Author results

5V2H
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RNA OCTAMER CONTAINING GLYCOL NUCLEIC ACID, SGNT
Descriptor:RNA (5'-R(*(CBV)P*GP*AP*AP*(ZTH)P*UP*CP*G)-3'), COBALT HEXAMMINE(III), MAGNESIUM ION
Authors:Harp, J.M., Egli, M.
Deposit date:2017-03-04
Release date:2017-06-14
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.080013 Å)
Cite:Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 139, 2017
5VR4
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RNA OCTAMER CONTAINING 2'-F-4'-OME U.
Descriptor:RNA (5'-R(*CP*GP*AP*AP*(UMO)P*UP*CP*G)-3'), COBALT TETRAAMMINE ION
Authors:Harp, J.M., Egli, M.
Deposit date:2017-05-10
Release date:2017-10-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing.
J. Am. Chem. Soc., 139, 2017
168D
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STABILIZING EFFECTS OF THE RNA 2'-SUBSTITUENT: CRYSTAL STRUCTURE OF AN OLIGODEOXYNUCLEOTIDE DUPLEX CONTAINING 2'-O-METHYLATED ADENOSINES
Descriptor:DNA/RNA (5'-D(*GP*CP*GP*TP*)-R(*(A2M)P*)-D(*TP*AP*CP*GP*C)-3')
Authors:Lubini, P., Zuercher, W., Egli, M.
Deposit date:1994-04-08
Release date:1994-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Stabilizing effects of the RNA 2'-substituent: crystal structure of an oligodeoxynucleotide duplex containing 2'-O-methylated adenosines.
Chem.Biol., 1, 1994
1CS7
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SYNTHETIC DNA HAIRPIN WITH STILBENEDIETHER LINKER
Descriptor:5'-D(GP*(BRU)P*TP*TP*TP*GP*(S02)*CP*AP*AP*AP*AP*C)-3', STRONTIUM ION
Authors:Lewis, F.D., Liu, X., Wu, Y., Miller, S.E., Wasielewski, M.R., Letsinger, R.L., Sanishvili, R., Joachimiak, A., Tereshko, V., Egli, M.
Deposit date:1999-08-17
Release date:2001-10-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure and Photoinduced Electron Transfer in Exceptionally Stable Synthetic DNA Hairpins with Stilbenediether Linkers
J.Am.Chem.Soc., 121, 1999
1D14
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STRUCTURE OF 11-DEOXYDAUNOMYCIN BOUND TO DNA CONTAINING A PHOSPHOROTHIOATE
Descriptor:DNA (5'-D(*CP*GP*TP*(AS)P*CP*G)-3'), 6-DEOXYDAUNOMYCIN
Authors:Williams, L.D., Egli, M., Ughetto, G., Van Der Marel, G.A., Van Boom, J.H., Quigley, G.J., Wang, A.H.-J., Rich, A., Frederick, C.A.
Deposit date:1989-10-20
Release date:1990-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of 11-deoxydaunomycin bound to DNA containing a phosphorothioate.
J.Mol.Biol., 215, 1990
1D32
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DRUG-INDUCED DNA REPAIR: X-RAY STRUCTURE OF A DNA-DITERCALINIUM COMPLEX
Descriptor:DNA (5'-D(*CP*GP*CP*G)-3'), DITERCALINIUM
Authors:Gao, Q., Williams, L.D., Egli, M., Rabinovich, D., Chen, S.-L., Quigley, G.J., Rich, A.
Deposit date:1991-01-23
Release date:1992-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Drug-induced DNA repair: X-ray structure of a DNA-ditercalinium complex.
Proc.Natl.Acad.Sci.USA, 88, 1991
1DAU
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ANALOG OF DICKERSON-DREW DNA DODECAMER WITH 6'-ALPHA-METHYL CARBOCYCLIC THYMIDINES, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:DNA (5'-D(*CP*GP*CP*GP*AP*AP*(T32)P*(T32)P*CP*GP*CP*G)-3')
Authors:Denisov, A., Bekiroglu, S., Maltseva, T., Sandstrom, A., Altmann, K.-H., Egli, M., Chattopadhyaya, J.
