Author results

1TYK
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SOLUTION STRUCTURE OF A TOXIN FROM THE TARANTULA, GRAMMOSTOLA SPATULATA, WHICH INHIBITS MECHANOSENSITIVE ION CHANNELS
Descriptor:Toxin GsMTx-4
Authors:Oswald, R.E., Suchyna, T.M., Mcfeeters, R., Gottlieb, P., Sachs, F.
Deposit date:2004-07-08
Release date:2004-07-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of Peptide Toxins that Block Mechanosensitive Ion Channels
J.Biol.Chem., 277, 2002
1LUP
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SOLUTION STRUCTURE OF A TOXIN (GSMTX2) FROM THE TARANTULA, GRAMMOSTOLA SPATULATA, WHICH INHIBITS MECHANOSENSITIVE ION CHANNELS
Descriptor:GsMTx2
Authors:Oswald, R.E., Suchyna, T.M., McFeeters, R., Gottlieb, P., Sachs, F.
Deposit date:2002-05-23
Release date:2002-08-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of peptide toxins that block mechanosensitive ion channels
J.Biol.Chem., 277, 2002
2NBT
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NEURONAL BUNGAROTOXIN, NMR, 10 STRUCTURES
Descriptor:NEURONAL BUNGAROTOXIN
Authors:Oswald, R.E., Sutcliffe, M.J., Bamberger, M., Loring, R.H., Braswell, E., Dobson, C.M.
Deposit date:1997-10-29
Release date:1998-03-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of neuronal bungarotoxin determined by two-dimensional NMR spectroscopy: calculation of tertiary structure using systematic homologous model building, dynamical simulated annealing, and restrained molecular dynamics.
Biochemistry, 31, 1992
1EES
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SOLUTION STRUCTURE OF CDC42HS COMPLEXED WITH A PEPTIDE DERIVED FROM P-21 ACTIVATED KINASE, NMR, 20 STRUCTURES
Descriptor:GTP-BINDING PROTEIN, P21-ACTIVATED KINASE
Authors:Gizachew, D., Guo, W., Chohan, K.C., Sutcliffe, M.J., Oswald, R.E.
Deposit date:2000-02-02
Release date:2000-03-29
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the complex of Cdc42Hs with a peptide derived from P-21 activated kinase.
Biochemistry, 39, 2000
1AJE
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CDC42 FROM HUMAN, NMR, 20 STRUCTURES
Descriptor:CDC42HS
Authors:Feltham, J.L., Dotsch, V., Raza, S., Manor, D., Cerione, R.A., Sutcliffe, M.J., Wagner, G., Oswald, R.E.
Deposit date:1997-05-02
Release date:1997-11-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Definition of the switch surface in the solution structure of Cdc42Hs.
Biochemistry, 36, 1997
2ASE
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NMR STRUCTURE OF THE F28L MUTANT OF CDC42HS
Descriptor:Cell division control protein 42 homolog
Authors:Adams, P.D., Oswald, R.E.
Deposit date:2005-08-23
Release date:2006-02-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of an Oncogenic Mutant of Cdc42Hs
Biochemistry, 45, 2006
2MOG
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SOLUTION STRUCTURE OF THE TERMINAL IG-LIKE DOMAIN FROM LEPTOSPIRA INTERROGANS LIGB
Descriptor:Bacterial Ig-like domain, group 2
Authors:Ptak, C.P., Hsieh, C., Lin, Y., Maltsev, A.S., Raman, R., Sharma, Y., Oswald, R.E., Chang, Y.
Deposit date:2014-04-25
Release date:2014-08-13
Last modified:2014-09-03
Method:SOLUTION NMR
Cite:NMR Solution Structure of the Terminal Immunoglobulin-like Domain from the Leptospira Host-Interacting Outer Membrane Protein, LigB.
Biochemistry, 53, 2014
3DLN
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CRYSTAL STRUCTURE OF THE BINDING DOMAIN OF THE AMPA SUBUNIT GLUR3 BOUND TO GLUTAMATE
Descriptor:Glutamate receptor 3, ZINC ION, GLUTAMIC ACID
Authors:Ahmed, A.H., Wang, Q., Sondermann, H., Oswald, R.E.
