Author results

4MPJ
  • Download 4mpj
  • View 4mpj
Molmil generated image of 4mpj
PHOSPHORYLATION OF AN ACTIVE SITE THREONINE IN THE BENZYOLFORMATE DECARBOXYLASE MUTANT S26T BY PHOSPHONATE INACTIVATION
Descriptor:Benzoylformate decarboxylase, CALCIUM ION, MAGNESIUM ION, ...
Authors:Andrews, F.H., McLeish, M.J.
Deposit date:2013-09-12
Release date:2015-03-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Phosphorylation of an active site threonine in the benzyolformate decarboxylase mutant S26T by phosphonate inactivation
To be Published
4MPP
  • Download 4mpp
  • View 4mpp
Molmil generated image of 4mpp
CRYSTAL STRUCTURE OF BENZOYLFORMATE DECARBOXYLASE MUTANT H281Y/T377P/F397T/A460I
Descriptor:Benzoylformate decarboxylase, CALCIUM ION, SODIUM ION, ...
Authors:Andrews, F.H., McLeish, M.J.
Deposit date:2013-09-13
Release date:2015-03-18
Method:X-RAY DIFFRACTION (1.501 Å)
Cite:A pseudo study of thiamin diphosphate-dependent decarboxylases
To be Published
4MPR
  • Download 4mpr
  • View 4mpr
Molmil generated image of 4mpr
BENZOYLFORMATE DECARBOXYLASE: IS THE TETRAMER VITAL FOR ACTIVITY?
Descriptor:Benzoylformate decarboxylase, CALCIUM ION, THIAMINE DIPHOSPHATE, ...
Authors:Andrews, F.H., McLeish, M.J.
Deposit date:2013-09-13
Release date:2014-08-27
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:Perturbation of the monomer-monomer interfaces of the benzoylformate decarboxylase tetramer.
Biochemistry, 53, 2014
4MQ5
  • Download 4mq5
  • View 4mq5
Molmil generated image of 4mq5
CRYSTAL STRUCTURE OF BENZOYLFORMATE DECARBOXYLASE MUTANT A306F
Descriptor:Benzoylformate decarboxylase, CALCIUM ION, THIAMINE DIPHOSPHATE, ...
Authors:Andrews, F.H., McLeish, M.J.
Deposit date:2013-09-15
Release date:2014-08-27
Method:X-RAY DIFFRACTION (1.502 Å)
Cite:Perturbation of the monomer-monomer interfaces of the benzoylformate decarboxylase tetramer.
Biochemistry, 53, 2014
4MZX
  • Download 4mzx
  • View 4mzx
Molmil generated image of 4mzx
CRYSTAL STRUCTURE OF BENZOYLFORMATE DECARBOXYLASE MUTANT T377L/A460Y
Descriptor:Benzoylformate decarboxlyase, CALCIUM ION, GLYCEROL, ...
Authors:Andrews, F.H., McLeish, M.J.
Deposit date:2013-09-30
Release date:2015-04-01
Method:X-RAY DIFFRACTION (1.558 Å)
Cite:Mechanistic and structural insight to an evolved benzoylformate decarboxylase with enhanced activity towards pyruvate
To be Published
4Q9D
  • Download 4q9d
  • View 4q9d
Molmil generated image of 4q9d
X-RAY STRUCTURE OF A PUTATIVE THIAMIN DIPHOSPHATE-DEPENDENT ENZYME ISOLATED FROM MYCOBACTERIUM SMEGMATIS
Descriptor:Benzoylformate decarboxylase, MAGNESIUM ION, FORMIC ACID
Authors:Andrews, F.H., Horton, J.D., Yoon, H.J., Malik, A.M.K., Logsdon, M.G., Shin, D.H., Kneen, M.M., Suh, S.W., McLeish, M.J.
