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Crystal structure of the human Notch1 Negative Regulatory Region (NRR) bound to the fab fragment of an antagonist antibody
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neurogenic locus notch homolog protein 1, ...
Authors:	Hymowitz, S.G, de Leon, G.P.
Deposit date:	2010-01-04
Release date:	2010-03-09
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.19 Å)
Cite:	Therapeutic antibody targeting of individual Notch receptors. Nature, 464, 2010

Bruton's tyrosine kinase (BTK) with GDC-0853
Descriptor:	1,2-ETHANEDIOL, 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, SULFATE ION, ...
Authors:	Steinbacher, S, Eigenbrot, C.
Deposit date:	2017-04-07
Release date:	2018-02-28
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (1.59 Å)
Cite:	Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development. J. Med. Chem., 61, 2018

Bruton's tyrosine kinase (BTK) with pyridazinone compound 9
Descriptor:	2-(2-METHOXYETHOXY)ETHANOL, 6-~{tert}-butyl-8-fluoranyl-2-[3-(hydroxymethyl)-4-[1-methyl-6-oxidanylidene-5-(pyrimidin-4-ylamino)pyridin-3-yl]pyridin-2-yl]phthalazin-1-one, GLYCEROL, ...
Authors:	Eigenbrot, C, Yu, C.
Deposit date:	2016-07-13
Release date:	2016-09-14
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.389 Å)
Cite:	Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations. Acs Chem.Biol., 11, 2016