Author results

1J4H
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CRYSTAL STRUCTURE ANALYSIS OF THE FKBP12 COMPLEXED WITH 000107 SMALL MOLECULE
Descriptor:FKBP12, 3-PHENYL-2-{[4-(TOLUENE-4-SULFONYL)-THIOMORPHOLINE-3-CARBONYL]-AMINO}-PROPIONIC ACID ETHYL ESTER
Authors:Li, P., Ding, Y., Wang, L., Wu, B., Shu, C., Li, S., Shen, B., Rao, Z.
Deposit date:2001-09-30
Release date:2003-06-03
Last modified:2019-10-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design and structure-based study of new potential FKBP12 inhibitors.
Biophys.J., 85, 2003
1J4I
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CRYSTAL STRUCTURE ANALYSIS OF THE FKBP12 COMPLEXED WITH 000308 SMALL MOLECULE
Descriptor:FKBP12, 4-METHYL-2-{[4-(TOLUENE-4-SULFONYL)-THIOMORPHOLINE-3-CARBONYL]-AMINO}-PENTANOIC ACID
Authors:Li, P., Ding, Y., Wang, L., Wu, B., Shu, C., Li, S., Shen, B., Rao, Z.
Deposit date:2001-09-30
Release date:2003-06-03
Last modified:2019-10-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design and structure-based study of new potential FKBP12 inhibitors.
Biophys.J., 85, 2003
2GNC
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CRYSTAL STRUCTURE OF SRGAP1 SH3 DOMAIN IN THE SLIT-ROBO SIGNALING PATHWAY
Descriptor:SLIT-ROBO Rho GTPase-activating protein 1
Authors:Li, X., Liu, Y., Gao, F., Bartlam, M., Wu, J.Y., Rao, Z.
Deposit date:2006-04-10
Release date:2006-07-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis of Robo Proline-rich Motif Recognition by the srGAP1 Src Homology 3 Domain in the Slit-Robo Signaling Pathway
J.Biol.Chem., 281, 2006
3AKA
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STRUCTURAL BASIS FOR PROKARYOTIC CALCIUM-MEDIATED REGULATION BY A STREPTOMYCES COELICOLOR CALCIUM-BINDING PROTEIN
Descriptor:Putative calcium binding protein, CALCIUM ION
Authors:Zhao, X., Pang, H., Wang, S., Zhou, W., Yang, K., Bartlam, M.
Deposit date:2010-07-09
Release date:2011-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for prokaryotic calciummediated regulation by a Streptomyces coelicolor calcium binding protein
Protein Cell, 1, 2010
3EWO
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IBV NSP3 ADRP DOMAIN
Descriptor:Non-structural protein 3
Authors:Xu, Y., Cong, L., Chen, C., Wei, L., Zhao, Q., Xu, X., Ma, Y., Bartlam, M., Rao, Z.
Deposit date:2008-10-16
Release date:2009-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of two coronavirus ADP-ribose-1''-monophosphatases and their complexes with ADP-Ribose: a systematic structural analysis of the viral ADRP domain.
J.Virol., 83, 2009
3NGQ
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CRYSTAL STRUCTURE OF THE HUMAN CNOT6L NUCLEASE DOMAIN
Descriptor:CCR4-NOT transcription complex subunit 6-like, 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, MAGNESIUM ION
Authors:Wang, H., Morita, M., Yang, W., Bartlam, M., Yamamoto, T., Rao, Z.
Deposit date:2010-06-13
Release date:2010-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity.
Embo J., 2010
5DV4
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CRYSTAL STRUCTURE OF HUMAN CNOT6L IN COMPLEX WITH NEOMYCIN
Descriptor:CCR4-NOT transcription complex subunit 6-like, NEOMYCIN, SULFATE ION
Authors:Zhang, Q., Bartlam, M.
Deposit date:2015-09-21
Release date:2016-10-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for inhibition of the deadenylase activity of human CNOT6L
Febs Lett., 590, 2016
6INB
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CRYSTAL STRUCTURE OF AN ACETOLACTATE DECARBOXYLASE FROM KLEBSIELLA PNEUMONIAE
Descriptor:Alpha-acetolactate decarboxylase, ZINC ION, CHLORIDE ION
Authors:Wu, W., Zhang, Q., Bartlam, M.
