Author results

3N5T
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STRUCTURE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 6,6'-(2,2'-(PYRIDINE-3,5-DIYL)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, ACETATE ION, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N5V
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-(3-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PHENETHYL)-6-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N5W
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6,6'-(2,2'-(PYRIDINE-3,5-DIYL)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 6,6'-(pyridine-3,5-diyldiethane-2,1-diyl)bis(4-methylpyridin-2-amine), ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N5X
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-(2-(5-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PYRIDIN-3-YL)ETHYL)-6-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 6-(2-{5-[2-(2-amino-6-methylpyridin-4-yl)ethyl]pyridin-3-yl}ethyl)-4-methylpyridin-2-amine, ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N5Y
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6,6'-(2,2'-(PYRIDINE-2,6-DIYL)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N5Z
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-(2-(6-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PYRIDIN-2-YL)ETHYL)-6-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N60
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6,6'-(2,2'-(5-AMINO-1,3-PHENYLENE)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 6,6'-[(5-aminobenzene-1,3-diyl)diethane-2,1-diyl]bis(4-methylpyridin-2-amine), ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N61
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE D597N/M336V MUTANT HEME DOMAIN IN COMPLEX WITH 6,6'-(2,2'-(PYRIDINE-3,5-DIYL)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 6,6'-(pyridine-3,5-diyldiethane-2,1-diyl)bis(4-methylpyridin-2-amine), ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N62
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE D597N MUTANT HEME DOMAIN IN COMPLEX WITH 6,6'-(2,2'-(PYRIDINE-3,5-DIYL)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 6,6'-(pyridine-3,5-diyldiethane-2,1-diyl)bis(4-methylpyridin-2-amine), ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N63
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE D597N/M336V MUTANT HEME DOMAIN IN COMPLEX WITH 6,6'-(2,2'-(5-AMINO-1,3-PHENYLENE)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 6,6'-[(5-aminobenzene-1,3-diyl)diethane-2,1-diyl]bis(4-methylpyridin-2-amine), ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N64
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE D597N MUTANT HEME DOMAIN IN COMPLEX WITH 6,6'-(2,2'-(5-AMINO-1,3-PHENYLENE)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 6,6'-[(5-aminobenzene-1,3-diyl)diethane-2,1-diyl]bis(4-methylpyridin-2-amine), ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N65
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE S602H MUTANT HEME DOMAIN IN COMPLEX WITH 6,6'-(2,2'-(PYRIDINE-3,5-DIYL)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N66
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE S602H MUTANT HEME DOMAIN IN COMPLEX WITH 6,6'-(2,2'-(5-AMINO-1,3-PHENYLENE)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 6,6'-[(5-aminobenzene-1,3-diyl)diethane-2,1-diyl]bis(4-methylpyridin-2-amine), ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N67
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STRUCTURE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE N368D/V106M DOUBLE MUTANT HEME DOMAIN COMPLEXED WITH 6,6'-(2,2'-(5-AMINO-1,3-PHENYLENE)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, ACETATE ION, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N68
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STRUCTURE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN N368D/V106M DOUBLE MUTANT COMPLEXED WITH 4-(3-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PHENETHYL)-6-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N69
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STRUCTURE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE N368D/V106M DOUBLE MUTANT HEME DOMAIN COMPLEXED WITH 6,6'-(2,2'-(PYRIDINE-3,5-DIYL)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, ACETATE ION, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N6A
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STRUCTURE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE N368D/V106M DOUBLE MUTANT HEME DOMAIN COMPLEXED WITH 4-(2-(5-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PYRIDIN-3-YL)ETHYL)-6-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, ACETATE ION, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N6B
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STRUCTURE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE H373S SINGLE MUTANT HEME DOMAIN COMPLEXED WITH 6,6'-(2,2'-(PYRIDINE-3,5-DIYL)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N6C
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STRUCTURE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE H373S SINGLE MUTANT HEME DOMAIN COMPLEXED WITH 4-(2-(6-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PYRIDIN-2-YL)ETHYL)-6-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (3.06 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N6D
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STRUCTURE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE H373S SINGLE MUTANT HEME DOMAIN COMPLEXED WITH 6,6'-(2,2'-(5-AMINO-1,3-PHENYLENE)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N6E
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STRUCTURE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE N368D MUTANT HEME DOMAIN COMPLEXED WITH 6,6'-(2,2'-(5-AMINO-1,3-PHENYLENE)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, ACETATE ION, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N6F
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STRUCTURE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE N368D SINGLE MUTANT HEME DOMAIN COMPLEXED WITH 6,6'-(2,2'-(PYRIDINE-3,5-DIYL)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:'Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, ACETATE ION, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N6G
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STRUCTURE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE N368D SINGLE MUTANT HEME DOMAIN COMPLEXED WITH 4-(2-(5-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PYRIDIN-3-YL)ETHYL)-6-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, ACETATE ION, ...
Authors:Delker, S.L., Li, H., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3RQJ
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STRUCTURE OF THE NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-(((3R,4R)-4-(2-((1S,2R)-2-(3-FLUOROPHENYL)CYCLOPROPYLAMINO)ETHOXY)PYRROLIDIN-3-YL)METHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2011-04-28
Release date:2012-05-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase.
Bioorg.Med.Chem., 21, 2013
3RQK
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STRUCTURE OF THE NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-{[(3R,4R)-4-(2-{[(1R,2S)-2-(3-METHYLPHENYL)CYCLOPROPYL]AMINO}ETHOXY)PYRROLIDIN-3-YL]METHYL}PYRIDIN-2-AMINE AND ITS ISOMER
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2011-04-28
Release date:2012-05-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase.
Bioorg.Med.Chem., 21, 2013