Author results

2J7B
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BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH GLUCO- TETRAZOLE
分子名称:BETA-GLUCOSIDASE A, NOJIRIMYCINE TETRAZOLE, ACETATE ION, ...
著者Gloster, T.M., Zechel, D., Vasella, A., Davies, G.J.
登録日2006-10-06
公開日2006-10-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Glycosidase Inhibition: An Assessment of the Binding of 18 Putative Transition-State Mimics.
J.Am.Chem.Soc., 129, 2007
2J7C
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BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH PHENYLAMINOMETHYL-DERIVED GLUCOIMIDAZOLE
分子名称:BETA-GLUCOSIDASE A, (5R,6R,7S,8S)-3-(ANILINOMETHYL)-5,6,7,8-TETRAHYDRO-5-(HYDROXYMETHYL)-IMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL, ACETATE ION, ...
著者Gloster, T.M., Zechel, D., Vasella, A., Davies, G.J.
登録日2006-10-06
公開日2006-10-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Glycosidase Inhibition: An Assessment of the Binding of 18 Putative Transition-State Mimics.
J.Am.Chem.Soc., 129, 2007
2J7D
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BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH METHOXYCARBONYL-SUBSTITUTED GLUCOIMIDAZOLE
分子名称:BETA-GLUCOSIDASE A, METHOXYCARBONYL-SUBSTITUTED GLUCOIMIDAZOLE, ACETATE ION, ...
著者Gloster, T.M., Zechel, D., Vasella, A., Davies, G.J.
登録日2006-10-06
公開日2006-10-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Glycosidase Inhibition: An Assessment of the Binding of 18 Putative Transition-State Mimics.
J.Am.Chem.Soc., 129, 2007
2J7E
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BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH METHYL ACETATE-SUBSTITUTED GLUCOIMIDAZOLE
分子名称:BETA-GLUCOSIDASE A, METHYL ACETATE-SUBSTITUTED GLUCOIMIDAZOLE, ACETATE ION, ...
著者Gloster, T.M., Zechel, D., Vasella, A., Davies, G.J.
登録日2006-10-07
公開日2006-10-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Glycosidase Inhibition: An Assessment of the Binding of 18 Putative Transition-State Mimics.
J.Am.Chem.Soc., 129, 2007
2J7F
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BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH CARBOXYLATE- SUBSTITUTED GLUCOIMIDAZOLE
分子名称:BETA-GLUCOSIDASE A, CARBOXYLATE-SUBSTITUTED GLUCOIMIDAZOLE, ACETATE ION, ...
著者Gloster, T.M., Zechel, D., Vasella, A., Davies, G.J.
登録日2006-10-07
公開日2006-10-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Glycosidase Inhibition: An Assessment of the Binding of 18 Putative Transition-State Mimics.
J.Am.Chem.Soc., 129, 2007
2J7G
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BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH METHYL ACETIC ACID-SUBSTITUTED GLUCOIMIDAZOLE
分子名称:BETA-GLUCOSIDASE A, METHYL ACETIC ACID-SUBSTITUTED GLUCOIMIDAZOLE, ACETATE ION, ...
著者Gloster, T.M., Zechel, D., Vasella, A., Davies, G.J.
登録日2006-10-07
公開日2006-10-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Glycosidase Inhibition: An Assessment of the Binding of 18 Putative Transition-State Mimics.
J.Am.Chem.Soc., 129, 2007
2VJX
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STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES
分子名称:BETA-MANNOSIDASE, (3S,4R,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)PIPERIDIN-2-ONE, 1,2-ETHANEDIOL, ...
著者Tailford, L.E., Offen, W.A., Smith, N.L., Dumon, C., Moreland, C., Gratien, J., Heck, M.P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
登録日2007-12-14
公開日2008-04-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
2VL4
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STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES
分子名称:BETA-MANNOSIDASE, (2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-HYDROXYMETHYL-PIPERIDINE, 1,2-ETHANEDIOL, ...
著者Tailford, L.E., Offen, W.A., Smith, N.L., Dumon, C., Moreland, C., Gratien, J., Heck, M.P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
登録日2008-01-08
公開日2008-04-01
最終更新日2019-10-16
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
2VMF
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STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES
分子名称:BETA-MANNOSIDASE, (5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL, 1,2-ETHANEDIOL, ...
著者Tailford, L.E., Offen, W.A., Smith, N.L., Dumon, C., Moreland, C., Gratien, J., Heck, M.P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
登録日2008-01-25
公開日2008-04-01
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
2VO5
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STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES
分子名称:BETA-MANNOSIDASE, (1R,4R,5R,7R,8R)-2-Benzyl-5-hydroxymethyl-2-aza-bicyclo[2.2.2]octane-4,7,8-triol, 1,2-ETHANEDIOL, ...
著者Tailford, L.E., Offen, W.A., Smith, N.L., Dumon, C., Moreland, C., Gratien, J., Heck, M.P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
登録日2008-02-08
公開日2008-04-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
2VOT
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STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES
分子名称:BETA-MANNOSIDASE, (5R,6R,7S,8R)-6,7,8-trihydroxy-5-(hydroxymethyl)-2-[(phenylamino)methyl]-5,6,7,8-tetrahydro-1H-imidazo[1,2-a]pyridin-4-ium, 1,2-ETHANEDIOL, ...
