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5C0Z
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THE STRUCTURE OF OXIDIZED RAT CYTOCHROME C AT 1.13 ANGSTROMS RESOLUTION
Descriptor:Cytochrome c, somatic, HEME C, ...
Authors:Edwards, B.F.P., Mahapatra, G., Vaishnav, A.A., Brunzelle, J.S., Huttemann, M.
Deposit date:2015-06-12
Release date:2016-09-21
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.1236 Å)
Cite:Oxidized rat cytochrome c - native
To Be Published
5C9M
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THE STRUCTURE OF OXIDIZED RAT CYTOCHROME C (T28A) AT 1.362 ANGSTROMS RESOLUTION.
Descriptor:Cytochrome c, somatic, HEME C, ...
Authors:Edwards, B.F.P., Mahapatra, G., Vaishnav, A.A., Brunzelle, J.S., Huttemann, M.
Deposit date:2015-06-28
Release date:2016-09-21
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.362 Å)
Cite:The structure of oxidized rat cytochrome c (T28A) at 1.362 angstroms resolution.
To Be Published
5DF5
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THE STRUCTURE OF OXIDIZED RAT CYTOCHROME C (T28E) AT 1.30 ANGSTROMS RESOLUTION.
Descriptor:Cytochrome c, somatic, HEME C, ...
Authors:Edwards, B.F.P., Mahapatra, G., Vaishnav, A.A., Brunzelle, J.S., Huttemann, M.
Deposit date:2015-08-26
Release date:2016-09-14
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.301 Å)
Cite:The structure of oxidized rat cytochrome c (T28E) at 1.30 angstroms resolution.
To Be Published
4BJH
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CRYSTAL STRUCTURE OF THE AQUIFEX REACTOR COMPLEX FORMED BY DIHYDROOROTASE (H180A, H232A) WITH DIHYDROOROTATE AND ASPARTATE TRANSCARBAMOYLASE WITH N-(PHOSPHONACETYL)-L-ASPARTATE (PALA)
Descriptor:DIHYDROOROTASE, ASPARTATE CARBAMOYLTRANSFERASE, ZINC ION, ...
Authors:Edwards, B.F.P., Martin, P.D., Grimley, E., Vaishnav, A., Fernando, R., Brunzelle, J.S., Cordes, M., Evans, H.G., Evans, D.R.
Deposit date:2013-04-18
Release date:2013-12-18
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Mononuclear Metal Center of Type-I Dihydroorotase from Aquifex Aeolicus.
Bmc Biochem., 14, 2013
1NAP
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THE CRYSTAL STRUCTURE OF RECOMBINANT HUMAN NEUTROPHIL-ACTIVATING PEPTIDE-2 (M6L) AT 1.9-ANGSTROMS RESOLUTION
Descriptor:NEUTROPHIL ACTIVATING PEPTIDE-2
Authors:Malkowski, M.G., Edwards, B.F.P.
Deposit date:1994-12-19
Release date:1995-12-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution.
J.Biol.Chem., 270, 1995
1SSC
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THE 1.6 ANGSTROMS STRUCTURE OF A SEMISYNTHETIC RIBONUCLEASE CRYSTALLIZED FROM AQUEOUS ETHANOL. COMPARISON WITH CRYSTALS FROM SALT SOLUTIONS AND WITH RNASE A FROM AQUEOUS ALCOHOL SOLUTIONS
Descriptor:RIBONUCLEASE A, PHOSPHATE ION
Authors:De Mel, V.S.J., Doscher, M.S., Martin, P.D., Rodier, F., Edwards, B.F.P.
Deposit date:1994-10-05
Release date:1995-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:1.6 A structure of semisynthetic ribonuclease crystallized from aqueous ethanol. Comparison with crystals from salt solutions and with ribonuclease A from aqueous alcohol solutions.
Acta Crystallogr.,Sect.D, 51, 1995
2ATC
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CRYSTAL AND MOLECULAR STRUCTURES OF NATIVE AND CTP-LIGANDED ASPARTATE CARBAMOYLTRANSFERASE FROM ESCHERICHIA COLI
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE, CATALYTIC CHAIN, REGULATORY CHAIN, ...
