Author results

2XUT
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CRYSTAL STRUCTURE OF A PROTON DEPENDENT OLIGOPEPTIDE (POT) FAMILY TRANSPORTER.
Descriptor:PROTON/PEPTIDE SYMPORTER FAMILY PROTEIN
Authors:Newstead, S., Drew, D., Cameron, A.D., Postis, V.L., Xia, X., Fowler, P.W., Ingram, J.C., Carpenter, E.P., Sansom, M.S.P., McPherson, M.J., Baldwin, S.A., Iwata, S.
Deposit date:2010-10-21
Release date:2010-12-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.62 Å)
Cite:Crystal Structure of a Prokaryotic Homologue of the Mammalian Oligopeptide-Proton Symporters, Pept1 and Pept2.
Embo J., 30, 2011
3FVQ
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CRYSTAL STRUCTURE OF THE NUCLEOTIDE BINDING DOMAIN FBPC COMPLEXED WITH ATP
Descriptor:Fe(3+) ions import ATP-binding protein fbpC, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION
Authors:Newstead, S., Bilton, P., Carpenter, E.P., Campopiano, D., Iwata, S.
Deposit date:2009-01-16
Release date:2009-08-25
Last modified:2012-10-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Insights into how nucleotide-binding domains power ABC transport.
Structure, 17, 2009
2BER
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Y370G ACTIVE SITE MUTANT OF THE SIALIDASE FROM MICROMONOSPORA VIRIDIFACIENS IN COMPLEX WITH BETA-NEU5AC (SIALIC ACID).
Descriptor:BACTERIAL SIALIDASE, 5-N-ACETYL-BETA-D-NEURAMINIC ACID, SODIUM ION
Authors:Newstead, S., Watson, J.N., Bennet, A.J., Taylor, G.L.
Deposit date:2004-11-30
Release date:2005-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and Mechanism of Action of an Inverting Mutant Sialidase.
Biochemistry, 44, 2005
1W8N
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CONTRIBUTION OF THE ACTIVE SITE ASPARTIC ACID TO CATALYSIS IN THE BACTERIAL NEURAMINIDASE FROM MICROMONOSPORA VIRIDIFACIENS.
Descriptor:BACTERIAL SIALIDASE, BETA-D-GALACTOSE, 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, ...
Authors:Newstead, S., Watson, J.N., Dookhun, V., Bennet, A.J., Taylor, G.
Deposit date:2004-09-24
Release date:2004-09-30
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Contribution of the Active Site Aspartic Acid to Catalysis in the Bacterial Neuraminidase from Micromonospora Viridifaciens
FEBS Lett., 577, 2004
1W8O
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CONTRIBUTION OF THE ACTIVE SITE ASPARTIC ACID TO CATALYSIS IN THE BACTERIAL NEURAMINIDASE FROM MICROMONOSPORA VIRIDIFACIENS
Descriptor:BACTERIAL SIALIDASE, ALPHA-LACTOSE, CITRIC ACID, ...
Authors:Newstead, S., Watson, J.N., Dookhun, V., Bennet, A.J., Taylor, G.
Deposit date:2004-09-24
Release date:2004-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Contribution of the Active Site Aspartic Acid to Catalysis in the Bacterial Neuraminidase from Micromonospora Viridifaciens
FEBS Lett., 577, 2004
1WCQ
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MUTAGENESIS OF THE NUCLEOPHILIC TYROSINE IN A BACTERIAL SIALIDASE TO PHENYLALANINE.
Descriptor:SIALIDASE, SODIUM ION, GLYCEROL, ...
Authors:Newstead, S., Watson, J.N., Bennet, A.J., Taylor, G.
Deposit date:2004-11-19
Release date:2005-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Two Nucleophilic Mutants of the Micromonospora Viridifaciens Sialidase Operate with Retention of Configuration by Two Different Mechanisms.
Chembiochem, 6, 2005
5OGE
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CRYSTAL STRUCTURE OF A NUCLEOTIDE SUGAR TRANSPORTER
Descriptor:GDP-mannose transporter 1, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Authors:Newstead, S., Parker, J.L.
Deposit date:2017-07-12
Release date:2017-11-22
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:Structural basis of nucleotide sugar transport across the Golgi membrane.
Nature, 551, 2017
5OGK
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CRYSTAL STRUCTURE OF A NUCLEOTIDE SUGAR TRANSPORTER WITH BOUND NUCLEOTIDE SUGAR.
Descriptor:GDP-mannose transporter 1, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Authors:Newstead, S., Parker, J.L.
Deposit date:2017-07-13
Release date:2017-11-22
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis of nucleotide sugar transport across the Golgi membrane.
