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1OIF
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FAMILY 1 B-GLUCOSIDASE FROM THERMOTOGA MARITIMA
Descriptor:BETA-GLUCOSIDASE, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE
Authors:Gloster, T., Zechel, D., Boraston, A.B., Boraston, C.M., Macdonald, J.M., Tilbrook, D.M., Stick, R.V., Davies, G.J.
Deposit date:2003-06-16
Release date:2003-11-25
Last modified:2015-07-22
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Iminosugar Glycosidase Inhibitors: Structural and Thermodynamic Dissection of the Binding of Isofagomine and 1-Deoxynojirimycin to Beta-Glucosidases
J.Am.Chem.Soc., 125, 2003
1OIM
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FAMILY 1 B-GLUCOSIDASE FROM THERMOTOGA MARITIMA
Descriptor:BETA-GLUCOSIDASE A, 1-DEOXYNOJIRIMYCIN
Authors:Gloster, T., Zechel, D.L., Boraston, A.B., Boraston, C.M., Macdonald, J.M., Tilbrook, D.M., Stick, R.V., Davies, G.J.
Deposit date:2003-06-19
Release date:2003-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Iminosugar Glycosidase Inhibitors: Structural and Thermodynamic Dissection of the Binding of Isofagomine and 1-Deoxynojirimycin to Beta-Glucosidases
J.Am.Chem.Soc., 125, 2003
1UZ1
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FAMILY 1 B-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH ISOFAGOMINE LACTAM
Descriptor:BETA-GLUCOSIDASE A, (3S,4R,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)PIPERIDIN-2-ONE
Authors:Gloster, T.M., Macdonald, J., Stick, R.V., Davies, G.J.
Deposit date:2004-03-03
Release date:2004-11-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Common Inhibition of Both -Glucosidases and -Mannosidases by Isofagomine Lactam Reflects Different Conformational Itineraries for Pyranoside Hydrolysis
Chembiochem, 5, 2004
1W3J
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FAMILY 1 B-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH TETRAHYDROOXAZINE
Descriptor:BETA-GLUCOSIDASE, TETRAHYDROOXAZINE
Authors:Gloster, T.M., Macdonald, J.M., Tarling, C.A., Stick, R.V., Withers, S.W., Davies, G.J.
Deposit date:2004-07-16
Release date:2004-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural, Thermodynamic, and Kinetic Analyses of Tetrahydrooxazine-Derived Inhibitors Bound to {Beta}-Glucosidases
J.Biol.Chem., 279, 2004
1OCN
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MUTANT D416A OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS IN COMPLEX WITH A CELLOBIO-DERIVED ISOFAGOMINE AT 1.3 ANGSTROM RESOLUTION
Descriptor:CELLOBIOHYDROLASE II, N-ACETYL-D-GLUCOSAMINE, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, ...
Authors:Varrot, A., Macdonald, J., Stick, R.V., Pell, G., Gilbert, H.J., Davies, G.J.
Deposit date:2003-02-09
Release date:2003-05-22
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Distortion of a Cellobio-Derived Isofagomine Highlights the Potential Conformational Itinerary of Inverting Beta-Glucosidases
Chem.Commun.(Camb.), 21, 2003
1OCQ
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COMPLEX OF THE ENDOGLUCANASE CEL5A FROM BACILLUS AGARADHEARANS AT 1.08 ANGSTROM RESOLUTION WITH CELLOBIO-DERIVED ISOFAGOMINE
Descriptor:ENDOGLUCANASE 5A, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, BETA-D-GLUCOSE, ...
Authors:Varrot, A., Macdonald, J., Stick, R.V., Withers, S.G., Davies, G.J.