Deposit date:2008-06-27
Release date:2008-11-25
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Structure of the S1S2 glutamate binding domain of GLuR3.
Proteins, 75, 2008
3DP4
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CRYSTAL STRUCTURE OF THE BINDING DOMAIN OF THE AMPA SUBUNIT GLUR3 BOUND TO AMPA
Descriptor:Glutamate receptor 3, ZINC ION, (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID
Authors:Ahmed, A.H., Wang, Q., Sondermann, H., Oswald, R.E.
Deposit date:2008-07-07
Release date:2008-11-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Structure of the S1S2 glutamate binding domain of GLuR3.
Proteins, 75, 2008
3DP6
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CRYSTAL STRUCTURE OF THE BINDING DOMAIN OF THE AMPA SUBUNIT GLUR2 BOUND TO GLUTAMATE
Descriptor:Glutamate receptor 2, ZINC ION, GLUTAMIC ACID
Authors:Ahmed, A.H., Wang, Q., Sondermann, H., Oswald, R.E.
Deposit date:2008-07-07
Release date:2008-11-25
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of the S1S2 glutamate binding domain of GLuR3.
Proteins, 75, 2008
3H03
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CRYSTAL STRUCTURE OF THE BINDING DOMAIN OF THE AMPA SUBUNIT GLUR2 BOUND TO UBP277
Descriptor:Glutamate receptor 2, 3-[3-(2-carboxyethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]-L-alanine, ZINC ION
Authors:Ahmed, A.H., Oswald, R.E.
Deposit date:2009-04-08
Release date:2009-05-05
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain.
Biochemistry, 48, 2009
3H06
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CRYSTAL STRUCTURE OF THE BINDING DOMAIN OF THE AMPA SUBUNIT GLUR2 BOUND TO THE WILLARDIINE ANTAGONIST, UBP282
Descriptor:Glutamate receptor 2, 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid
Authors:Ahmed, A.H., Oswald, R.E.
Deposit date:2009-04-08
Release date:2009-05-05
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain.
Biochemistry, 48, 2009
3IJO
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CRYSTAL STRUCTURE OF THE AMPA SUBUNIT GLUR2 BOUND TO THE ALLOSTERIC MODULATOR, ALTHIAZIDE
Descriptor:Glutamate receptor 2, GLUTAMIC ACID, (3S)-6-chloro-3-[(prop-2-en-1-ylsulfanyl)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, ...
Authors:Ptak, C.P., Ahmed, A.H., Oswald, R.E.
Deposit date:2009-08-04
Release date:2009-09-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
Biochemistry, 48, 2009
3IJX
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CRYSTAL STRUCTURE OF THE AMPA SUBUNIT GLUR2 BOUND TO THE ALLOSTERIC MODULATOR, HYDROCHLOROTHIAZIDE
Descriptor:Glutamate receptor 2, GLUTAMIC ACID, 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, ...
Authors:Ptak, C.P., Ahmed, A.H., Oswald, R.E.
Deposit date:2009-08-05
Release date:2009-09-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.881 Å)
Cite:Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
Biochemistry, 48, 2009
3IK6
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CRYSTAL STRUCTURE OF THE AMPA SUBUNIT GLUR2 BOUND TO THE ALLOSTERIC MODULATOR, CHLOROTHIAZIDE
Descriptor:Glutamate receptor 2, GLUTAMIC ACID, 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, ...
Authors:Ptak, C.P., Ahmed, A.H., Oswald, R.E.
Deposit date:2009-08-05
Release date:2009-09-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
Biochemistry, 48, 2009
3IL1
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CRYSTAL STRUCTURE OF THE AMPA SUBUNIT GLUR2 BOUND TO THE ALLOSTERIC MODULATOR, IDRA-21
Descriptor:Glutamate receptor 2, GLUTAMIC ACID, ZINC ION, ...
Authors:Ahmed, A.H., Ptak, C.P., Oswald, R.E.
Deposit date:2009-08-06
Release date:2009-09-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
Biochemistry, 48, 2009
3ILT
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CRYSTAL STRUCTURE OF THE AMPA SUBUNIT GLUR2 BOUND TO THE ALLOSTERIC MODULATOR, TRICHLORMETHIAZIDE
Descriptor:Glutamate receptor 2, GLUTAMIC ACID, ZINC ION, ...
