Author results

1RDQ
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HYDROLYSIS OF ATP IN THE CRYSTAL OF Y204A MUTANT OF CAMP-DEPENDENT PROTEIN KINASE
Descriptor:cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase inhibitor, ...
Authors:Yang, J., Ten Eyck, L.F., Xuong, N.H., Taylor, S.S.
Deposit date:2003-11-05
Release date:2004-04-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Crystal Structure of a cAMP-dependent Protein Kinase Mutant at 1.26A: New Insights into the Catalytic Mechanism.
J.Mol.Biol., 336, 2004
1J3H
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CRYSTAL STRUCTURE OF APOENZYME CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT
Descriptor:cAMP-dependent protein kinase, alpha-catalytic subunit, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Akamine, P., Madhusudan, Wu, J., Xuong, N.H., Ten Eyck, L.F., Taylor, S.S.
Deposit date:2003-01-31
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Dynamic Features of cAMP-dependent Protein Kinase Revealed by Apoenzyme Crystal Structure
J.Mol.Biol., 327, 2003
1CX4
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CRYSTAL STRUCTURE OF A DELETION MUTANT OF THE TYPE II BETA REGULATORY SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE
Descriptor:CAMP-DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT TYPE II BETA, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
Authors:Diller, T.C., Xuong, N.H., Taylor, S.S.
Deposit date:1999-08-28
Release date:2001-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase: crystal structure of the type II beta regulatory subunit.
Structure, 9, 2001
1JBP
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CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A SUBSTRATE PEPTIDE, ADP AND DETERGENT
Descriptor:CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR, ...
Authors:Madhusudan, Trafny, E.A., Xuong, N.H., Adams, J.A., Ten Eyck, L.F., Taylor, S.S., Sowadski, J.M.
Deposit date:2001-06-06
Release date:2001-06-27
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:cAMP-dependent protein kinase: crystallographic insights into substrate recognition and phosphotransfer.
Protein Sci., 3, 1994
1RE8
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CRYSTAL STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH BALANOL ANALOG 2
Descriptor:cAMP-dependent protein kinase, alpha-catalytic subunit, 3-[(4-HYDROXYBENZOYL)AMINO]AZEPAN-4-YL 4-(2-HYDROXYBENZOYL)BENZOATE, ...
Authors:Akamine, P., Madhusudan, Brunton, L.L., Ou, H.D., Canaves, J.M., Xuong, N.H., Taylor, S.S.
Deposit date:2003-11-06
Release date:2004-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit
Biochemistry, 43, 2004
1REJ
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CRYSTAL STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH BALANOL ANALOG 1
Descriptor:cAMP-dependent protein kinase, alpha-catalytic subunit, 3-[(4-HYDROXYBENZOYL)AMINO]AZEPAN-4-YL 4-HYDROXYBENZOATE
Authors:Akamine, P., Madhusudan, Brunton, L.L., Ou, H.D., Canaves, J.M., Xuong, N.H., Taylor, S.S.
Deposit date:2003-11-06
Release date:2004-02-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit
Biochemistry, 43, 2004
1REK
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CRYSTAL STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH BALANOL ANALOG 8
Descriptor:cAMP-dependent protein kinase, alpha-catalytic subunit, 3-[(3-SEC-BUTYL-4-HYDROXYBENZOYL)AMINO]AZEPAN-4-YL 4-(2-HYDROXY-5-METHOXYBENZOYL)BENZOATE, ...
Authors:Akamine, P., Madhusudan, Brunton, L.L., Ou, H.D., Canaves, J.M., Xuong, N.H., Taylor, S.S.
Deposit date:2003-11-06
Release date:2004-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit
Biochemistry, 43, 2004
1CHG
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CHYMOTRYPSINOGEN,2.5 ANGSTROMS CRYSTAL STRUCTURE, COMPARISON WITH ALPHA-CHYMOTRYPSIN,AND IMPLICATIONS FOR ZYMOGEN ACTIVATION
Descriptor:CHYMOTRYPSINOGEN A
Authors:Freer, S.T., Kraut, J., Robertus, J.D., Wright, H.T., Xuong, N.H.
Deposit date:1975-03-01
Release date:1976-11-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Chymotrypsinogen: 2.5-angstrom crystal structure, comparison with alpha-chymotrypsin, and implications for zymogen activation.
Biochemistry, 9, 1970
1DHR
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CRYSTAL STRUCTURE OF RAT LIVER DIHYDROPTERIDINE REDUCTASE
Descriptor:DIHYDROPTERIDINE REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Varughese, K.I., Skinner, M.M., Whiteley, J.M., Matthews, D.A., Xuong, N.H.