Deposit date:2014-04-30
Release date:2015-04-29
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The kinetic characterization and X-ray structure of a putative benzoylformate decarboxylase from M. smegmatis highlights the difficulties in the functional annotation of ThDP-dependent enzymes.
Biochim.Biophys.Acta, 1854, 2015
4QEL
  • Download 4qel
  • View 4qel
Molmil generated image of 4qel
CRYSTAL STRUCTURE OF BENZOYLFORMATE DECARBOXYLASE MUTANT H70A
Descriptor:Benzoylformate decarboxylase, CALCIUM ION, CHLORIDE ION, ...
Authors:Andrews, F.H., Rogers, M.P., Brodkin, H.R., McLeish, M.J.
Deposit date:2014-05-16
Release date:2015-05-20
Method:X-RAY DIFFRACTION (1.432 Å)
Cite:Structural investigation of benzoylformate decarboxylase active site variants
To be Published
5IOK
  • Download 5iok
  • View 5iok
Molmil generated image of 5iok
CRYSTAL STRUCTURE OF TAF14 YEATS DOMAIN IN COMPLEX WITH HISTONE H3K9CR
Descriptor:Transcription initiation factor TFIID subunit 14, (ACE)QTAR(KCR)ST, DI(HYDROXYETHYL)ETHER
Authors:Andrews, F.H., Kuateladze, T.G.
Deposit date:2016-03-08
Release date:2016-04-20
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:The Taf14 YEATS domain is a reader of histone crotonylation.
Nat.Chem.Biol., 12, 2016
5U28
  • Download 5u28
  • View 5u28
Molmil generated image of 5u28
BRD4 FIRST BROMODOMAIN (BD1) IN COMPLEX WITH DUAL PI3 KINASE INHIBITOR SF2523
Descriptor:Bromodomain-containing protein 4, 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(morpholin-4-yl)-7H-thieno[3,2-b]pyran-7-one, DI(HYDROXYETHYL)ETHER, ...
Authors:Andrews, F.H., Kutateladze, T.G.
Deposit date:2016-11-30
Release date:2017-02-08
Last modified:2017-03-01
Method:X-RAY DIFFRACTION (1.798 Å)
Cite:Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U2C
  • Download 5u2c
  • View 5u2c
Molmil generated image of 5u2c
BRD4 SECOND BROMODOMAIN (BD2) IN COMPLEX WITH DUAL PI3 KINASE (PI3K) INHIBITOR SF2558HA
Descriptor:Bromodomain-containing protein 4, N-hydroxy-4-[5-(morpholin-4-yl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]benzamide
Authors:Andrews, F.H., Kutateladze, T.G.
Deposit date:2016-11-30
Release date:2017-02-08
Last modified:2017-03-01
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U2E
  • Download 5u2e
  • View 5u2e
Molmil generated image of 5u2e
BRD4 FIRST BROMODOMAIN (BD1) IN COMPLEX WITH DUAL PI3 KINASE (PI3K) INHIBITOR SF2535
Descriptor:Bromodomain-containing protein 4, ethyl 4-[5-(morpholin-4-yl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]benzoate
Authors:Andrews, F.H., Kutateladze, T.G.
Deposit date:2016-11-30
Release date:2017-02-08
Last modified:2017-03-01
Method:X-RAY DIFFRACTION (1.991 Å)
Cite:Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U2F
  • Download 5u2f
  • View 5u2f
Molmil generated image of 5u2f
BRD4 FIRST BROMODOMAIN (BD1) IN COMPLEX WITH DUAL PI3 KINASE (PI3K) INHIBITOR SF2558HA
Descriptor:Bromodomain-containing protein 4, N-hydroxy-4-[5-(morpholin-4-yl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]benzamide
Authors:Andrews, F.H., Kutateladze, T.G.
