Author results

2ICK
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HUMAN ISOPENTENYL DIPHOPHATE ISOMERASE COMPLEXED WITH SUBSTRATE ANALOG
Descriptor:Isopentenyl-diphosphate delta isomerase, MANGANESE (II) ION, DIMETHYLALLYL DIPHOSPHATE
Authors:Zheng, W., Bartlam, M., Rao, Z.
Deposit date:2006-09-12
Release date:2007-03-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:The crystal structure of human isopentenyl diphosphate isomerase at 1.7 A resolution reveals its catalytic mechanism in isoprenoid biosynthesis
J.Mol.Biol., 366, 2007
2HU5
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BINDING OF INHIBITORS BY ACYLAMINOACYL-PEPTIDASE
Descriptor:Acylamino-acid-releasing enzyme, GLYCINE, PHENYLALANINE, ...
Authors:Kiss, A.L., Hornung, B., Radi, K., Gengeliczki, Z., Sztaray, B., Harmat, V., Polgar, L.
Deposit date:2006-07-26
Release date:2007-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Acylaminoacyl Peptidase from Aeropyrum pernix K1 Thought to Be an Exopeptidase Displays Endopeptidase Activity
J.Mol.Biol., 368, 2007
2HU7
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BINDING OF INHIBITORS BY ACYLAMINOACYL PEPTIDASE
Descriptor:Acylamino-acid-releasing enzyme, ACETYL GROUP, PHENYLALANINE, ...
Authors:Kiss, A.L., Hornung, B., Radi, K., Gengeliczki, Z., Sztaray, B., Harmat, V., Polgar, L.
Deposit date:2006-07-26
Release date:2007-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:The Acylaminoacyl Peptidase from Aeropyrum pernix K1 Thought to Be an Exopeptidase Displays Endopeptidase Activity
J.Mol.Biol., 368, 2007
2HU8
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BINDING OF INHIBITORS BY ACYLAMINOACYL PEPTIDASE
Descriptor:Acylamino-acid-releasing enzyme, 2-AMINOBENZOIC ACID, GLYCINE, ...
Authors:Kiss, A.L., Hornung, B., Radi, K., Gengeliczki, Z., Sztaray, B., Harmat, V., Polgar, L.
Deposit date:2006-07-26
Release date:2007-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Acylaminoacyl Peptidase from Aeropyrum pernix K1 Thought to Be an Exopeptidase Displays Endopeptidase Activity
J.Mol.Biol., 368, 2007
2HOB
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CRYSTAL STRUCTURE OF SARS-COV MAIN PROTEASE WITH AUTHENTIC N AND C-TERMINI IN COMPLEX WITH A MICHAEL ACCEPTOR N3
Descriptor:Replicase polyprotein 1ab, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE
Authors:Xue, X., Yang, H., Shen, W., Zhao, Q., Li, J., Rao, Z.
Deposit date:2006-07-14
Release date:2007-04-03
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Production of authentic SARS-CoV M(pro) with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction
J.Mol.Biol., 366, 2007
2H88
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AVIAN MITOCHONDRIAL RESPIRATORY COMPLEX II AT 1.8 ANGSTROM RESOLUTION
Descriptor:SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT, Succinate dehydrogenase Ip subunit, SUCCINATE DEHYDROGENASE CYTOCHROME B, ...
Authors:Huang, L.S., Shen, J.T., Wang, A.C., Berry, E.A.
Deposit date:2006-06-06
Release date:2006-06-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystallographic studies of the binding of ligands to the dicarboxylate site of Complex II, and the identity of the ligand in the
Biochim.Biophys.Acta, 1757
2H89
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AVIAN RESPIRATORY COMPLEX II WITH MALONATE BOUND
Descriptor:SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT, Succinate dehydrogenase Ip subunit, SUCCINATE DEHYDROGENASE CYTOCHROME B, ...
Authors:Huang, L.S., Shen, J.T., Wang, A.C., Berry, E.A.
Deposit date:2006-06-06
Release date:2006-06-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic studies of the binding of ligands to the dicarboxylate site of Complex II, and the identity of the ligand in the
Biochim.Biophys.Acta, 1757
2H2Z
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CRYSTAL STRUCTURE OF SARS-COV MAIN PROTEASE WITH AUTHENTIC N AND C-TERMINI
Descriptor:Replicase polyprotein 1ab
Authors:Yang, H., Xue, X., Shen, W., Zhao, Q., Rao, Z.
