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1AUJ
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BU of 1auj by Molmil
BOVINE TRYPSIN COMPLEXED TO META-CYANO-BENZYLIC INHIBITOR
Descriptor: 1-{[1-(2-AMINO-3-PHENYL-PROPIONYL)-PYRROLIDINE-2-CARBONYL]-AMINO}-2-(3-CYANO-PHENYL)-ETHANEBORONIC ACID, CALCIUM ION, TRYPSIN
Authors:Alexander, R, Smallwood, A, Kettner, C.
Deposit date:1997-08-28
Release date:1998-10-14
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:New inhibitors of thrombin and other trypsin-like proteases: hydrogen bonding of an aromatic cyano group with a backbone amide of the P1 binding site replaces binding of a basic side chain.
Biochemistry, 36, 1997
1P01
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BU of 1p01 by Molmil
Serine protease mechanism. structure of an inhibitory complex oF ALPHA-LYTIC Protease and a tightly bound peptide boronic acid
Descriptor: ALPHA-LYTIC PROTEASE, N-(tert-butoxycarbonyl)-L-alanyl-N-[(1R)-1-(dihydroxyboranyl)-2-methylpropyl]-L-prolinamide, SULFATE ION
Authors:Bone, R, Agard, D.A.
Deposit date:1989-04-24
Release date:1990-04-15
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Serine protease mechanism: structure of an inhibitory complex of alpha-lytic protease and a tightly bound peptide boronic acid.
Biochemistry, 26, 1987
1P10
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BU of 1p10 by Molmil
STRUCTURAL PLASTICITY AS A DETERMINANT OF ENZYME SPECIFICITY. CREATING BROADLY SPECIFIC PROTEASES
Descriptor: ALPHA-LYTIC PROTEASE, METHOXYSUCCINYL-ALA-ALA-PRO-VALINE BORONIC ACID INHIBITOR, SULFATE ION
Authors:Bone, R, Agard, D.A.
Deposit date:1989-04-24
Release date:1990-04-15
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural plasticity broadens the specificity of an engineered protease.
Nature, 339, 1989
1P09
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BU of 1p09 by Molmil
STRUCTURAL PLASTICITY AS A DETERMINANT OF ENZYME SPECIFICITY. CREATING BROADLY SPECIFIC PROTEASES
Descriptor: ALPHA-LYTIC PROTEASE, SULFATE ION
Authors:Bone, R, Agard, D.A.
Deposit date:1989-04-24
Release date:1990-04-15
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural plasticity broadens the specificity of an engineered protease.
Nature, 339, 1989
2FZZ
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BU of 2fzz by Molmil
Factor Xa in complex with the inhibitor 1-(3-amino-1,2-benzisoxazol-5-yl)-6-(2'-(((3r)-3-hydroxy-1-pyrrolidinyl)methyl)-4-biphenylyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7h-pyrazolo[3,4-c]pyridin-7-one
Descriptor: 1-(3-AMINO-1,2-BENZISOXAZOL-5-YL)-6-(2'-{[(3R)-3-HYDROXYPYRROLIDIN-1-YL]METHYL}BIPHENYL-4-YL)-3-(TRIFLUOROMETHYL)-1,4,5,6-TETRAHYDRO-7H-PYRAZOLO[3,4-C]PYRIDIN-7-ONE, Coagulation factor X
Authors:Alexander, R.S.
Deposit date:2006-02-10
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:1-[3-Aminobenzisoxazol-5'-yl]-3-trifluoromethyl-6-[2'-(3-(R)-hydroxy-N-pyrrolidinyl)methyl-[1,1']-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.
Bioorg.Med.Chem.Lett., 16, 2006

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