Deposit date:2016-11-30
Release date:2017-02-08
Last modified:2017-03-01
Method:X-RAY DIFFRACTION (2.525 Å)
Cite:Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4GG1
  • Download 4gg1
  • View 4gg1
Molmil generated image of 4gg1
CRYSTAL STRUCTURE OF BENZOYLFORMATE DECARBOXYLASE MUTANT L403T
Descriptor:Benzoylformate decarboxylase, 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, CALCIUM ION, ...
Authors:Novak, W.R.P., Andrews, F.H., Tom, A.R., Gunderman, P.R., McLeish, M.J.
Deposit date:2012-08-04
Release date:2013-05-22
Method:X-RAY DIFFRACTION (1.069 Å)
Cite:A bulky hydrophobic residue is not required to maintain the v-conformation of enzyme-bound thiamin diphosphate.
Biochemistry, 52, 2013
4GM0
  • Download 4gm0
  • View 4gm0
Molmil generated image of 4gm0
CRYSTAL STRUCTURE OF BENZOYLFORMATE DECARBOXYLASE MUTANT L403N
Descriptor:Benzoylformate decarboxylase, 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, CALCIUM ION, ...
Authors:Novak, W.R.P., Andrews, F.H., Tom, A.R., Gunderman, P.R., McLeish, M.J.
Deposit date:2012-08-15
Release date:2013-05-22
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.07 Å)
Cite:A bulky hydrophobic residue is not required to maintain the v-conformation of enzyme-bound thiamin diphosphate.
Biochemistry, 52, 2013
4GM1
  • Download 4gm1
  • View 4gm1
Molmil generated image of 4gm1
CRYSTAL STRUCTURE OF BENZOYLFORMATE DECARBOXYLASE MUTANT L403S
Descriptor:Benzoylformate decarboxylase, CALCIUM ION, SODIUM ION, ...
Authors:Novak, W.R.P., Andrews, F.H., Tom, A.R., Gunderman, P.R., McLeish, M.J.
Deposit date:2012-08-15
Release date:2013-05-22
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:A bulky hydrophobic residue is not required to maintain the v-conformation of enzyme-bound thiamin diphosphate.
Biochemistry, 52, 2013
4GM4
  • Download 4gm4
  • View 4gm4
Molmil generated image of 4gm4
CRYSTAL STRUCTURE OF BENZOYLFORMATE DECARBOXYLASE MUTANT L403I
Descriptor:Benzoylformate decarboxylase, CALCIUM ION, GLYCEROL, ...
Authors:Novak, W.R.P., Andrews, F.H., Tom, A.R., Gunderman, P.R., McLeish, M.J.
Deposit date:2012-08-15
Release date:2013-05-22
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:A bulky hydrophobic residue is not required to maintain the v-conformation of enzyme-bound thiamin diphosphate.
Biochemistry, 52, 2013
4GP9
  • Download 4gp9
  • View 4gp9
Molmil generated image of 4gp9
CRYSTAL STRUCTURE OF BENZOYLFORMATE DECARBOXYLASE MUTANT L403F
Descriptor:Benzoylformate decarboxylase, CALCIUM ION, 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, ...
Authors:Novak, W.R.P., Andrews, F.H., Tom, A.R., Gunderman, P.R., McLeish, M.J.
Deposit date:2012-08-20
Release date:2013-05-22
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.07 Å)
Cite:A bulky hydrophobic residue is not required to maintain the v-conformation of enzyme-bound thiamin diphosphate.
Biochemistry, 52, 2013
4GPE
  • Download 4gpe
  • View 4gpe
Molmil generated image of 4gpe
CRYSTAL STRUCTURE OF BENZOYLFORMATE DECARBOXYLASE MUTANT L403M
Descriptor:Benzoylformate decarboxylase, CALCIUM ION, SODIUM ION, ...
Authors:Novak, W.R.P., Andrews, F.H., Tom, A.R., Gunderman, P.R., McLeish, M.J.
Deposit date:2012-08-20
Release date:2013-05-22
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:A bulky hydrophobic residue is not required to maintain the v-conformation of enzyme-bound thiamin diphosphate.