著者Tailford, L.N., Offen, W.A., Smith, N., Dumon, C., Moreland, C., Gratien, J., Heck, M.-P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
登録日2008-02-20
公開日2008-04-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
2VQT
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STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES
分子名称:BETA-MANNOSIDASE, (2Z,3R,4S,5R,6R)-2-[(2-aminoethyl)imino]-6-(hydroxymethyl)piperidine-3,4,5-triol, 1,2-ETHANEDIOL, ...
著者Tailford, L.E., Offen, W.A., Smith, N.L., Dumon, C., Moreland, C., Gratien, J., Heck, M.P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
登録日2008-03-18
公開日2008-04-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
2VQU
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STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES
分子名称:BETA-MANNOSIDASE, 1,2-ETHANEDIOL, (2R,3S,4R,5R)-5-(HYDROXYMETHYL)PIPERIDINE-2,3,4-TRIOL, ...
著者Tailford, L.E., Offen, W.A., Smith, N.L., Dumon, C., Moreland, C., Gratien, J., Heck, M.P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
登録日2008-03-18
公開日2008-04-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
2VR4
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TRANSITION-STATE MIMICRY IN MANNOSIDE HYDROLYSIS: CHARACTERISATION OF TWENTY SIX INHIBITORS AND INSIGHT INTO BINDING FROM LINEAR FREE ENERGY RELATIONSHIPS AND 3-D STRUCTURE
分子名称:BETA-MANNOSIDASE, (2Z,3R,4S,5R,6R)-2-[(4-aminobutyl)imino]-6-(hydroxymethyl)piperidine-3,4,5-triol, 1,2-ETHANEDIOL, ...
著者Tailford, L.E., Offen, W.A., Smith, N.L., Dumon, C., Moreland, C., Gratien, J., Heck, M.P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
登録日2008-03-25
公開日2008-04-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
4AQY
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STRUCTURE OF RIBOSOME-APRAMYCIN COMPLEXES
分子名称:16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ...
著者Matt, T., Ng, C.L., Lang, K., Sha, S.H., Akbergenov, R., Shcherbakov, D., Meyer, M., Duscha, S., Xie, J., Dubbaka, S.R., Perez-Fernandez, D., Vasella, A., Ramakrishnan, V., Schacht, J., Bottger, E.C.
登録日2012-04-20
公開日2012-07-18
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Dissociation of Antibacterial Activity and Aminoglycoside Ototoxicity in the 4-Monosubstituted 2-Deoxystreptamine Apramycin.
Proc.Natl.Acad.Sci.USA, 109, 2012
4B3M
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CRYSTAL STRUCTURE OF THE 30S RIBOSOME IN COMPLEX WITH COMPOUND 1
分子名称:16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ...
著者Ng, C.L., Lang, K., Shcherbakov, D., Matt, T., Perez-Fernandez, D., Patak, R., Meyer, M., Duscha, S., Akbergenov, R., Boukari, H., Freihofer, P., Kudyba, I., Reddy, M.S.K., Nandurikar, R.S., Ramakrishnan, V., Vasella, A., Bottger, E.C.
登録日2012-07-25
公開日2013-08-07
最終更新日2019-03-06
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献4'-O-Substitutions Determine Selectivity of Aminoglycoside Antibiotics
Nat.Commun., 5, 2014
4B3R
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CRYSTAL STRUCTURE OF THE 30S RIBOSOME IN COMPLEX WITH COMPOUND 30
分子名称:16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ...
著者Ng, C.L., Lang, K., Shcherbakov, D., Matt, T., Perez-Fernandez, D., Patak, R., Meyer, M., Duscha, S., Akbergenov, R., Boukari, H., Freihofer, P., Kudyba, I., Reddy, M.S.K., Nandurikar, R.S., Ramakrishnan, V., Vasella, A., Bottger, E.C.
登録日2012-07-26
公開日2013-08-07
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献4'-O-Substitutions Determine Selectivity of Aminoglycoside Antibiotics
Nat.Commun., 5, 2014
4B3S
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CRYSTAL STRUCTURE OF THE 30S RIBOSOME IN COMPLEX WITH COMPOUND 37
分子名称:16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ...
著者Ng, C.L., Lang, K., Shcherbakov, D., Matt, T., Perez-Fernandez, D., Patak, R., Meyer, M., Duscha, S., Akbergenov, R., Boukari, H., Freihofer, P., Kudyba, I., Reddy, M.S.K., Nandurikar, R.S., Ramakrishnan, V., Vasella, A., Bottger, E.C.
登録日2012-07-26
公開日2013-08-07
最終更新日2019-03-06
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献4'-O-Substitutions Determine Selectivity of Aminoglycoside Antibiotics
Nat.Commun., 5, 2014
4B3T
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CRYSTAL STRUCTURE OF THE 30S RIBOSOME IN COMPLEX WITH COMPOUND 39
分子名称:16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ...
