11BG
| A POTENTIAL ALLOSTERIC SUBSITE GENERATED BY DOMAIN SWAPPING IN BOVINE SEMINAL RIBONUCLEASE | Descriptor: | PROTEIN (BOVINE SEMINAL RIBONUCLEASE), SULFATE ION, URIDYLYL-2'-5'-PHOSPHO-GUANOSINE | Authors: | Vitagliano, L, Adinolfi, S, Sica, F, Merlino, A, Zagari, A, Mazzarella, L. | Deposit date: | 1999-03-11 | Release date: | 1999-11-05 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A potential allosteric subsite generated by domain swapping in bovine seminal ribonuclease. J.Mol.Biol., 293, 1999
|
|
11BA
| BINDING OF A SUBSTRATE ANALOGUE TO A DOMAIN SWAPPING PROTEIN IN THE COMPLEX OF BOVINE SEMINAL RIBONUCLEASE WITH URIDYLYL-2',5'-ADENOSINE | Descriptor: | PROTEIN (RIBONUCLEASE, SEMINAL), SULFATE ION, ... | Authors: | Vitagliano, L, Adinolfi, S, Riccio, A, Sica, F, Zagari, A, Mazzarella, L. | Deposit date: | 1999-03-17 | Release date: | 1999-03-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Binding of a substrate analog to a domain swapping protein: X-ray structure of the complex of bovine seminal ribonuclease with uridylyl(2',5')adenosine. Protein Sci., 7, 1998
|
|
1LY7
| The solution structure of the the c-terminal domain of frataxin, the protein responsible for friedreich ataxia | Descriptor: | frataxin | Authors: | Musco, G, Stier, G, Kolmerer, B, Adinolfi, S, Martin, S, Frenkiel, T, Gibson, T, Pastore, A. | Deposit date: | 2002-06-07 | Release date: | 2002-06-26 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Towards a structural understanding of Friedreich's
ataxia: the solution structure of frataxin Structure Fold.Des., 8, 2000
|
|
2BZT
| NMR structure of the bacterial protein YFHJ from E. coli | Descriptor: | PROTEIN ISCX | Authors: | Pastore, C, Kelly, G, Adinolfi, S, Mc Cormick, J.E, Pastore, A. | Deposit date: | 2005-08-22 | Release date: | 2006-12-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | YfhJ, a molecular adaptor in iron-sulfur cluster formation or a frataxin-like protein? Structure, 14, 2006
|
|
2BKD
| Structure of the N-terminal domain of Fragile X Mental Retardation Protein | Descriptor: | Fragile X messenger ribonucleoprotein 1 | Authors: | Ramos, A, Hollingworth, D, Adinolfi, S, Castets, M, Kelly, G, Frenkiel, T.A, Bardoni, B, Pastore, A. | Deposit date: | 2005-02-15 | Release date: | 2006-01-18 | Last modified: | 2023-02-01 | Method: | SOLUTION NMR | Cite: | The structure of the N-terminal domain of the fragile X mental retardation protein: a platform for protein-protein interaction. Structure, 14, 2006
|
|
1SOY
| Solution structure of the bacterial frataxin orthologue, CyaY | Descriptor: | CyaY protein | Authors: | Nair, M, Adinolfi, S, Pastore, C, Kelly, G, Temussi, P, Pastore, A. | Deposit date: | 2004-03-16 | Release date: | 2004-11-23 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution Structure of the Bacterial Frataxin Ortholog, CyaY; Mapping the Iron Binding Sites Structure, 12, 2004
|
|
8RB6
| Structure of Aldo-Keto Reductase 1C3 (AKR1C3) in complex with an inhibitor M689, with the 3-hydroxy-benzoisoxazole moiety. Resolution 2.0A | Descriptor: | 1,2-ETHANEDIOL, 4-[[4-(3-hydroxyphenyl)phenyl]amino]-1,2-benzoxazol-3-ol, Aldo-keto reductase family 1 member C3, ... | Authors: | Frydenvang, K, Mirza, O.A. | Deposit date: | 2023-12-03 | Release date: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer. Eur.J.Med.Chem., 268, 2024
|
|
6F78