Biochemistry, 52, 2013
4JD5
  • Download 4jd5
  • View 4jd5
Molmil generated image of 4jd5
CRYSTAL STRUCTURE OF BENZOYLFORMATE DECARBOXYLASE MUTANT L403E
Descriptor:Benzoylformate decarboxylase, 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, CALCIUM ION, ...
Authors:Novak, W.R.P., Andrews, F.H., Tom, A.R., Gunderman, P.R., McLeish, M.J.
Deposit date:2013-02-23
Release date:2013-05-22
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:A bulky hydrophobic residue is not required to maintain the v-conformation of enzyme-bound thiamin diphosphate.
Biochemistry, 52, 2013
5D7E
  • Download 5d7e
  • View 5d7e
Molmil generated image of 5d7e
CRYSTAL STRUCTURE OF TAF14 YEATS DOMAIN IN COMPLEX WITH H3K9AC
Descriptor:Transcription initiation factor TFIID subunit 14, H3K9ac, DI(HYDROXYETHYL)ETHER, ...
Authors:Andrews, F.H., Shanle, E.K., Strahl, B.D., Kutateladze, T.G.
Deposit date:2015-08-13
Release date:2015-09-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response.
Genes Dev., 29, 2015
5SVI
  • Download 5svi
  • View 5svi
Molmil generated image of 5svi
MORC3 CW DOMAIN IN COMPLEX WITH UNMODIFIED HISTONE H3
Descriptor:MORC family CW-type zinc finger protein 3, ALA-ARG-THR-LYS-GLN-THR-ALA-ARG, ZINC ION
Authors:Tong, Q., Andrews, F.H., Kutateladze, T.G.
Deposit date:2016-08-06
Release date:2016-12-14
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (1.613 Å)
Cite:Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.
Cell Rep, 16, 2016
5SVX
  • Download 5svx
  • View 5svx
Molmil generated image of 5svx
MORC3 CW IN COMPLEX WITH HISTONE H3K4ME3
Descriptor:MORC family CW-type zinc finger protein 3, H3K4me3, ZINC ION
Authors:Tong, Q., Andrews, F.H., Kutateladze, T.G.
Deposit date:2016-08-08
Release date:2016-10-05
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.
Cell Rep, 16, 2016
5SVY
  • Download 5svy
  • View 5svy
Molmil generated image of 5svy
MORC3 CW IN COMPLEX WITH HISTONE H3K4ME1
Descriptor:MORC family CW-type zinc finger protein 3, H3K4me1, ACETATE ION, ...
Authors:Tong, Q., Andrews, F.H., Kutateladze, T.G.
Deposit date:2016-08-08
Release date:2016-10-05
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.
Cell Rep, 16, 2016
5TDR
  • Download 5tdr
  • View 5tdr
Molmil generated image of 5tdr
SET3 PHD FINGER IN COMPLEX WITH HISTONE H3K4ME2
Descriptor:SET domain-containing protein 3, Histone H3, ZINC ION, ...
Authors:Andrews, F.H., Ali, M., Kutateladze, T.G.
Deposit date:2016-09-19
Release date:2016-11-02
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Structural Insight into Recognition of Methylated Histone H3K4 by Set3.
J. Mol. Biol., 429, 2017
5TDW
  • Download 5tdw
  • View 5tdw
Molmil generated image of 5tdw
SET3 PHD FINGER IN COMPLEX WITH HISTONE H3K4ME3
Descriptor:SET domain-containing protein 3, histone H3K4me3, ZINC ION, ...
Authors:Andrews, F.H., Ali, M., Kutateladze, T.G.
Deposit date:2016-09-19
Release date:2016-10-19
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Insight into Recognition of Methylated Histone H3K4 by Set3.
J. Mol. Biol., 429, 2017
<123>
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2019 Protein Data Bank Japan