Deposit date:2003-02-09
Release date:2003-06-26
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.08 Å)
Cite:Direct Observation of the Protonation State of an Imino Sugar Glycosidase Inhibitor Upon Binding
J.Am.Chem.Soc., 125, 2003
1OD0
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FAMILY 1 B-GLUCOSIDASE FROM THERMOTOGA MARITIMA
Descriptor:BETA-GLUCOSIDASE A
Authors:Gloster, T., Zechel, D.L., Boraston, A.B., Boraston, C.M., Macdonald, J.M., Tilbrook, D.M., Stick, R.V., Davies, G.J.
Deposit date:2003-02-12
Release date:2003-03-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Iminosugar Glycosidase Inhibitors: Structural and Thermodynamic Dissection of the Binding of Isofagomine and 1-Deoxynojirimycin to Beta-Glucosidases
J.Am.Chem.Soc., 125, 2003
1OIN
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FAMILY 1 B-GLUCOSIDASE FROM THERMOTOGA MARITIMA
Descriptor:BETA-GLUCOSIDASE A, 2-deoxy-2-fluoro-alpha-D-glucopyranose
Authors:Gloster, T., Zechel, D.L., Boraston, A.B., Boraston, C.M., Macdonald, J.M., Tilbrook, D.M., Stick, R.V., Davies, G.J.
Deposit date:2003-06-19
Release date:2003-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Iminosugar Glycosidase Inhibitors: Structural and Thermodynamic Dissection of the Binding of Isofagomine and 1-Deoxynojirimycin to Beta-Glucosidases
J.Am.Chem.Soc., 125, 2003
1W3K
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ENDOGLUCANASE CEL5A FROM BACILLUS AGARADHAERENS IN COMPLEX WITH CELLOBIO DERIVED-TETRAHYDROOXAZINE
Descriptor:ENDOGLUCANASE 5A, BETA-D-GLUCOSE, TETRAHYDROOXAZINE, ...
Authors:Gloster, T.M., Macdonald, J.M., Tarling, C.A., Stick, R.V., Withers, S.W., Davies, G.J.
Deposit date:2004-07-16
Release date:2004-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural, Thermodynamic, and Kinetic Analyses of Tetrahydrooxazine-Derived Inhibitors Bound to {Beta}-Glucosidases
J.Biol.Chem., 279, 2004
1W3L
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ENDOGLUCANASE CEL5A FROM BACILLUS AGARADHAERENS IN COMPLEX WITH CELLOTRI DERIVED-TETRAHYDROOXAZINE
Descriptor:ENDOGLUCANASE 5A, GLYCEROL, SULFATE ION, ...
Authors:Gloster, T.M., Macdonald, J.M., Tarling, C.A., Stick, R.V., Withers, S.W., Davies, G.J.
Deposit date:2004-07-16
Release date:2004-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.04 Å)
Cite:Structural, Thermodynamic, and Kinetic Analyses of Tetrahydrooxazine-Derived Inhibitors Bound to {Beta}-Glucosidases
J.Biol.Chem., 279, 2004
2BV9
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HOW FAMILY 26 GLYCOSIDE HYDROLASES ORCHESTRATE CATALYSIS ON DIFFERENT POLYSACCHARIDES. STRUCTURE AND ACTIVITY OF A CLOSTRIDIUM THERMOCELLUM LICHENASE, CTLIC26A
Descriptor:ENDOGLUCANASE H
Authors:Taylor, E.J., Goyal, A., Guerreiro, C.I.P.D., Prates, J.A.M., Money, V.A., Ferry, N., Morland, C., Planas, A., Macdonald, J.A., Stick, R.V., Gilbert, H.J., Fontes, C.M.G.A., Davies, G.J.
Deposit date:2005-06-23
Release date:2005-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:How Family 26 Glycoside Hydrolases Orchestrate Catalysis on Different Polysaccharides: Structure and Activity of a Clostridium Thermocellum Lichenase, Ctlic26A.