Nature, 551, 2017
6EI3
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CRYSTAL STRUCTURE OF AUTO INHIBITED POT FAMILY PEPTIDE TRANSPORTER
Descriptor:Proton-dependent oligopeptide transporter family protein, (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
Authors:Newstead, S., Brinth, A., Vogeley, L., Caffrey, M.
Deposit date:2017-09-17
Release date:2017-11-22
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Proton movement and coupling in the POT family of peptide transporters.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6BQO
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STRUCTURE OF A DUAL TOPOLOGY FLUORIDE CHANNEL WITH MONOBODY S8
Descriptor:Fluoride ion transporter CrcB, Monobody S8, FLUORIDE ION, ...
Authors:Stockbridge, R.B., Newstead, S., McIlwain, B.C.
Deposit date:2017-11-28
Release date:2018-03-07
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Cork-in-Bottle Occlusion of Fluoride Ion Channels by Crystallization Chaperones.
Structure, 26, 2018
2W1B
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THE STRUCTURE OF THE EFFLUX PUMP ACRB IN COMPLEX WITH BILE ACID
Descriptor:ACRIFLAVIN RESISTANCE PROTEIN B, (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID
Authors:Drew, D., Klepsch, M.M., Newstead, S., Flaig, R., De Gier, J.W., Iwata, S., Beis, K.
Deposit date:2008-10-17
Release date:2008-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.85 Å)
Cite:The Structure of the Efflux Pump Acrb in Complex with Bile Acid.
Mol.Membr.Biol., 25, 2008
4APS
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CRYSTAL STRUCTURE OF A POT FAMILY PEPTIDE TRANSPORTER IN AN INWARD OPEN CONFORMATION.
Descriptor:DI-OR TRIPEPTIDE H+ SYMPORTER, CADMIUM ION
Authors:Solcan, N., Kwok, J., Fowler, P.W., Cameron, A.D., Drew, D., Iwata, S., Newstead, S.
Deposit date:2012-04-05
Release date:2012-06-13
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Alternating Access Mechanism in the Pot Family of Oligopeptide Transporters.
Embo J., 31, 2012
5A40
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CRYSTAL STRUCTURE OF A DUAL TOPOLOGY FLUORIDE ION CHANNEL.
Descriptor:PUTATIVE FLUORIDE ION TRANSPORTER CRCB, MONOBODIES, MERCURY (II) ION
Authors:Stockbridge, R.B., Kolmakova-Partensky, L., Shane, T., Koide, A., Koide, S., Miller, C., Newstead, S.
Deposit date:2015-06-04
Release date:2015-09-02
Last modified:2015-09-30
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Crystal Structures of a Double-Barrelled Fluoride Ion Channel.
Nature, 525, 2015
5A43
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CRYSTAL STRUCTURE OF A DUAL TOPOLOGY FLUORIDE ION CHANNEL.
Descriptor:PUTATIVE FLUORIDE ION TRANSPORTER CRCB, MONOBODIES, FLUORIDE ION, ...
Authors:Stockbridge, R.B., Kolmakova-Partensky, L., Shane, T., Koide, A., Koide, S., Miller, C., Newstead, S.
Deposit date:2015-06-04
Release date:2015-09-02
Last modified:2015-09-30
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Crystal Structures of a Double-Barrelled Fluoride Ion Channel.
Nature, 525, 2015
5L7D
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STRUCTURE OF HUMAN SMOOTHENED IN COMPLEX WITH CHOLESTEROL
Descriptor:Smoothened homolog,Soluble cytochrome b562,Smoothened homolog, N-ACETYL-D-GLUCOSAMINE, CHOLESTEROL, ...
Authors:Byrne, E.F.X., Sircar, R., Miller, P.S., Hedger, G., Luchetti, G., Nachtergaele, S., Tully, M.D., Mydock-McGrane, L., Covey, D.F., Rambo, R.P., Sansom, M.S.P., Newstead, S., Rohatgi, R., Siebold, C.
Deposit date:2016-06-03
Release date:2016-07-20
Last modified:2016-08-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis of Smoothened regulation by its extracellular domains.
Nature, 535, 2016
5L7I
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STRUCTURE OF HUMAN SMOOTHENED IN COMPLEX WITH VISMODEGIB
Descriptor:Smoothened homolog,Soluble cytochrome b562,Smoothened homolog, N-ACETYL-D-GLUCOSAMINE, 2-chloranyl-~{N}-(4-chloranyl-3-pyridin-2-yl-phenyl)-4-methylsulfonyl-benzamide, ...
Authors:Byrne, E.X.B., Sircar, R., Miller, P.S., Hedger, G., Luchetti, G., Nachtergaele, S., Tully, M.D., Mydock-McGrane, L., Covey, D.F., Rambo, R.F., Sansom, M.S.P., Newstead, S., Rohatgi, R., Siebold, C.
Deposit date:2016-06-03
Release date:2016-07-20
Last modified:2016-08-10
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis of Smoothened regulation by its extracellular domains.
