1TZB | | CRYSTAL STRUCTURE OF NATIVE PHOSPHOGLUCOSE/PHOSPHOMANNOSE ISOMERASE FROM PYROBACULUM AEROPHILUM | | Descriptor: | glucose-6-phosphate isomerase, conjectural, SULFATE ION, ... | | Authors: | Swan, M.K., Hansen, T., Schoenheit, P., Davies, C. | | Deposit date: | 2004-07-09 | | Release date: | 2004-07-20 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (1.16 Å) | | Cite: | A novel phosphoglucose/phosphomannose isomease from the crenarchaeon Pyrobaculum aerophilum is a member of the PGI superfamily: structural evidence at 1.16 A resolution
J.Biol.Chem., 279, 2004
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1X9I | | CRYSTAL STRUCTURE OF CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE/PHOSPHOMANNOSE PHOSPHOGLUCOSE/PHOSPHOMANNOSEISOMERASE FROM PYROBACULUM AEROPHILUM IN COMPLEX WITH GLUCOSE 6-PHOSPHATE | | Descriptor: | glucose-6-phosphate isomerase, GLUCOSE-6-PHOSPHATE, GLYCEROL | | Authors: | Swan, M.K., Hansen, T., Schoenheit, P., Davies, C. | | Deposit date: | 2004-08-21 | | Release date: | 2004-12-07 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.16 Å) | | Cite: | Structural basis for phosphomannose isomerase activity in phosphoglucose isomerase from Pyrobaculum aerophilum: a subtle difference between distantly related enzymes.
Biochemistry, 43, 2004
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1TZC | | CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE/PHOSPHOMANNOSE ISOMERASE FROM PYROBACULUM AEROPHILUM IN COMPLEX WITH 5-PHOSPHOARABINONATE | | Descriptor: | glucose-6-phosphate isomerase, conjectural, SULFATE ION, ... | | Authors: | Swan, M.K., Hansen, T., Schoenheit, P., Davies, C. | | Deposit date: | 2004-07-09 | | Release date: | 2004-07-20 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | A novel phosphoglucose/phosphomannose isomease from the crenarchaeon Pyrobaculum aerophilum is a member of the PGI superfamily: structural evidence at 1.16 A resolution
J.Biol.Chem., 279, 2004
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1WHI | | RIBOSOMAL PROTEIN L14 | | Descriptor: | RIBOSOMAL PROTEIN L14 | | Authors: | Davies, C., White, S.W., Ramakrishnan, V. | | Deposit date: | 1996-01-10 | | Release date: | 1996-08-17 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | The crystal structure of ribosomal protein L14 reveals an important organizational component of the translational apparatus.
Structure, 4, 1996
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1X9H | | CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE/PHOSPHOMANNOSE ISOMERASE FROM PYROBACULUM AEROPHILUM IN COMPLEX WITH FRUCTOSE 6-PHOSPHATE | | Descriptor: | glucose-6-phosphate isomerase, SULFATE ION, FRUCTOSE -6-PHOSPHATE, ... | | Authors: | Swan, M.K., Hansen, T., Schoenheit, P., Davies, C. | | Deposit date: | 2004-08-21 | | Release date: | 2004-12-07 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural basis for phosphomannose isomerase activity in phosphoglucose isomerase from Pyrobaculum aerophilum: a subtle difference between distantly related enzymes.
Biochemistry, 43, 2004
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3MZF | | STRUCTURE OF PENICILLIN-BINDING PROTEIN 5 FROM E. COLI: IMIPENEM ACYL-ENZYME COMPLEX | | Descriptor: | D-alanyl-D-alanine carboxypeptidase dacA, (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid, GLYCEROL | | Authors: | Nicola, G., Tomberg, J., Pratt, R.F., Nicholas, R.A., Davies, C. | | Deposit date: | 2010-05-12 | | Release date: | 2011-03-16 | | Last modified: | 2019-07-17 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal structures of covalent complexes of beta-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity
Biochemistry, 49, 2010
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1U0E | | CRYSTAL STRUCTURE OF MOUSE PHOSPHOGLUCOSE ISOMERASE | | Descriptor: | Glucose-6-phosphate isomerase, SULFATE ION, BETA-MERCAPTOETHANOL, ... | | Authors: | Solomons, J.T.G., Zimmerly, E.M., Burns, S., Krishnamurthy, N., Swan, M.K., Krings, S., Muirhead, H., Chirgwin, J., Davies, C. | | Deposit date: | 2004-07-13 | | Release date: | 2004-11-02 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | The crystal structure of mouse phosphoglucose isomerase at 1.6A resolution and its complex with glucose 6-phosphate reveals the catalytic mechanism of sugar ring opening.
