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2IEW
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BU of 2iew by Molmil
Crystal structure of Inositol Phosphate Multikinase Ipk2 from S. cerevisiae
Descriptor: CALCIUM ION, Inositol polyphosphate multikinase
Authors:Holmes, W, Jogl, G.
Deposit date:2006-09-19
Release date:2006-10-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of inositol phosphate multikinase 2 and implications for substrate specificity.
J.Biol.Chem., 281, 2006
2IF8
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BU of 2if8 by Molmil
Crystal structure of Inositol Phosphate Multikinase Ipk2 in complex with ADP and Mn2+ from S. cerevisiae
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Inositol polyphosphate multikinase, ...
Authors:Holmes, W, Jogl, G.
Deposit date:2006-09-20
Release date:2006-10-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of inositol phosphate multikinase 2 and implications for substrate specificity.
J.Biol.Chem., 281, 2006
6YSU
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BU of 6ysu by Molmil
Structure of the P+0 ArfB-ribosome complex in the post-hydrolysis state
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Chan, K.-H, Petrychenko, V, Mueller, C, Maracci, C, Holtkamp, W, Wilson, D.N, Fischer, N, Rodnina, M.V.
Deposit date:2020-04-23
Release date:2020-08-19
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Mechanism of ribosome rescue by alternative ribosome-rescue factor B.
Nat Commun, 11, 2020
6YST
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BU of 6yst by Molmil
Structure of the P+9 ArfB-ribosome complex with P/E hybrid tRNA in the post-hydrolysis state
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Chan, K.-H, Petrychenko, V, Mueller, C, Maracci, C, Holtkamp, W, Wilson, D.N, Fischer, N, Rodnina, M.V.
Deposit date:2020-04-23
Release date:2020-08-19
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Mechanism of ribosome rescue by alternative ribosome-rescue factor B.
Nat Commun, 11, 2020
6YSS
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BU of 6yss by Molmil
Structure of the P+9 ArfB-ribosome complex in the post-hydrolysis state
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Chan, K.-H, Petrychenko, V, Mueller, C, Maracci, C, Holtkamp, W, Wilson, D.N, Fischer, N, Rodnina, M.V.
Deposit date:2020-04-23
Release date:2020-08-19
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Mechanism of ribosome rescue by alternative ribosome-rescue factor B.
Nat Commun, 11, 2020
6YSR
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BU of 6ysr by Molmil
Structure of the P+9 stalled ribosome complex
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Chan, K.-H, Petrychenko, V, Mueller, C, Maracci, C, Holtkamp, W, Wilson, D.N, Fischer, N, Rodnina, M.V.
Deposit date:2020-04-23
Release date:2020-08-19
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Mechanism of ribosome rescue by alternative ribosome-rescue factor B.
Nat Commun, 11, 2020
1C25
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BU of 1c25 by Molmil
HUMAN CDC25A CATALYTIC DOMAIN
Descriptor: CDC25A
Authors:Fauman, E.B, Cogswell, J.P, Lovejoy, B, Rocque, W.J, Holmes, W, Montana, V.G, Piwnica-Worms, H, Rink, M.J, Saper, M.A.
Deposit date:1998-04-17
Release date:1998-08-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A.
Cell(Cambridge,Mass.), 93, 1998
4NSY
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BU of 4nsy by Molmil
Wild-type lysobacter enzymogenes lysc endoproteinase covalently inhibited by TLCK
Descriptor: CALCIUM ION, CHLORIDE ION, Lysyl endopeptidase, ...
Authors:Asztalos, P, Muller, A, Holke, W, Sobek, H, Rudolph, M.G.
Deposit date:2013-11-29
Release date:2014-04-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Atomic resolution structure of a lysine-specific endoproteinase from Lysobacter enzymogenes suggests a hydroxyl group bound to the oxyanion hole.
