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6DJ6
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THE X-RAY CRYSTAL STRUCTURE OF THE STREPTOCOCCUS PNEUMONIAE FATTY ACID KINASE (FAK) B2 PROTEIN LOADED WITH CIS-OLEIC ACID TO 1.9 ANGSTROM RESOLUTION
Descriptor:Fatty Acid Kinase (Fak) B2 protein (SPR1019), GLYCEROL, OLEIC ACID, ...
Authors:Cuypers, M.G., Subramanian, C., White, S.W., Rock, C.O.
Deposit date:2018-05-24
Release date:2019-05-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The X-ray crystal structure of the Streptococcus pneumoniae Fatty Acid Kinase (Fak) B2 protein (SPR1019) loaded with cis-oleic acid to 1.9 Angstrom resolution
To Be Published
6DKE
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THE X-RAY CRYSTAL STRUCTURE OF STREPTOCOCCUS PNEUMONIAE FATTY ACID KINASE (FAK) B1 PROTEIN LOADED WITH PALMITIC ACID (C16:0) TO 1.76 ANGSTROM RESOLUTION
Descriptor:Fatty Acid Kinase (Fak) B1 protein, PALMITIC ACID
Authors:Cuypers, M.G., Subramanian, C., White, S.W., Rock, C.O.
Deposit date:2018-05-29
Release date:2019-05-29
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:The X-ray crystal structure of Streptococcus pneumoniae Fatty Acid Kinase (Fak) B1 protein loaded with palmitic acid (C16:0) to 1.76 Angstrom resolution
To Be Published
1JYK
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CATALYTIC MECHANISM OF CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE FROM STREPTOCOCCUS PNEUMONIAE (LICC)
Descriptor:CTP:phosphocholine Cytidylyltransferase
Authors:Kwak, B.-Y., Yun, M., Park, H.-w.
Deposit date:2001-09-12
Release date:2002-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure and mechanism of CTP:phosphocholine cytidylyltransferase (LicC) from Streptococcus pneumoniae.
J.Biol.Chem., 277, 2002
1JYL
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CATALYTIC MECHANISM OF CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE FROM STREPTOCOCCUS PNEUMONIAE (LICC)
Descriptor:CTP:phosphocholine Cytidylyltransferase, MAGNESIUM ION, [2-CYTIDYLATE-O'-PHOSPHONYLOXYL]-ETHYL-TRIMETHYL-AMMONIUM
Authors:Kwak, B.-Y., Yun, M., Park, H.-w.
Deposit date:2001-09-12
Release date:2002-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure and mechanism of CTP:phosphocholine cytidylyltransferase (LicC) from Streptococcus pneumoniae.
J.Biol.Chem., 277, 2002
2AQ7
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STRUCTURE-ACTIVITY RELATIONSHIPS AT THE 5-POSIITON OF THIOLACTOMYCIN: AN INTACT 5(R)-ISOPRENE UNIT IS REQUIRED FOR ACTIVITY AGAINST THE CONDENSING ENZYMES FROM MYCOBACTERIUM TUBERCULOSIS AND ESCHERICHIA COLI
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase I, (5R)-4-HYDROXY-3,5-DIMETHYL-5-[(1E,3E)-2-METHYLPENTA-1,3-DIENYL]THIOPHEN-2(5H)-ONE
Authors:Kim, P., Zhang, Y.M., Shenoy, G., Nguyen, Q.A., Boshoff, H.I., Manjunatha, U.H., Goodwin, M.B., Lonsdale, J., Price, A.C., Miller, D.J.
Deposit date:2005-08-17
Release date:2006-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli
J.Med.Chem., 49, 2006
2AQB
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STRUCTURE-ACTIVITY RELATIONSHIPS AT THE 5-POSITION OF THIOLACTOMYCIN: AN INTACT 5(R)-ISOPRENE UNIT IS REQUIRED FOR ACTIVITY AGAINST THE CONDENSING ENZYMES FROM MYCOBACTERIUM TUBERCULOSIS AND ESCHERCHIA COLI
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase I, (5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE
Authors:Kim, P., Zhang, Y.M., Shenoy, G., Nguyen, Q.A., Boshoff, H.I., Manjunatha, U.H., Goodwin, M.B., Lonsdale, J., Price, A.C., Miller, D.J.
