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5IET
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ATP-INDEPENDENT PROTEASOME ACTIVATOR
Descriptor:Bacterial proteasome activator, SULFATE ION, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Bai, L., Hu, K., Wang, T., Jastrab, J.B., Darwin, K.H., Li, H.
Deposit date:2016-02-25
Release date:2016-03-30
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5IEU
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ATP-INDEPENDENT PROTEASOME ACTIVATOR TETRAMER
Descriptor:Bacterial proteasome activator
Authors:Bai, L., Hu, K., Wang, T., Jastrab, J.B., Darwin, K.H., Li, H.
Deposit date:2016-02-25
Release date:2016-03-30
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5UN0
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS PROTEASOME-ASSEMBLY CHAPERONE HOMOLOGUE RV2125
Descriptor:proteasome assembly chaperone 2 (PAC2) homologue Rv2125
Authors:Bai, L., Jastrab, J.B., Hu, K., Yu, H., Darwin, K.H., Li, H.
Deposit date:2017-01-30
Release date:2017-03-01
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Analysis of Mycobacterium tuberculosis Homologues of the Eukaryotic Proteasome Assembly Chaperone 2 (PAC2).
J. Bacteriol., 199, 2017
6C26
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THE CRYO-EM STRUCTURE OF A EUKARYOTIC OLIGOSACCHARYL TRANSFERASE COMPLEX
Descriptor:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST5, ...
Authors:Bai, L., Li, H.
Deposit date:2018-01-06
Release date:2018-01-31
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:The atomic structure of a eukaryotic oligosaccharyltransferase complex.
Nature, 555, 2018
6P25
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STRUCTURE OF S. CEREVISIAE PROTEIN O-MANNOSYLTRANSFERASE PMT1-PMT2 COMPLEX BOUND TO THE SUGAR DONOR AND A PEPTIDE ACCEPTOR
Descriptor:Dolichyl-phosphate-mannose--protein mannosyltransferase 1, Dolichyl-phosphate-mannose--protein mannosyltransferase 2, acceptor peptide, ...
Authors:Bai, L., Li, H.
Deposit date:2019-05-21
Release date:2019-07-10
Last modified:2019-12-04
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the eukaryotic protein O-mannosyltransferase Pmt1-Pmt2 complex.
Nat.Struct.Mol.Biol., 26, 2019
6P28
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CRYSTAL STRUCTURE OF THE MIR DOMAIN (AA 337-532) OF THE S. CEREVISIAE MANNOSYLTRANSFERASE PMT2
Descriptor:Dolichyl-phosphate-mannose--protein mannosyltransferase 2
Authors:Bai, L., Li, H.
Deposit date:2019-05-21
Release date:2019-07-10
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure of the eukaryotic protein O-mannosyltransferase Pmt1-Pmt2 complex.
Nat.Struct.Mol.Biol., 26, 2019
6P2R
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STRUCTURE OF S. CEREVISIAE PROTEIN O-MANNOSYLTRANSFERASE PMT1-PMT2 COMPLEX BOUND TO THE SUGAR DONOR
Descriptor:Dolichyl-phosphate-mannose--protein mannosyltransferase 1, Dolichyl-phosphate-mannose--protein mannosyltransferase 2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Bai, L., Li, H.
Deposit date:2019-05-21
Release date:2019-07-10
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the eukaryotic protein O-mannosyltransferase Pmt1-Pmt2 complex.
Nat.Struct.Mol.Biol., 26, 2019
6PSX
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CRYO-EM STRUCTURE OF S. CEREVISIAE DRS2P-CDC50P IN THE PI4P-ACTIVATED FORM
Descriptor:Probable phospholipid-transporting ATPase DRS2, Cell division control protein 50, N-ACETYL-D-GLUCOSAMINE
Authors:Bai, L., Li, H.
Deposit date:2019-07-14
Release date:2019-09-25
Last modified:2019-12-04
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p.
Nat Commun, 10, 2019
6PSY
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CRYO-EM STRUCTURE OF S. CEREVISIAE DRS2P-CDC50P IN THE AUTOINHIBITED APO FORM
Descriptor:Probable phospholipid-transporting ATPase DRS2, Cell division control protein 50, N-ACETYL-D-GLUCOSAMINE
Authors:Bai, L., Li, H.