Deposit date:2006-05-20
Release date:2007-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Production of authentic SARS-CoV M(pro) with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction
J.Mol.Biol., 366, 2007
2GTH
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CRYSTAL STRUCTURE OF THE WILDTYPE MHV CORONAVIRUS NON-STRUCTURAL PROTEIN NSP15
Descriptor:Replicase polyprotein 1ab
Authors:Xu, X., Zhai, Y., Sun, F., Lou, Z., Su, D., Rao, Z.
Deposit date:2006-04-28
Release date:2006-08-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:New Antiviral Target Revealed by the Hexameric Structure of Mouse Hepatitis Virus Nonstructural Protein nsp15
J.Virol., 80, 2006
2GTI
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MUTATION OF MHV CORONAVIRUS NON-STRUCTURAL PROTEIN NSP15 (F307L)
Descriptor:Replicase polyprotein 1ab, SULFATE ION, GLYCEROL
Authors:Xu, X., Zhai, Y., Sun, F., Lou, Z., Su, D., Rao, Z.
Deposit date:2006-04-28
Release date:2006-08-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:New Antiviral Target Revealed by the Hexameric Structure of Mouse Hepatitis Virus Nonstructural Protein nsp15
J.Virol., 80, 2006
2GR9
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CRYSTAL STRUCTURE OF P5CR COMPLEXED WITH NADH
Descriptor:Pyrroline-5-carboxylate reductase 1, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLUTAMIC ACID
Authors:Meng, Z., Lou, Z., Liu, Z., Rao, Z.
Deposit date:2006-04-23
Release date:2006-10-03
Last modified:2013-11-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of human pyrroline-5-carboxylate reductase
J.Mol.Biol., 359, 2006
2GRA
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CRYSTAL STRUCTURE OF HUMAN PYRROLINE-5-CARBOXYLATE REDUCTASE COMPLEXED WITH NADP
Descriptor:Pyrroline-5-carboxylate reductase 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLUTAMIC ACID
Authors:Meng, Z., Lou, Z., Liu, Z., Rao, Z.
Deposit date:2006-04-23
Release date:2006-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of human pyrroline-5-carboxylate reductase
J.Mol.Biol., 359, 2006
2GNC
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CRYSTAL STRUCTURE OF SRGAP1 SH3 DOMAIN IN THE SLIT-ROBO SIGNALING PATHWAY
Descriptor:SLIT-ROBO Rho GTPase-activating protein 1
Authors:Li, X., Liu, Y., Gao, F., Bartlam, M., Wu, J.Y., Rao, Z.
Deposit date:2006-04-10
Release date:2006-07-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis of Robo Proline-rich Motif Recognition by the srGAP1 Src Homology 3 Domain in the Slit-Robo Signaling Pathway
J.Biol.Chem., 281, 2006
2GER
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CRYSTAL STRUCTURE AND OXIDATIVE MECHANISM OF HUMAN PYRROLINE-5-CARBOXYLATE REDUCTASE
Descriptor:Pyrroline-5-carboxylate reductase 1
Authors:Meng, Z., Lou, Z., Liu, Z., Rao, Z.
Deposit date:2006-03-20
Release date:2006-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of human pyrroline-5-carboxylate reductase
J.Mol.Biol., 359, 2006
2GA6
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THE CRYSTAL STRUCTURE OF SARS NSP10 WITHOUT ZINC ION AS ADDITIVE
Descriptor:orf1a polyprotein, ZINC ION
Authors:Su, D., Lou, Z., Sun, F., Zhai, Y., Yang, H., Rao, Z.
Deposit date:2006-03-08
Release date:2006-08-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Dodecamer Structure of Severe Acute Respiratory Syndrome Coronavirus Nonstructural Protein nsp10
J.Virol., 80, 2006
2G9T
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CRYSTAL STRUCTURE OF THE SARS CORONAVIRUS NSP10 AT 2.1A
Descriptor:orf1a polyprotein, ZINC ION
Authors:Su, D., Lou, Z., Yang, H., Sun, F., Rao, Z.
Deposit date:2006-03-07
Release date:2006-08-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Dodecamer Structure of Severe Acute Respiratory Syndrome Coronavirus Nonstructural Protein nsp10
J.Virol., 80, 2006
2FR7
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CRYSTAL STRUCTURE OF CYTOCHROME P450 CYP199A2
Descriptor:putative cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE
Authors:Rao, Z., Wong, L.L., Xu, F., Bell, S.G.
