Author results

4KAG
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CRYSTAL STRUCTURE ANALYSIS OF A SINGLE AMINO ACID DELETION MUTATION IN EGFP
Descriptor:Green fluorescent protein, 1,2-ETHANEDIOL, SULFATE ION, ...
Authors:Arpino, J.A.J., Rizkallah, P.J.
Deposit date:2013-04-22
Release date:2014-08-06
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Structural and dynamic changes associated with beneficial engineered single-amino-acid deletion mutations in enhanced green fluorescent protein.
Acta Crystallogr.,Sect.D, 70, 2014
4KEX
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CRYSTAL STRUCTURE ANALYSIS OF A SINGLE AMINO ACID DELETION MUTATION IN EGFP
Descriptor:Green fluorescent protein
Authors:Arpino, J.A.J., Rizkallah, P.J.
Deposit date:2013-04-26
Release date:2014-08-06
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and dynamic changes associated with beneficial engineered single-amino-acid deletion mutations in enhanced green fluorescent protein.
Acta Crystallogr.,Sect.D, 70, 2014
4PHJ
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THE STRUCTURAL BASIS OF DIFFERENTIAL INHIBITION OF HUMAN CALPAIN BY INDOLE AND PHENYL ALPHA-MERCAPTOACRYLIC ACIDS: HUMAN UNLIGANDED PROTEIN
Descriptor:Calpain small subunit 1, CALCIUM ION
Authors:Adams, S.E., Rizkallah, P.J., Allemann, R.K., Miller, D.J., Hallett, M.B., Robinson, E.
Deposit date:2014-05-06
Release date:2014-08-13
Last modified:2014-09-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The structural basis of differential inhibition of human calpain by indole and phenyl alpha-mercaptoacrylic acids.
J.Struct.Biol., 187, 2014
4PHN
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THE STRUCTURAL BASIS OF DIFFERENTIAL INHIBITION OF HUMAN CALPAIN BY INDOLE AND PHENYL ALPHA-MERCAPTOACRYLIC ACIDS
Descriptor:Calpain small subunit 1, CALCIUM ION
Authors:Allemann, R.K., Rizkallah, P.J., Adams, S.E., Miller, D.J., Hallett, M.B.
Deposit date:2014-05-06
Release date:2014-08-13
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:The structural basis of differential inhibition of human calpain by indole and phenyl alpha-mercaptoacrylic acids.
J.Struct.Biol., 187, 2014
4V4M
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1.45 ANGSTROM STRUCTURE OF STNV COAT PROTEIN
Descriptor:Coat protein, CALCIUM ION
Authors:Lane, S.W., Dennis, C.A., Lane, C.L., Trinh, C.H., Rizkallah, P.J., Stockley, P.G., Phillips, S.E.V.
Deposit date:2011-04-28
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Construction and crystal structure of recombinant STNV capsids.
J.Mol.Biol., 413, 2011
4WQ2
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HUMAN CALPAIN PEF(S) WITH (Z)-3-(6-BROMONDOL-3-YL)-2-MERCAPTOACRYLIC ACID BOUND
Descriptor:Calpain small subunit 1, (2Z)-3-(6-bromo-1H-indol-3-yl)-2-sulfanylprop-2-enoic acid, CALCIUM ION, ...
Authors:Adams, S.E., Rizkallah, P.J., Miller, D.J., Hallett, M.B., Allemann, R.K.
Deposit date:2014-10-21
Release date:2015-09-02
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Conformationally restricted calpain inhibitors.
Chem Sci, 6, 2015
4WQ3
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HUMAN CALPAIN PEF(S) WITH (2Z,2Z')-2,2'-DISULFANEDIYLBIS(3-(6-BROMOINDOL-3-YL)ACRYLIC ACID) BOUND
Descriptor:Calpain small subunit 1, CALCIUM ION, (2Z)-3-(6-bromo-1H-indol-3-yl)-2-sulfanylprop-2-enoic acid
Authors:Adams, S.E., Robinson, E.J., Rizkallah, P.J., Miller, D.J., Hallett, M.B., Allemann, R.K.