Authors:Honzatko, R.B., Crawford, J.L., Monaco, H.L., Ladner, J.E., Edwards, B.F.P., Evans, D.R., Warren, S.G., Wiley, D.C., Ladner, R.C., Lipscomb, W.N.
Deposit date:1982-03-24
Release date:1982-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal and molecular structures of native and CTP-liganded aspartate carbamoyltransferase from Escherichia coli.
J.Mol.Biol., 160, 1982
1PLF
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THE THREE-DIMENSIONAL STRUCTURE OF BOVINE PLATELET FACTOR 4 AT 3.0 ANGSTROMS RESOLUTION
Descriptor:PLATELET FACTOR 4, TETRACYANONICKELATE ION
Authors:St Charles, R., Edwards, B.F.P.
Deposit date:1993-10-20
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The three-dimensional structure of bovine platelet factor 4 at 3.0-A resolution.
J.Biol.Chem., 264, 1989
1SSA
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A STRUCTURAL INVESTIGATION OF CATALYTICALLY MODIFIED F12OL AND F12OY SEMISYNTHETIC RIBONUCLEASES
Descriptor:RIBONUCLEASE A, SULFATE ION
Authors:deMel, V.S.J., Doscher, M.S., Glinn, M.A., Martin, P.D., Ram, M.L., Edwards, B.F.P.
Deposit date:1993-08-03
Release date:1994-09-30
Last modified:2013-01-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural investigation of catalytically modified F120L and F120Y semisynthetic ribonucleases.
Protein Sci., 3, 1994
1SSB
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A STRUCTURAL INVESTIGATION OF CATALYTICALLY MODIFIED F12OL AND F12OY SEMISYNTHETIC RIBONUCLEASES
Descriptor:RIBONUCLEASE A, SULFATE ION
Authors:Demel, V.S.J., Doscher, M.S., Glinn, M.A., Martin, P.D., Ram, M.L., Edwards, B.F.P.
Deposit date:1993-08-03
Release date:1994-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural investigation of catalytically modified F120L and F120Y semisynthetic ribonucleases.
Protein Sci., 3, 1994
3D6N
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CRYSTAL STRUCTURE OF AQUIFEX DIHYDROOROTASE ACTIVATED BY ASPARTATE TRANSCARBAMOYLASE
Descriptor:Dihydroorotase, Aspartate carbamoyltransferase, ZINC ION, ...
Authors:Edwards, B.F.P.
Deposit date:2008-05-20
Release date:2009-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Dihydroorotase from the hyperthermophile Aquifiex aeolicus is activated by stoichiometric association with aspartate transcarbamoylase and forms a one-pot reactor for pyrimidine biosynthesis.
Biochemistry, 48, 2009
1ACM
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ARGININE 54 IN THE ACTIVE SITE OF ESCHERICHIA COLI ASPARTATE TRANSCARBAMOYLASE IS CRITICAL FOR CATALYSIS: A SITE-SPECIFIC MUTAGENESIS, NMR AND X-RAY CRYSTALLOGRAPHY STUDY
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE, CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
Authors:Stevens, R.C., Kantrowitz, E.R., Lipscomb, W.N.
Deposit date:1992-07-08
Release date:1992-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Arginine 54 in the active site of Escherichia coli aspartate transcarbamoylase is critical for catalysis: a site-specific mutagenesis, NMR, and X-ray crystallographic study.
Protein Sci., 1, 1992
1AT1
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CRYSTAL STRUCTURES OF PHOSPHONOACETAMIDE LIGATED T AND PHOSPHONOACETAMIDE AND MALONATE LIGATED R STATES OF ASPARTATE CARBAMOYLTRANSFERASE AT 2.8-ANGSTROMS RESOLUTION AND NEUTRAL P*H
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE, CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
Authors:Gouaux, J.E., Lipscomb, W.N.