Acta Crystallogr.,Sect.D, 70, 2014
4NSV
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BU of 4nsv by Molmil
Lysobacter enzymogenes lysc endoproteinase K30R mutant covalently inhibited by TLCK
Descriptor: CHLORIDE ION, Lysyl endopeptidase, N-[(2S,3S)-7-amino-1-chloro-2-hydroxyheptan-3-yl]-4-methylbenzenesulfonamide (Bound Form), ...
Authors:Asztalos, P, Muller, A, Holke, W, Sobek, H, Rudolph, M.G.
Deposit date:2013-11-29
Release date:2014-04-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (0.9 Å)
Cite:Atomic resolution structure of a lysine-specific endoproteinase from Lysobacter enzymogenes suggests a hydroxyl group bound to the oxyanion hole.
Acta Crystallogr.,Sect.D, 70, 2014
3STB
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BU of 3stb by Molmil
A complex of two editosome proteins and two nanobodies
Descriptor: MP18 RNA editing complex protein, RNA-editing complex protein MP42, single domain antibody VHH
Authors:Park, Y.-J, Hol, W.
Deposit date:2011-07-09
Release date:2011-11-02
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody.
Nucleic Acids Res., 40, 2012
1LT4
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BU of 1lt4 by Molmil
HEAT-LABILE ENTEROTOXIN MUTANT S63K
Descriptor: HEAT-LABILE ENTEROTOXIN, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
Authors:Van Den Akker, F, Hol, W.G.J.
Deposit date:1997-04-14
Release date:1997-06-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a non-toxic mutant of heat-labile enterotoxin, which is a potent mucosal adjuvant.
Protein Sci., 6, 1997
1LTG
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BU of 1ltg by Molmil
THE ARG7LYS MUTANT OF HEAT-LABILE ENTEROTOXIN EXHIBITS GREAT FLEXIBILITY OF ACTIVE SITE LOOP 47-56 OF THE A SUBUNIT
Descriptor: HEAT-LABILE ENTEROTOXIN
Authors:Van Den Akker, F, Hol, W.G.J.
Deposit date:1995-06-13
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Arg7Lys mutant of heat-labile enterotoxin exhibits great flexibility of active site loop 47-56 of the A subunit.
Biochemistry, 34, 1995
3K81
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BU of 3k81 by Molmil
Structure of the central interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies
Descriptor: MP18 RNA editing complex protein, Single strand antibody VHH domain
Authors:Park, Y.-J, Hol, W.
Deposit date:2009-10-13
Release date:2010-11-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies.
J.Struct.Biol., 174, 2011
1HTL
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BU of 1htl by Molmil
MUTATION OF A BURIED RESIDUE CAUSES LACK OF ACTIVITY BUT NO CONFORMATIONAL CHANGE: CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN MUTANT VAL 97--> LYS
Descriptor: HEAT-LABILE ENTEROTOXIN, SUBUNIT A, SUBUNIT B
Authors:Merritt, E.A, Hol, W.G.J.
Deposit date:1995-02-15
Release date:1995-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutation of a buried residue causes loss of activity but no conformational change in the heat-labile enterotoxin of Escherichia coli.
Nat.Struct.Biol., 2, 1995
1SKZ
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BU of 1skz by Molmil
PROTEASE INHIBITOR
Descriptor: ANTISTASIN, CHLORIDE ION
Authors:Krengel, U, Dijkstra, B.W.
Deposit date:1997-04-16
Release date:1997-10-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray structure of antistasin at 1.9 A resolution and its modelled complex with blood coagulation factor Xa.
EMBO J., 16, 1997
1LPF
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BU of 1lpf by Molmil
THREE-DIMENSIONAL STRUCTURE OF LIPOAMIDE DEHYDROGENASE FROM PSEUDOMONAS FLUORESCENS AT 2.8 ANGSTROMS RESOLUTION. ANALYSIS OF REDOX AND THERMOSTABILITY PROPERTIES
Descriptor: DIHYDROLIPOAMIDE DEHYDROGENASE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Mattevi, A, Hol, W.
Deposit date:1992-10-26
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Three-dimensional structure of lipoamide dehydrogenase from Pseudomonas fluorescens at 2.8 A resolution. Analysis of redox and thermostability properties.
