Author results

3PE1
  • Download 3pe1
  • View 3pe1
Molmil generated image of 3pe1
CRYSTAL STRUCTURE OF HUMAN PROTEIN KINASE CK2 ALPHA SUBUNIT IN COMPLEX WITH THE INHIBITOR CX-4945
Descriptor:Casein kinase II subunit alpha, 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, SULFATE ION
Authors:Battistutta, R., Papinutto, E., Lolli, G., Pierre, F., Haddach, M., Ryckman, D.M.
Deposit date:2010-10-25
Release date:2011-09-07
Last modified:2012-01-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer.
Biochemistry, 50, 2011
3PE2
  • Download 3pe2
  • View 3pe2
Molmil generated image of 3pe2
CRYSTAL STRUCTURE OF HUMAN PROTEIN KINASE CK2 IN COMPLEX WITH THE INHIBITOR CX-5011
Descriptor:Casein kinase II subunit alpha, 5-[(3-ethynylphenyl)amino]pyrimido[4,5-c]quinoline-8-carboxylic acid, SULFATE ION
Authors:Battistutta, R., Papinutto, E., Lolli, G., Pierre, F., Haddach, M., Ryckman, D.M.
Deposit date:2010-10-25
Release date:2011-09-07
Last modified:2012-01-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer.
Biochemistry, 50, 2011
3R0T
  • Download 3r0t
  • View 3r0t
Molmil generated image of 3r0t
CRYSTAL STRUCTURE OF HUMAN PROTEIN KINASE CK2 ALPHA SUBUNIT IN COMPLEX WITH THE INHIBITOR CX-5279
Descriptor:Casein kinase II subunit alpha, 3-(cyclopropylamino)-5-{[3-(trifluoromethyl)phenyl]amino}pyrimido[4,5-c]quinoline-8-carboxylic acid, SULFATE ION, ...
Authors:Battistutta, R., Papinutto, E., Lolli, G., Pierre, F., Haddach, M., Ryckman, D.M.
Deposit date:2011-03-09
Release date:2011-12-07
Last modified:2014-10-29
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer.
Biochemistry, 50, 2011
1B9C
  • Download 1b9c
  • View 1b9c
Molmil generated image of 1b9c
GREEN FLUORESCENT PROTEIN MUTANT F99S, M153T AND V163A
Descriptor:PROTEIN (GREEN FLUORESCENT PROTEIN)
Authors:Battistutta, R., Negro, A., Zanotti, G.
Deposit date:1999-02-09
Release date:2000-11-17
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure and refolding properties of the mutant F99S/M153T/V163A of the green fluorescent protein.
Proteins, 41, 2000
1DS5
  • Download 1ds5
  • View 1ds5
Molmil generated image of 1ds5
DIMERIC CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT IN COMPLEX WITH TWO BETA PEPTIDES MIMICKING THE ARCHITECTURE OF THE TETRAMERIC PROTEIN KINASE CK2 HOLOENZYME.
Descriptor:CASEIN KINASE, ALPHA CHAIN, BETA CHAIN, ...
Authors:Battistutta, R., Sarno, S., De Moliner, E., Marin, O., Zanotti, G., Pinna, L.A.
Deposit date:2000-01-07
Release date:2001-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:The crystal structure of the complex of Zea mays alpha subunit with a fragment of human beta subunit provides the clue to the architecture of protein kinase CK2 holoenzyme.
Eur.J.Biochem., 267, 2000
1F0Q
  • Download 1f0q
  • View 1f0q
Molmil generated image of 1f0q
CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT OF PROTEIN KINASE CK2 IN COMPLEX WITH THE NUCLEOTIDE COMPETITIVE INHIBITOR EMODIN
Descriptor:PROTEIN KINASE CK2, ALPHA SUBUNIT, 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE
Authors:Battistutta, R., Sarno, S., De Moliner, E., Papinutto, E., Zanotti, G., Pinna, L.A.
