Author results

1TPB
  • Download 1tpb
  • View 1tpb
Molmil generated image of 1tpb
OFFSET OF A CATALYTIC LESION BY A BOUND WATER SOLUBLE
Descriptor:TRIOSEPHOSPHATE ISOMERASE, PHOSPHOGLYCOLOHYDROXAMIC ACID
Authors:Zhang, Z., Sugio, S., Komives, E.A., Liu, K.D., Knowles, J.R., Petsko, G.A., Ringe, D.
Deposit date:1994-02-03
Release date:1995-02-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The structural basis for pseudoreversion of the E165D lesion by the secondary S96P mutation in triosephosphate isomerase depends on the positions of active site water molecules.
Biochemistry, 34, 1995
1TPC
  • Download 1tpc
  • View 1tpc
Molmil generated image of 1tpc
OFFSET OF A CATALYTIC LESION BY A BOUND WATER SOLUBLE
Descriptor:TRIOSEPHOSPHATE ISOMERASE, PHOSPHOGLYCOLOHYDROXAMIC ACID
Authors:Zhang, Z., Sugio, S., Komives, E.A., Liu, K.D., Knowles, J.R., Petsko, G.A., Ringe, D.
Deposit date:1994-02-03
Release date:1995-02-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The structural basis for pseudoreversion of the E165D lesion by the secondary S96P mutation in triosephosphate isomerase depends on the positions of active site water molecules.
Biochemistry, 34, 1995
1ASA
  • Download 1asa
  • View 1asa
Molmil generated image of 1asa
THE STRUCTURAL BASIS FOR THE REDUCED ACTIVITY OF THE Y226F(Y225F) ACTIVE SITE MUTANT OF E. COLI ASPARTATE AMINOTRANSFERASE
Descriptor:ASPARTATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, MALEIC ACID
Authors:Schumacher, C., Ringe, D.
Deposit date:1993-08-27
Release date:1994-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Structural Basis for the Reduced Activity of the Y226F(Y225F) Active Site Mutant of E. Coli Aspartate Aminotransferase
To be Published
2GYI
  • Download 2gyi
  • View 2gyi
Molmil generated image of 2gyi
DESIGN, SYNTHESIS, AND CHARACTERIZATION OF A POTENT XYLOSE ISOMERASE INHIBITOR, D-THREONOHYDROXAMIC ACID, AND HIGH-RESOLUTION X-RAY CRYSTALLOGRAPHIC STRUCTURE OF THE ENZYME-INHIBITOR COMPLEX
Descriptor:XYLOSE ISOMERASE, MAGNESIUM ION, 2,3,4,N-TETRAHYDROXY-BUTYRIMIDIC ACID
Authors:Allen, K.N., Lavie, A., Petsko, G.A., Ringe, D.
Deposit date:1994-09-01
Release date:1995-07-10
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Design, Synthesis, and Characterization of a Potent Xylose Isomerase Inhibitor, D-Threonohydroxamic Acid, and High-Resolution X-Ray Crystallographic Structure of the Enzyme-Inhibitor Complex
Biochemistry, 34, 1995
3FZW
  • Download 3fzw
  • View 3fzw
Molmil generated image of 3fzw
CRYSTAL STRUCTURE OF KETOSTEROID ISOMERASE D40N-D103N FROM PSEUDOMONAS PUTIDA (PKSI) WITH BOUND EQUILENIN
Descriptor:Steroid Delta-isomerase, EQUILENIN, GLYCEROL, ...
Authors:Caaveiro, J.M.M., Ringe, D., Petsko, G.A.
Deposit date:2009-01-26
Release date:2009-06-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Hydrogen bond coupling in the ketosteroid isomerase active site.
Biochemistry, 48, 2009
1DAA
  • Download 1daa
  • View 1daa
Molmil generated image of 1daa
CRYSTALLOGRAPHIC STRUCTURE OF D-AMINO ACID AMINOTRANSFERASE COMPLEXED WITH PYRIDOXAL-5'-PHOSPHATE
Descriptor:D-AMINO ACID AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Sugio, S., Peisach, D., Ringe, D.
Deposit date:1995-06-09
Release date:1995-09-15
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystal structure of a D-amino acid aminotransferase: how the protein controls stereoselectivity.
