Author results

2QJ6
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CRYSTAL STRUCTURE ANALYSIS OF A 14 REPEAT C-TERMINAL FRAGMENT OF TOXIN TCDA IN CLOSTRIDIUM DIFFICILE
Descriptor:Toxin A
Authors:Albesa-Jove, D., Bertrand, T., Carpenter, L., Lim, J., Brown, K.A., Fairweather, N.
Deposit date:2007-07-06
Release date:2008-07-15
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Solution and crystal structures of the cell binding domain of toxins TcdA and TcdB from Clostridium difficile
To be Published
4NXI
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RV2466C MEDIATES THE ACTIVATION OF TP053 TO KILL REPLICATING AND NON-REPLICATING MYCOBACTERIUM TUBERCULOSIS
Descriptor:Uncharacterized protein, MAGNESIUM ION, 1,2-ETHANEDIOL
Authors:Albesa-Jove, D., Urresti, S., Comino, N., Guerin, M.E.
Deposit date:2013-12-09
Release date:2014-10-22
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis.
Acs Chem.Biol., 9, 2014
4Y6N
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CRYSTAL STRUCTURE OF GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH MN2+, URIDINE-DIPHOSPHATE-GLUCOSE (UDP-GLC) AND PHOSPHOGLYCERIC ACID (PGA) - GPGS MN2+ UDP-GLC PGA-1
Descriptor:Glucosyl-3-phosphoglycerate synthase, MANGANESE (II) ION, 3-PHOSPHOGLYCERIC ACID, ...
Authors:Albesa-Jove, D., Rodrigo-Unzueta, A., Cifuente, J.O., Urresti, S., Comino, N., Sancho-Vaello, E., Guerin, M.E.
Deposit date:2015-02-13
Release date:2015-07-15
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (2.348 Å)
Cite:A Native Ternary Complex Trapped in a Crystal Reveals the Catalytic Mechanism of a Retaining Glycosyltransferase.
Angew.Chem.Int.Ed.Engl., 54, 2015
4Y6U
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MYCOBACTERIAL PROTEIN
Descriptor:Glucosyl-3-phosphoglycerate synthase, MANGANESE (II) ION, CHLORIDE ION, ...
Authors:Albesa-Jove, D., Rodrigo-Unzueta, A., Cifuente, J.O., Urresti, S., Comino, N., Sancho-Vaello, E., Guerin, M.E.
Deposit date:2015-02-13
Release date:2015-07-15
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (2.271 Å)
Cite:A Native Ternary Complex Trapped in a Crystal Reveals the Catalytic Mechanism of a Retaining Glycosyltransferase.
Angew.Chem.Int.Ed.Engl., 54, 2015
4Y7F
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CRYSTAL STRUCTURE OF GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH MN2+, URIDINE-DIPHOSPHATE-GLUCOSE (UDP-GLC) AND 3-(PHOSPHONOOXY)PROPANOIC ACID (PPA) - GPGS MN2+ UDP-GLC PPA
Descriptor:Glucosyl-3-phosphoglycerate synthase, MANGANESE (II) ION, 3-(phosphonooxy)propanoic acid, ...
Authors:Albesa-Jove, D., Rodrigo-Unzueta, A., Cifuente, J.O., Urresti, S., Comino, N., Sancho-Vaello, E., Guerin, M.E.
Deposit date:2015-02-14
Release date:2015-07-15
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (3.231 Å)
Cite:A Native Ternary Complex Trapped in a Crystal Reveals the Catalytic Mechanism of a Retaining Glycosyltransferase.
Angew.Chem.Int.Ed.Engl., 54, 2015
4Y7G
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CRYSTAL STRUCTURE OF GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH MN2+, URIDINE-DIPHOSPHATE-GLUCOSE (UDP-GLC) AND GLYCEROL 3-PHOSPHATE (G3P) - GPGS MN2+ UDP-GLC G3P
Descriptor:Glucosyl-3-phosphoglycerate synthase, MANGANESE (II) ION, SN-GLYCEROL-3-PHOSPHATE, ...
Authors:Albesa-Jove, D., Rodrigo-Unzueta, A., Cifuente, J.O., Urresti, S., Comino, N., Sancho-Vaello, E., Guerin, M.E.
Deposit date:2015-02-14
Release date:2015-07-15
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:A Native Ternary Complex Trapped in a Crystal Reveals the Catalytic Mechanism of a Retaining Glycosyltransferase.