J.Mol.Biol., 342, 2004
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1U0F | | CRYSTAL STRUCTURE OF MOUSE PHOSPHOGLUCOSE ISOMERASE IN COMPLEX WITH GLUCOSE 6-PHOSPHATE | | Descriptor: | Glucose-6-phosphate isomerase, ALPHA-D-GLUCOSE-6-PHOSPHATE, GLUCOSE-6-PHOSPHATE, ... | | Authors: | Solomons, J.T.G., Zimmerly, E.M., Burns, S., Krishnamurthy, N., Swan, M.K., Krings, S., Muirhead, H., Chirgwin, J., Davies, C. | | Deposit date: | 2004-07-13 | | Release date: | 2004-11-02 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | The crystal structure of mouse phosphoglucose isomerase at 1.6A resolution and its complex with glucose 6-phosphate reveals the catalytic mechanism of sugar ring opening.
J.Mol.Biol., 342, 2004
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1Z6F | | CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 5 FROM E. COLI IN COMPLEX WITH A BORONIC ACID INHIBITOR | | Descriptor: | Penicillin-binding protein 5, N1-[(1R)-1-(DIHYDROXYBORYL)ETHYL]-N2-[(TERT-BUTOXYCARBONYL)-D-GAMMA-GLUTAMYL]-N6-[(BENZYLOXY)CARBONYL-L-LYSINAMIDE, GLYCEROL | | Authors: | Nicola, G., Peddi, S., Stefanova, M., Nicholas, R.A., Gutheil, W.G., Davies, C. | | Deposit date: | 2005-03-22 | | Release date: | 2005-06-21 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal Structure of Escherichia coli Penicillin-Binding Protein 5 Bound to a Tripeptide Boronic Acid Inhibitor: A Role for Ser-110 in Deacylation.
Biochemistry, 44, 2005
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3BEC | |
1IAT | | CRYSTAL STRUCTURE OF HUMAN PHOSPHOGLUCOSE ISOMERASE/NEUROLEUKIN/AUTOCRINE MOTILITY FACTOR/MATURATION FACTOR | | Descriptor: | PHOSPHOGLUCOSE ISOMERASE, SULFATE ION, BETA-MERCAPTOETHANOL | | Authors: | Read, J.A., Pearce, J., Li, X., Muirhead, H., Chirgwin, J., Davies, C. | | Deposit date: | 2001-03-23 | | Release date: | 2001-05-30 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | The crystal structure of human phosphoglucose isomerase at 1.6 A resolution: implications for catalytic mechanism, cytokine activity and haemolytic anaemia.
J.Mol.Biol., 309, 2001
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1QXR | | CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE ISOMERASE FROM PYROCOCCUS FURIOSUS IN COMPLEX WITH 5-PHOSPHOARABINONATE | | Descriptor: | Glucose-6-phosphate isomerase, NICKEL (II) ION, 5-PHOSPHOARABINONIC ACID | | Authors: | Swan, M.K., Solomons, J.T.G., Beeson, C.C., Hansen, P., Schonheit, P., Davies, C. | | Deposit date: | 2003-09-08 | | Release date: | 2003-12-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural evidence for a hydride transfer mechanism of catalysis in phosphoglucose isomerase from Pyrococcus furiosus
J.Biol.Chem., 278, 2003
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1U0G | | CRYSTAL STRUCTURE OF MOUSE PHOSPHOGLUCOSE ISOMERASE IN COMPLEX WITH ERYTHROSE 4-PHOSPHATE | | Descriptor: | Glucose-6-phosphate isomerase, SULFATE ION, ERYTHOSE-4-PHOSPHATE, ... | | Authors: | Solomons, J.T.G., Zimmerly, E.M., Burns, S., Krishnamurthy, N., Swan, M.K., Krings, S., Muirhead, H., Chirgwin, J., Davies, C. | | Deposit date: | 2004-07-13 | | Release date: | 2004-11-02 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The crystal structure of mouse phosphoglucose isomerase at 1.6A resolution and its complex with glucose 6-phosphate reveals the catalytic mechanism of sugar ring opening.