Deposit date:2014-10-21
Release date:2015-09-02
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Conformationally restricted calpain inhibitors.
Chem Sci, 6, 2015
4ZIN
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GENETICALLY ENCODED PHENYL AZIDE PHOTOCHEMISTRY DRIVE POSITIVE AND NEGATIVE FUNCTIONAL MODULATION OF A RED FLUORESCENT PROTEIN
Descriptor:MCherry fluorescent protein, SULFATE ION, 1,2-ETHANEDIOL
Authors:Reddington, S.C., Driezis, S., Hartley, A.M., Watson, P.D., Rizkallah, P.J., Jones, D.D.
Deposit date:2015-04-28
Release date:2015-09-16
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Genetically encoded phenyl azide photochemistry drives positive and negative functional modulation of a red fluorescent protein
Rsc Adv, 5, 2015
4ZIO
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IRRADIATED STATE OF MCHERRY143AZF
Descriptor:mCherry, SULFATE ION
Authors:Reddington, S.C., Driezis, S., Hartley, A.M., Watson, P.D., Rizkallah, P.J., Jones, D.D.
Deposit date:2015-04-28
Release date:2015-09-16
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Genetically encoded phenyl azide photochemistry drives positive and negative functional modulation of a red fluorescent protein
Rsc Adv, 5, 2015
5BRZ
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MAGE-A3 REACTIVE TCR IN COMPLEX WITH MAGE-A3 IN HLA-A1
Descriptor:HLA class I histocompatibility antigen, A-1 alpha chain, Beta-2-microglobulin, ...
Authors:Raman, M.C.C., Rizkallah, P.J., Simmons, R., Donnellan, Z., Dukes, J., Bossi, G., LeProvost, G., Mahon, T., Hickman, E., LomaX, M., Oates, J., Hassan, N., Vuidepot, A., Sami, M., Cole, D.K., Jakobsen, B.K.
Deposit date:2015-06-01
Release date:2016-03-02
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.
Sci Rep, 6, 2016
5BS0
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MAGE-A3 REACTIVE TCR IN COMPLEX WITH TITIN EPITOPE IN HLA-A1
Descriptor:HLA class I histocompatibility antigen, A-1 alpha chain, Beta-2-microglobulin, ...
Authors:Raman, M.C.C., Rizkallah, P.J., Simmons, R., Donellan, Z., Dukes, J., Bossi, G., LeProvost, G., Mahon, T., Hickman, E., Lomax, M., Oates, J., Hassan, N., Vuidepot, A., Sami, M., Cole, D.K., Jakobsen, B.K.
Deposit date:2015-06-01
Release date:2016-03-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.
Sci Rep, 6, 2016
5BT0
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SWITCHING GFP FLUORESCENCE USING GENETICALLY ENCODED PHENYL AZIDE CHEMISTRY THROUGH TWO DIFFERENT NON-NATIVE POST-TRANSLATIONAL MODIFICATIONS ROUTES AT THE SAME POSITION.
Descriptor:Green fluorescent protein, SULFATE ION
Authors:Hartley, A.M., Worthy, H.L., Reddington, S.C., Rizkallah, P.J., Jones, D.D.
Deposit date:2015-06-02
Release date:2016-07-13
Last modified:2017-05-10
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Molecular basis for functional switching of GFP by two disparate non-native post-translational modifications of a phenyl azide reaction handle.
Chem Sci, 7, 2016
5BTT
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SWITCHING GFP FLUORESCENCE USING GENETICALLY ENCODED PHENYL AZIDE CHEMISTRY THROUGH TWO DIFFERENT NON-NATIVE POST-TRANSLATIONAL MODIFICATIONS ROUTES AT THE SAME POSITION.