Angew.Chem.Int.Ed.Engl., 54, 2015
4Y9X
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CRYSTAL STRUCTURE OF GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH MN2+, URIDINE-DIPHOSPHATE-GLUCOSE (UDP-GLC) AND PHOSPHOGLYCERIC ACID (PGA) - GPGS MN2+ UDP-GLC PGA-3
Descriptor:Glucosyl-3-phosphoglycerate synthase, MANGANESE (II) ION, CHLORIDE ION, ...
Authors:Albesa-Jove, D., Rodrigo-Unzueta, A., Cifuente, J.O., Urresti, S., Comino, N., Sancho-Vaello, E., Guerin, M.E.
Deposit date:2015-02-17
Release date:2015-07-15
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (2.637 Å)
Cite:A Native Ternary Complex Trapped in a Crystal Reveals the Catalytic Mechanism of a Retaining Glycosyltransferase.
Angew.Chem.Int.Ed.Engl., 54, 2015
4ZIL
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CRYSTAL STRUCTURE OF RV2466C AND OXIDOREDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS IN ITS REDUCED STATE
Descriptor:DSBA oxidoreductase, MAGNESIUM ION
Authors:Albesa-Jove, D., Urresti, S., Comino, N., Tersa, M., Guerin, M.E.
Deposit date:2015-04-28
Release date:2015-11-18
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (1.507 Å)
Cite:The Redox State Regulates the Conformation of Rv2466c to Activate the Antitubercular Prodrug TP053.
J.Biol.Chem., 290, 2015
5F2T
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CRYSTAL STRUCTURE OF MEMBRANE ASSOCIATED PATA FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH PALMITATE - C 2 SPACE GROUP
Descriptor:Phosphatidylinositol mannoside acyltransferase, PALMITIC ACID, MAGNESIUM ION
Authors:Albesa-Jove, D., Svetlikova, Z., Carreras-Gonzalez, A., Tersa, M., Sancho-Vaello, E., Cifuente, J.O., Mikusova, K., Guerin, M.E.
Deposit date:2015-12-02
Release date:2016-03-09
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.
Nat Commun, 7, 2016
5F2Z
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CRYSTAL STRUCTURE OF MEMBRANE ASSOCIATED PATA FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH PALMITATE - P21 SPACE GROUP
Descriptor:Phosphatidylinositol mannoside acyltransferase, PALMITIC ACID
Authors:Albesa-Jove, D., Svetlikova, Z., Carreras-Gonzalez, A., Tersa, M., Sancho-Vaello, E., Cifuente, J.O., Mikusova, K., Guerin, M.E.
Deposit date:2015-12-02
Release date:2016-03-09
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.
Nat Commun, 7, 2016
5F31
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CRYSTAL STRUCTURE OF MEMBRANE ASSOCIATED PATA FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH PALMITATE - P 42 21 2 SPACE GROUP
Descriptor:Phosphatidylinositol mannoside acyltransferase, PALMITIC ACID, ETHANOL, ...
Authors:Albesa-Jove, D., Svetlikova, Z., Carreras-Gonzalez, A., Tersa, M., Sancho-Vaello, E., Cifuente, J.O., Mikusova, K., Guerin, M.E.
Deposit date:2015-12-02
Release date:2016-03-09
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.
Nat Commun, 7, 2016
5F34
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CRYSTAL STRUCTURE OF MEMBRANE ASSOCIATED PATA FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH S-HEXADECYL COENZYME A - P21 SPACE GROUP
Descriptor:Phosphatidylinositol mannoside acyltransferase, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3~{S})-4-[[3-(2-hexadecylsulfanylethylamino)-3-oxidanylidene-propyl]amino]-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-butyl] hydrogen phosphate
Authors:Albesa-Jove, D., Svetlikova, Z., Carreras-Gonzalez, A., Tersa, M., Sancho-Vaello, E., Cifuente, J.O., Mikusova, K., Guerin, M.E.
Deposit date:2015-12-02
Release date:2016-03-09
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (3.281 Å)
Cite:Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.
Nat Commun, 7, 2016
5JQQ
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CRYSTAL STRUCTURE OF GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS - APO FORM
Descriptor:Glucosyl-3-phosphoglycerate synthase, GLYCEROL
Authors:Albesa-Jove, D., Urresti, S., Gest, P.M., van der Woerd, M., Jackson, M., Guerin, M.E.