J.Mol.Biol., 342, 2004
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2O2P | | CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF RAT 10'FORMYLTETRAHYDROFOLATE DEHYDROGENASE | | Descriptor: | Formyltetrahydrofolate dehydrogenase, SULFATE ION, GLYCEROL | | Authors: | Tsybovsky, Y., Donato, H., Krupenko, N.I., Davies, C., Krupenko, S.A. | | Deposit date: | 2006-11-30 | | Release date: | 2007-03-06 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structures of the carboxyl terminal domain of rat 10-formyltetrahydrofolate dehydrogenase: implications for the catalytic mechanism of aldehyde dehydrogenases.
Biochemistry, 46, 2007
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1EBL | | THE 1.8 A CRYSTAL STRUCTURE AND ACTIVE SITE ARCHITECTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE III (FABH) FROM ESCHERICHIA COLI | | Descriptor: | BETA-KETOACYL-ACP SYNTHASE III, COENZYME A | | Authors: | Davies, C., Heath, R.J., White, S.W., Rock, C.O. | | Deposit date: | 2000-01-24 | | Release date: | 2000-02-11 | | Last modified: | 2018-01-31 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The 1.8 A crystal structure and active-site architecture of beta-ketoacyl-acyl carrier protein synthase III (FabH) from escherichia coli.
Structure Fold.Des., 8, 2000
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1QXJ | | CRYSTAL STRUCTURE OF NATIVE PHOSPHOGLUCOSE ISOMERASE FROM PYROCOCCUS FURIOSUS | | Descriptor: | Glucose-6-phosphate isomerase, NICKEL (II) ION | | Authors: | Swan, M.K., Solomons, J.T.G., Beeson, C.C., Hansen, T., Schonheit, P., Davies, C. | | Deposit date: | 2003-09-07 | | Release date: | 2003-12-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural evidence for a hydride transfer mechanism of catalysis in phosphoglucose isomerase from Pyrococcus furiosus
J.Biol.Chem., 278, 2003
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1QY4 | | CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE ISOMERASE FROM PYROCOCCUS FURIOSUS IN COMPLEX WITH GLUCONATE 6-PHOSPHATE | | Descriptor: | Glucose-6-phosphate isomerase, 6-PHOSPHOGLUCONIC ACID, NICKEL (II) ION | | Authors: | Swan, M.K., Solomons, J.T.G., Beeson, C.C., Hansen, T., Schonheit, P., Davies, C. | | Deposit date: | 2003-09-09 | | Release date: | 2003-12-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural evidence for a hydride transfer mechanism of catalysis in phosphoglucose isomerase from Pyrococcus furiosus
J.Biol.Chem., 278, 2003
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1NZO | | THE CRYSTAL STRUCTURE OF WILD TYPE PENICILLIN-BINDING PROTEIN 5 FROM E. COLI | | Descriptor: | Penicillin-binding protein 5, BETA-MERCAPTOETHANOL | | Authors: | Nicholas, R.A., Krings, S., Tomberg, J., Nicola, G., Davies, C. | | Deposit date: | 2003-02-19 | | Release date: | 2004-01-13 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal structure of wild-type penicillin-binding protein 5 from Escherichia coli: implications for deacylation of the acyl-enzyme complex.
J.Biol.Chem., 278, 2003
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6BR7 | |
1NJ4 | |
1SEI | | STRUCTURE OF 30S RIBOSOMAL PROTEIN S8 | | Descriptor: | RIBOSOMAL PROTEIN S8 | | Authors: | Davies, C., Ramakrishnan, V., White, S.W. | | Deposit date: | 1996-08-14 | | Release date: | 1997-03-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural evidence for specific S8-RNA and S8-protein interactions within the 30S ribosomal subunit: ribosomal protein S8 from Bacillus stearothermophilus at 1.9 A resolution.