Nature, 535, 2016
4UVM
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IN MESO CRYSTAL STRUCTURE OF THE POT FAMILY TRANSPORTER PEPTSO
Descriptor:GLUTATHIONE UPTAKE TRANSPORTER, (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE
Authors:Lyons, J.A., Solcan, N., Caffrey, M., Newstead, S.
Deposit date:2014-08-07
Release date:2015-02-04
Last modified:2015-02-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Gating Topology of the Proton-Coupled Oligopeptide Symporters.
Structure, 23, 2015
5NKQ
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CRYSTAL STRUCTURE OF A DUAL TOPOLOGY FLUORIDE ION CHANNEL.
Descriptor:Putative fluoride ion transporter CrcB, Monobody, SODIUM ION, ...
Authors:Stockbridge, R., Miller, C., Newstead, S.
Deposit date:2017-03-31
Release date:2017-04-26
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Crystal structures of a double-barrelled fluoride ion channel.
Nature, 525, 2015
4D2B
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STRUCTURE OF A LIGAND FREE POT FAMILY PEPTIDE TRANSPORTER
Descriptor:DI-OR TRIPEPTIDE\:H+ SYMPORTER, (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, ...
Authors:Lyons, J.A., Parker, J.L., Solcan, N., Brinth, A., Li, D., Shah, S.T.A., Caffrey, M., Newstead, S.
Deposit date:2014-05-09
Release date:2014-06-25
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural Basis for Polyspecificity in the Pot Family of Proton-Coupled Oligopeptide Transporters.
Embo Rep., 15, 2014
4D2C
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STRUCTURE OF A DI PEPTIDE BOUND POT FAMILY PEPTIDE TRANSPORTER
Descriptor:Di-or tripeptide:H+ symporter, (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, ...
Authors:Lyons, J.A., Parker, J.L., Solcan, N., Brinth, A., Li, D., Shah, S.T.A., Caffrey, M., Newstead, S.
Deposit date:2014-05-09
Release date:2014-06-25
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Structural Basis for Polyspecificity in the Pot Family of Proton-Coupled Oligopeptide Transporters.
Embo Rep., 15, 2014
4D2D
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STRUCTURE OF A TRI PEPTIDE BOUND POT FAMILY PEPTIDE TRANSPORTER
Descriptor:DI-OR TRIPEPTIDE\:H+ SYMPORTER, ALANINE-TRIPEPTIDE, (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, ...
Authors:Lyons, J.A., Parker, J.L., Solcan, N., Brinth, A., Li, D., Shah, S.T.A., Caffrey, M., Newstead, S.
Deposit date:2014-05-09
Release date:2014-06-25
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (2.522 Å)
Cite:Structural Basis for Polyspecificity in the Pot Family of Proton-Coupled Oligopeptide Transporters.
Embo Rep., 15, 2014
5A2N
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CRYSTAL STRUCTURE OF THE NITRATE TRANSPORTER NRT1.1 FROM ARABIDOPSIS THALIANA.
Descriptor:PROTEIN NRT1/ PTR FAMILY 6.3
Authors:Parker, J.L., Newstead, S.
Deposit date:2015-05-20
Release date:2015-06-17
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Molecular Basis of Nitrate Uptake by the Plant Nitrate Transporter Nrt1.1.
Nature, 507, 2014
5A2O
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CRYSTAL STRUCTURE OF THE NITRATE TRANSPORTER NRT1.1 FROM ARABIDOPSIS THALIANA IN COMPLEX WITH NITRATE.
Descriptor:NITRATE TRANSPORTER 1.1, NITRATE ION
Authors:Parker, J.L., Newstead, S.
Deposit date:2015-05-20
Release date:2015-06-17
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (3.71 Å)
Cite:Molecular Basis of Nitrate Uptake by the Plant Nitrate Transporter Nrt1.1.
Nature, 507, 2014
5A9D
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF PEPT1
Descriptor:SOLUTE CARRIER FAMILY 15 MEMBER 1, GLYCEROL
Authors:Beale, J.H., Bird, L.E., Owens, R.J., Newstead, S.
Deposit date:2015-07-20
Release date:2015-09-09
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of the Extracellular Domain from Pept1 and Pept2 Provide Novel Insights Into Mammalian Peptide Transport
Structure, 23, 2015
5A9H
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF PEPT2
Descriptor:SOLUTE CARRIER FAMILY 15 MEMBER 2, GLYCEROL, CESIUM ION, ...
Authors:Beale, J.H., Newstead, S.
Deposit date:2015-07-21
Release date:2015-09-09
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Crystal Structures of the Extracellular Domain from Pept1 and Pept2 Provide Novel Insights Into Mammalian Peptide Transport
Structure, 23, 2015
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