Author results

1EVJ
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CRYSTAL STRUCTURE OF GLUCOSE-FRUCTOSE OXIDOREDUCTASE (GFOR) DELTA1-22 S64D
Descriptor:GLUCOSE-FRUCTOSE OXIDOREDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Lott, J.S., Halbig, D., Baker, H.M., Hardman, M.J., Sprenger, G.A., Baker, E.N.
Deposit date:2000-04-20
Release date:2000-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of a truncated mutant of glucose-fructose oxidoreductase shows that an N-terminal arm controls tetramer formation.
J.Mol.Biol., 304, 2000
1WVQ
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STRUCTURE OF CONSERVED HYPOTHETICAL PROTEIN PAE2307 FROM PYROBACULUM AEROPHILUM
Descriptor:hypothetical protein PAE2307, PHOSPHATE ION
Authors:Lott, J.S., Delbaere, L.T., Banfield, M.J., Sigrell-Simon, J.A., Baker, E.N.
Deposit date:2004-12-24
Release date:2006-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The structure of an ancient conserved domain establishes a structural basis for stable histidine phosphorylation and identifies a new family of adenosine-specific kinases.
J.Biol.Chem., 281, 2006
2GL0
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STRUCTURE OF PAE2307 IN COMPLEX WITH ADENOSINE
Descriptor:conserved hypothetical protein, ADENOSINE, PHOSPHATE ION
Authors:Lott, J.S., Paget, B., Johnston, J.M., Baker, E.N.
Deposit date:2006-04-04
Release date:2006-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The Structure of an Ancient Conserved Domain Establishes a Structural Basis for Stable Histidine Phosphorylation and Identifies a New Family of Adenosine-specific Kinases.
J.Biol.Chem., 281, 2006
4NF7
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CRYSTAL STRUCTURE OF THE GH5 FAMILY CATALYTIC DOMAIN OF ENDO-1,4-BETA-GLUCANASE CEL5C FROM BUTYRIVIBRIO PROTEOCLASTICUS.
Descriptor:Endo-1,4-beta-glucanase Cel5C
Authors:Lott, J.S., Colbert, D.A.
Deposit date:2013-10-30
Release date:2014-11-05
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.111 Å)
Cite:Structural and functional characterisation of endo-1,4-beta-glucanase Cel5C from bovine rumen microbe Butyrivibrio proteoclasticus
To be Published
1H5Y
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HISF PROTEIN FROM PYROBACULUM AEROPHILUM
Descriptor:HISF, PHOSPHATE ION, GLYCEROL
Authors:Banfield, M.J., Lott, J.S., McCarthy, A.A., Baker, E.N.
Deposit date:2001-05-31
Release date:2001-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Hisf, a Histidine Biosynthetic Protein from Pyrobaculum Aerophilum
Acta Crystallogr.,Sect.D, 57, 2001
1XKF
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CRYSTAL STRUCTURE OF HYPOXIC RESPONSE PROTEIN I (HRPI) WITH TWO COORDINATED ZINC IONS
Descriptor:hypothetical protein RV2626C, ZINC ION
Authors:Sharpe, M.L., Baker, E.N., Lott, J.S.
