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1TZB
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CRYSTAL STRUCTURE OF NATIVE PHOSPHOGLUCOSE/PHOSPHOMANNOSE ISOMERASE FROM PYROBACULUM AEROPHILUM
Descriptor:glucose-6-phosphate isomerase, conjectural, SULFATE ION, ...
Authors:Swan, M.K., Hansen, T., Schoenheit, P., Davies, C.
Deposit date:2004-07-09
Release date:2004-07-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:A novel phosphoglucose/phosphomannose isomease from the crenarchaeon Pyrobaculum aerophilum is a member of the PGI superfamily: structural evidence at 1.16 A resolution
J.Biol.Chem., 279, 2004
1X9I
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CRYSTAL STRUCTURE OF CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE/PHOSPHOMANNOSE PHOSPHOGLUCOSE/PHOSPHOMANNOSEISOMERASE FROM PYROBACULUM AEROPHILUM IN COMPLEX WITH GLUCOSE 6-PHOSPHATE
Descriptor:glucose-6-phosphate isomerase, GLUCOSE-6-PHOSPHATE, GLYCEROL
Authors:Swan, M.K., Hansen, T., Schoenheit, P., Davies, C.
Deposit date:2004-08-21
Release date:2004-12-07
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:Structural basis for phosphomannose isomerase activity in phosphoglucose isomerase from Pyrobaculum aerophilum: a subtle difference between distantly related enzymes.
Biochemistry, 43, 2004
1TZC
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CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE/PHOSPHOMANNOSE ISOMERASE FROM PYROBACULUM AEROPHILUM IN COMPLEX WITH 5-PHOSPHOARABINONATE
Descriptor:glucose-6-phosphate isomerase, conjectural, SULFATE ION, ...
Authors:Swan, M.K., Hansen, T., Schoenheit, P., Davies, C.
Deposit date:2004-07-09
Release date:2004-07-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:A novel phosphoglucose/phosphomannose isomease from the crenarchaeon Pyrobaculum aerophilum is a member of the PGI superfamily: structural evidence at 1.16 A resolution
J.Biol.Chem., 279, 2004
1WHI
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RIBOSOMAL PROTEIN L14
Descriptor:RIBOSOMAL PROTEIN L14
Authors:Davies, C., White, S.W., Ramakrishnan, V.
Deposit date:1996-01-10
Release date:1996-08-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The crystal structure of ribosomal protein L14 reveals an important organizational component of the translational apparatus.
Structure, 4, 1996
1X9H
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CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE/PHOSPHOMANNOSE ISOMERASE FROM PYROBACULUM AEROPHILUM IN COMPLEX WITH FRUCTOSE 6-PHOSPHATE
Descriptor:glucose-6-phosphate isomerase, SULFATE ION, FRUCTOSE -6-PHOSPHATE, ...
Authors:Swan, M.K., Hansen, T., Schoenheit, P., Davies, C.
Deposit date:2004-08-21
Release date:2004-12-07
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for phosphomannose isomerase activity in phosphoglucose isomerase from Pyrobaculum aerophilum: a subtle difference between distantly related enzymes.
Biochemistry, 43, 2004
3MZF
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STRUCTURE OF PENICILLIN-BINDING PROTEIN 5 FROM E. COLI: IMIPENEM ACYL-ENZYME COMPLEX
Descriptor:D-alanyl-D-alanine carboxypeptidase dacA, (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid, GLYCEROL
Authors:Nicola, G., Tomberg, J., Pratt, R.F., Nicholas, R.A., Davies, C.
Deposit date:2010-05-12
Release date:2011-03-16
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structures of covalent complexes of beta-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity
Biochemistry, 49, 2010
1U0E
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CRYSTAL STRUCTURE OF MOUSE PHOSPHOGLUCOSE ISOMERASE
Descriptor:Glucose-6-phosphate isomerase, SULFATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Solomons, J.T.G., Zimmerly, E.M., Burns, S., Krishnamurthy, N., Swan, M.K., Krings, S., Muirhead, H., Chirgwin, J., Davies, C.
Deposit date:2004-07-13
Release date:2004-11-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The crystal structure of mouse phosphoglucose isomerase at 1.6A resolution and its complex with glucose 6-phosphate reveals the catalytic mechanism of sugar ring opening.