Deposit date:2000-05-17
Release date:2001-05-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:The replacement of ATP by the competitive inhibitor emodin induces conformational modifications in the catalytic site of protein kinase CK2.
J.Biol.Chem., 275, 2000
1J91
  • Download 1j91
  • View 1j91
Molmil generated image of 1j91
CRYSTAL STRUCTURE OF Z. MAYS CK2 KINASE ALPHA SUBUNIT IN COMPLEX WITH THE ATP-COMPETITIVE INHIBITOR 4,5,6,7-TETRABROMOBENZOTRIAZOLE
Descriptor:CASEIN KINASE II, ALPHA CHAIN, 4,5,6,7-TETRABROMOBENZOTRIAZOLE
Authors:Battistutta, R., De Moliner, E., Sarno, S., Zanotti, G., Pinna, L.A.
Deposit date:2001-05-23
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structural features underlying selective inhibition of protein kinase CK2 by ATP site-directed tetrabromo-2-benzotriazole.
Protein Sci., 10, 2001
1JAM
  • Download 1jam
  • View 1jam
Molmil generated image of 1jam
CRYSTAL STRUCTURE OF APO-FORM OF Z. MAYS CK2 PROTEIN KINASE ALPHA SUBUNIT
Descriptor:CASEIN KINASE II, ALPHA CHAIN
Authors:Battistutta, R., De Moliner, E., Sarno, S., Zanotti, G., Pinna, L.A.
Deposit date:2001-05-31
Release date:2002-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structural features underlying selective inhibition of protein kinase CK2 by ATP site-directed tetrabromo-2-benzotriazole.
Protein Sci., 10, 2001
1ZOE
  • Download 1zoe
  • View 1zoe
Molmil generated image of 1zoe
CRYSTAL STRUCTURE OF PROTEIN KINASE CK2 IN COMPLEX WITH TBB-DERIVATIVES INHIBITORS
Descriptor:Protein kinase CK2, alpha Subunit, CHLORIDE ION, ...
Authors:Battistutta, R., Mazzorana, M., Sarno, S., Kazimierczuk, Z., Zanotti, G., Pinna, L.A.
Deposit date:2005-05-13
Release date:2005-11-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole.
Chem.Biol., 12, 2005
1ZOG
  • Download 1zog
  • View 1zog
Molmil generated image of 1zog
CRYSTAL STRUCTURE OF PROTEIN KINASE CK2 IN COMPLEX WITH TBB-DERIVATIVES
Descriptor:PROTEIN KINASE CK2, alpha SUBUNIT, 4,5,6,7-TETRABROMO-2-(METHYLSULFANYL)-1H-BENZIMIDAZOLE
Authors:Battistutta, R., Mazzorana, M., Sarno, S., Kazimierczuk, Z., Zanotti, G., Pinna, L.A.
Deposit date:2005-05-13
Release date:2005-11-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole.
Chem.Biol., 12, 2005
1ZOH
  • Download 1zoh
  • View 1zoh
Molmil generated image of 1zoh
CRYSTAL STRUCTURE OF PROTEIN KINASE CK2 IN COMPLEX WITH TBB-DERIVATIVES INHIBITORS
Descriptor:PROTEIN KINASE CK2, ALPHA SUBUNIT, SODIUM ION, ...
Authors:Battistutta, R., Mazzorana, M., Sarno, S., Kazimierczuk, Z., Zanotti, G., Pinna, L.A.
Deposit date:2005-05-13
Release date:2005-11-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole.
Chem.Biol., 12, 2005
2OXD
  • Download 2oxd
  • View 2oxd
Molmil generated image of 2oxd
PROTEIN KINASE CK2 IN COMPLEX WITH TETRABROMOBENZOIMIDAZOLE K17, K22 AND K32 INHIBITORS
Descriptor:Casein kinase II subunit alpha, 4,5,6,7-TETRABROMO-1H,3H-BENZIMIDAZOL-2-ONE
Authors:Battistutta, R., Zanotti, G., Cendron, L.