Deposit date:2019-07-14
Release date:2019-09-25
Last modified:2019-12-04
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p.
Nat Commun, 10, 2019
4GIW
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CRYSTAL STRUCTURE OF THE RUN DOMAIN OF HUMAN NESCA
Descriptor:RUN and SH3 domain-containing protein 1
Authors:Bai, L., Sun, Q., Jiang, T.
Deposit date:2012-08-09
Release date:2012-08-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure and functional implication of the RUN domain of human NESCA
Protein Cell, 3, 2012
5O4H
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HCGC FROM METHANOCOCCUS MARIPALUDIS COCRYSTALLIZED WITH SAM AND PYRIDINOL
Descriptor:HcgC, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ...
Authors:Wagner, T., Bai, L., Xu, T., Hu, X., Ermler, U., Shima, S.
Deposit date:2017-05-29
Release date:2017-07-19
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A Water-Bridged H-Bonding Network Contributes to the Catalysis of the SAM-Dependent C-Methyltransferase HcgC.
Angew. Chem. Int. Ed. Engl., 56, 2017
5O4J
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HCGC FROM METHANOCOCCUS MARIPALUDIS COCRYSTALLIZED WITH SAH AND PYRIDINOL
Descriptor:HcgC, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ...
Authors:Wagner, T., Bai, L., Xu, T., Hu, X., Ermler, U., Shima, S.
Deposit date:2017-05-29
Release date:2017-07-19
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A Water-Bridged H-Bonding Network Contributes to the Catalysis of the SAM-Dependent C-Methyltransferase HcgC.
Angew. Chem. Int. Ed. Engl., 56, 2017
5O4M
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FRESH CRYSTALS OF HCGC FROM METHANOCOCCUS MARIPALUDIS COCRYSTALLIZED WITH SAH AND PYRIDINOL
Descriptor:HcgC, S-ADENOSYL-L-HOMOCYSTEINE, 6-carboxy methyl-4-hydroxy-2-pyridinol, ...
Authors:Wagner, T., Bai, L., Xu, T., Hu, X., Ermler, U., Shima, S.
Deposit date:2017-05-29
Release date:2017-07-19
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Water-Bridged H-Bonding Network Contributes to the Catalysis of the SAM-Dependent C-Methyltransferase HcgC.
Angew. Chem. Int. Ed. Engl., 56, 2017
5O4N
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APO HCGC FROM METHANOCOCCUS MARIPALUDIS SOAKED WITH SAH AND PYRIDINOL
Descriptor:HcgC, S-ADENOSYL-L-HOMOCYSTEINE, 6-carboxy methyl-4-hydroxy-2-pyridinol, ...
Authors:Wagner, T., Bai, L., Xu, T., Hu, X., Ermler, U., Shima, S.
Deposit date:2017-05-29
Release date:2017-07-19
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:A Water-Bridged H-Bonding Network Contributes to the Catalysis of the SAM-Dependent C-Methyltransferase HcgC.
Angew. Chem. Int. Ed. Engl., 56, 2017
3HFX
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CRYSTAL STRUCTURE OF CARNITINE TRANSPORTER
Descriptor:L-carnitine/gamma-butyrobetaine antiporter, MERCURY (II) ION, CARNITINE
Authors:Tang, L., Wang, W.-H., Bai, L., Jiang, T.
Deposit date:2009-05-13
Release date:2010-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Crystal structure of the carnitine transporter and insights into the antiport mechanism
Nat.Struct.Mol.Biol., 17, 2010
3GGR
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CRYSTAL STRUCTURE OF THE HUMAN RAD9-HUS1-RAD1 COMPLEX
Descriptor:Cell cycle checkpoint control protein RAD9A, Checkpoint protein HUS1, Cell cycle checkpoint protein RAD1
Authors:Xu, M., Bai, L., Hang, H.Y., Jiang, T.
Deposit date:2009-03-02
Release date:2009-06-16
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure and functional implications of the human rad9-hus1-rad1 cell cycle checkpoint complex
J.Biol.Chem., 284, 2009
3JC5
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STRUCTURE OF THE EUKARYOTIC REPLICATIVE CMG HELICASE AND PUMPJACK MOTION
Descriptor:DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ...