Descriptor:Green fluorescent protein, SULFATE ION, GLYCEROL
Authors:Hartley, A.M., Worthy, H.L., Reddington, S.C., Rizkallah, P.J., Jones, D.D.
Deposit date:2015-06-03
Release date:2016-07-13
Last modified:2017-05-10
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Molecular basis for functional switching of GFP by two disparate non-native post-translational modifications of a phenyl azide reaction handle.
Chem Sci, 7, 2016
5D69
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HUMAN CALPAIN PEF(S) WITH (2Z,2Z')-2,2'-DISULFANEDIYLBIS(3-(6-IODOINDOL-3-YL)ACRYLIC ACID) BOUND
Descriptor:Calpain small subunit 1, CALCIUM ION, (2E,2'Z)-2,2'-disulfanediylbis[3-(4-iodophenyl)prop-2-enoic acid], ...
Authors:Adams, S.E., Robinson, E.J., Rizkallah, P.J., Miller, D.J., Hallett, M.B., Allemann, R.K.
Deposit date:2015-08-11
Release date:2015-09-02
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Conformationally restricted calpain inhibitors.
Chem Sci, 6, 2015
5DY6
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ENHANCED SUPERFOLDER GFP WITH DBCO AT 148
Descriptor:Green fluorescent protein, SULFATE ION
Authors:Jones, D.D., Rizkallah, P.J., Worthy, H.L.
Deposit date:2015-09-24
Release date:2016-07-13
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Molecular basis for functional switching of GFP by two disparate non-native post-translational modifications of a phenyl azide reaction handle.
Chem Sci, 7, 2016
5NHN
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SUPER-FOLDER GREEN FLUORESCENT PROTEIN ARTIFICIALL DIMER LINKED VIA 148 POSITION
Descriptor:Green fluorescent protein, [(4~{S})-4,5,6,7,8,9-hexahydro-1~{H}-cycloocta[d][1,2,3]triazol-4-yl] hydrogen carbonate, GLYCEROL, ...
Authors:Worthy, H.L., Rizkallah, P.J.
Deposit date:2017-03-22
Release date:2018-09-26
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Super-Folder Green Fluorescent Protein Artificiall dimer linked via 148 position
To Be Published
5NI3
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SFGFP 204-204 MUTANT DIMER
Descriptor:Green fluorescent protein, SODIUM ION, [(4~{S})-4,5,6,7,8,9-hexahydro-1~{H}-cycloocta[d][1,2,3]triazol-4-yl] hydrogen carbonate, ...
Authors:Worthy, H.L., Rizkallah, P.J.
Deposit date:2017-03-23
Release date:2018-09-12
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:sfGFP 204-204 mutant dimer
to be published
1KI2
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CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH GANCICLOVIR
Descriptor:THYMIDINE KINASE, SULFATE ION, 9-(1,3-DIHYDROXY-PROPOXYMETHANE)GUANINE
Authors:Champness, J.N., Bennett, M.S., Wien, F., Brown, D.G., Visse, R., Sandhu, G., Davies, A., Rizkallah, P.J., Melitz, C., Summers, W.C., Sanderson, M.R.
Deposit date:1998-05-15
Release date:1998-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Proteins, 32, 1998
1KIM
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CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH DEOXYTHYMIDINE
Descriptor:THYMIDINE KINASE, SULFATE ION, THYMIDINE
Authors:Champness, J.N., Bennett, M.S., Wien, F., Brown, D.G., Visse, R., Sandhu, G., Davies, A., Rizkallah, P.J., Melitz, C., Summers, W.C., Sanderson, M.R.
Deposit date:1997-11-12
Release date:1998-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Proteins, 32, 1998
5HYJ
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1E6 TCR IN COMPLEX WITH HLA-A02 CARRYING AQWGPDPAAA
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Bulek, A.M., Cole, D.K., Sewell, A.K.
Deposit date:2016-02-01
Release date:2016-05-04
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (3.06 Å)
Cite:A "hotspot" for autoimmune T cells in type 1 diabetes.