Deposit date:2018-10-24
Release date:2019-01-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural characterization of an acetolactate decarboxylase from Klebsiella pneumoniae
Biochem. Biophys. Res. Commun., 509, 2019
6IN9
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CRYSTAL STRUCTURE OF MUCB IN COMPLEX WITH MUCA(PERI)
Descriptor:Sigma factor AlgU regulatory protein MucB, Sigma factor AlgU negative regulatory protein
Authors:Li, S., Zhang, Q., Bartlam, M.
Deposit date:2018-10-24
Release date:2019-07-24
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Structural basis for the recognition of MucA by MucB and AlgU in Pseudomonas aeruginosa.
Febs J., 2019
3HW5
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CRYSTAL STRUCTURE OF AVIAN INFLUENZA VIRUS PA_N IN COMPLEX WITH AMP
Descriptor:Polymerase acidic protein, MAGNESIUM ION, ADENOSINE MONOPHOSPHATE
Authors:Zhao, C., Lou, Z., Guo, Y., Ma, M., Chen, Y., Liang, S., Rao, Z.
Deposit date:2009-06-17
Release date:2009-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center
J.Virol., 83, 2009
2AMD
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CRYSTAL STRUCTURE OF SARS_COV MPRO IN COMPLEX WITH AN INHIBITOR N9
Descriptor:3C-like proteinase, N-(3-FUROYL)-D-VALYL-L-VALYL-N~1~-((1R,2Z)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-D-LEUCINAMIDE
Authors:Yang, H., Xue, X., Yang, K., Zhao, Q., Bartlam, M., Rao, Z.
Deposit date:2005-08-09
Release date:2005-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
1Q1C
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CRYSTAL STRUCTURE OF N(1-260) OF HUMAN FKBP52
Descriptor:FK506-binding protein 4, DIMETHYL SULFOXIDE, 1,2-ETHANEDIOL
Authors:Wu, B., Li, P., Lou, Z., Ding, Y., Shu, C., Shen, B., Rao, Z.
Deposit date:2003-07-18
Release date:2004-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:3D structure of human FK506-binding protein 52: Implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex
Proc.Natl.Acad.Sci.USA, 101, 2004
1UJ1
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CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (3CLPRO)
Descriptor:3C-like proteinase
Authors:Yang, H., Yang, M., Liu, Y., Bartlam, M., Ding, Y., Lou, Z., Sun, L., Zhou, Z., Ye, S., Anand, K., Pang, H., Gao, G.F., Hilgenfeld, R., Rao, Z.
Deposit date:2003-07-25
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
Proc.Natl.Acad.Sci.USA, 100, 2003
3B9O
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LONG-CHAIN ALKANE MONOOXYGENASE (LADA) IN COMPLEX WITH COENZYME FMN
Descriptor:Alkane monooxygenase, FLAVIN MONONUCLEOTIDE
Authors:Li, L., Yang, W., Xu, F., Bartlam, M., Rao, Z.
Deposit date:2007-11-06
Release date:2008-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of long-chain alkane monooxygenase (LadA) in complex with coenzyme FMN: unveiling the long-chain alkane hydroxylase
J.Mol.Biol., 376, 2008
3FAN
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CRYSTAL STRUCTURE OF CHYMOTRYPSIN-LIKE PROTEASE/PROTEINASE (3CLSP/NSP4) OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV)
Descriptor:Non-structural protein, PHOSPHATE ION
Authors:Gao, F., Peng, H., Tian, X., Lu, G., Liu, Y., Gao, G.F.
Deposit date:2008-11-17
Release date:2009-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and cleavage specificity of the chymotrypsin-like serine protease (3CLSP/nsp4) of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV).
J.Mol.Biol., 392, 2009
3HW3
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THE CRYSTAL STRUCTURE OF AVIAN INFLUENZA VIRUS PA_N IN COMPLEX WITH UMP
Descriptor:Polymerase acidic protein, MAGNESIUM ION, URIDINE-5'-MONOPHOSPHATE
Authors:Zhao, C., Lou, Z., Guo, Y., Ma, M., Chen, Y., Rao, Z.
Deposit date:2009-06-17
Release date:2009-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center
J.Virol., 83, 2009
3HW4
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CRYSTAL STRUCTURE OF AVIAN INFLUENZA A VIRUS IN COMPLEX WITH TMP
Descriptor:Polymerase acidic protein, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE
Authors:Zhao, C., Lou, Z., Guo, Y., Ma, M., Chen, Y., Rao, Z.