J.Biol.Chem., 280, 2005
2BVD
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HOW FAMILY 26 GLYCOSIDE HYDROLASES ORCHESTRATE CATALYSIS ON DIFFERENT POLYSACCHARIDES. STRUCTURE AND ACTIVITY OF A CLOSTRIDIUM THERMOCELLUM LICHENASE, CTLIC26A
Descriptor:ENDOGLUCANASE H, GLUCOSE BETA-1,3-ISOFAGAMINE
Authors:Taylor, E.J., Goyal, A., Guerreiro, C.I.P.D., Prates, J.A.M., Money, V.A., Ferry, N., Morland, C., Planas, A., Macdonald, J.A., Stick, R.V., Gilbert, H.J., Fontes, C.M.G.A., Davies, G.J.
Deposit date:2005-06-27
Release date:2005-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:How Family 26 Glycoside Hydrolases Orchestrate Catalysis on Different Polysaccharides: Structure and Activity of a Clostridium Thermocellum Lichenase, Ctlic26A.
J.Biol.Chem., 280, 2005
2CIP
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STRUCTURE OF THE MICHAELIS COMPLEX OF A FAMILY 26 LICHENASE
Descriptor:ENDOGLUCANASE H, BETA-D-GLUCOSE, 4-METHYL-2H-CHROMEN-2-ONE
Authors:Money, V.A., Smith, N.L., Scaffidi, A., Stick, R.V., Gilbert, H.J., Davies, G.J.
Deposit date:2006-03-24
Release date:2006-07-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Substrate Distortion by a Lichenase Highlights the Different Conformational Itineraries Harnessed by Related Glycoside Hydrolases.
Angew.Chem.Int.Ed.Engl., 45, 2006
2CIT
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STRUCTURE OF THE COVALENT INTERMEDIATE OF A FAMILY 26 LICHENASE
Descriptor:ENDOGLUCANASE H, 2-deoxy-2-fluoro-alpha-D-glucopyranose, BETA-D-GLUCOSE
Authors:Money, V.A., Smith, N.L., Scaffidi, A., Stick, R.V., Gilbert, H.J., Davies, G.J.
Deposit date:2006-03-24
Release date:2006-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Substrate Distortion by a Lichenase Highlights the Different Conformational Itineraries Harnessed by Related Glycoside Hydrolases.
Angew.Chem.Int.Ed.Engl., 45, 2006
2J75
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BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH NOEUROMYCIN
Descriptor:BETA-GLUCOSIDASE A, ACETATE ION, (2R,3S,4R,5R)-5-(HYDROXYMETHYL)PIPERIDINE-2,3,4-TRIOL, ...
Authors:Gloster, T.M., Meloncelli, P., Stick, R.V., Zechel, D., Davies, G.J.
Deposit date:2006-10-06
Release date:2006-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Glycosidase Inhibition: An Assessment of the Binding of 18 Putative Transition-State Mimics.
J.Am.Chem.Soc., 129, 2007
2J7H
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BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH AZAFAGOMINE
Descriptor:BETA-GLUCOSIDASE A, AZAFAGOMINE, CALCIUM ION, ...
Authors:Gloster, T.M., Meloncelli, P., Stick, R.V., Zechel, D., Davies, G.J.
Deposit date:2006-10-08
Release date:2006-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Glycosidase Inhibition: An Assessment of the Binding of 18 Putative Transition-State Mimics.
J.Am.Chem.Soc., 129, 2007
2V38
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FAMILY 5 ENDOGLUCANASE CEL5A FROM BACILLUS AGARADHAERENS IN COMPLEX WITH CELLOBIO-DERIVED NOEUROMYCIN
Descriptor:ENDOGLUCANASE 5A, GLYCEROL, SULFATE ION, ...
Authors:Gloster, T.M., Meloncelli, P.J., Money, V.A., Tarling, C.A., Davies, G.J., Withers, S.G., Stick, R.V.