J.Mol.Biol., 342, 2004
1U0F
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CRYSTAL STRUCTURE OF MOUSE PHOSPHOGLUCOSE ISOMERASE IN COMPLEX WITH GLUCOSE 6-PHOSPHATE
Descriptor:Glucose-6-phosphate isomerase, ALPHA-D-GLUCOSE-6-PHOSPHATE, GLUCOSE-6-PHOSPHATE, ...
Authors:Solomons, J.T.G., Zimmerly, E.M., Burns, S., Krishnamurthy, N., Swan, M.K., Krings, S., Muirhead, H., Chirgwin, J., Davies, C.
Deposit date:2004-07-13
Release date:2004-11-02
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The crystal structure of mouse phosphoglucose isomerase at 1.6A resolution and its complex with glucose 6-phosphate reveals the catalytic mechanism of sugar ring opening.
J.Mol.Biol., 342, 2004
1Z6F
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 5 FROM E. COLI IN COMPLEX WITH A BORONIC ACID INHIBITOR
Descriptor:Penicillin-binding protein 5, N1-[(1R)-1-(DIHYDROXYBORYL)ETHYL]-N2-[(TERT-BUTOXYCARBONYL)-D-GAMMA-GLUTAMYL]-N6-[(BENZYLOXY)CARBONYL-L-LYSINAMIDE, GLYCEROL
Authors:Nicola, G., Peddi, S., Stefanova, M., Nicholas, R.A., Gutheil, W.G., Davies, C.
Deposit date:2005-03-22
Release date:2005-06-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of Escherichia coli Penicillin-Binding Protein 5 Bound to a Tripeptide Boronic Acid Inhibitor: A Role for Ser-110 in Deacylation.
Biochemistry, 44, 2005
3BEC
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CRYSTAL STRUCTURE OF E. COLI PENICILLIN-BINDING PROTEIN 5 IN COMPLEX WITH A PEPTIDE-MIMETIC CEPHALOSPORIN
Descriptor:Penicillin-binding protein 5, GLYCEROL, (2R)-2-[(R)-{[(6S)-6-amino-6-carboxyhexanoyl]amino}(carboxy)methyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
Authors:Powell, A.J., Davies, C.
Deposit date:2007-11-16
Release date:2008-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of complexes of bacterial DD-peptidases with peptidoglycan-mimetic ligands: the substrate specificity puzzle
J.Mol.Biol., 381, 2008
1IAT
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CRYSTAL STRUCTURE OF HUMAN PHOSPHOGLUCOSE ISOMERASE/NEUROLEUKIN/AUTOCRINE MOTILITY FACTOR/MATURATION FACTOR
Descriptor:PHOSPHOGLUCOSE ISOMERASE, SULFATE ION, BETA-MERCAPTOETHANOL
Authors:Read, J.A., Pearce, J., Li, X., Muirhead, H., Chirgwin, J., Davies, C.
Deposit date:2001-03-23
Release date:2001-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:The crystal structure of human phosphoglucose isomerase at 1.6 A resolution: implications for catalytic mechanism, cytokine activity and haemolytic anaemia.
J.Mol.Biol., 309, 2001
1QXR
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CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE ISOMERASE FROM PYROCOCCUS FURIOSUS IN COMPLEX WITH 5-PHOSPHOARABINONATE
Descriptor:Glucose-6-phosphate isomerase, NICKEL (II) ION, 5-PHOSPHOARABINONIC ACID
Authors:Swan, M.K., Solomons, J.T.G., Beeson, C.C., Hansen, P., Schonheit, P., Davies, C.
Deposit date:2003-09-08
Release date:2003-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural evidence for a hydride transfer mechanism of catalysis in phosphoglucose isomerase from Pyrococcus furiosus
J.Biol.Chem., 278, 2003
1U0G
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CRYSTAL STRUCTURE OF MOUSE PHOSPHOGLUCOSE ISOMERASE IN COMPLEX WITH ERYTHROSE 4-PHOSPHATE
Descriptor:Glucose-6-phosphate isomerase, SULFATE ION, ERYTHOSE-4-PHOSPHATE, ...
Authors:Solomons, J.T.G., Zimmerly, E.M., Burns, S., Krishnamurthy, N., Swan, M.K., Krings, S., Muirhead, H., Chirgwin, J., Davies, C.
Deposit date:2004-07-13
Release date:2004-11-02
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The crystal structure of mouse phosphoglucose isomerase at 1.6A resolution and its complex with glucose 6-phosphate reveals the catalytic mechanism of sugar ring opening.
