1DGZ
 
 | | RIBOSMAL PROTEIN L36 FROM THERMUS THERMOPHILUS: NMR STRUCTURE ENSEMBLE | | Descriptor: | PROTEIN (L36 RIBOSOMAL PROTEIN), ZINC ION | | Authors: | Hard, T, Rak, A, Allard, P, Kloo, L, Garber, M. | | Deposit date: | 1999-11-27 | | Release date: | 1999-12-08 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | The solution structure of ribosomal protein L36 from Thermus thermophilus reveals a zinc-ribbon-like fold.
J.Mol.Biol., 296, 2000
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1DFE
 | | NMR STRUCTURE OF RIBOSOMAL PROTEIN L36 FROM THERMUS THERMOPHILUS | | Descriptor: | L36 RIBOSOMAL PROTEIN, ZINC ION | | Authors: | Hard, T, Rak, A, Allard, P, Kloo, L, Garber, M. | | Deposit date: | 1999-11-19 | | Release date: | 1999-12-01 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | The solution structure of ribosomal protein L36 from Thermus thermophilus reveals a zinc-ribbon-like fold.
J.Mol.Biol., 296, 2000
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1UTR
 | | UTEROGLOBIN-PCB COMPLEX (REDUCED FORM) | | Descriptor: | 4,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYL, UTEROGLOBIN | | Authors: | Hard, T, Barnes, H.J, Larsson, C, Gustafsson, J.-A, Lund, J. | | Deposit date: | 1995-09-01 | | Release date: | 1995-12-07 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Solution structure of a mammalian PCB-binding protein in complex with a PCB.
Nat.Struct.Biol., 2, 1995
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2M5A
 | | Protein A binding by an engineered Affibody molecule | | Descriptor: | Immunoglobulin G-binding protein A, ZpA963 | | Authors: | Hard, T. | | Deposit date: | 2013-02-19 | | Release date: | 2013-08-21 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | High-affinity binding to staphylococcal protein A by an engineered dimeric Affibody molecule.
Protein Eng.Des.Sel., 26, 2013
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2KZJ
 | | Solution structure of the ZHER2 Affibody (alternative) | | Descriptor: | Engineered protein, ZHER2 Affibody | | Authors: | Hard, T. | | Deposit date: | 2010-06-18 | | Release date: | 2010-08-04 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structural basis for high-affinity HER2 receptor binding by an engineered protein.
Proc.Natl.Acad.Sci.USA, 107, 2010
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2KZI
 | | Solution structure of the ZHER2 Affibody | | Descriptor: | Engineered protein, ZHER2 Affibody | | Authors: | Hard, T. | | Deposit date: | 2010-06-18 | | Release date: | 2010-08-04 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structural basis for high-affinity HER2 receptor binding by an engineered protein.
Proc.Natl.Acad.Sci.USA, 107, 2010
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7NI3
 | | CRYSTAL STRUCTURE OF NATIVE HUMAN MYELOPEROXIDASE IN COMPLEX WITH CPD 3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-sulfanylidene-3-[(2R)-tetrahydro-2-furanylmethyl]-1,2,3,7-tetrahydro-6H-purin-6-one, CALCIUM ION, ... | | Authors: | Sjogren, T, Inghardt, T. | | Deposit date: | 2021-02-11 | | Release date: | 2022-02-23 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction.
J.Med.Chem., 65, 2022
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7NI1
 | | CRYSTAL STRUCTURE OF NATIVE HUMAN MYELOPEROXIDASE IN COMPLEX WITH CPD 9 | | Descriptor: | (S)-1-(2-(amino(phenyl)methyl)benzyl)-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Sjogren, T, Inghardt, T. | | Deposit date: | 2021-02-11 | | Release date: | 2022-02-23 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction.
J.Med.Chem., 65, 2022
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2X39
 | | Structure of 4-Amino-N-(4-chlorobenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin- 4-yl)piperidine-4-carboxamide bound to PKB | | Descriptor: | 4-AMINO-N-(4-CHLOROBENZYL)-1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDINE-4-CARBOXAMIDE, GLYCOGEN SYNTHASE KINASE-3 BETA, RAC-BETA SERINE/THREONINE-PROTEIN KINASE | | Authors: | Davies, T.G, McHardy, T, Caldwell, J.J, Cheung, K.M, Hunter, L.J, Taylor, K, Rowlands, M, Ruddle, R, Henley, A, Brandon, A.D, Valenti, M, Fazal, L, Seavers, L, Raynaud, F.I, Eccles, S.A, Aherne, G.W, Garrett, M.D, Collins, I. | | Deposit date: | 2010-01-22 | | Release date: | 2010-02-23 | | Last modified: | 2011-09-21 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Discovery of 4-Amino-1-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Piperidine-4-Carboxamides as Selective, Orally Active Inhibitors of Protein Kinase B (Akt).