Deposit date:1998-01-21
Release date:1998-05-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution conformation of a carbocyclic analog of the Dickerson-Drew dodecamer: comparison with its own X-ray structure and that of the NMR structure of the native counterpart.
J.Biomol.Struct.Dyn., 16, 1998
1EH4
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BINARY COMPLEX OF CASEIN KINASE-1 FROM S. POMBE WITH AN ATP COMPETITIVE INHIBITOR, IC261
Descriptor:CASEIN KINASE-1, SULFATE ION, 3-[(2,4,6-TRIMETHOXY-PHENYL)-METHYLENE]-INDOLIN-2-ONE
Authors:Mashhoon, N., Demaggio, A.J., Tereshko, V., Bergmeier, S.C., Egli, M., Hoekstra, M.F., Kuret, J.
Deposit date:2000-02-18
Release date:2001-09-19
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of a Conformation-Selective Casein Kinase-1 Inhibitor
J.Biol.Chem., 275, 2000
1G2J
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RNA OCTAMER R(CCCP*GGGG) CONTAINING PHENYL RIBONUCLEOTIDE
Descriptor:5'-R(*CP*CP*CP*(PYY)P*GP*GP*GP*G)-3', CALCIUM ION
Authors:Minasov, G., Matulic-Adamic, J., Wilds, C.J., Haeberli, P., Usman, N., Beigelman, L., Egli, M.
Deposit date:2000-10-20
Release date:2000-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Crystal structure of an RNA duplex containing phenyl-ribonucleotides, hydrophobic isosteres of the natural pyrimidines.
RNA, 6, 2000
1I2X
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2.4 A STRUCTURE OF A-DUPLEX WITH BULGED ADENOSINE, SPERMIDINE FORM
Descriptor:DNA/RNA (5'-R(*GP*CP*G)-D(P*AP*TP*AP*T)-R(P*AP*CP*GP*U)-3'), SPERMIDINE
Authors:Tereshko, V., Wallace, S., Usman, N., Wincott, F., Egli, M.
Deposit date:2001-02-12
Release date:2001-04-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray crystallographic observation of "in-line" and "adjacent" conformations in a bulged self-cleaving RNA/DNA hybrid.
RNA, 7, 2001
1I2Y
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1.66 A STRUCTURE OF A-DUPLEX WITH BULGED ADENOSINE, SPERMINE FORM
Descriptor:DNA/RNA (5'-R(*GP*CP*G)-D(P*AP*TP*AP*T)-R(P*AP*CP*GP*U)-3'), SPERMINE
Authors:Tereshko, V., Wallace, S., Usman, N., Wincott, F., Egli, M.
Deposit date:2001-02-12
Release date:2001-04-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:X-ray crystallographic observation of "in-line" and "adjacent" conformations in a bulged self-cleaving RNA/DNA hybrid.
RNA, 7, 2001
1N1O
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CRYSTAL STRUCTURE OF A B-FORM DNA DUPLEX CONTAINING (L)-ALPHA-THREOFURANOSYL (3'-2') NUCLEOSIDES: A FOUR-CARBON SUGAR IS EASILY ACCOMMODATED INTO THE BACKBONE OF DNA
Descriptor:5'-D(*CP*GP*CP*GP*AP*AP*(TFT)P*TP*CP*GP*CP*G)-3', MAGNESIUM ION
Authors:Wilds, C.J., Wawrzak, Z., Krishnamurthy, R., Eschenmoser, A., Egli, M.
Deposit date:2002-10-18
Release date:2002-11-15
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal Structure of a B-Form DNA Duplex Containing (L)-alpha-Threofuranosyl (3'-->2') Nucleosides: A Four-Carbon Sugar Is Easily Accommodated into the Backbone of DNA
J.Am.Chem.Soc., 124, 2002
1PWF
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ONE SUGAR PUCKER FITS ALL: PAIRING VERSATILITY DESPITE CONFORMATIONAL UNIFORMITY IN TNA
Descriptor:5'-D(*GP*CP*GP*TP*AP*(2MU)P*(FA2)P*CP*GP*C)-3', SPERMINE
Authors:Pallan, P.S., Wilds, C.J., Wawrzak, Z., Krishnamurthy, R., Eschenmoser, A., Egli, M.