Deposit date:2004-09-28
Release date:2005-10-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The structure and unusual protein chemistry of hypoxic response protein 1, a latency antigen and highly expressed member of the DosR regulon in Mycobacterium tuberculosis
J.Mol.Biol., 383, 2008
1XVW
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CRYSTAL STRUCTURE OF AHPE FROM MYCOBACTERIUM TUBERCULOSIS, A 1-CYS PEROXIREDOXIN
Descriptor:Hypothetical protein Rv2238c/MT2298
Authors:Li, S., Peterson, N.A., Kim, M.Y., Kim, C.Y., Hung, L.W., Yu, M., Lekin, T., Segelke, B.W., Lott, J.S., Baker, E.N., TB Structural Genomics Consortium (TBSGC)
Deposit date:2004-10-28
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys Peroxiredoxin
J.Mol.Biol., 346, 2005
1XXU
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CRYSTAL STRUCTURE OF AHPE FROM MYCROBACTERIUM TUBERCULOSIS, A 1-CYS PEROXIREDOXIN
Descriptor:Hypothetical protein Rv2238c/MT2298
Authors:Li, S., Peterson, N.A., Kim, M.Y., Kim, C.Y., Hung, L.W., Yu, M., Lekin, T., Segelke, B.W., Lott, J.S., Baker, E.N., TB Structural Genomics Consortium (TBSGC)
Deposit date:2004-11-08
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys Peroxiredoxin
J.Mol.Biol., 346, 2005
1Y5H
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CRYSTAL STRUCTURE OF TRUNCATED SE-MET HYPOXIC RESPONSE PROTEIN I (HRPI)
Descriptor:hypothetical protein RV2626C
Authors:Sharpe, M.L., Baker, E.N., Lott, J.S.
Deposit date:2004-12-02
Release date:2005-11-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The structure and unusual protein chemistry of hypoxic response protein 1, a latency antigen and highly expressed member of the DosR regulon in Mycobacterium tuberculosis
J.Mol.Biol., 383, 2008
1ZVW
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THE CRYSTAL STRUCTURE OF TRPD (RV2192C) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH PRPP AND MAGNESIUM
Descriptor:Anthranilate phosphoribosyltransferase, MAGNESIUM ION, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, ...
Authors:Lee, C.E., Lott, J.S., Baker, E.N., Arcus, V.L., Javid-Majd, F., Goodfellow, C., Hung, L.-W., TB Structural Genomics Consortium (TBSGC)
Deposit date:2005-06-02
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Crystal Structure of TrpD, a Metabolic Enzyme Essential for Lung Colonization by Mycobacterium tuberculosis, in Complex with its Substrate Phosphoribosylpyrophosphate.
J.Mol.Biol., 355, 2006
2B7O
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THE STRUCTURE OF 3-DEOXY-D-ARABINO-HEPTULOSONATE 7-PHOSPHATE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG, MANGANESE (II) ION, SULFATE ION, ...
Authors:Webby, C.J., Baker, H.M., Lott, J.S., Baker, E.N., Parker, E.J., Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2005-10-05
Release date:2005-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes
J.Mol.Biol., 354, 2005
2BPQ
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (APO STRUCTURE)
Descriptor:ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE, BENZAMIDINE, GLYCEROL
Authors:Lee, C.E., Goodfellow, C., Javid-Majd, F., Baker, E.N., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2005-04-22
Release date:2006-01-04
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Crystal Structure of Trpd, a Metabolic Enzyme Essential for Lung Colonization by Mycobacterium Tuberculosis, in Complex with its Substrate Phosphoribosylpyrophosphate
J.Mol.Biol., 355, 2006
2G5F
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THE STRUCTURE OF MBTI FROM MYCOBACTERIUM TUBERCULOSIS, THE FIRST ENZYME IN THE SYNTHESIS OF MYCOBACTIN, REVEALS IT TO BE A SALICYLATE SYNTHASE
Descriptor:COG0147: Anthranilate/para-aminobenzoate synthases component I, PYRUVIC ACID, IMIDAZOLE, ...
Authors:Harrison, A.J., Lott, J.S., Yu, M., Ramsay, R., Baker, E.N., TB Structural Genomics Consortium (TBSGC)
Deposit date:2006-02-22
Release date:2006-09-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Structure of MbtI from Mycobacterium tuberculosis, the First Enzyme in the Biosynthesis of the Siderophore Mycobactin, Reveals It To Be a Salicylate Synthase
J.Bacteriol., 188, 2006
2JB7
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PAE2307 WITH AMP
Descriptor:HYPOTHETICAL PROTEIN PAE2307, ADENOSINE MONOPHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Rajasekaran, K., Lott, J.S., Johnston, J.M.