Deposit date:2007-06-13
Release date:2007-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:D-Glucosylated Derivatives of Isofagomine and Noeuromycin and Their Potential as Inhibitors of Beta-Glycoside Hydrolases
To be Published
2V3G
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STRUCTURE OF A FAMILY 26 LICHENASE IN COMPLEX WITH NOEUROMYCIN
Descriptor:ENDOGLUCANASE H, BETA-D-GLUCOSE, (2R,3S,4R,5R)-5-(HYDROXYMETHYL)PIPERIDINE-2,3,4-TRIOL
Authors:Meloncelli, P.J., Gloster, T.M., Money, V.A., Tarling, C.A., Davies, G.J., Withers, S.G., Stick, R.V.
Deposit date:2007-06-18
Release date:2007-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:D-Glucosylated Derivatives of Isofagomine and Noeuromycin and Their Potential as Inhibitors of Beta-Glycoside Hydrolases
To be Published
2VJX
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STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES
Descriptor:BETA-MANNOSIDASE, (3S,4R,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)PIPERIDIN-2-ONE, 1,2-ETHANEDIOL, ...
Authors:Tailford, L.E., Offen, W.A., Smith, N.L., Dumon, C., Moreland, C., Gratien, J., Heck, M.P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
Deposit date:2007-12-14
Release date:2008-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
2VL4
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STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES
Descriptor:BETA-MANNOSIDASE, (2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-HYDROXYMETHYL-PIPERIDINE, 1,2-ETHANEDIOL, ...
Authors:Tailford, L.E., Offen, W.A., Smith, N.L., Dumon, C., Moreland, C., Gratien, J., Heck, M.P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
Deposit date:2008-01-08
Release date:2008-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
2VMF
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STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES
Descriptor:BETA-MANNOSIDASE, (5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL, 1,2-ETHANEDIOL, ...
Authors:Tailford, L.E., Offen, W.A., Smith, N.L., Dumon, C., Moreland, C., Gratien, J., Heck, M.P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
Deposit date:2008-01-25
Release date:2008-04-01
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
2VO5
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STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES
Descriptor:BETA-MANNOSIDASE, (1R,4R,5R,7R,8R)-2-Benzyl-5-hydroxymethyl-2-aza-bicyclo[2.2.2]octane-4,7,8-triol, 1,2-ETHANEDIOL, ...
Authors:Tailford, L.E., Offen, W.A., Smith, N.L., Dumon, C., Moreland, C., Gratien, J., Heck, M.P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
Deposit date:2008-02-08
Release date:2008-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
2VOT
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STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES
Descriptor:BETA-MANNOSIDASE, (5R,6R,7S,8R)-6,7,8-trihydroxy-5-(hydroxymethyl)-2-[(phenylamino)methyl]-5,6,7,8-tetrahydro-1H-imidazo[1,2-a]pyridin-4-ium, 1,2-ETHANEDIOL, ...
Authors:Tailford, L.N., Offen, W.A., Smith, N., Dumon, C., Moreland, C., Gratien, J., Heck, M.-P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
Deposit date:2008-02-20
Release date:2008-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
2VQT
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STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES
Descriptor:BETA-MANNOSIDASE, (2Z,3R,4S,5R,6R)-2-[(2-aminoethyl)imino]-6-(hydroxymethyl)piperidine-3,4,5-triol, 1,2-ETHANEDIOL, ...
Authors:Tailford, L.E., Offen, W.A., Smith, N.L., Dumon, C., Moreland, C., Gratien, J., Heck, M.P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
Deposit date:2008-03-18
Release date:2008-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
2VQU
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STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES
Descriptor:BETA-MANNOSIDASE, 1,2-ETHANEDIOL, (2R,3S,4R,5R)-5-(HYDROXYMETHYL)PIPERIDINE-2,3,4-TRIOL, ...
Authors:Tailford, L.E., Offen, W.A., Smith, N.L., Dumon, C., Moreland, C., Gratien, J., Heck, M.P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
Deposit date:2008-03-18
Release date:2008-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
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