Deposit date:2016-05-05
Release date:2016-12-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of glucosyl-3-phosphoglycerate synthase from Mycobacterium tuberculosis - apo form
To Be Published
5JQX
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CRYSTAL STRUCTURE OF GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH PHOSPHOGLYCERIC ACID (PGA) - GPGS*PGA
Descriptor:Glucosyl-3-phosphoglycerate synthase, 3-PHOSPHOGLYCERIC ACID
Authors:Albesa-Jove, D., Sancho-Vaello, E., Rodrigo-Unzueta, A., Comino, N., Carreras-Gonzalez, A., Arrasate, P., Urresti, S., Guerin, M.E.
Deposit date:2016-05-05
Release date:2017-05-24
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Structural Snapshots and Loop Dynamics along the Catalytic Cycle of Glycosyltransferase GpgS.
Structure, 25, 2017
5JSX
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CRYSTAL STRUCTURE OF GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH MN2+ AND URIDINE-DIPHOSPHATE-GLUCOSE (UDP-GLC)
Descriptor:glucosyl-3-phosphoglycerate synthase, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE-GLUCOSE, ...
Authors:Albesa-Jove, D., Sancho-Vaello, E., Rodrigo-Unzueta, A., Comino, N., Carreras-Gonzalez, A., Arrasate, P., Urresti, S., Guerin, M.E.
Deposit date:2016-05-09
Release date:2017-05-24
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural Snapshots and Loop Dynamics along the Catalytic Cycle of Glycosyltransferase GpgS.
Structure, 25, 2017
5JT0
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CRYSTAL STRUCTURE OF GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH MN2+, URIDINE-DIPHOSPHATE (UDP) AND GLUCOSYL-3-PHOSPHOGLYCERATE (GPG) - GPGS*GPG*UDP*MN2+
Descriptor:Glucosyl-3-phosphoglycerate synthase, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ...
Authors:Albesa-Jove, D., Sancho-Vaello, E., Rodrigo-Unzueta, A., Comino, N., Carreras-Gonzalez, A., Arrasate, P., Urresti, S., Guerin, M.E.
Deposit date:2016-05-09
Release date:2017-05-24
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Snapshots and Loop Dynamics along the Catalytic Cycle of Glycosyltransferase GpgS.
Structure, 25, 2017
5JUC
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CRYSTAL STRUCTURE OF GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH MN2+, URIDINE-DIPHOSPHATE (UDP) AND GLUCOSYL-3-PHOSPHOGLYCERATE (GPG) - GPGS*GPG*UDP*MN2+_2
Descriptor:Glucosyl-3-phosphoglycerate synthase, URIDINE-5'-DIPHOSPHATE, 1,2-ETHANEDIOL, ...
Authors:Albesa-Jove, D., Sancho-Vaello, E., Rodrigo-Unzueta, A., Comino, N., Carreras-Gonzalez, A., Arrasate, P., Urresti, S., Guerin, M.E.
Deposit date:2016-05-10
Release date:2017-05-24
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Snapshots and Loop Dynamics along the Catalytic Cycle of Glycosyltransferase GpgS.
Structure, 25, 2017
5JUD
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CRYSTAL STRUCTURE OF GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH URIDINE-DIPHOSPHATE (UDP) - GPGS*UDP
Descriptor:Glucosyl-3-phosphoglycerate synthase, URIDINE-5'-DIPHOSPHATE
Authors:Albesa-Jove, D., Sancho-Vaello, E., Rodrigo-Unzueta, A., Comino, N., Carreras-Gonzalez, A., Arrasate, P., Urresti, S., Guerin, M.E.
Deposit date:2016-05-10
Release date:2017-05-24
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural Snapshots and Loop Dynamics along the Catalytic Cycle of Glycosyltransferase GpgS.
Structure, 25, 2017
5NR9
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A NATIVE TERNARY COMPLEX OF ALPHA-1,3-GALACTOSYLTRANSFERASE (ALPHA-3GALT) SUPPORTS A CONSERVED REACTION MECHANISM FOR RETAINING GLYCOSYLTRANSFERASES - UNLIGANDED ALPHA-3GALT
Descriptor:N-acetyllactosaminide alpha-1,3-galactosyltransferase, GLYCEROL
Authors:Albesa-Jove, D., Marina, A., Sainz-Polo, M.A., Guerin, M.E.
Deposit date:2017-04-22
Release date:2017-10-11
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Snapshots of alpha-1,3-Galactosyltransferase with Native Substrates: Insight into the Catalytic Mechanism of Retaining Glycosyltransferases.