Deposit date:2005-08-17
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli
J.Med.Chem., 49, 2006
2B4Q
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PSEUDOMONAS AERUGINOSA RHLG/NADP ACTIVE-SITE COMPLEX
Descriptor:Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Miller, D.J., White, S.W.
Deposit date:2005-09-26
Release date:2006-05-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of RhlG, an Essential beta-Ketoacyl Reductase in the Rhamnolipid Biosynthetic Pathway of Pseudomonas aeruginosa.
J.Biol.Chem., 281, 2006
2EWS
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CRYSTAL STRUCTURE OF S.AUREUS PANTOTHENATE KINASE
Descriptor:Pantothenate kinase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Hong, B.S., Park, H.W., Structural Genomics Consortium (SGC)
Deposit date:2005-11-06
Release date:2006-09-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Prokaryotic Type II and Type III Pantothenate Kinases: The Same Monomer Fold Creates Dimers with Distinct Catalytic Properties.
Structure, 14, 2006
2I7N
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CRYSTAL STRUCTURE OF HUMAN PANK1 ALPHA: THE CATALYTIC CORE DOMAIN IN COMPLEX WITH ACCOA
Descriptor:Pantothenate kinase 1, ACETYL COENZYME *A
Authors:Hong, B.S., Wang, L., Tempel, W., Loppnau, P., Allali-Hassani, A., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H.W.
Deposit date:2006-08-31
Release date:2006-12-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.
J.Biol.Chem., 282, 2007
2I7P
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CRYSTAL STRUCTURE OF HUMAN PANK3 IN COMPLEX WITH ACCOA
Descriptor:Pantothenate kinase 3, ACETYL COENZYME *A
Authors:Hong, B.S., Wang, L., Shen, L., Tempel, W., Loppnau, P., Finerty, P., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H.W., Structural Genomics Consortium (SGC)
Deposit date:2006-08-31
Release date:2006-12-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.
J.Biol.Chem., 282, 2007
2K92
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STRUCTURAL MODIFICATION OF ACYL CARRIER PROTEIN BY BUTYRYL GROUP
Descriptor:Acyl carrier protein
Authors:Wu, B.N.
Deposit date:2008-09-29
Release date:2009-01-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural modification of acyl carrier protein by butyryl group.
Protein Sci., 18, 2009
2K93
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STRUCTURAL MODIFICATION OF ACYL CARRIER PROTEIN BY BUTYRYL GROUP
Descriptor:Acyl carrier protein
Authors:Wu, B.N.
Deposit date:2008-09-29
Release date:2009-01-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural modification of acyl carrier protein by butyryl group.
Protein Sci., 18, 2009
2K94
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STRUCTURAL MODIFICATION OF ACYL CARRIER PROTEIN BY BUTYRYL GROUP
Descriptor:Acyl carrier protein
Authors:Wu, B.N.
Deposit date:2008-09-29
Release date:2009-01-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural modification of acyl carrier protein by butyryl group.
Protein Sci., 18, 2009
3LSJ
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CRYSTAL STRUCTURE OF DEST IN COMPLEX WITH PALMITOYL-COA
Descriptor:DesT, PALMITIC ACID, COENZYME A
Authors:Miller, D.J., White, S.W.
Deposit date:2010-02-12
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the transcriptional regulation of membrane lipid homeostasis.
Nat.Struct.Mol.Biol., 17, 2010
3LSP
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CRYSTAL STRUCTURE OF DEST BOUND TO DESCB PROMOTER AND OLEOYL-COA
Descriptor:DesT, DNA (5'-D(*TP*TP*AP*CP*AP*TP*CP*AP*GP*TP*GP*AP*AP*CP*GP*CP*TP*TP*GP*TP*TP*GP*AP*CP*TP*CP*GP*AP*TP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*AP*TP*CP*GP*AP*GP*TP*CP*AP*AP*CP*AP*AP*GP*CP*GP*TP*TP*CP*AP*CP*TP*GP*AP*TP*GP*TP*A)-3'), ...
Authors:Miller, D.J., White, S.W.