Biochemistry, 34, 1995
1G2W
  • Download 1g2w
  • View 1g2w
Molmil generated image of 1g2w
E177S MUTANT OF THE PYRIDOXAL-5'-PHOSPHATE ENZYME D-AMINO ACID AMINOTRANSFERASE
Descriptor:D-ALANINE AMINOTRANSFERASE, ACETATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Lepore, B.W., Ringe, D.
Deposit date:2000-10-21
Release date:2000-11-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Studies on an Active Site Residue, E177, That Affects Binding of the Coenzyme in D-Amino Acid Transaminase, and Mechanistic Studies on a Suicide Substrate
Biochemistry and Molecular Biology of Vitamin B6 and PQQ-dependent Proteins, 10th Annual International Symposium on Vitamin B6, 2000
1AAM
  • Download 1aam
  • View 1aam
Molmil generated image of 1aam
THE STRUCTURAL BASIS FOR THE ALTERED SUBSTRATE SPECIFICITY OF THE R292D ACTIVE SITE MUTANT OF ASPARTATE AMINOTRANSFERASE FROM E. COLI
Descriptor:ASPARTATE AMINOTRANSFERASE, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Almo, S.C., Smith, D.L., Danishefsky, A.T., Ringe, D.
Deposit date:1993-07-13
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structural basis for the altered substrate specificity of the R292D active site mutant of aspartate aminotransferase from E. coli.
Protein Eng., 7, 1994
1AAW
  • Download 1aaw
  • View 1aaw
Molmil generated image of 1aaw
THE STRUCTURAL BASIS FOR THE ALTERED SUBSTRATE SPECIFICITY OF THE R292D ACTIVE SITE MUTANT OF ASPARTATE AMINOTRANSFERASE FROM E. COLI
Descriptor:ASPARTATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Almo, S.C., Smith, D.L., Danishefsky, A.T., Ringe, D.
Deposit date:1993-07-13
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The structural basis for the altered substrate specificity of the R292D active site mutant of aspartate aminotransferase from E. coli.
Protein Eng., 7, 1994
1ASB
  • Download 1asb
  • View 1asb
Molmil generated image of 1asb
THE STRUCTURAL BASIS FOR THE REDUCED ACTIVITY OF THE D223A(D222A) ACTIVE SITE MUTANT OF E. COLI ASPARTATE AMINOTRANSFERASE
Descriptor:ASPARTATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, MALEIC ACID
Authors:Schumacher, C., Ringe, D.
Deposit date:1993-08-27
Release date:1994-04-30
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Structural Basis for the Reduced Activity of the D223A(D222A) Active Site Mutant of E. Coli Aspartate Aminotransferase
To be Published
1ASC
  • Download 1asc
  • View 1asc
Molmil generated image of 1asc
THE STRUCTURAL BASIS FOR THE REDUCED ACTIVITY OF THE D223A(D222A) ACTIVE SITE MUTANT OF E. COLI ASPARTATE AMINOTRANSFERASE
Descriptor:ASPARTATE AMINOTRANSFERASE, N-METHYL-4-DEOXY-4-AMINO-PYRIDOXAL-5-PHOSPHATE
Authors:Schumacher, C., Ringe, D.
Deposit date:1993-08-27
Release date:1994-04-30
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Structural Basis for the Reduced Activity of the D223A(D222A) Active Site Mutant of E. Coli Aspartate Aminotransferase
To be Published
1ASD
  • Download 1asd
  • View 1asd
Molmil generated image of 1asd
THE STRUCTURE OF WILD TYPE E. COLI ASPARTATE AMINOTRANSFERASE RECONSTITUTED WITH N-MEPLP
Descriptor:ASPARTATE AMINOTRANSFERASE, N-METHYL-PYRIDOXAL-5'-PHOSPHATE, MALEIC ACID
Authors:Schumacher, C., Ringe, D.
Deposit date:1993-08-27
Release date:1994-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Structure of Wild Type E. Coli Aspartate Aminotransferase Reconstituted with N-Meplp
To be Published
1ASE
  • Download 1ase
  • View 1ase
Molmil generated image of 1ase
THE STRUCTURE OF WILD TYPE E. COLI ASPARTATE AMINOTRANSFERASE RECONSTITUTED WITH PLP-N-OXIDE
Descriptor:ASPARTATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE-N-OXIDE, MALEIC ACID
Authors:Schumacher, C., Ringe, D.