Structure, 4, 1996
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3MZD | | STRUCTURE OF PENICILLIN-BINDING PROTEIN 5 FROM E. COLI: CLOXACILLIN ACYL-ENZYME COMPLEX | | Descriptor: | D-alanyl-D-alanine carboxypeptidase dacA, (2R,4S)-2-[(1S)-1-({[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, GLYCEROL | | Authors: | Nicola, G., Tomberg, J., Pratt, R.F., Nicholas, R.A., Davies, C. | | Deposit date: | 2010-05-12 | | Release date: | 2011-03-16 | | Last modified: | 2019-07-17 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structures of covalent complexes of beta-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity
Biochemistry, 49, 2010
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5AAU | | OPTIMIZATION OF A NOVEL BINDING MOTIF TO TO (E)-3-(3,5-DIFLUORO-4-((1R,3R)-2-(2-FLUORO-2-METHYLPROPYL)-3-METHYL-2,3,4,9-TETRAHYDRO-1H- PYRIDO(3,4-B)INDOL-1-YL)PHENYL)ACRYLIC ACID (AZD9496), A POTENT AND ORALLY BIOAVAILABLE SELECTIVE ESTROGEN RECEPTOR DOWNREGULATOR AND ANTAGONIST | | Descriptor: | ESTROGEN RECEPTOR, 3-(1-(4-Chlorophenyl)-3,4-dihydro-1H-pyrido(3,4-b)indol-2(9H)-yl)propanoic acid | | Authors: | Norman, R.A., Bradbury, R.H., de Almeida, C., Andrews, D.M., Ballard, P., Buttar, D., Callis, R.J., Currie, G.S., Curwen, J.O., Davies, C.D., de Savi, C., Donald, C.S., Feron, L.J.L., Glossop, S.C., Hayter, B.R., Karoutchi, G., Lamont, S.G., MacFaul, P., Moss, T., Pearson, S.E., Rabow, A.A., Tonge, M., Walker, G.E., Weir, H.M., Wilson, Z. | | Deposit date: | 2015-07-28 | | Release date: | 2015-10-14 | | Last modified: | 2016-10-12 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-Fluoro-2-Methylpropyl)-3-Methyl-2, 3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indol-1-Yl)Phenyl)Acrylic Acid (Azd9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.
J.Med.Chem., 58, 2015
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2G5D | |
5AAV | | OPTIMIZATION OF A NOVEL BINDING MOTIF TO TO (E)-3-(3,5-DIFLUORO-4-((1R,3R)-2-(2-FLUORO-2-METHYLPROPYL)-3-METHYL-2,3,4,9-TETRAHYDRO-1H- PYRIDO(3,4-B)INDOL-1-YL)PHENYL)ACRYLIC ACID (AZD9496), A POTENT AND ORALLY BIOAVAILABLE SELECTIVE ESTROGEN RECEPTOR DOWNREGULATOR AND ANTAGONIST | | Descriptor: | ESTROGEN RECEPTOR, (2E)-3-{4-[(1E)-1,2-DIPHENYLBUT-1-ENYL]PHENYL}ACRYLIC ACID | | Authors: | Norman, R.A., Bradbury, R.H., de Almeida, C., Andrews, D.M., Ballard, P., Buttar, D., Callis, R.J., Currie, G.S., Curwen, J.O., Davies, C.D., de Savi, C., Donald, C.S., Feron, L.J.L., Glossop, S.C., Hayter, B.R., Karoutchi, G., Lamont, S.G., MacFaul, P., Moss, T., Pearson, S.E., Rabow, A.A., Tonge, M., Walker, G.E., Weir, H.M., Wilson, Z. | | Deposit date: | 2015-07-29 | | Release date: | 2015-10-14 | | Last modified: | 2016-10-12 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-Fluoro-2-Methylpropyl)-3-Methyl-2, 3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indol-1-Yl)Phenyl)Acrylic Acid (Azd9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.
J.Med.Chem., 58, 2015
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