J.Clin.Invest., 126, 2016
1GKA
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THE MOLECULAR BASIS OF THE COLORATION MECHANISM IN LOBSTER SHELL. BETA-CRUSTACYANIN AT 3.2 A RESOLUTION
Descriptor:CRUSTACYANIN A1 SUBUNIT, CRUSTACYANIN A2 SUBUNIT, ASTAXANTHIN, ...
Authors:Cianci, M., Rizkallah, P.J., Olczak, A., Raftery, J., Chayen, N.E., Zagalsky, P.F., Helliwell, J.R.
Deposit date:2001-08-10
Release date:2002-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.23 Å)
Cite:The Molecular Basis of the Coloration Mechanism in Lobster Shell: Beta -Crustacyanin at 3.2-A Resolution
Proc.Natl.Acad.Sci.USA, 99, 2002
2BNQ
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STRUCTURAL AND KINETIC BASIS FOR HEIGHTENED IMMUNOGENICITY OF T CELL VACCINES
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, BETA-2-MICROGLOBULIN, SYNTHETIC PEPTIDE, ...
Authors:Chen, J.-L., Stewart-Jones, G., Bossi, G., Lissin, N.M., Wooldridge, L., Choi, E.M.L., Held, G., Dunbar, P.R., Esnouf, R.M., Sami, M., Boultier, J.M., Rizkallah, P.J., Renner, C., Sewell, A., van der Merwe, P.A., Jackobsen, B.K., Griffiths, G., Jones, E.Y., Cerundolo, V.
Deposit date:2005-03-31
Release date:2005-05-23
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines
J.Exp.Med., 201, 2005
2BNR
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STRUCTURAL AND KINETIC BASIS FOR HEIGHTENED IMMUNOGENICITY OF T CELL VACCINES
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, BETA-2-MICROGLOBULIN, SYNTHETIC PEPTIDE, ...
Authors:Chen, J.-L., Stewart-Jones, G., Bossi, G., Lissin, N.M., Wooldridge, L., Choi, E.M.L., Held, G., Dunbar, P.R., Esnouf, R.M., Sami, M., Boultier, J.M., Rizkallah, P.J., Renner, C., Sewell, A., van der Merwe, P.A., Jackobsen, B.K., Griffiths, G., Jones, E.Y., Cerundolo, V.
Deposit date:2005-03-31
Release date:2005-05-23
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines
J.Exp.Med., 201, 2005
2BNU
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STRUCTURAL AND KINETIC BASIS FOR HEIGHTENED IMMUNOGENICITY OF T CELL VACCINES
Descriptor:T-CELL RECEPTOR ALPHA CHAIN C REGION, T-CELL RECEPTOR BETA CHAIN C REGION
Authors:Chen, J.-L., Stewart-Jones, G., Bossi, G., Lissin, N.M., Wooldridge, L., Choi, E.M.L., Held, G., Dunbar, P.R., Esnouf, R.M., Sami, M., Boultier, J.M., Rizkallah, P.J., Renner, C., Sewell, A., Van Der Merwe, P.A., Jackobsen, B.K., Griffiths, G., Jones, E.Y., Cerundolo, V.
Deposit date:2005-04-04
Release date:2005-05-24
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines.
J.Exp.Med., 201, 2005
2V6H
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CRYSTAL STRUCTURE OF THE C1 DOMAIN OF CARDIAC MYOSIN BINDING PROTEIN-C
Descriptor:MYOSIN-BINDING PROTEIN C, CARDIAC-TYPE
Authors:Govata, L., Carpenter, L., Da Fonseca, P.C.A., Helliwell, J.R., Rizkallah, P.J., Flashman, E., Chayen, N.E., Redwood, C., Squire, J.M.
Deposit date:2007-07-18
Release date:2008-07-22
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of the C1 domain of cardiac myosin binding protein-C: implications for hypertrophic cardiomyopathy.
J. Mol. Biol., 378, 2008