Angew. Chem. Int. Ed. Engl., 56, 2017
5NRB
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A NATIVE TERNARY COMPLEX OF ALPHA-1,3-GALACTOSYLTRANSFERASE (A-3GALT) SUPPORTS A CONSERVED REACTION MECHANISM FOR RETAINING GLYCOSYLTRANSFERASES - ALPHA-3GALT IN COMPLEX WITH CO2+, UDP-GAL AND LACTOSE - A3GALT-CO2+-UDP-GAL-LAT-1
Descriptor:N-acetyllactosaminide alpha-1,3-galactosyltransferase, BETA-LACTOSE, COBALT (II) ION, ...
Authors:Albesa-Jove, D., Marina, A., Sainz-Polo, M.A., Guerin, M.E.
Deposit date:2017-04-22
Release date:2017-10-11
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structural Snapshots of alpha-1,3-Galactosyltransferase with Native Substrates: Insight into the Catalytic Mechanism of Retaining Glycosyltransferases.
Angew. Chem. Int. Ed. Engl., 56, 2017
5NRD
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A NATIVE TERNARY COMPLEX OF ALPHA-1,3-GALACTOSYLTRANSFERASE (A-3GALT) SUPPORTS A CONSERVED REACTION MECHANISM FOR RETAINING GLYCOSYLTRANSFERASES - ALPHA-3GALT IN COMPLEX WITH CO2+, UDP-GAL AND LACTOSE - A3GALT-CO2+-UDP-GAL-LAT-2
Descriptor:N-acetyllactosaminide alpha-1,3-galactosyltransferase, BETA-LACTOSE, COBALT (II) ION, ...
Authors:Albesa-Jove, D., Marina, A., Sainz-Polo, M.A., Guerin, M.E.
Deposit date:2017-04-22
Release date:2017-10-11
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural Snapshots of alpha-1,3-Galactosyltransferase with Native Substrates: Insight into the Catalytic Mechanism of Retaining Glycosyltransferases.
Angew. Chem. Int. Ed. Engl., 56, 2017
5NRE
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A NATIVE TERNARY COMPLEX OF ALPHA-1,3-GALACTOSYLTRANSFERASE (A3GALT) SUPPORTS A CONSERVED REACTION MECHANISM FOR RETAINING GLYCOSYLTRANSFERASES - A3GALT IN COMPLEX WITH LACTOSE - A3GALT-LAT
Descriptor:N-acetyllactosaminide alpha-1,3-galactosyltransferase, BETA-LACTOSE
Authors:Albesa-Jove, D., Marina, A., Sainz-Polo, M.A., Guerin, M.E.
Deposit date:2017-04-22
Release date:2017-10-11
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural Snapshots of alpha-1,3-Galactosyltransferase with Native Substrates: Insight into the Catalytic Mechanism of Retaining Glycosyltransferases.
Angew. Chem. Int. Ed. Engl., 56, 2017
4DDZ
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CRYSTAL STRUCTURE OF GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE (GpgS), GLYCEROL
Authors:Albesa-Jove, D., Urresti, S., Gest, P.M., van der Woerd, M., Jackson, M., Guerin, M.E.
Deposit date:2012-01-19
Release date:2012-06-06
Last modified:2013-01-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria.
J.Biol.Chem., 287, 2012
4DE7
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CRYSTAL STRUCTURE OF GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH MG2+ AND URIDINE-DIPHOSPHATE (UDP)
Descriptor:GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE (GpgS), URIDINE-5'-DIPHOSPHATE, GLYCEROL
Authors:Albesa-Jove, D., Urresti, S., van der Woerd, M., Guerin, M.E.
Deposit date:2012-01-20
Release date:2012-06-06
Last modified:2013-01-09
Method:X-RAY DIFFRACTION (3 Å)
Cite:Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria.
J.Biol.Chem., 287, 2012
4DEC
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CRYSTAL STRUCTURE OF GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH MN2+, URIDINE-DIPHOSPHATE (UDP) AND PHOSPHOGLYCERIC ACID (PGA)
Descriptor:GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE (GpgS), URIDINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Albesa-Jove, D., Urresti, S., van der Woerd, M., Guerin, M.E.
Deposit date:2012-01-20
Release date:2012-06-06
Last modified:2013-01-09
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria.
J.Biol.Chem., 287, 2012
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