J.Mol.Biol., 342, 2004
2O2P
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF RAT 10'FORMYLTETRAHYDROFOLATE DEHYDROGENASE
Descriptor:Formyltetrahydrofolate dehydrogenase, SULFATE ION, GLYCEROL
Authors:Tsybovsky, Y., Donato, H., Krupenko, N.I., Davies, C., Krupenko, S.A.
Deposit date:2006-11-30
Release date:2007-03-06
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures of the carboxyl terminal domain of rat 10-formyltetrahydrofolate dehydrogenase: implications for the catalytic mechanism of aldehyde dehydrogenases.
Biochemistry, 46, 2007
1EBL
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THE 1.8 A CRYSTAL STRUCTURE AND ACTIVE SITE ARCHITECTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE III (FABH) FROM ESCHERICHIA COLI
Descriptor:BETA-KETOACYL-ACP SYNTHASE III, COENZYME A
Authors:Davies, C., Heath, R.J., White, S.W., Rock, C.O.
Deposit date:2000-01-24
Release date:2000-02-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The 1.8 A crystal structure and active-site architecture of beta-ketoacyl-acyl carrier protein synthase III (FabH) from escherichia coli.
Structure Fold.Des., 8, 2000
1QXJ
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CRYSTAL STRUCTURE OF NATIVE PHOSPHOGLUCOSE ISOMERASE FROM PYROCOCCUS FURIOSUS
Descriptor:Glucose-6-phosphate isomerase, NICKEL (II) ION
Authors:Swan, M.K., Solomons, J.T.G., Beeson, C.C., Hansen, T., Schonheit, P., Davies, C.
Deposit date:2003-09-07
Release date:2003-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural evidence for a hydride transfer mechanism of catalysis in phosphoglucose isomerase from Pyrococcus furiosus
J.Biol.Chem., 278, 2003
1QY4
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CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE ISOMERASE FROM PYROCOCCUS FURIOSUS IN COMPLEX WITH GLUCONATE 6-PHOSPHATE
Descriptor:Glucose-6-phosphate isomerase, 6-PHOSPHOGLUCONIC ACID, NICKEL (II) ION
Authors:Swan, M.K., Solomons, J.T.G., Beeson, C.C., Hansen, T., Schonheit, P., Davies, C.
Deposit date:2003-09-09
Release date:2003-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural evidence for a hydride transfer mechanism of catalysis in phosphoglucose isomerase from Pyrococcus furiosus
J.Biol.Chem., 278, 2003
1NZO
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THE CRYSTAL STRUCTURE OF WILD TYPE PENICILLIN-BINDING PROTEIN 5 FROM E. COLI
Descriptor:Penicillin-binding protein 5, BETA-MERCAPTOETHANOL
Authors:Nicholas, R.A., Krings, S., Tomberg, J., Nicola, G., Davies, C.
Deposit date:2003-02-19
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of wild-type penicillin-binding protein 5 from Escherichia coli: implications for deacylation of the acyl-enzyme complex.
J.Biol.Chem., 278, 2003
6BR7
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BERYLLIUM FLUORINATED RECEIVER DOMAIN OF BFMR FROM ACINETOBACTER BAUMANNII
Descriptor:Two-component system response regulator protein, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION
Authors:Milton, M.E., Cavanagh, J.
Deposit date:2017-11-30
Release date:2018-02-21
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:The Structure of the Biofilm-controlling Response Regulator BfmR from Acinetobacter baumannii Reveals Details of Its DNA-binding Mechanism.
J. Mol. Biol., 430, 2018
1NJ4
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CRYSTAL STRUCTURE OF A DEACYLATION-DEFECTIVE MUTANT OF PENICILLIN-BINDING PROTEIN 5 AT 1.9 A RESOLUTION
Descriptor:Penicillin-binding protein 5
Authors:Nicola, G., Nicholas, R.A., Davies, C.
Deposit date:2002-12-30
Release date:2003-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of wild-type penicillin-binding protein 5 from Escherichia coli: implications for deacylation of the acyl-enzyme complex.
J.Biol.Chem., 278, 2003
1SEI
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STRUCTURE OF 30S RIBOSOMAL PROTEIN S8
Descriptor:RIBOSOMAL PROTEIN S8
Authors:Davies, C., Ramakrishnan, V., White, S.W.