J.Med.Chem., 53, 2010
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2M9S
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2M9R
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2XH5
 | | Structure of 4-(4-tert-Butylbenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4- yl)piperidin-4-amine bound to PKB | | Descriptor: | 4-(4-tert-butylbenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium, GLYCOGEN SYNTHASE KINASE-3 BETA, RAC-BETA SERINE/THREONINE-PROTEIN KINASE | | Authors: | Davies, T.G, McHardy, T, Caldwell, J.J, Cheung, K.M, Hunter, L.J, Taylor, K, Rowlands, M, Ruddle, R, Henley, A, Brandon, A.D, Valenti, M, Fazal, L, Seavers, L, Raynaud, F.I, Eccles, S.A, Aherne, G.W, Garrett, M.D, Collins, I. | | Deposit date: | 2010-06-09 | | Release date: | 2010-06-16 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.72 Å) | | Cite: | Discovery of 4-Amino-1-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Piperidine-4-Carboxamides as Selective, Orally Active Inhibitors of Protein Kinase B (Akt).
J.Med.Chem., 53, 2010
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1BBX
 | | NON-SPECIFIC PROTEIN-DNA INTERACTIONS IN THE SSO7D-DNA COMPLEX, NMR, 1 STRUCTURE | | Descriptor: | DNA (5'-D(*CP*TP*AP*GP*CP*GP*CP*GP*CP*TP*AP*G)-3'), DNA-BINDING PROTEIN 7D | | Authors: | Agback, P, Baumann, H, Knapp, S, Ladenstein, R, Hard, T. | | Deposit date: | 1998-04-24 | | Release date: | 1998-10-14 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | Architecture of Nonspecific Protein-DNA Interactions in the Sso7D-DNA Complex
Nat.Struct.Biol., 5, 1998
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2GDA
 | | REFINED SOLUTION STRUCTURE OF THE GLUCOCORTICOID RECEPTOR DNA-BINDING DOMAIN | | Descriptor: | GLUCOCORTICOID RECEPTOR, ZINC ION | | Authors: | Baumann, H, Paulsen, K, Kovacs, H, Berglund, H, Wright, A.P.H, Gustafsson, J.-A, Hard, T. | | Deposit date: | 1994-03-15 | | Release date: | 1994-06-22 | | Last modified: | 2022-03-09 | | Method: | SOLUTION NMR | | Cite: | Refined solution structure of the glucocorticoid receptor DNA-binding domain.
Biochemistry, 32, 1993
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1GDC
 | | REFINED SOLUTION STRUCTURE OF THE GLUCOCORTICOID RECEPTOR DNA-BINDING DOMAIN | | Descriptor: | GLUCOCORTICOID RECEPTOR, ZINC ION | | Authors: | Baumann, H, Paulsen, K, Kovacs, H, Berglund, H, Wright, A.P.H, Gustafsson, J.-A, Hard, T. | | Deposit date: | 1994-03-15 | | Release date: | 1994-06-22 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Refined solution structure of the glucocorticoid receptor DNA-binding domain.
Biochemistry, 32, 1993
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1SSO
 | | SOLUTION STRUCTURE AND DNA-BINDING PROPERTIES OF A THERMOSTABLE PROTEIN FROM THE ARCHAEON SULFOLOBUS SOLFATARICUS | | Descriptor: | SSO7D | | Authors: | Baumann, H, Knapp, S, Lundback, T, Ladenstein, R, Hard, T. | | Deposit date: | 1995-03-31 | | Release date: | 1995-05-08 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Solution structure and DNA-binding properties of a thermostable protein from the archaeon Sulfolobus solfataricus.