J.Mol.Biol., 230, 1993
4DK3
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BU of 4dk3 by Molmil
Structure of Editosome protein
Descriptor: RNA-editing complex protein MP81, single domain antibody VHH
Authors:Park, Y.-J, Hol, W.
Deposit date:2012-02-03
Release date:2012-07-04
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA-editing ligase L2.
Nucleic Acids Res., 40, 2012
4DKA
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BU of 4dka by Molmil
Structure of Editosome protein
Descriptor: RNA-editing complex protein MP81, SODIUM ION, single domain antibody VHH
Authors:Park, Y.-J, Hol, W.
Deposit date:2012-02-03
Release date:2012-07-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA-editing ligase L2.
Nucleic Acids Res., 40, 2012
4DNI
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BU of 4dni by Molmil
Structure of Editosome protein
Descriptor: Fusion protein of RNA-editing complex proteins MP42 and MP18
Authors:Park, Y.-J, Hol, W.
Deposit date:2012-02-08
Release date:2012-12-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Explorations of linked editosome domains leading to the discovery of motifs defining conserved pockets in editosome OB-folds.
J.Struct.Biol., 180, 2012
4DK6
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BU of 4dk6 by Molmil
Structure of Editosome protein
Descriptor: RNA-editing complex protein MP81, single domain antibody VHH
Authors:Park, Y.-J, Hol, W.
Deposit date:2012-02-03
Release date:2012-07-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA-editing ligase L2.
Nucleic Acids Res., 40, 2012
1MC0
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BU of 1mc0 by Molmil
Regulatory Segment of Mouse 3',5'-Cyclic Nucleotide Phosphodiesterase 2A, Containing the GAF A and GAF B Domains
Descriptor: 3',5'-cyclic nucleotide phosphodiesterase 2A, CYCLIC GUANOSINE MONOPHOSPHATE
Authors:Martinez, S, Wu, A, Glavas, N, Tang, X, Turley, S, Hol, W, Beavo, J.
Deposit date:2002-08-04
Release date:2002-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding.
Proc.Natl.Acad.Sci.USA, 99, 2002
1GYQ
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BU of 1gyq by Molmil
CRYSTAL STRUCTURE OF GLYCOSOMAL GLYCERALDEHYDE FROM LEISHMANIA MEXICANA IN COMPLEX WITH N6-BENZYL-NAD
Descriptor: N6-BENZYL-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PROTEIN (GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE)
Authors:Suresh, S, Hol, W.
Deposit date:1999-03-05
Release date:1999-03-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase.
Proc.Natl.Acad.Sci.USA, 96, 1999
4PHT
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BU of 4pht by Molmil
ATPase GspE in complex with the cytoplasmic domain of GspL from the Vibrio vulnificus type II Secretion system
Descriptor: General secretory pathway protein E, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Lu, C, Korotkov, K, Hol, W.
Deposit date:2014-05-06
Release date:2014-11-26
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Crystal structure of the full-length ATPase GspE from the Vibrio vulnificus type II secretion system in complex with the cytoplasmic domain of GspL.
J.Struct.Biol., 187, 2014
4U56
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BU of 4u56 by Molmil
Crystal structure of Blasticidin S bound to the yeast 80S ribosome
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M.
Deposit date:2014-07-24
Release date:2014-10-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
4U50
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Crystal structure of Verrucarin bound to the yeast 80S ribosome
Descriptor: (4S,5R,10E,12Z,16R,16aS,17S,18R,19aR,23aR)-4-hydroxy-5,16a,21-trimethyl-4,5,6,7,16,16a,22,23-octahydro-3H,18H,19aH-spiro[16,18-methano[1,6,12]trioxacyclooctadecino[3,4-d]chromene-17,2'-oxirane]-3,9,14-trione, 18S ribosomal RNA, 25S ribosomal RNA, ...
Authors:Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M.
Deposit date:2014-07-24
Release date:2014-10-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014

 

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