Author results

4H58
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BRAF IN COMPLEX WITH COMPOUND 3
Descriptor:Serine/threonine-protein kinase B-raf, N-(4-{[(2-methoxyethyl)amino]methyl}phenyl)-6-(pyridin-4-yl)quinazolin-2-amine, CHLORIDE ION
Authors:Vasbinder, M., Aquila, B., Augustin, M., Chueng, T., Cook, D., Drew, L., Fauber, B., Glossop, S., Godin, R., Grondine, M., Hennessy, E., Johannes, J., Lee, S., Lyne, P., Moertl, M., Omer, C., Palakurthi, S., Pontz, T., Read, J., Sha, L., Shen, M., Steinbacher, S., Wang, H., Wu, A., Ye, M., Bagal, B.
Deposit date:2012-09-18
Release date:2013-02-27
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Discovery and Optimization of a Novel Series of Potent Mutant B-Raf(V600E) Selective Kinase Inhibitors.
J.Med.Chem., 56, 2013
5O49
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HUMAN FGF IN COMPLEX WITH A COVALENT INHIBITOR
Descriptor:Fibroblast growth factor receptor 1, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl 3-fluorosulfonylbenzoate, SULFATE ION
Authors:Debreczeni, J., Breed, J., Mukherjee, H., Aquila, B., Kaiser, C., Tentarelli, S., Whitty, A., Grimster, N.
Deposit date:2017-05-26
Release date:2018-02-07
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:A study of the reactivity of S(VI)-F containing warheads with nucleophilic amino-acid side chains under physiological conditions.
Org. Biomol. Chem., 15, 2017
5O4A
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HUMAN FGF IN COMPLEX WITH A COVALENT INHIBITOR
Descriptor:Fibroblast growth factor receptor 1, SULFATE ION, GLYCEROL, ...
Authors:Debreczeni, J., Breed, J., Mukherjee, H., Aquila, B., Kaiser, C., Tentarelli, S., Whitty, A., Grimster, N.
Deposit date:2017-05-26
Release date:2018-02-07
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:A study of the reactivity of S(VI)-F containing warheads with nucleophilic amino-acid side chains under physiological conditions.
Org. Biomol. Chem., 15, 2017
4BB4
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EPHB4 KINASE DOMAIN INHIBITOR COMPLEX
Descriptor:EPHRIN TYPE-B RECEPTOR 4, N-(2-methoxyethyl)-4-[(6-pyridin-4-ylquinazolin-2-yl)amino]benzamide, MAGNESIUM ION
Authors:Read, J., Brassington, C.A., Green, I., McCall, E.J., Valentine, A.L.
Deposit date:2012-09-19
Release date:2013-02-27
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Discovery and Optimization of a Novel Series of Potent Mutant B-Raf V600E Selective Kinase Inhibitors.
J.Med.Chem., 56, 2013