Deposit date:2010-02-12
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Structural basis for the transcriptional regulation of membrane lipid homeostasis.
Nat.Struct.Mol.Biol., 17, 2010
3LSR
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CRYSTAL STRUCTURE OF DEST IN COMPLEX WITH DUPLEX DNA
Descriptor:DesT, DNA (27-MER), SULFATE ION
Authors:Miller, D.J., White, S.W.
Deposit date:2010-02-12
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural basis for the transcriptional regulation of membrane lipid homeostasis.
Nat.Struct.Mol.Biol., 17, 2010
3MK6
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SUBSTRATE AND INHIBITOR BINDING TO PANK
Descriptor:Pantothenate kinase 3, ACETYL COENZYME *A, GLYCEROL
Authors:Yun, M.-K., White, S.W.
Deposit date:2010-04-14
Release date:2010-09-15
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Modulation of Pantothenate Kinase 3 Activity by Small Molecules that Interact with the Substrate/Allosteric Regulatory Domain.
Chem.Biol., 17, 2010
5KPR
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PANK3-AMPPNP-PANTOTHENATE COMPLEX
Descriptor:Pantothenate kinase 3, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:White, S.W., Yun, M.
Deposit date:2016-07-05
Release date:2016-08-31
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (1.827 Å)
Cite:Allosteric Regulation of Mammalian Pantothenate Kinase.
J.Biol.Chem., 291, 2016
5KPT
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PANK3-AMPPNP COMPLEX
Descriptor:Pantothenate kinase 3, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:White, S.W., Yun, M.
Deposit date:2016-07-05
Release date:2016-08-31
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Allosteric Regulation of Mammalian Pantothenate Kinase.
J.Biol.Chem., 291, 2016
5KPZ
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PANK3-ADP-PHOSPHOPANTOTHENATE COMPLEX
Descriptor:Pantothenate kinase 3, N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanine, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:White, S.W., Yun, M.
Deposit date:2016-07-05
Release date:2016-08-31
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Allosteric Regulation of Mammalian Pantothenate Kinase.
J.Biol.Chem., 291, 2016
5KQ8
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PANK3-AMPPN COMPLEX
Descriptor:Pantothenate kinase 3, AMP PHOSPHORAMIDATE, MAGNESIUM ION, ...
Authors:White, S.W., Yun, M.
Deposit date:2016-07-05
Release date:2016-08-31
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Allosteric Regulation of Mammalian Pantothenate Kinase.
J.Biol.Chem., 291, 2016
5KQD
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PANK3:PALMITOYL-COA COMPLEX
Descriptor:Pantothenate kinase 3, Palmitoyl-CoA, SULFATE ION
Authors:White, S.W., Yun, M.
Deposit date:2016-07-06
Release date:2016-08-31
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Allosteric Regulation of Mammalian Pantothenate Kinase.
J.Biol.Chem., 291, 2016
6B3V
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PANK3 COMPLEX WITH COMPOUND PZ-2891
Descriptor:Pantothenate kinase 3, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:White, S.W., Yun, M.
Deposit date:2017-09-25
Release date:2018-08-29
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:A therapeutic approach to pantothenate kinase associated neurodegeneration.
Nat Commun, 9, 2018
6CLU
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STAPHYLOCOCCUS AUREUS DIHYDROPTEROATE SYNTHASE (SADHPS) F17L E208K DOUBLE MUTANT STRUCTURE
Descriptor:Dihydropteroate synthase
Authors:Gajewski, S., Griffith, E.C., Wu, Y., White, S.W.
Deposit date:2018-03-02
Release date:2018-08-22
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations inStaphylococcus aureusDihydropteroate Synthase.
Front Microbiol, 9, 2018
6CLV
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STAPHYLOCOCCUS AUREUS DIHYDROPTEROATE SYNTHASE (SADHPS) F17L E208K DOUBLE MUTANT STRUCTURE
Descriptor:Dihydropteroate synthase, 4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzene-1-sulfonamide
Authors:Gajewski, S., Griffith, E.C., Wu, Y., White, S.W.
Deposit date:2018-03-02
Release date:2018-08-22
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations inStaphylococcus aureusDihydropteroate Synthase.
Front Microbiol, 9, 2018
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