| Potent and selective Aldo-Keto Reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: Application of a Bioisosteric Scaffold Hopping Approach to Flufenamic acid | Descriptor: | 4-[[3,5-bis(trifluoromethyl)phenyl]amino]-1,2-benzoxazol-3-one, Aldo-keto reductase family 1 member C3, CHLORIDE ION, ... | Authors: | Goyal, P, Wahlgren, W.Y, Friemann, R. | Deposit date: | 2017-12-07 | Release date: | 2018-04-04 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid. Eur J Med Chem, 150, 2018
|
|
1R5D
| X-ray structure of bovine seminal ribonuclease swapping dimer from a new crystal form | Descriptor: | Ribonuclease, seminal | Authors: | Merlino, A, Vitagliano, L, Sica, F, Zagari, A, Mazzarella, L. | Deposit date: | 2003-10-10 | Release date: | 2004-04-13 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Population shift vs induced fit: The case of bovine seminal ribonuclease swapping dimer Biopolymers, 73, 2004
|
|
1R5C
| X-ray structure of the complex of Bovine seminal ribonuclease swapping dimer with d(CpA) | Descriptor: | 2'-DEOXYCYTIDINE-2'-DEOXYADENOSINE-3',5'-MONOPHOSPHATE, Ribonuclease, seminal | Authors: | Merlino, A, Vitagliano, L, Sica, F, Zagari, A, Mazzarella, L. | Deposit date: | 2003-10-10 | Release date: | 2004-04-13 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Population shift vs induced fit: The case of bovine seminal ribonuclease swapping dimer Biopolymers, 73, 2004
|
|
1V06
| |
1N3Z
| Crystal structure of the [S-carboxyamidomethyl-Cys31, S-carboxyamidomethyl-Cys32] monomeric derivative of the bovine seminal ribonuclease in the liganded state | Descriptor: | 3'-URIDINEMONOPHOSPHATE, ADENOSINE, Ribonuclease, ... | Authors: | Sica, F, Di Fiore, A, Zagari, A, Mazzarella, L. | Deposit date: | 2002-10-30 | Release date: | 2003-08-26 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The unswapped chain of bovine seminal ribonuclease: Crystal structure of the free and liganded monomeric derivative Proteins, 52, 2003
|
|
3BCP
| Crystal Structure of The Swapped non covalent form of P19A/L28Q/N67D BS-RNase | Descriptor: | Seminal ribonuclease | Authors: | Merlino, A, Ercole, C, Picone, D, Pizzo, E, Mazzarella, L, Sica, F. | Deposit date: | 2007-11-13 | Release date: | 2008-02-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme J.Mol.Biol., 376, 2008
|
|
3BCM
| Crystal Structure of The Unswapped Form of P19A/L28Q/N67D BS-RNase | Descriptor: | PHOSPHATE ION, Seminal ribonuclease | Authors: | Merlino, A, Ercole, C, Picone, D, Pizzo, E, Mazzarella, L, Sica, F. | Deposit date: | 2007-11-13 | Release date: | 2008-02-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme J.Mol.Biol., 376, 2008
|
|
3BCO
| Crystal Structure of The Swapped FOrm of P19A/L28Q/N67D BS-RNase | Descriptor: | Seminal ribonuclease | Authors: | Merlino, A, Ercole, C, Picone, D, Pizzo, E, Mazzarella, L, Sica, F. | Deposit date: | 2007-11-13 | Release date: | 2008-02-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme J.Mol.Biol., 376, 2008
|
|
6F2U
| Potent and selective Aldo-Keto Reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a Bioisosteric Scaffold Hopping Approach to Flufenamic acid | Descriptor: | 3-[(4-methoxyphenyl)methyl]-5-oxidanyl-~{N}-[3-(trifluoromethyl)phenyl]-1,2,3-triazole-4-carboxamide, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Goyal, P, Wahlgren, W.Y, Friemann, R. | Deposit date: | 2017-11-27 | Release date: | 2018-04-04 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid. Eur J Med Chem, 150, 2018