Deposit date:1993-08-27
Release date:1994-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Structure of Wild Type E. Coli Aspartate Aminotransferase Reconstituted with Plp-N-Oxide
To be Published
1ASF
  • Download 1asf
  • View 1asf
Molmil generated image of 1asf
THE STRUCTURAL BASIS FOR THE REDUCED ACTIVITY OF THE Y226F(Y225F) ACTIVE SITE MUTANT OF E. COLI ASPARTATE AMINOTRANSFERASE
Descriptor:ASPARTATE AMINOTRANSFERASE, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Schumacher, C., Ringe, D.
Deposit date:1993-08-27
Release date:1994-04-30
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Structural Basis for the Reduced Activity of the Y226F(Y225F) Active Site Mutant of E. Coli Aspartate Aminotransferase
To be Published
1ASG
  • Download 1asg
  • View 1asg
Molmil generated image of 1asg
THE STRUCTURAL BASIS FOR THE REDUCED ACTIVITY OF THE Y226F(Y225F) ACTIVE SITE MUTANT OF E. COLI ASPARTATE AMINOTRANSFERASE
Descriptor:ASPARTATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, MALEIC ACID
Authors:Schumacher, C., Ringe, D.
Deposit date:1993-08-27
Release date:1994-04-30
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Structural Basis for the Reduced Activity of the Y226F(Y225F) Active Site Mutant of E. Coli Aspartate Aminotransferase
To be Published
1DDN
  • Download 1ddn
  • View 1ddn
Molmil generated image of 1ddn
DIPHTHERIA TOX REPRESSOR (C102D MUTANT)/TOX DNA OPERATOR COMPLEX
Descriptor:33 BASE DNA CONTAINING TOXIN OPERATOR, DIPHTHERIA TOX REPRESSOR, NICKEL (II) ION
Authors:White, A., Ding, X., Vanderspek, J.C., Murphy, J.R., Ringe, D.
Deposit date:1998-06-23
Release date:1998-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the metal-ion-activated diphtheria toxin repressor/tox operator complex.
Nature, 394, 1998
1DPR
  • Download 1dpr
  • View 1dpr
Molmil generated image of 1dpr
STRUCTURES OF THE APO-AND METAL ION ACTIVATED FORMS OF THE DIPHTHERIA TOX REPRESSOR FROM CORYNEBACTERIUM DIPHTHERIAE
Descriptor:DIPHTHERIA TOX REPRESSOR
Authors:Schiering, N., Tao, X., Murphy, J., Petsko, G.A., Ringe, D.
Deposit date:1995-02-06
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of the apo- and the metal ion-activated forms of the diphtheria tox repressor from Corynebacterium diphtheriae.
Proc.Natl.Acad.Sci.USA, 92, 1995
1XYA
  • Download 1xya
  • View 1xya
Molmil generated image of 1xya
X-RAY CRYSTALLOGRAPHIC STRUCTURES OF D-XYLOSE ISOMERASE-SUBSTRATE COMPLEXES POSITION THE SUBSTRATE AND PROVIDE EVIDENCE FOR METAL MOVEMENT DURING CATALYSIS
Descriptor:XYLOSE ISOMERASE, MAGNESIUM ION, HYDROXIDE ION
Authors:Lavie, A., Allen, K.N., Petsko, G.A., Ringe, D.
Deposit date:1994-01-03
Release date:1994-05-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis.
Biochemistry, 33, 1994
1XYB
  • Download 1xyb
  • View 1xyb
Molmil generated image of 1xyb
X-RAY CRYSTALLOGRAPHIC STRUCTURES OF D-XYLOSE ISOMERASE-SUBSTRATE COMPLEXES POSITION THE SUBSTRATE AND PROVIDE EVIDENCE FOR METAL MOVEMENT DURING CATALYSIS
Descriptor:XYLOSE ISOMERASE, D-GLUCOSE IN LINEAR FORM, MAGNESIUM ION
Authors:Lavie, A., Allen, K.N., Petsko, G.A., Ringe, D.
