Author results

1ENW
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ELONGATION FACTOR TFIIS DOMAIN II
Descriptor:TRANSCRIPTION ELONGATION FACTOR S-II
Authors:Morin, P.E., Awrey, D.E., Edwards, A.M., Arrowsmith, C.H.
Deposit date:2000-03-21
Release date:2000-04-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Elongation factor TFIIS contains three structural domains: solution structure of domain II.
Proc.Natl.Acad.Sci.USA, 93, 1996
4JS8
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CRYSTAL STRUCTURE OF TTK KINASE DOMAIN WITH AN INHIBITOR: 401348
Descriptor:Dual specificity protein kinase TTK, 4-(cyclohexylmethoxy)-3-{4-[(1-methylpiperidin-4-yl)oxy]phenyl}-2H-indazole, SULFATE ION, ...
Authors:Qiu, W., Plotnikov, A.N., Plotnikova, O., Feher, M., Awrey, D.E., Chirgadze, N.Y.
Deposit date:2013-03-22
Release date:2014-03-26
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystal structure of TTK kinase domain with an inhibitor: 401348
To be Published
4JT3
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CRYSTAL STRUCTURE OF TTK KINASE DOMAIN WITH AN INHIBITOR: 400740
Descriptor:Dual specificity protein kinase TTK, PHOSPHATE ION, 2-phenyl-N-[3-(3-sulfamoylphenyl)-2H-indazol-5-yl]acetamide, ...
Authors:Qiu, W., Harris-Brandts, M., Feher, M., Awrey, D.E., Chirgadze, N.Y.
Deposit date:2013-03-22
Release date:2014-03-26
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of TTK kinase domain with an inhibitor: 400740
To be Published
4JXF
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CRYSTAL STRUCTURE OF PLK4 KINASE WITH AN INHIBITOR: 400631 ((1R,2S)-2-{3-[(E)-2-{4-[(DIMETHYLAMINO)METHYL]PHENYL}ETHENYL]-2H-INDAZOL-6-YL}-5'-METHOXYSPIRO[CYCLOPROPANE-1,3'-INDOL]-2'(1'H)-ONE)
Descriptor:Serine/threonine-protein kinase PLK4, (1R,2S)-2-{3-[(E)-2-{4-[(dimethylamino)methyl]phenyl}ethenyl]-2H-indazol-6-yl}-5'-methoxyspiro[cyclopropane-1,3'-indol]-2'(1'H)-one, 1,2-ETHANEDIOL
Authors:Qiu, W., Plotnikova, O., Feher, M., Awrey, D.E., Chirgadze, N.Y.
Deposit date:2013-03-28
Release date:2014-04-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of PLK4 Kinase with an inhibitor: 400631
To be Published
4O6L
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CRYSTAL STRUCTURE OF TTK KINASE DOMAIN WITH AN INHIBITOR: 401498 (N-[(1R)-1-(2-CHLOROPHENYL)PROPYL]-3-{4-[(1-METHYLPIPERIDIN-4-YL)OXY]PHENYL}-1H-INDAZOLE-5-CARBOXAMIDE)
Descriptor:Dual specificity protein kinase TTK, N-[(1R)-1-(2-chlorophenyl)propyl]-3-{4-[(1-methylpiperidin-4-yl)oxy]phenyl}-1H-indazole-5-carboxamide, GLYCEROL
Authors:Qiu, W., Plotnikova, O., Feher, M., Awrey, D.E., Chirgadze, N.Y.
Deposit date:2013-12-22
Release date:2014-12-24
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal Structure of TTK kinase domain with an inhibitor: 401498
TO BE PUBLISHED
4ZEG
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CRYSTAL STRUCTURE OF TTK KINASE DOMAIN IN COMPLEX WITH A PYRAZOLOPYRIMIDINE INHIBITOR
Descriptor:Dual specificity protein kinase TTK, GLYCEROL, DI(HYDROXYETHYL)ETHER, ...
Authors:Qiu, W., Plotnikova, O., Feher, M., Awrey, D.E., Battaile, K., Chirgadze, N.Y.
Deposit date:2015-04-20
Release date:2016-04-27
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Crystal structure of TTK kinase domain in complex with a pyrazolopyrimidine inhibitor.
To Be Published
4FS3
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS ENOYL-ACP REDUCTASE IN COMPLEX WITH NADP AND AFN-1252
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI, [[(2R,3S,4R,5R)-5-(3-aminocarbonyl-4H-pyridin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate, N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)propanamide
Authors:Kaplan, N., Yethon, J., Bardouniotis, E., Thalakada, R., Albert, M., Awrey, D.E., Romanov, V., Dorsey, M., Ramnauth, J., Clarke, T.E., Schmid, M.B., Berman, J., Pauls, H.W.
Deposit date:2012-06-26
Release date:2012-09-19
Last modified:2012-11-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mode of Action, In Vitro Activity, and In Vivo Efficacy of AFN-1252, a Selective Antistaphylococcal FabI Inhibitor.
Antimicrob.Agents Chemother., 56, 2012