Deposit date:1989-09-22
Release date:1990-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of phosphonoacetamide ligated T and phosphonoacetamide and malonate ligated R states of aspartate carbamoyltransferase at 2.8-A resolution and neutral pH.
Biochemistry, 29, 1990
2AT1
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CRYSTAL STRUCTURES OF PHOSPHONOACETAMIDE LIGATED T AND PHOSPHONOACETAMIDE AND MALONATE LIGATED R STATES OF ASPARTATE CARBAMOYLTRANSFERASE AT 2.8-ANGSTROMS RESOLUTION AND NEUTRAL PH
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE (R STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
Authors:Gouaux, J.E., Lipscomb, W.N.
Deposit date:1989-09-22
Release date:1990-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of phosphonoacetamide ligated T and phosphonoacetamide and malonate ligated R states of aspartate carbamoyltransferase at 2.8-A resolution and neutral pH.
Biochemistry, 29, 1990
3AT1
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CRYSTAL STRUCTURES OF PHOSPHONOACETAMIDE LIGATED T AND PHOSPHONOACETAMIDE AND MALONATE LIGATED R STATES OF ASPARTATE CARBAMOYLTRANSFERASE AT 2.8-ANGSTROMS RESOLUTION AND NEUTRAL PH
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE (T STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
Authors:Gouaux, J.E., Lipscomb, W.N.
Deposit date:1989-09-22
Release date:1990-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of phosphonoacetamide ligated T and phosphonoacetamide and malonate ligated R states of aspartate carbamoyltransferase at 2.8-A resolution and neutral pH.
Biochemistry, 29, 1990
4AT1
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STRUCTURAL CONSEQUENCES OF EFFECTOR BINDING TO THE T STATE OF ASPARTATE CARBAMOYLTRANSFERASE. CRYSTAL STRUCTURES OF THE UNLIGATED AND ATP-, AND CTP-COMPLEXED ENZYMES AT 2.6-ANGSTROMS RESOLUTION
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE (T STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
Authors:Stevens, R.C., Gouaux, J.E., Lipscomb, W.N.
Deposit date:1990-04-26
Release date:1990-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural consequences of effector binding to the T state of aspartate carbamoyltransferase: crystal structures of the unligated and ATP- and CTP-complexed enzymes at 2.6-A resolution.
Biochemistry, 29, 1990
5AT1
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STRUCTURAL CONSEQUENCES OF EFFECTOR BINDING TO THE T STATE OF ASPARTATE CARBAMOYLTRANSFERASE. CRYSTAL STRUCTURES OF THE UNLIGATED AND ATP-, AND CTP-COMPLEXED ENZYMES AT 2.6-ANGSTROMS RESOLUTION
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE (T STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
Authors:Stevens, R.C., Gouaux, J.E., Lipscomb, W.N.
Deposit date:1990-04-26
Release date:1990-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural consequences of effector binding to the T state of aspartate carbamoyltransferase: crystal structures of the unligated and ATP- and CTP-complexed enzymes at 2.6-A resolution.
Biochemistry, 29, 1990
6AT1
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STRUCTURAL CONSEQUENCES OF EFFECTOR BINDING TO THE T STATE OF ASPARTATE CARBAMOYLTRANSFERASE. CRYSTAL STRUCTURES OF THE UNLIGATED AND ATP-, AND CTP-COMPLEXED ENZYMES AT 2.6-ANGSTROMS RESOLUTION
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE (T STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
Authors:Stevens, R.C., Gouaux, J.E., Lipscomb, W.N.
Deposit date:1990-04-26
Release date:1990-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural consequences of effector binding to the T state of aspartate carbamoyltransferase: crystal structures of the unligated and ATP- and CTP-complexed enzymes at 2.6-A resolution.
Biochemistry, 29, 1990
7AT1
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CRYSTAL STRUCTURES OF ASPARTATE CARBAMOYLTRANSFERASE LIGATED WITH PHOSPHONOACETAMIDE, MALONATE, AND CTP OR ATP AT 2.8-ANGSTROMS RESOLUTION AND NEUTRAL P*H
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE (R STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
Authors:Gouaux, J.E., Stevens, R.C., Lipscomb, W.N.