Deposit date:1994-01-03
Release date:1994-05-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis.
Biochemistry, 33, 1994
1XYC
  • Download 1xyc
  • View 1xyc
Molmil generated image of 1xyc
X-RAY CRYSTALLOGRAPHIC STRUCTURES OF D-XYLOSE ISOMERASE-SUBSTRATE COMPLEXES POSITION THE SUBSTRATE AND PROVIDE EVIDENCE FOR METAL MOVEMENT DURING CATALYSIS
Descriptor:XYLOSE ISOMERASE, 3-O-METHYLFRUCTOSE IN LINEAR FORM, MAGNESIUM ION
Authors:Lavie, A., Allen, K.N., Petsko, G.A., Ringe, D.
Deposit date:1994-01-03
Release date:1994-05-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis.
Biochemistry, 33, 1994
1XYL
  • Download 1xyl
  • View 1xyl
Molmil generated image of 1xyl
THE ROLE OF THE DIVALENT METAL ION IN SUGAR BINDING, RING OPENING, AND ISOMERIZATION BY D-XYLOSE ISOMERASE: REPLACEMENT OF A CATALYTIC METAL BY AN AMINO-ACID
Descriptor:XYLOSE ISOMERASE, MAGNESIUM ION, HYDROXIDE ION
Authors:Allen, K.N., Lavie, A., Petsko, G.A., Ringe, D.
Deposit date:1993-12-07
Release date:1994-05-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Role of the divalent metal ion in sugar binding, ring opening, and isomerization by D-xylose isomerase: replacement of a catalytic metal by an amino acid.
Biochemistry, 33, 1994
1XYM
  • Download 1xym
  • View 1xym
Molmil generated image of 1xym
THE ROLE OF THE DIVALENT METAL ION IN SUGAR BINDING, RING OPENING, AND ISOMERIZATION BY D-XYLOSE ISOMERASE: REPLACEMENT OF A CATALYTIC METAL BY AN AMINO-ACID
Descriptor:XYLOSE ISOMERASE, D-GLUCOSE IN LINEAR FORM, MAGNESIUM ION, ...
Authors:Allen, K.N., Lavie, A., Petsko, G.A., Ringe, D.
Deposit date:1993-12-07
Release date:1994-05-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Role of the divalent metal ion in sugar binding, ring opening, and isomerization by D-xylose isomerase: replacement of a catalytic metal by an amino acid.
Biochemistry, 33, 1994
2SFP
  • Download 2sfp
  • View 2sfp
Molmil generated image of 2sfp
ALANINE RACEMASE WITH BOUND PROPIONATE INHIBITOR
Descriptor:PROTEIN (ALANINE RACEMASE), PYRIDOXAL-5'-PHOSPHATE, PROPANOIC ACID
Authors:Morollo, A.A., Petsko, G.A., Ringe, D.
Deposit date:1999-02-16
Release date:1999-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a Michaelis complex analogue: propionate binds in the substrate carboxylate site of alanine racemase.
Biochemistry, 38, 1999
2TDX
  • Download 2tdx
  • View 2tdx
Molmil generated image of 2tdx
DIPHTHERIA TOX REPRESSOR (C102D MUTANT) COMPLEXED WITH NICKEL
Descriptor:DIPHTHERIA TOX REPRESSOR, NICKEL (II) ION
Authors:White, A., Ding, X., Zheng, H., Schiering, N., Ringe, D., Murphy, J.R.
Deposit date:1998-06-22
Release date:1998-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the metal-ion-activated diphtheria toxin repressor/tox operator complex.
Nature, 394, 1998
3AAT
  • Download 3aat
  • View 3aat
Molmil generated image of 3aat
ACTIVITY AND STRUCTURE OF THE ACTIVE-SITE MUTANTS R386Y AND R386F OF ESCHERICHIA COLI ASPARTATE AMINOTRANSFERASE
Descriptor:ASPARTATE AMINOTRANSFERASE, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Danishefsky, A.T., Ringe, D., Petsko, G.A.
Deposit date:1990-12-06
Release date:1992-01-15
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Activity and structure of the active-site mutants R386Y and R386F of Escherichia coli aspartate aminotransferase.
Biochemistry, 30, 1991