Author results

3HHM
  • Download 3hhm
  • View 3hhm
Molmil generated image of 3hhm
CRYSTAL STRUCTURE OF P110ALPHA H1047R MUTANT IN COMPLEX WITH NISH2 OF P85ALPHA AND THE DRUG WORTMANNIN
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, niSH2 p85alpha, (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
Authors:Amzel, L.M., Vogelstein, B., Gabelli, S.B., Mandelker, D.
Deposit date:2009-05-15
Release date:2009-09-29
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A frequent kinase domain mutation that changes the interaction between PI3K{alpha} and the membrane.
Proc.Natl.Acad.Sci.USA, 106, 2009
3HIZ
  • Download 3hiz
  • View 3hiz
Molmil generated image of 3hiz
CRYSTAL STRUCTURE OF P110ALPHA H1047R MUTANT IN COMPLEX WITH NISH2 OF P85ALPHA
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha
Authors:Amzel, L.M., Vogelstein, B., Gabelli, S.B., Mandelker, D.
Deposit date:2009-05-20
Release date:2009-09-29
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:A frequent kinase domain mutation that changes the interaction between PI3K{alpha} and the membrane.
Proc.Natl.Acad.Sci.USA, 106, 2009
2RD0
  • Download 2rd0
  • View 2rd0
Molmil generated image of 2rd0
STRUCTURE OF A HUMAN P110ALPHA/P85ALPHA COMPLEX
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha
Authors:Huang, C., Gabelli, S.B., Amzel, L.M.
Deposit date:2007-09-20
Release date:2007-12-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.
Science, 318, 2007