Deposit date:2003-07-01
Release date:2004-07-13
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:Why does TNA cross-pair more strongly with RNA than with DNA? an answer from X-ray analysis.
ANGEW.CHEM.INT.ED.ENGL., 42, 2003
1RXA
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CRYSTAL STRUCTURE OF R(CCCCGGGG) IN TWO DISTINCT LATTICES
Descriptor:RNA (5'-R(*CP*CP*CP*CP*GP*GP*GP*G)-3')
Authors:Portmann, S., Usman, N., Egli, M.
Deposit date:1995-05-05
Release date:1996-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The crystal structure of r(CCCCGGGG) in two distinct lattices.
Biochemistry, 34, 1995
1RXB
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CRYSTAL STRUCTURE OF R(CCCCGGGG) IN TWO DISTINCT LATTICES
Descriptor:RNA (5'-R(*CP*CP*CP*CP*GP*GP*GP*G)-3')
Authors:Portmann, S., Usman, N., Egli, M.
Deposit date:1995-05-05
Release date:1996-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The crystal structure of r(CCCCGGGG) in two distinct lattices.
Biochemistry, 34, 1995
1TF7
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CRYSTAL STRUCTURE OF CIRCADIAN CLOCK PROTEIN KAIC
Descriptor:KaiC, ADENOSINE-5'-TRIPHOSPHATE
Authors:Pattanayek, R., Wang, J., Mori, T., Xu, Y., Johnson, C.H., Egli, M.
Deposit date:2004-05-26
Release date:2004-08-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Visualizing a Circadian Clock Protein; Crystal Structure of KaiC and Functional Insights
Mol.Cell, 15, 2004
1U9I
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CRYSTAL STRUCTURE OF CIRCADIAN CLOCK PROTEIN KAIC WITH PHOSPHORYLATION SITES
Descriptor:KaiC, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Xu, Y., Mori, T., Pattanayek, R., Pattanayek, S., Egli, M., Johnson, C.H.
Deposit date:2004-08-09
Release date:2005-04-19
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Identification of key phosphorylation sites in the circadian clock protein KaiC by crystallographic and mutagenetic analyses
PROC.NATL.ACAD.SCI.USA, 101, 2004
1VRO
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SELENIUM-ASSISTED NUCLEIC ACID CRYSTALLOGRAPHY: USE OF PHOSPHOROSELENOATES FOR MAD PHASING OF A DNA STRUCTURE
Descriptor:5'-D(*CP*(GMS)P*CP*GP*CP*G)-3', SPERMINE, MAGNESIUM ION
Authors:Wilds, C.J., Pattanayek, R., Pan, C., Wawrzak, Z., Egli, M.
Deposit date:2005-04-14
Release date:2005-04-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Selenium-Assisted Nucleic Acid Crystallography: Use of Phosphoroselenoates for MAD Phasing of a DNA Structure
J.Am.Chem.Soc., 124, 2002
247D
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CRYSTAL STRUCTURES OF AN A-FORM DUPLEX WITH SINGLE-ADENOSINE BULGES AND A CONFORMATIONAL BASIS FOR SITE SPECIFIC RNA SELF-CLEAVAGE
Descriptor:DNA/RNA (5'-R(*GP*CP*GP*)-D(*AP*TP*AP*TP*AP*)-R(*CP*GP*C)-3')
Authors:Portmann, S., Grimm, S., Workman, C., Usman, N., Egli, M.
Deposit date:1996-02-02
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of an A-form duplex with single-adenosine bulges and a conformational basis for site-specific RNA self-cleavage.
Chem.Biol., 3, 1996
248D
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CRYSTAL STRUCTURES OF AN A-FORM DUPLEX WITH SINGLE-ADENOSINE BULGES AND A CONFORMATIONAL BASIS FOR SITE SPECIFIC RNA SELF-CLEAVAGE
Descriptor:DNA/RNA (5'-R(*GP*CP*GP*)-D(*AP*TP*AP*TP*AP*)-R(*CP*GP*C)-3'), ORTHORHOMBIC, SPERMINE
Authors:Portmann, S., Grimm, S., Workman, C., Usman, N., Egli, M.
