-04-11
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase from Escherichia coli.
EMBO J., 16, 1997
3UAG
  • Download 3uag
  • View 3uag
Molmil generated image of 3uag
UDP-N-ACETYLMURAMOYL-L-ALANINE:D-GLUTAMATE LIGASE
分子名称:PROTEIN (UDP-N-ACETYLMURAMOYL-L-ALANINE:D-GLUTAMATE LIGASE), MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE-N-ACETYLMURAMOYL-L-ALANINE, ...
著者Bertrand, J.A., Auger, G., Martin, L., Fanchon, E., Blanot, D., Le Beller, D., Van Heijenoort, J., Dideberg, O.
登録日1999-02-24
公開日2000-02-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Determination of the MurD mechanism through crystallographic analysis of enzyme complexes.
J.Mol.Biol., 289, 1999
1QDD
  • Download 1qdd
  • View 1qdd
Molmil generated image of 1qdd
CRYSTAL STRUCTURE OF HUMAN LITHOSTATHINE TO 1.3 A RESOLUTION
分子名称:LITHOSTATHINE, O-SIALIC ACID, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
著者Gerbaud, V., Pignol, D., Loret, E., Bertrand, J.A., Berland, Y., Fontecilla-Camps, J.C., Canselier, J.P., Gabas, N., Verdier, J.M.
登録日1999-05-20
公開日1999-05-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Mechanism of calcite crystal growth inhibition by the N-terminal undecapeptide of lithostathine.
J.Biol.Chem., 275, 2000
1BJU
  • Download 1bju
  • View 1bju
Molmil generated image of 1bju
BETA-TRYPSIN COMPLEXED WITH ACPU
分子名称:BETA-TRYPSIN, CALCIUM ION, SULFATE ION, ...
著者Presnell, S., Patil, G., Mura, C., Jude, K., Conley, J., Kam, C., Bertrand, J., Powers, J., Williams, L.
登録日1998-06-29
公開日1998-12-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Oxyanion-mediated inhibition of serine proteases.
Biochemistry, 37, 1998
1BJV
  • Download 1bjv
  • View 1bjv
Molmil generated image of 1bjv
BETA-TRYPSIN COMPLEXED WITH APPU
分子名称:BETA-TRYPSIN, CALCIUM ION, SULFATE ION, ...
著者Presnell, S., Patil, G., Mura, C., Jude, K., Conley, J., Kam, C., Bertrand, J., Powers, J., Williams, L.
登録日1998-06-29
公開日1998-12-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Oxyanion-mediated inhibition of serine proteases.
Biochemistry, 37, 1998
4O3M
  • Download 4o3m
  • View 4o3m
Molmil generated image of 4o3m
TERNARY COMPLEX OF BLOOM'S SYNDROME HELICASE
分子名称:Bloom syndrome protein, 5'-D(*AP*GP*CP*GP*TP*CP*GP*AP*GP*AP*TP*CP*CP*AP*AP*G)-3', 5'-D(*CP*TP*TP*GP*GP*AP*TP*CP*TP*CP*GP*AP*CP*GP*CP*TP*CP*TP*CP*CP*CP*TP*TP*A)-3', ...
著者Swan, M.K., Bertrand, J.
登録日2013-12-18
公開日2014-03-12
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA.
Acta Crystallogr.,Sect.D, 70, 2014
3FSF
  • Download 3fsf
  • View 3fsf
Molmil generated image of 3fsf
P38 KINASE CRYSTAL STRUCTURE IN COMPLEX WITH 3-(2,6-DICHLORO-PHENYL)-7-[4-(2-DIETHYLAMINO-ETHOXY)-PHENYLAMINO]-1-METHYL-3,4-DIHYDRO-1H-PYRIMIDO[4,5-D]PYRIMIDIN-2-ONE
分子名称:Mitogen-activated protein kinase 14, 3-(2,6-dichlorophenyl)-7-({4-[(diethylamino)methoxy]phenyl}amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one
著者Kuglstatter, A., Bertrand, J., Lovejoy, B.
登録日2009-01-09
公開日2009-12-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Discovery of Pamapimod and R1487 as Orally Bioavailable and Highly Selective Inhibitors of p38 Map Kinase
To be Published
3FSK
  • Download 3fsk
  • View 3fsk
Molmil generated image of 3fsk
P38 KINASE CRYSTAL STRUCTURE IN COMPLEX WITH RO6257
分子名称:Mitogen-activated protein kinase 14, 3-(2-chlorophenyl)-7-[(trans-4-hydroxycyclohexyl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one
著者Kuglstatter, A., Bertrand, J., Takahara, P., Villasenor, A.
登録日2009-01-09
公開日2009-12-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Mapping Binding Pocket Volume: Potential Applications towards Ligand Design and Selectivity
To be Published