Deposit date:2006-01-19
Release date:2007-01-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal structure of CYP199A2, a para-substituted benzoic acid oxidizing cytochrome P450 from Rhodopseudomonas palustris
J.Mol.Biol., 383, 2008
2FBW
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AVIAN RESPIRATORY COMPLEX II WITH CARBOXIN BOUND
Descriptor:Succinate dehydrogenase flavoprotein subunit, succinate dehydrogenase Ip subunit, Succinate dehydrogenase cytochrome B, ...
Authors:Huang, L.S., Sun, G., Cobessi, D., Wang, A.C., Shen, J.T., Tung, E.Y., Anderson, V.E., Berry, E.A.
Deposit date:2005-12-10
Release date:2005-12-20
Last modified:2014-10-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme.
J.Biol.Chem., 281, 2006
2ESW
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ATOMIC STRUCTURE OF THE N-TERMINAL SH3 DOMAIN OF MOUSE BETA PIX,P21-ACTIVATED KINASE (PAK)-INTERACTING EXCHANGE FACTOR
Descriptor:Rho guanine nucleotide exchange factor 7, MERCURY (II) ION, CHLORIDE ION
Authors:Rao, Z.
Deposit date:2005-10-27
Release date:2006-04-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal structure of the N-terminal SH3 domain of mouse betaPIX, p21-activated kinase-interacting exchange factor
Biochem.Biophys.Res.Commun., 339, 2006
2D2D
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CRYSTAL STRUCTURE OF SARS-COV MPRO IN COMPLEX WITH AN INHIBITOR I2
Descriptor:3C-like proteinase, ETHYL (2E,4S)-4-[((2R)-2-{[N-(TERT-BUTOXYCARBONYL)-L-VALYL]AMINO}-2-PHENYLETHANOYL)AMINO]-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENT-2-ENOATE
Authors:Yang, H., Bartlam, M., Xue, X., Yang, K., Liang, W., Ding, Y., Rao, Z.
Deposit date:2005-09-08
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
2AMP
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CRYSTAL STRUCTURE OF PORCINE TRANSMISSIBLE GASTROENTERITIS VIRUS MPRO IN COMPLEX WITH AN INHIBITOR N1
Descriptor:3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]-L-ALANYL-L-VALYL-N~1~-((1S)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE
Authors:Yang, H., Xue, X., Yang, K., Zhao, Q., Bartlam, M., Rao, Z.
Deposit date:2005-08-10
Release date:2005-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
2AMQ
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CRYSTAL STRUCTURE OF SARS_COV MPRO IN COMPLEX WITH AN INHIBITOR N3
Descriptor:3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE
Authors:Yang, H., Xue, X., Yang, K., Zhao, Q., Bartlam, M., Rao, Z.
Deposit date:2005-08-10
Release date:2005-09-13
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
2AMD
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CRYSTAL STRUCTURE OF SARS_COV MPRO IN COMPLEX WITH AN INHIBITOR N9
Descriptor:3C-like proteinase, N-(3-FUROYL)-D-VALYL-L-VALYL-N~1~-((1R,2Z)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-D-LEUCINAMIDE
Authors:Yang, H., Xue, X., Yang, K., Zhao, Q., Bartlam, M., Rao, Z.
Deposit date:2005-08-09
Release date:2005-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
2AHM
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CRYSTAL STRUCTURE OF SARS-COV SUPER COMPLEX OF NON-STRUCTURAL PROTEINS: THE HEXADECAMER
Descriptor:Replicase polyprotein 1ab, light chain, heavy chain, ...
Authors:Zhai, Y.J., Sun, F., Bartlam, M., Rao, Z.
Deposit date:2005-07-28
Release date:2005-11-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamer
NAT.STRUCT.MOL.BIOL., 12, 2005
1ZS9
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CRYSTAL STRUCTURE OF HUMAN ENOLASE-PHOSPHATASE E1
Descriptor:E-1 ENZYME, MAGNESIUM ION
Authors:Wang, H., Pang, H., Bartlam, M., Rao, Z.
Deposit date:2005-05-23
Release date:2005-06-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of Human E1 Enzyme and its Complex with a Substrate Analog Reveals the Mechanism of its Phosphatase/Enolase
J.Mol.Biol., 348, 2005