著者Ng, C.L., Lang, K., Shcherbakov, D., Matt, T., Perez-Fernandez, D., Patak, R., Meyer, M., Duscha, S., Akbergenov, R., Boukari, H., Freihofer, P., Kudyba, I., Reddy, M.S.K., Nandurikar, R.S., Ramakrishnan, V., Vasella, A., Bottger, E.C.
登録日2012-07-26
公開日2013-08-07
最終更新日2019-03-06
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献4'-O-Substitutions Determine Selectivity of Aminoglycoside Antibiotics
Nat.Commun., 5, 2014
6O97
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PROPYLAMYCIN AND BOUND TO MRNA AND A-, P-, AND E-SITE TRNAS AT 2.75A RESOLUTION
分子名称:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
著者Matsushita, T., Sati, G.C., Kondasinghe, N., Pirrone, M.G., Kato, T., Waduge, P., Kumar, H.S., Sanchon, A.C., Dobosz-Bartoszek, M., Shcherbakov, D., Juhas, M., Hobbie, S.N., Schrepfer, T., Chow, C.S., Polikanov, Y.S., Schacht, J., Vasella, A., Bottger, E.C., Crich, D.
登録日2019-03-13
公開日2019-04-17
最終更新日2019-04-24
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens.
J. Am. Chem. Soc., 141, 2019
1DIL
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SIALIDASE FROM SALMONELLA TYPHIMURIUM COMPLEXED WITH APANA AND EPANA INHIBITORS
分子名称:SIALIDASE, (4-ACETAMIDO-2,4-DIDEOXY-D-GLYCERO-ALPHA-D-GALACTO-1-OCTOPYRANOSYL)PHOSPHONIC ACID, 4-ACETAMIDO-2,4-DIDEXOY-D-GLYCERO-BETA-D-GALACTO-OCTOPYRANOSYLPHOSPHONIC ACID (AN AXIAL PHOSPHONATE), ...
著者Garman, E.F., Crennell, S.C., Vimr, E.R., Laver, W.G., Taylor, G.L.
登録日1996-04-23
公開日1996-12-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The structures of Salmonella typhimurium LT2 neuraminidase and its complexes with three inhibitors at high resolution.
J.Mol.Biol., 259, 1996
1DIM
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SIALIDASE FROM SALMONELLA TYPHIMURIUM COMPLEXED WITH EPANA INHIBITOR
分子名称:SIALIDASE, POTASSIUM ION, (4-ACETAMIDO-2,4-DIDEOXY-D-GLYCERO-ALPHA-D-GALACTO-1-OCTOPYRANOSYL)PHOSPHONIC ACID
著者Garman, E.F., Crennell, S.C., Vimr, E.R., Laver, W.G., Taylor, G.L.
登録日1996-04-23
公開日1996-12-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The structures of Salmonella typhimurium LT2 neuraminidase and its complexes with three inhibitors at high resolution.
J.Mol.Biol., 259, 1996
1AXR
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COOPERATIVITY BETWEEN HYDROGEN-BONDING AND CHARGE-DIPOLE INTERACTIONS IN THE INHIBITION OF BETA-GLYCOSIDASES BY AZOLOPYRIDINES: EVIDENCE FROM A STUDY WITH GLYCOGEN PHOSPHORYLASE B
分子名称:GLYCOGEN PHOSPHORYLASE, PHOSPHATE ION, PYRIDOXAL-5'-PHOSPHATE, ...
著者Oikonomakos, N.G., Heightman, T.D.
登録日1997-10-20
公開日1998-01-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Cooperative interactions of the catalytic nucleophile and the catalytic acid in the inhibition of beta-glycosidases. Calculations and their validation by comparative kinetic and structural studies of the inhibition of glycogen phosphorylase b.
HELV.CHIM.ACTA, 81, 1998
1HF6
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ENDOGLUCANASE CEL5A FROM BACILLUS AGARADHAERENS IN THE ORTHORHOMBIC CRYSTAL FORM IN COMPLEX WITH CELLOTRIOSE
分子名称:ENDOGLUCANASE B, CELLOTRIOSE, SULFATE ION, ...
著者Varrot, A., Withers, S., Vasella, A., Schulein, M., Davies, G.J.
登録日2000-11-29
公開日2001-11-29
最終更新日2019-07-24
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Direct Experimental Observation of the Hydrogen-Bonding Network of a Glycosidase Along its Reaction Coordinate Revealed by Atomic Resolution Analyses of Endoglucanase Cel5A
Acta Crystallogr.,Sect.D, 59, 2003
1V02
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CRYSTAL STRUCTURE OF THE SORGHUM BICOLOR DHURRINASE 1
分子名称:DHURRINASE
著者Moriniere, J., Verdoucq, L., Bevan, D.R., Esen, A., Henrissat, B., Czjzek, M.
登録日2004-03-22
公開日2004-05-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Determinants of Substrate Specificity in Family 1 Beta-Glucosidases: Novel Insights from the Crystal Structure of Sorghum Dhurrinase-1, a Plant Beta-Glucosidase with Strict Specificity, in Complex with its Natural Substrate
J.Biol.Chem., 279, 2004