Deposit date:2007-02-20
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The ATP-Binding Site of Protein Kinase CK2 Holds a Positive Electrostatic Area and Conserved Water Molecules.
Chembiochem, 8, 2007
2OXX
  • Download 2oxx
  • View 2oxx
Molmil generated image of 2oxx
PROTEIN KINASE CK2 IN COMPLEX WITH TETRABROMOBENZOIMIDAZOLE DERIVATIVES K17, K22 AND K32
Descriptor:Casein kinase II subunit alpha, 4,5,6,7-TETRABROMO-1H,3H-BENZIMIDAZOL-2-THIONE
Authors:Battistutta, R., Zanotti, G., Cendron, L.
Deposit date:2007-02-21
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The ATP-Binding Site of Protein Kinase CK2 Holds a Positive Electrostatic Area and Conserved Water Molecules.
Chembiochem, 8, 2007
2OXY
  • Download 2oxy
  • View 2oxy
Molmil generated image of 2oxy
PROTEIN KINASE CK2 IN COMPLEX WITH TETRABROMOBENZOIMIDAZOLE DERIVATIVES K17, K22 AND K32
Descriptor:Casein kinase II subunit alpha, 4,5,6,7-TETRABROMO-BENZIMIDAZOLE
Authors:Battistutta, R., Zanotti, G., Cendron, L.
Deposit date:2007-02-21
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.812 Å)
Cite:The ATP-Binding Site of Protein Kinase CK2 Holds a Positive Electrostatic Area and Conserved Water Molecules.
Chembiochem, 8, 2007
3PWD
  • Download 3pwd
  • View 3pwd
Molmil generated image of 3pwd
CRYSTAL STRUCTURE OF MAIZE CK2 IN COMPLEX WITH NBC (Z1)
Descriptor:Casein kinase II subunit alpha, 8-hydroxy-4-methyl-9-nitro-2H-benzo[g]chromen-2-one
Authors:Battistutta, R., Mazzorana, M.
Deposit date:2010-12-08
Release date:2011-11-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A
Cell.Mol.Life Sci., 69, 2012
1OM1
  • Download 1om1
  • View 1om1
Molmil generated image of 1om1
CRYSTAL STRUCTURE OF MAIZE CK2 ALPHA IN COMPLEX WITH IQA
Descriptor:Casein kinase II, alpha chain, (5-OXO-5,6-DIHYDRO-INDOLO[1,2-A]QUINAZOLIN-7-YL)-ACETIC ACID
Authors:Battistutta, R., De Moliner, E., Zanotti, G.
Deposit date:2003-02-24
Release date:2004-02-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA).
Biochem.J., 374, 2003
2QC6
  • Download 2qc6
  • View 2qc6
Molmil generated image of 2qc6
PROTEIN KINASE CK2 IN COMPLEX WITH DBC
Descriptor:Casein kinase II subunit alpha, 3,8-DIBROMO-7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE
Authors:Battistutta, R.
Deposit date:2007-06-19
Release date:2008-02-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Coumarin as attractive casein kinase 2 (CK2) inhibitor scaffold: an integrate approach to elucidate the putative binding motif and explain structure-activity relationships.
J.Med.Chem., 51, 2008
3PZH
  • Download 3pzh
  • View 3pzh
Molmil generated image of 3pzh
CRYSTAL STRUCTURE OF MAIZE CK2 ALPHA IN COMPLEX WITH EMODIN AT 1.92 A RESOLUTION
Descriptor:Casein kinase II subunit alpha, 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, ACETATE ION, ...
Authors:Battistutta, R., Mazzorana, M.
Deposit date:2010-12-14
Release date:2011-12-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.919 Å)
Cite:Structural and functional analysis of the flexible regions of the catalytic alpha-subunit of protein kinase CK2
to be published
3Q04
  • Download 3q04
  • View 3q04
Molmil generated image of 3q04
CRYSTAL STRUCTURE OF THE APO-FORM OF HUMAN CK2 ALPHA AT PH 8.5
Descriptor:Casein kinase II subunit alpha, SULFATE ION, 1,2-ETHANEDIOL
Authors:Battistutta, R., Ranchio, A., Papinutto, E.