Deposit date:1996-02-02
Release date:1996-03-08
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Crystal structures of an A-form duplex with single-adenosine bulges and a conformational basis for site-specific RNA self-cleavage.
Chem.Biol., 3, 1996
290D
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CRYSTAL STRUCTURES OF OLIGODEOXYRIBONUCLEOTIDES CONTAINING 6'-ALPHA-METHYL AND 6'-ALPHA-HYDROXY CARBOCYCLIC THYMIDINES
Descriptor:DNA (5'-D(*CP*GP*CP*GP*AP*AP*(T32)P*(T32)P*CP*GP*CP*G)-3')
Authors:Portmann, S., Altmann, K.-H., Reynes, N., Egli, M.
Deposit date:1996-10-10
Release date:1996-11-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of Oligodeoxyribonucleotides Containing 6'-alpha-Methyl and 6'-alpha-Hydroxy Carbocyclic Thymidines
J.Am.Chem.Soc., 119, 1997
291D
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CRYSTAL STRUCTURES OF OLIGODEOXYRIBONUCLEOTIDES CONTAINING 6'-ALPHA-METHYL AND 6'-ALPHA-HYDROXY CARBOCYCLIC THYMIDINES
Descriptor:DNA (5'-D(*CP*GP*CP*GP*AP*AP*(T48)P*(T48)P*CP*GP*CP*G)-3'), MAGNESIUM ION
Authors:Portmann, S., Altmann, K.-H., Reynes, N., Egli, M.
Deposit date:1996-10-10
Release date:1996-11-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal Structures of Oligodeoxyribonucleotides Containing 6'-alpha-Methyl and 6'-alpha-Hydroxy Carbocyclic Thymidines
J.Am.Chem.Soc., 119, 1997
2A0P
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CRYSTAL STRUCTURE OF RNA OLIGOMER CONTAINING 4'-THIORIBOSE
Descriptor:5'-R(*CP*CP*(S4C)P*CP*GP*GP*GP*G)-3'
Authors:Haeberli, P., Berger, I., Pallan, P.S., Egli, M.
Deposit date:2005-06-16
Release date:2005-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Syntheses of 4'-thioribonucleosides and thermodynamic stability and crystal structure of RNA oligomers with incorporated 4'-thiocytosine
Nucleic Acids Res., 33, 2005
2A43
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CRYSTAL STRUCTURE OF A LUTEOVIRAL RNA PSEUDOKNOT AND MODEL FOR A MINIMAL RIBOSOMAL FRAMESHIFTING MOTIF
Descriptor:RNA Pseudoknot, MAGNESIUM ION
Authors:Pallan, P.S., Marshall, W.S., Harp, J., Jewett III, F.C., Wawrzak, Z., Brown II, B.A., Rich, A., Egli, M.
Deposit date:2005-06-27
Release date:2005-09-27
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Crystal Structure of a Luteoviral RNA Pseudoknot and Model for a Minimal Ribosomal Frameshifting Motif
Biochemistry, 44, 2005
2BQ3
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DNA ADDUCT BYPASS POLYMERIZATION BY SULFOLOBUS SOLFATARICUS DPO4. ANALYSIS AND CRYSTAL STRUCTURES OF MULTIPLE BASE-PAIR SUBSTITUTION AND FRAMESHIFT PRODUCTS WITH THE ADDUCT 1,N2-ETHENOGUANINE
Descriptor:DNA POLYMERASE IV, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *TP*TP*CP*A)-3', 5'-D(*TP*CP*AP*TP*GNEP*GP*AP*AP*TP*CP*CP *TP*TP*CP*CP*CP*CP*C)-3', ...
Authors:Irimia, A., Loukachevitch, L.V., Egli, M.
Deposit date:2005-04-27
Release date:2005-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:DNA Adduct Bypass Polymerization by Sulfolobus Solfataricus DNA Polymerase Dpo4: Analysis and Crystal Structures of Multiple Base Pair Substitution and Frameshift Products with the Adduct 1,N2-Ethenoguanine.
J.Biol.Chem., 280, 2005