Deposit date:1992-03-30
Release date:1993-07-15
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of rat liver dihydropteridine reductase.
Proc.Natl.Acad.Sci.USA, 89, 1992
1DIR
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CRYSTAL STRUCTURE OF A MONOCLINIC FORM OF DIHYDROPTERIDINE REDUCTASE FROM RAT LIVER
Descriptor:DIHYDROPTERIDINE REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Varughese, K.I., Su, Y., Skinner, M.M., Matthews, D.A., Whitely, J.M., Xuong, N.H.
Deposit date:1994-04-18
Release date:1994-07-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a monoclinic form of dihydropteridine reductase from rat liver.
Acta Crystallogr.,Sect.D, 50, 1994
1HDR
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THE CRYSTALLOGRAPHIC STRUCTURE OF A HUMAN DIHYDROPTERIDINE REDUCTASE NADH BINARY COMPLEX EXPRESSED IN ESCHERICHIA COLI BY A CDNA CONSTRUCTED FROM ITS RAT HOMOLOGUE
Descriptor:DIHYDROPTERIDINE REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Varughese, K.I., Su, Y., Xuong, N.H., Whiteley, J.M.
Deposit date:1993-08-18
Release date:1994-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue.
J.Biol.Chem., 268, 1993
1NAT
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CRYSTAL STRUCTURE OF SPOOF FROM BACILLUS SUBTILIS
Descriptor:SPORULATION RESPONSE REGULATORY PROTEIN
Authors:Madhusudan, Zapf, J., Hoch, J.A., Whiteley, J.M., Xuong, N.H., Varughese, K.I.
Deposit date:1997-09-09
Release date:1998-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:A response regulatory protein with the site of phosphorylation blocked by an arginine interaction: crystal structure of Spo0F from Bacillus subtilis.
Biochemistry, 36, 1997
1NE4
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CRYSTAL STRUCTURE OF RP-CAMP BINDING R1A SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE
Descriptor:cAMP-dependent protein kinase type I-alpha regulatory chain, 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL
Authors:Wu, J., Jones, J.M., Xuong, N.H., Taylor, S.S.
Deposit date:2002-12-10
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of RIalpha Subunit of Cyclic Adenosine 5'-Monophosphate (cAMP)-Dependent Protein Kinase Complexed with (R(p))-Adenosine 3',5'-Cyclic Monophosphothioate and (S(p))-Adenosine 3',5'-Cyclic Monophosphothioate, the Phosphothioate Analogues of cAMP.
Biochemistry, 43, 2004
1NE6
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CRYSTAL STRUCTURE OF SP-CAMP BINDING R1A SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE
Descriptor:cAMP-dependent protein kinase type I-alpha regulatory chain, 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL
Authors:Wu, J., Jones, J.M., Xuong, N.H., Taylor, S.S.
Deposit date:2002-12-10
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of RIalpha Subunit of Cyclic Adenosine 5'-Monophosphate (cAMP)-Dependent Protein Kinase Complexed with (R(p))-Adenosine 3',5'-Cyclic Monophosphothioate and (S(p))-Adenosine 3',5'-Cyclic Monophosphothioate, the Phosphothioate Analogues of cAMP.
Biochemistry, 43, 2004
1SRR
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CRYSTAL STRUCTURE OF A PHOSPHATASE RESISTANT MUTANT OF SPORULATION RESPONSE REGULATOR SPO0F FROM BACILLUS SUBTILIS
Descriptor:SPORULATION RESPONSE REGULATORY PROTEIN, CALCIUM ION
Authors:Madhusudan, Whiteley, J.M., Hoch, J.A., Zapf, J., Xuong, N.H., Varughese, K.I.
Deposit date:1996-04-10
Release date:1997-04-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a phosphatase-resistant mutant of sporulation response regulator Spo0F from Bacillus subtilis.
Structure, 4, 1996
1SYK
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CRYSTAL STRUCTURE OF E230Q MUTANT OF CAMP-DEPENDENT PROTEIN KINASE REVEALS UNEXPECTED APOENZYME CONFORMATION
Descriptor:cAMP-dependent protein kinase, alpha-catalytic subunit
Authors:Wu, J., Yang, J., Madhusudan, N., Xuong, N.H., Ten Eyck, L.F., Taylor, S.S.
Deposit date:2004-04-01
Release date:2005-05-17
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix.
Protein Sci., 14, 2005
1BX6
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CRYSTAL STRUCTURE OF THE POTENT NATURAL PRODUCT INHIBITOR BALANOL IN COMPLEX WITH THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE
Descriptor:CAMP-DEPENDENT PROTEIN KINASE, BALANOL
Authors:Narayana, N., Xuong, N.-H., Ten Eyck, L.F., Taylor, S.S.