Deposit date:2010-12-15
Release date:2011-12-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and functional analysis of the flexible regions of the catalytic alpha-subunit of protein kinase CK2
to be published
3Q9W
  • Download 3q9w
  • View 3q9w
Molmil generated image of 3q9w
CRYSTAL STRUCTURE OF HUMAN CK2 ALPHA IN COMPLEX WITH EMODIN AT PH 8.5
Descriptor:Casein kinase II subunit alpha, 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, SULFATE ION
Authors:Battistutta, R., Ranchio, A., Papinutto, E.
Deposit date:2011-01-10
Release date:2012-01-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and functional analysis of the flexible regions of the catalytic alpha-subunit of protein kinase CK2
To be Published
3Q9X
  • Download 3q9x
  • View 3q9x
Molmil generated image of 3q9x
CRYSTAL STRUCTURE OF HUMAN CK2 ALPHA IN COMPLEX WITH EMODIN AT PH 6.5
Descriptor:Casein kinase II subunit alpha, 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, 1,2-ETHANEDIOL, ...
Authors:Battistutta, R., Ranchio, A., Papinutto, E.
Deposit date:2011-01-10
Release date:2012-01-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and functional analysis of the flexible regions of the catalytic alpha-subunit of protein kinase CK2
To be Published
3Q9Y
  • Download 3q9y
  • View 3q9y
Molmil generated image of 3q9y
CRYSTAL STRUCTURE OF HUMAN CK2 ALPHA IN COMPLEX WITH QUINALIZARIN AT PH 8.5
Descriptor:Casein kinase II subunit alpha, 1,2,5,8-tetrahydroxyanthracene-9,10-dione, SULFATE ION
Authors:Battistutta, R., Ranchio, A., Papinutto, E.
Deposit date:2011-01-10
Release date:2012-01-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and functional analysis of the flexible regions of the catalytic alpha-subunit of protein kinase CK2
To be Published
3Q9Z
  • Download 3q9z
  • View 3q9z
Molmil generated image of 3q9z
CRYSTAL STRUCTURE OF HUMAN CK2 ALPHA IN COMPLEX WITH QUINALIZARIN AT PH 6.5
Descriptor:Casein kinase II subunit alpha, SULFATE ION, 1,2,5,8-tetrahydroxyanthracene-9,10-dione, ...
Authors:Battistutta, R., Ranchio, A., Papinutto, E.
Deposit date:2011-01-10
Release date:2012-01-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and functional analysis of the flexible regions of the catalytic alpha-subunit of protein kinase CK2
To be Published
3QA0
  • Download 3qa0
  • View 3qa0
Molmil generated image of 3qa0
CRYSTAL STRUCTURE OF THE APO-FORM OF HUMAN CK2 ALPHA AT PH 6.5
Descriptor:Casein kinase II subunit alpha, SULFATE ION, 1,2-ETHANEDIOL
Authors:Battistutta, R., Ranchio, A., Papinutto, E.
Deposit date:2011-01-10
Release date:2012-01-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and functional analysis of the flexible regions of the catalytic alpha-subunit of protein kinase CK2
To be Published
2FJC
  • Download 2fjc
  • View 2fjc
Molmil generated image of 2fjc
CRYSTAL STRUCTURE OF ANTIGEN TPF1 FROM TREPONEMA PALLIDUM
Descriptor:Antigen TpF1, FE (III) ION
Authors:Thumiger, A., Polenghi, A., Papinutto, E., Battistutta, R., Montecucco, C., Zanotti, G.
Deposit date:2006-01-02
Release date:2006-01-10
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of antigen TpF1 from Treponema pallidum.
Proteins, 62, 2006