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3TTZ
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CRYSTAL STRUCTURE OF A TOPOISOMERASE ATPASE INHIBITOR
Descriptor:DNA gyrase subunit B, 2-[(3S,4R)-4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-fluoropiperidin-1-yl]-1,3-thiazole-5-carboxylic acid, MAGNESIUM ION
Authors:Boriack-Sjodin, P.A., Read, J., Eakin, A.E., Sherer, B.A.
Deposit date:2011-09-15
Release date:2011-11-16
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy.
Bioorg.Med.Chem.Lett., 21, 2011
4LP0
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CRYSTAL STRUCTURE OF A TOPOISOMERASE ATP INHIBITOR
Descriptor:Topoisomerase IV subunit B, 6'-[(ethylcarbamoyl)amino]-4'-[4-(trifluoromethyl)-1,3-thiazol-2-yl]-3,3'-bipyridine-5-carboxylic acid
Authors:Basarab, G.S., Manchester, J.I., Bist, S., Boriack-Sjodin, P.A., Dangel, B., Illingsworth, R., Uria-Nickelsen, M., Sherer, B.A., Sriram, S., Eakin, A.E.
Deposit date:2013-07-14
Release date:2013-11-13
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Fragment-to-Hit-to-Lead Discovery of a Novel Pyridylurea Scaffold of ATP Competitive Dual Targeting Type II Topoisomerase Inhibiting Antibacterial Agents.
J.Med.Chem., 56, 2013
3U2D
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S. AUREUS GYRB ATPASE DOMAIN IN COMPLEX WITH SMALL MOLECULE INHIBITOR
Descriptor:DNA gyrase subunit B, 4-bromo-5-methyl-N-[1-(3-nitropyridin-2-yl)piperidin-4-yl]-1H-pyrrole-2-carboxamide, MAGNESIUM ION
Authors:Boriack-Sjodin, P.A., Prince, D.B., Eakin, A.E., Sherer, B.A.
Deposit date:2011-10-03
Release date:2012-01-11
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Pyrrolamide DNA gyrase inhibitors: fragment-based nuclear magnetic resonance screening to identify antibacterial agents.
Antimicrob.Agents Chemother., 56, 2012
3U2K
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S. AUREUS GYRB ATPASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR
Descriptor:DNA gyrase subunit B, 2-chloro-6-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)pyridine-4-carboxamide, MAGNESIUM ION
Authors:Boriack-Sjodin, P.A., Prince, D.B., Eakin, A.E., Sherer, B.A.
Deposit date:2011-10-03
Release date:2012-01-11
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Pyrrolamide DNA gyrase inhibitors: fragment-based nuclear magnetic resonance screening to identify antibacterial agents.
Antimicrob.Agents Chemother., 56, 2012
4LPB
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CRYSTAL STRUCTURE OF A TOPOISOMERASE ATPASE INHIBITOR
Descriptor:Topoisomerase IV subunit B, 1-ethyl-3-{5'-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-4-[4-(trifluoromethyl)-1,3-thiazol-2-yl]-3,3'-bipyridin-6-yl}urea
Authors:Boriack-Sjodin, A.
Deposit date:2013-07-15
Release date:2013-10-30
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Fragment-to-Hit-to-Lead Discovery of a Novel Pyridylurea Scaffold of ATP Competitive Dual Targeting Type II Topoisomerase Inhibiting Antibacterial Agents.
J.Med.Chem., 56, 2013