Deposit date:1989-09-22
Release date:1990-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of aspartate carbamoyltransferase ligated with phosphonoacetamide, malonate, and CTP or ATP at 2.8-A resolution and neutral pH.
Biochemistry, 29, 1990
8AT1
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CRYSTAL STRUCTURES OF ASPARTATE CARBAMOYLTRANSFERASE LIGATED WITH PHOSPHONOACETAMIDE, MALONATE, AND CTP OR ATP AT 2.8-ANGSTROMS RESOLUTION AND NEUTRAL P*H
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE (R STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
Authors:Gouaux, J.E., Stevens, R.C., Lipscomb, W.N.
Deposit date:1989-09-22
Release date:1990-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of aspartate carbamoyltransferase ligated with phosphonoacetamide, malonate, and CTP or ATP at 2.8-A resolution and neutral pH.
Biochemistry, 29, 1990
8ATC
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COMPLEX OF N-PHOSPHONACETYL-L-ASPARTATE WITH ASPARTATE CARBAMOYLTRANSFERASE. X-RAY REFINEMENT, ANALYSIS OF CONFORMATIONAL CHANGES AND CATALYTIC AND ALLOSTERIC MECHANISMS
Descriptor:ASPARTATE CARBAMOYLTRANSFERASE (R STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
Authors:Ke, H., Lipscomb, W.N., Cho, Y., Honzatko, R.B.
Deposit date:1989-08-25
Release date:1990-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Complex of N-phosphonacetyl-L-aspartate with aspartate carbamoyltransferase. X-ray refinement, analysis of conformational changes and catalytic and allosteric mechanisms.
J.Mol.Biol., 204, 1988
1TVX
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NEUTROPHIL ACTIVATING PEPTIDE-2 VARIANT FORM M6L WITH FIVE ADDITIONAL AMINO TERMINAL RESIDUES (DSDLY)
Descriptor:NEUTROPHIL ACTIVATING PEPTIDE 2 VARIANT
Authors:Malkowski, M.G., Edwards, B.F.P.
Deposit date:1996-11-05
Release date:1997-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The amino-terminal residues in the crystal structure of connective tissue activating peptide-III (des10) block the ELR chemotactic sequence.
J.Mol.Biol., 266, 1997
1MKW
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THE CO-CRYSTAL STRUCTURE OF UNLIGANDED BOVINE ALPHA-THROMBIN AND PRETHROMBIN-2: MOVEMENT OF THE YPPW SEGMENT AND ACTIVE SITE RESIDUES UPON LIGAND BINDING
Descriptor:ALPHA-THROMBIN, PRETHROMBIN-2
Authors:Malkowski, M.G., Edwards, B.F.P.
Deposit date:1997-03-13
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding.
Protein Sci., 6, 1997
1MKX
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THE CO-CRYSTAL STRUCTURE OF UNLIGANDED BOVINE ALPHA-THROMBIN AND PRETHROMBIN-2: MOVEMENT OF THE YPPW SEGMENT AND ACTIVE SITE RESIDUES UPON LIGAND BINDING
Descriptor:ALPHA-THROMBIN, PRETHROMBIN-2
Authors:Malkowski, M.G., Edwards, B.F.P.
Deposit date:1997-03-13
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding.
Protein Sci., 6, 1997
1YCP
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THE CRYSTAL STRUCTURE OF FIBRINOGEN-AA PEPTIDE 1-23 (F8Y) BOUND TO BOVINE THROMBIN EXPLAINS WHY THE MUTATION OF PHE-8 TO TYROSINE STRONGLY INHIBITS NORMAL CLEAVAGE AT ARGININE-16
Descriptor:EPSILON THROMBIN, ALPHA THROMBIN, FIBRINOPEPTIDE A-ALPHA
Authors:Malkowski, M.G., Edwards, B.F.P.
Deposit date:1997-05-01
Release date:1998-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16.
Biochem.J., 326, 1997
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