Nat.Struct.Biol., 1, 1994
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1N88
 | | NMR structure of the ribosomal protein L23 from Thermus thermophilus. | | Descriptor: | Ribosomal protein L23 | | Authors: | Ohman, A, Rak, A, Dontsova, M, Garber, M.B, Hard, T. | | Deposit date: | 2002-11-20 | | Release date: | 2003-06-10 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | NMR structure of the ribosomal protein L23 from Thermus thermophilus.
J.Biomol.NMR, 26, 2003
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1QKH
 | | SOLUTION STRUCTURE OF THE RIBOSOMAL PROTEIN S19 FROM THERMUS THERMOPHILUS | | Descriptor: | 30S RIBOSOMAL PROTEIN S19 | | Authors: | Helgstrand, M, Rak, A.V, Allard, P, Davydova, N, Garber, M.B, Hard, T. | | Deposit date: | 1999-07-20 | | Release date: | 1999-07-21 | | Last modified: | 2018-01-17 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the ribosomal protein S19 from Thermus thermophilus.
J. Mol. Biol., 292, 1999
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1ILF
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1ILY
 | | Solution Structure of Ribosomal Protein L18 of Thermus thermophilus | | Descriptor: | RIBOSOMAL PROTEIN L18 | | Authors: | Woestenenk, E.A, Gongadze, G.M, Shcherbakov, D.V, Rak, A.V, Garber, M.B, Hard, T, Berglund, H. | | Deposit date: | 2001-05-09 | | Release date: | 2002-05-01 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | The solution structure of ribosomal protein L18 from Thermus thermophilus reveals a conserved RNA-binding fold.
Biochem.J., 363, 2002
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1AB3
 | | RIBOSOMAL PROTEIN S15 FROM THERMUS THERMOPHILUS, NMR, 26 STRUCTURES | | Descriptor: | RIBOSOMAL RNA BINDING PROTEIN S15 | | Authors: | Berglund, H, Rak, A, Serganov, A, Garber, M, Hard, T. | | Deposit date: | 1997-02-03 | | Release date: | 1997-04-01 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the ribosomal RNA binding protein S15 from Thermus thermophilus.
Nat.Struct.Biol., 4, 1997
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1AWX
 | | SH3 DOMAIN FROM BRUTON'S TYROSINE KINASE, NMR, MINIMIZED AVERAGE STRUCTURE | | Descriptor: | BRUTON'S TYROSINE KINASE | | Authors: | Hansson, H, Mattsson, P.T, Allard, P, Haapaniemi, P, Vihinen, M, Smith, C.I.E, Hard, T. | | Deposit date: | 1997-10-06 | | Release date: | 1998-04-08 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the SH3 domain from Bruton's tyrosine kinase.
Biochemistry, 37, 1998
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1AWW
 | | SH3 DOMAIN FROM BRUTON'S TYROSINE KINASE, NMR, 42 STRUCTURES | | Descriptor: | BRUTON'S TYROSINE KINASE | | Authors: | Hansson, H, Mattsson, P.T, Allard, P, Haapaniemi, P, Vihinen, M, Smith, C.I.E, Hard, T. | | Deposit date: | 1997-10-06 | | Release date: | 1998-04-08 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the SH3 domain from Bruton's tyrosine kinase.
Biochemistry, 37, 1998
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2VRG
 | | Structure of human MCFD2 | | Descriptor: | CALCIUM ION, MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 | | Authors: | Guy, J.E, Wigren, E, Svard, M, Hard, T, Lindqvist, Y. | | Deposit date: | 2008-04-04 | | Release date: | 2008-07-15 | | Last modified: | 2018-02-07 | | Method: | SOLUTION NMR | | Cite: | New insights into multiple coagulation factor deficiency from the solution structure of human MCFD2.
J. Mol. Biol., 381, 2008
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2XET
 | | Conserved hydrophobic clusters on the surface of the Caf1A usher C-terminal domain are important for F1 antigen assembly | | Descriptor: | F1 CAPSULE-ANCHORING PROTEIN, SULFATE ION | | Authors: | Dubnovitsky, A.P, Duck, Z, Kersley, J.E, Hard, T, MacIntyre, S, Knight, S.D. | | Deposit date: | 2010-05-17 | | Release date: | 2010-09-22 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Conserved Hydrophobic Clusters on the Surface of the Caf1A Usher C-Terminal Domain are Important for F1 Antigen Assembly.
J.Mol.Biol., 403, 2010
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