Deposit date:2006-12-04
Release date:2008-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Pae2307 a Phosphotransferase
To be Published
3ITE
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THE THIRD ADENYLATION DOMAIN OF THE FUNGAL SIDN NON-RIBOSOMAL PEPTIDE SYNTHETASE
Descriptor:SidN siderophore synthetase, SULFATE ION, CHLORIDE ION
Authors:Lee, T.V., Lott, J.S., Johnson, R.D., Johnson, L.J., Arcus, V.L.
Deposit date:2009-08-28
Release date:2009-11-17
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a eukaryotic nonribosomal peptide synthetase adenylation domain that activates a large hydroxamate amino acid in siderophore biosynthesis
J.Biol.Chem., 285, 2010
3LOG
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CRYSTAL STRUCTURE OF MBTI FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Isochorismate synthase/isochorismate-pyruvate lyase mbtI, SUCCINIC ACID, GLYCEROL, ...
Authors:Bulloch, E.M.M., Lott, J.S., Baker, E.N., Johnston, J.M.
Deposit date:2010-02-03
Release date:2011-02-09
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI).
Chemmedchem, 5, 2010
3MNL
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THE CRYSTAL STRUCTURE OF KSTR (RV3574) FROM MYCOBACTERIUM TUBERCULOSIS H37RV
Descriptor:TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY), TRIETHYLENE GLYCOL
Authors:Gao, C., Bunker, R.D., ten Bokum, A., Kendall, S.L., Stoker, N.G., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2010-04-21
Release date:2011-04-27
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.
J. Biol. Chem., 291, 2016
3OA5
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THE STRUCTURE OF CHI1, A CHITINASE FROM YERSINIA ENTOMOPHAGA
Descriptor:Chi1, NONAETHYLENE GLYCOL, GLYCEROL
Authors:Busby, J.N., Lott, J.S., Hurst, M.R.H.
Deposit date:2010-08-04
Release date:2011-08-10
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural analysis of Chi1 Chitinase from Yen-Tc: the multisubunit insecticidal ABC toxin complex of Yersinia entomophaga
J.Mol.Biol., 415, 2012
3QQS
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (COMPLEX WITH INHIBITOR ACS172)
Descriptor:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
Authors:Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-02-16
Release date:2012-08-22
Last modified:2014-01-01
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3QR9
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (APO STRUCTURE)
Descriptor:Anthranilate phosphoribosyltransferase, GLYCEROL
Authors:Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-02-17
Release date:2011-06-15
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3QS8
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (COMPLEX WITH INHIBITOR ACS174)
Descriptor:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
Authors:Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-02-20
Release date:2012-08-22
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3QSA
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (COMPLEX WITH INHIBITOR TAMU-A7)
Descriptor:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
Authors:Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-02-20
Release date:2012-08-22
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Inhibition of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase by blocking of an active site entrance tunnel.
To be Published
3R6C
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (COMPLEX WITH INHIBITOR ACS179)
Descriptor:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
Authors:Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-03-21
Release date:2012-09-26
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3R88
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (COMPLEX WITH INHIBITOR ACS145)
Descriptor:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
Authors:Castell, A., Short, F.L., Lott, J.S.
Deposit date:2011-03-23
Release date:2012-09-26
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3RV6
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STRUCTURE OF A M. TUBERCULOSIS SALICYLATE SYNTHASE, MBTI, IN COMPLEX WITH AN INHIBITOR WITH PHENYL R-GROUP
Descriptor:Isochorismate synthase/isochorismate-pyruvate lyase mbtI, 3-{[(E)-1-carboxy-2-phenylethenyl]oxy}-2-hydroxybenzoic acid, MAGNESIUM ION, ...
Authors:Chi, G., Bulloch, E.M.M., Manos-Turvey, A., Payne, R.J., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-05-06
Release date:2012-05-09
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
Biochemistry, 51, 2012