|
|
6GXK
| Crystal structure of Aldo-Keto Reductase 1C3 (AKR1C3) complexed with inhibitor. | Descriptor: | 1,2-ETHANEDIOL, 4-[[1-(4-chlorophenyl)carbonyl-5-methoxy-2-methyl-indol-3-yl]methyl]-1,2,5-oxadiazol-3-one, Aldo-keto reductase family 1 member C3, ... | Authors: | Goyal, P, Wahlgren, W.Y, Friemann, R. | Deposit date: | 2018-06-27 | Release date: | 2019-05-08 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3. Acs Med.Chem.Lett., 10, 2019
|
|
1Y92
| Crystal structure of the P19A/N67D Variant Of Bovine seminal Ribonuclease | Descriptor: | Seminal ribonuclease | Authors: | Picone, D, Di Fiore, A, Ercole, C, Franzese, M, Sica, F, Tomaselli, S, Mazzarella, L. | Deposit date: | 2004-12-14 | Release date: | 2004-12-28 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Role of the Hinge Loop in Domain Swapping: THE SPECIAL CASE OF BOVINE SEMINAL RIBONUCLEASE. J.Biol.Chem., 280, 2005
|
|
1TQ9
| Non-covalent swapped dimer of Bovine Seminal Ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYADENOSINE-3',5'-MONOPHOSPHATE | Descriptor: | 2'-DEOXYCYTIDINE-2'-DEOXYADENOSINE-3',5'-MONOPHOSPHATE, Ribonuclease, seminal | Authors: | Sica, F, Di Fiore, A, Merlino, A, Mazzarella, L. | Deposit date: | 2004-06-17 | Release date: | 2004-09-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and Stability of the Non-covalent Swapped Dimer of Bovine Seminal Ribonuclease: AN ENZYME TAILORED TO EVADE RIBONUCLEASE PROTEIN INHIBITOR J.Biol.Chem., 279, 2004
|
|
1Y94
| Crystal structure of the G16S/N17T/P19A/S20A/N67D Variant Of Bovine seminal Ribonuclease | Descriptor: | Seminal ribonuclease | Authors: | Picone, D, Di Fiore, A, Ercole, C, Franzese, M, Sica, F, Tomaselli, S, Mazzarella, L. | Deposit date: | 2004-12-14 | Release date: | 2004-12-28 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Role of the Hinge Loop in Domain Swapping: THE SPECIAL CASE OF BOVINE SEMINAL RIBONUCLEASE. J.Biol.Chem., 280, 2005
|
|
4AQP
| The structure of the AXH domain of ataxin-1. | Descriptor: | ATAXIN-1, DI(HYDROXYETHYL)ETHER, SODIUM ION | Authors: | Rees, M, Chen, Y.W, de Chiara, C, Pastore, A. | Deposit date: | 2012-04-19 | Release date: | 2013-03-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.452 Å) | Cite: | Self-Assembly and Conformational Heterogeneity of the Axh Domain of Ataxin-1: An Unusual Example of a Chameleon Fold Biophys.J., 104, 2013
|
|
4APT
| The structure of the AXH domain of ataxin-1. | Descriptor: | ATAXIN-1, SODIUM ION | Authors: | Rees, M, Chen, Y.W, de Chiara, C, Pastore, A. | Deposit date: | 2012-04-05 | Release date: | 2013-03-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Self-Assembly and Conformational Heterogeneity of the Axh Domain of Ataxin-1: An Unusual Example of a Chameleon Fold Biophys.J., 104, 2013
|
|
2P1X
| |
1OA8
| |
1N1X
| Crystal Structure Analysis of the monomeric [S-carboxyamidomethyl-Cys31, S-carboxyamidomethyl-Cys32] Bovine seminal ribonuclease | Descriptor: | Ribonuclease, seminal | Authors: | Sica, F, Di Fiore, A, Zagari, A, Mazzarella, L. | Deposit date: | 2002-10-21 | Release date: | 2003-08-26 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The unswapped chain of bovine seminal ribonuclease: Crystal structure of the free and liganded monomeric derivative Proteins, 52, 2003
|
|