Deposit date:1998-10-13
Release date:1999-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase.
Biochemistry, 38, 1999
1FMO
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CRYSTAL STRUCTURE OF A POLYHISTIDINE-TAGGED RECOMBINANT CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH THE PEPTIDE INHIBITOR PKI(5-24) AND ADENOSINE
Descriptor:CAMP-DEPENDENT PROTEIN KINASE, HEAT STABLE RABBIT SKELETAL MUSCLE INHIBITOR PROTEIN, ADENOSINE
Authors:Narayana, N., Cox, S., Shaltiel, S., Taylor, S.S., Xuong, N.-H.
Deposit date:1997-07-08
Release date:1998-01-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine.
Biochemistry, 36, 1997
1L3R
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CRYSTAL STRUCTURE OF A TRANSITION STATE MIMIC OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE
Descriptor:CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR, ...
Authors:Madhusudan, Akamine, P., Xuong, N.-H., Taylor, S.S.
Deposit date:2002-02-28
Release date:2002-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase.
Nat.Struct.Biol., 9, 2002
1CMK
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CRYSTAL STRUCTURES OF THE MYRISTYLATED CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE REVEAL OPEN AND CLOSED CONFORMATIONS
Descriptor:cAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT, cAMP-dependent protein kinase inhibitor, alpha form, ...
Authors:Zheng, J., Knighton, D.R., Xuong, N.-H., Taylor, S.S., Sowadski, J.M., Ten Eyck, L.F.
Deposit date:1993-11-18
Release date:1994-05-31
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations.
Protein Sci., 2, 1993
1CTP
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STRUCTURE OF THE MAMMALIAN CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE AND AN INHIBITOR PEPTIDE DISPLAYS AN OPEN CONFORMATION
Descriptor:cAMP-DEPENDENT PROTEIN KINASE, cAMP-dependent protein kinase inhibitor, alpha form, ...
Authors:Karlsson, R., Zheng, J., Xuong, N.H., Taylor, S.S., Sowadski, J.M.
Deposit date:1993-04-08
Release date:1994-01-31
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the mammalian catalytic subunit of cAMP-dependent protein kinase and an inhibitor peptide displays an open conformation.
Acta Crystallogr.,Sect.D, 49, 1993
1HIP
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TWO-ANGSTROM CRYSTAL STRUCTURE OF OXIDIZED CHROMATIUM HIGH POTENTIAL IRON PROTEIN
Descriptor:HIGH POTENTIAL IRON PROTEIN, IRON/SULFUR CLUSTER
Authors:Carterjunior, C.W., Kraut, J., Freer, S.T., Xuong, N.-H., Alden, R.A., Bartsch, R.G.
Deposit date:1975-04-01
Release date:1976-11-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Two-Angstrom crystal structure of oxidized Chromatium high potential iron protein.
J.Biol.Chem., 249, 1974
1ATP
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2.2 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH MNATP AND A PEPTIDE INHIBITOR
Descriptor:cAMP-DEPENDENT PROTEIN KINASE, PEPTIDE INHIBITOR PKI(5-24), MANGANESE (II) ION, ...
Authors:Zheng, J., Trafny, E.A., Knighton, D.R., Xuong, N.-H., Taylor, S.S., Teneyck, L.F., Sowadski, J.M.
Deposit date:1993-01-08
Release date:1993-04-15
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor.
Acta Crystallogr.,Sect.D, 49, 1993
1APM
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2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT
Descriptor:cAMP-DEPENDENT PROTEIN KINASE, PEPTIDE INHIBITOR PKI(5-24), N-OCTANE
Authors:Knighton, D.R., Bell, S.M., Zheng, J., Teneyck, L.F., Xuong, N.-H., Taylor, S.S., Sowadski, J.M.
Deposit date:1993-01-18
Release date:1993-04-15
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:2.0 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with a peptide inhibitor and detergent.
Acta Crystallogr.,Sect.D, 49, 1993
1BKX
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A BINARY COMPLEX OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE AND ADENOSINE FURTHER DEFINES CONFORMATIONAL FLEXIBILITY
Descriptor:CAMP-DEPENDENT PROTEIN KINASE, ADENOSINE-5'-MONOPHOSPHATE
Authors:Narayana, N., Cox, S., Xuong, N., Ten Eyck, L.F., Taylor, S.S.
Deposit date:1997-07-01
Release date:1998-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility.
Structure, 5, 1997
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