Deposit date:2009-06-17
Release date:2009-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center
J.Virol., 83, 2009
3M4V
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CRYSTAL STRUCTURE OF THE A330P MUTANT OF CYTOCHROME P450 BM3
Descriptor:Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE
Authors:Yang, W., Whitehouse, C.J.C., Bell, S.G., Bartlam, M., Wong, L.L., Rao, Z.
Deposit date:2010-03-12
Release date:2011-03-23
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for the properties of two single-site proline mutants of CYP102A1 (P450BM3)
Chembiochem, 11, 2010
3OFT
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CRYSTAL STRUCTURE OF CYTOCHROME P450 CYP101C1
Descriptor:Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, (2R,5R)-hexane-2,5-diol
Authors:Zhou, W., Ma, M., Bell, S.G., Yang, W., Hao, Y., Rees, N.H., Bartlam, M., Wong, L.-L., Rao, Z.
Deposit date:2010-08-16
Release date:2011-07-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Analysis of CYP101C1 from Novosphingobium aromaticivorans DSM12444.
Chembiochem, 12, 2011
3PSX
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CRYSTAL STRUCTURE OF THE KT2 MUTANT OF CYTOCHROME P450 BM3
Descriptor:Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE
Authors:Yang, W., Whitehouse, C.J.C., Yorke, J.A., Bell, S.G., Zhou, W., Bartlam, M., Wong, L.L., Rao, Z.
Deposit date:2010-12-02
Release date:2011-12-07
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure, electronic properties and catalytic behaviour of an activity-enhancing CYP102A1 (P450(BM3)) variant
Dalton Trans, 40, 2011
3SYY
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CRYSTAL STRUCTURE OF AN ALKALINE EXONUCLEASE (LHK-EXO) FROM LARIBACTER HONGKONGENSIS
Descriptor:Exonuclease, MAGNESIUM ION
Authors:Yang, W., Chen, W.Y., Wang, H., Zhang, Q., Zhou, W., Bartlam, M., Watt, R.M., Rao, Z.
Deposit date:2011-07-18
Release date:2012-02-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and functional insight into the mechanism of an alkaline exonuclease from Laribacter hongkongensis.
Nucleic Acids Res., 39, 2011
2ICK
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HUMAN ISOPENTENYL DIPHOPHATE ISOMERASE COMPLEXED WITH SUBSTRATE ANALOG
Descriptor:Isopentenyl-diphosphate delta isomerase, MANGANESE (II) ION, DIMETHYLALLYL DIPHOSPHATE
Authors:Zheng, W., Bartlam, M., Rao, Z.
Deposit date:2006-09-12
Release date:2007-03-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:The crystal structure of human isopentenyl diphosphate isomerase at 1.7 A resolution reveals its catalytic mechanism in isoprenoid biosynthesis
J.Mol.Biol., 366, 2007
4PZ9
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THE NATIVE STRUCTURE OF MYCOBACTERIAL GLUCOSYL-3-PHOSPHOGLYCERATE PHOSPHATASE RV2419C
Descriptor:Glucosyl-3-phosphoglycerate phosphatase
Authors:Zhou, W.H., Zheng, Q.Q., Jiang, D.Q., Zhang, W., Zhang, Q.Q., Jin, J., Li, X., Yang, H.T., Shaw, N., Rao, Z.
Deposit date:2014-03-28
Release date:2014-06-11
Last modified:2014-10-29
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase
J.Biol.Chem., 289, 2014
2HOB
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CRYSTAL STRUCTURE OF SARS-COV MAIN PROTEASE WITH AUTHENTIC N AND C-TERMINI IN COMPLEX WITH A MICHAEL ACCEPTOR N3
Descriptor:Replicase polyprotein 1ab, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE
Authors:Xue, X., Yang, H., Shen, W., Zhao, Q., Li, J., Rao, Z.
Deposit date:2006-07-14
Release date:2007-04-03
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Production of authentic SARS-CoV M(pro) with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction
J.Mol.Biol., 366, 2007
2ZGC
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CRYSTAL STRUCTURE OF ACTIVE HUMAN GRANZYME M
Descriptor:Granzyme M, SULFATE ION
Authors:Wu, L.F., Wang, L., Hua, G.Q., Liu, K., Zhai, Y.J., Sun, F., Fan, Z.S.
Deposit date:2008-01-21
Release date:2009-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M
J.Immunol., 183, 2009