Authors:Ahmed, A.H., Ptak, C.P., Oswald, R.E.
Deposit date:2009-08-07
Release date:2009-09-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.107 Å)
Cite:Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
Biochemistry, 48, 2009
3ILU
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CRYSTAL STRUCTURE OF THE AMPA SUBUNIT GLUR2 BOUND TO THE ALLOSTERIC MODULATOR, HYDROFLUMETHIAZIDE
Descriptor:Glutamate receptor 2, GLUTAMIC ACID, 6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, ...
Authors:Ahmed, A.H., Ptak, C.P., Oswald, R.E.
Deposit date:2009-08-07
Release date:2009-09-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
Biochemistry, 48, 2009
3LSF
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PIRACETAM BOUND TO THE LIGAND BINDING DOMAIN OF GLUA2
Descriptor:Glutamate receptor 2, GLUTAMIC ACID, 2-(2-oxopyrrolidin-1-yl)acetamide, ...
Authors:Ahmed, A.H., Ptak, C.P., Oswald, R.E.
Deposit date:2010-02-12
Release date:2010-03-16
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors.
J.Med.Chem., 53, 2010
3LSL
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PIRACETAM BOUND TO THE LIGAND BINDING DOMAIN OF GLUA2 (FLOP FORM)
Descriptor:Glutamate receptor 2, GLUTAMIC ACID, 2-(2-oxopyrrolidin-1-yl)acetamide, ...
Authors:Ahmed, A.H., Oswald, R.E.
Deposit date:2010-02-12
Release date:2010-03-16
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.122 Å)
Cite:Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors.
J.Med.Chem., 53, 2010
3LSW
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ANIRACETAM BOUND TO THE LIGAND BINDING DOMAIN OF GLUA3
Descriptor:GluA2 S1S2 domain, GLUTAMIC ACID, 1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE, ...
Authors:Ahmed, A.H., Oswald, R.E.
Deposit date:2010-02-13
Release date:2010-03-16
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.752 Å)
Cite:Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors.
J.Med.Chem., 53, 2010
3LSX
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PIRACETAM BOUND TO THE LIGAND BINDING DOMAIN OF GLUA3
Descriptor:GluA3 S1S2 domain, GLUTAMIC ACID, 2-(2-oxopyrrolidin-1-yl)acetamide, ...
Authors:Ahmed, A.H., Oswald, R.E.
Deposit date:2010-02-13
Release date:2011-03-16
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.006 Å)
Cite:Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors.
J.Med.Chem., 53, 2010
3M3F
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PEPA BOUND TO THE LIGAND BINDING DOMAIN OF GLUA3 (FLOP FORM)
Descriptor:Glutamate receptor 3, GLUTAMIC ACID, 2-[2,6-difluoro-4-({2-[(phenylsulfonyl)amino]ethyl}sulfanyl)phenoxy]acetamide, ...
Authors:Ahmed, A.H., Ptak, C.P., Oswald, R.E.
Deposit date:2010-03-09
Release date:2010-03-23
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA.
Biochemistry, 49, 2010
3M3K
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LIGAND BINDING DOMAIN (S1S2) OF GLUA3 (FLOP)
Descriptor:Glutamate receptor 3, GLUTAMIC ACID, ZINC ION
Authors:Ahmed, A.H., Ptak, C.P., Oswald, R.E.
Deposit date:2010-03-09
Release date:2010-03-23
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.793 Å)
Cite:Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA.
Biochemistry, 49, 2010
3M3L
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PEPA BOUND TO THE LIGAND BINDING DOMAIN OF GLUA2 (FLOP FORM)
Descriptor:Glutamate receptor 2, GLUTAMIC ACID, 2-[2,6-difluoro-4-({2-[(phenylsulfonyl)amino]ethyl}sulfanyl)phenoxy]acetamide, ...
Authors:Ptak, C.P., Ahmed, A.H., Oswald, R.E.
Deposit date:2010-03-09
Release date:2010-03-23
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA.
Biochemistry, 49, 2010
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