Authors:Li, H., Bai, L., Yuan, Z., Sun, J., Georgescu, R.E., Liu, J., O'Donnell, M.E.
Deposit date:2015-11-24
Release date:2016-02-10
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.
Nat.Struct.Mol.Biol., 23, 2016
3JC6
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STRUCTURE OF THE EUKARYOTIC REPLICATIVE CMG HELICASE AND PUMPJACK MOTION
Descriptor:DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ...
Authors:Li, H., Bai, L., Yuan, Z., Sun, J., Georgescu, R.E., Liu, J., O'Donnell, M.E.
Deposit date:2015-11-24
Release date:2016-02-10
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.
Nat.Struct.Mol.Biol., 23, 2016
3JC7
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STRUCTURE OF THE EUKARYOTIC REPLICATIVE CMG HELICASE AND PUMPJACK MOTION
Descriptor:DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ...
Authors:Li, H., Bai, L., Yuan, Z., Sun, J., Georgescu, R.E., Liu, J., O'Donnell, M.E.
Deposit date:2015-11-24
Release date:2016-02-10
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.
Nat.Struct.Mol.Biol., 23, 2016
3OLC
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CRYSTAL STRUCTURE OF THE N-TERMINAL REGION OF TOPBP1
Descriptor:DNA topoisomerase 2-binding protein 1
Authors:Huo, Y.G., Bai, L., Xu, M., Jiang, T.
Deposit date:2010-08-25
Release date:2011-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the N-terminal region of human Topoisomerase II beta binding protein 1
Biochem.Biophys.Res.Commun., 401, 2010
4ZRA
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS LPRG BINDING TO TRIACYLGLYCERIDE
Descriptor:Lipoprotein LprG, Tripalmitoylglycerol
Authors:Martinot, A.J., Farrow, M., Bai, L., Layre, E., Cheng, T.Y., Tsai, J.H.C., Iqbal, J., Annand, J., Sullivan, Z., Hussain, M., Sacchettini, J., Moody, D.B., Seeliger, J., Rubin, E.J., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-05-12
Release date:2016-02-10
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis.
Plos Pathog., 12, 2016
5BK4
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CRYO-EM STRUCTURE OF MCM2-7 DOUBLE HEXAMER ON DSDNA
Descriptor:DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ...
Authors:Li, H., Yuan, Z., Bai, L.
Deposit date:2017-09-12
Release date:2017-10-25
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5KZF
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CRYSTAL STRUCTURE OF NEAR FULL-LENGTH HEXAMERIC MYCOBACTERIUM TUBERCULOSIS PROTEASOMAL ATPASE MPA IN APO FORM
Descriptor:Proteasome-associated ATPase
Authors:Li, H., Hu, K., Yang, S., Bai, L.
Deposit date:2016-07-25
Release date:2017-05-17
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (3.49 Å)
Cite:Mycobacterium tuberculosis proteasomal ATPase Mpa has a beta-grasp domain that hinders docking with the proteasome core protease.
Mol. Microbiol., 105, 2017
5V8F
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STRUCTURAL BASIS OF MCM2-7 REPLICATIVE HELICASE LOADING BY ORC-CDC6 AND CDT1
Descriptor:DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ...
Authors:Yuan, Z., Riera, A., Bai, L., Sun, J., Spanos, C., Chen, Z.A., Barbon, M., Rappsilber, J., Stillman, B., Speck, C., Li, H.
Deposit date:2017-03-21
Release date:2017-05-10
Last modified:2020-01-01
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1.
Nat. Struct. Mol. Biol., 24, 2017
6AVO
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CRYO-EM STRUCTURE OF HUMAN IMMUNOPROTEASOME WITH A NOVEL NONCOMPETITIVE INHIBITOR THAT SELECTIVELY INHIBITS ACTIVATED LYMPHOCYTES
Descriptor:Proteasome subunit beta type-9, Proteasome subunit beta type-10, Proteasome subunit beta type-8, ...
Authors:Li, H., Santos, R., Bai, L.
Deposit date:2017-09-04
Release date:2017-12-06
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes.
Nat Commun, 8, 2017
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