Deposit date:1996-08-14
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural evidence for specific S8-RNA and S8-protein interactions within the 30S ribosomal subunit: ribosomal protein S8 from Bacillus stearothermophilus at 1.9 A resolution.
Structure, 4, 1996
3MZD
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STRUCTURE OF PENICILLIN-BINDING PROTEIN 5 FROM E. COLI: CLOXACILLIN ACYL-ENZYME COMPLEX
Descriptor:D-alanyl-D-alanine carboxypeptidase dacA, (2R,4S)-2-[(1S)-1-({[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, GLYCEROL
Authors:Nicola, G., Tomberg, J., Pratt, R.F., Nicholas, R.A., Davies, C.
Deposit date:2010-05-12
Release date:2011-03-16
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of covalent complexes of beta-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity
Biochemistry, 49, 2010
5AAU
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OPTIMIZATION OF A NOVEL BINDING MOTIF TO TO (E)-3-(3,5-DIFLUORO-4-((1R,3R)-2-(2-FLUORO-2-METHYLPROPYL)-3-METHYL-2,3,4,9-TETRAHYDRO-1H- PYRIDO(3,4-B)INDOL-1-YL)PHENYL)ACRYLIC ACID (AZD9496), A POTENT AND ORALLY BIOAVAILABLE SELECTIVE ESTROGEN RECEPTOR DOWNREGULATOR AND ANTAGONIST
Descriptor:ESTROGEN RECEPTOR, 3-(1-(4-Chlorophenyl)-3,4-dihydro-1H-pyrido(3,4-b)indol-2(9H)-yl)propanoic acid
Authors:Norman, R.A., Bradbury, R.H., de Almeida, C., Andrews, D.M., Ballard, P., Buttar, D., Callis, R.J., Currie, G.S., Curwen, J.O., Davies, C.D., de Savi, C., Donald, C.S., Feron, L.J.L., Glossop, S.C., Hayter, B.R., Karoutchi, G., Lamont, S.G., MacFaul, P., Moss, T., Pearson, S.E., Rabow, A.A., Tonge, M., Walker, G.E., Weir, H.M., Wilson, Z.
Deposit date:2015-07-28
Release date:2015-10-14
Last modified:2016-10-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-Fluoro-2-Methylpropyl)-3-Methyl-2, 3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indol-1-Yl)Phenyl)Acrylic Acid (Azd9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.
J.Med.Chem., 58, 2015
2G5D
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CRYSTAL STRUCTURE OF MLTA FROM NEISSERIA GONORRHOEAE MONOCLINIC FORM
Descriptor:GNA33
Authors:Davies, C.
Deposit date:2006-02-22
Release date:2006-03-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structures of the Lytic Transglycosylase MltA from N.gonorrhoeae and E.coli: Insights into Interdomain Movements and Substrate Binding.
J.Mol.Biol., 359, 2006
5AAV
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OPTIMIZATION OF A NOVEL BINDING MOTIF TO TO (E)-3-(3,5-DIFLUORO-4-((1R,3R)-2-(2-FLUORO-2-METHYLPROPYL)-3-METHYL-2,3,4,9-TETRAHYDRO-1H- PYRIDO(3,4-B)INDOL-1-YL)PHENYL)ACRYLIC ACID (AZD9496), A POTENT AND ORALLY BIOAVAILABLE SELECTIVE ESTROGEN RECEPTOR DOWNREGULATOR AND ANTAGONIST
Descriptor:ESTROGEN RECEPTOR, (2E)-3-{4-[(1E)-1,2-DIPHENYLBUT-1-ENYL]PHENYL}ACRYLIC ACID
Authors:Norman, R.A., Bradbury, R.H., de Almeida, C., Andrews, D.M., Ballard, P., Buttar, D., Callis, R.J., Currie, G.S., Curwen, J.O., Davies, C.D., de Savi, C., Donald, C.S., Feron, L.J.L., Glossop, S.C., Hayter, B.R., Karoutchi, G., Lamont, S.G., MacFaul, P., Moss, T., Pearson, S.E., Rabow, A.A., Tonge, M., Walker, G.E., Weir, H.M., Wilson, Z.
Deposit date:2015-07-29
Release date:2015-10-14
Last modified:2016-10-12
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-Fluoro-2-Methylpropyl)-3-Methyl-2, 3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indol-1-Yl)Phenyl)Acrylic Acid (Azd9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.
J.Med.Chem., 58, 2015
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