Author results

1OKV
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CYCLIN A BINDING GROOVE INHIBITOR H-ARG-ARG-LEU-ILE-PHE-NH2
分子名称:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, H-ARG-ARG-LEU-ILE-PHE-NH2
著者Kontopidis, G., Andrews, M., McInnes, C., Cowan, A., Powers, H., Innes, L., Plater, A., Griffiths, G., Paterson, D., Zheleva, D., Lane, D., Green, S., Walkinshaw, M., Fischer, P.
登録日2003-07-30
公開日2003-12-11
最終更新日2015-09-16
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Insights Into Cyclin Groove Recognition. Complex Crystal Structures and Inhibitor Design Through Ligand Exchange
Structure, 11, 2003
1OKW
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CYCLIN A BINDING GROOVE INHIBITOR AC-ARG-ARG-LEU-ASN-(M-CL-PHE)-NH2
分子名称:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ACE-ARG-ARG-LEU-ASN-FCL-NH2
著者Kontopidis, G., Andrews, M., McInnes, C., Cowan, A., Powers, H., Innes, L., Plater, A., Griffiths, G., Paterson, D., Zheleva, D., Lane, D., Green, S., Walkinshaw, M., Fischer, P.
登録日2003-07-31
公開日2003-12-11
最終更新日2016-12-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Insights Into Cyclin Groove Recognition. Complex Crystal Structures and Inhibitor Design Through Ligand Exchange
Structure, 11, 2003
1OL1
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CYCLIN A BINDING GROOVE INHIBITOR H-CIT-CIT-LEU-ILE-(P-F-PHE)-NH2
分子名称:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, CIR-CIR-LEU-ILE-PFF-NH2
著者Kontopidis, G., Andrews, M., McInnes, C., Cowan, A., Powers, H., Innes, L., Plater, A., Griffiths, G., Paterson, D., Zheleva, D., Lane, D., Green, S., Walkinshaw, M., Fischer, P.
登録日2003-08-04
公開日2003-12-11
最終更新日2017-02-15
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Insights Into Cyclin Groove Recognition. Complex Crystal Structures and Inhibitor Design Through Ligand Exchange
Structure, 11, 2003
1OL2
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CYCLIN A BINDING GROOVE INHIBITOR H-ARG-ARG-LEU-ASN-(P-F-PHE)-NH2
分子名称:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ARG-ARG-LEU-ASN-PFF-NH2
著者Kontopidis, G., Andrews, M., McInnes, C., Cowan, A., Powers, H., Innes, L., Plater, A., Griffiths, G., Paterson, D., Zheleva, D., Lane, D., Green, S., Walkinshaw, M., Fischer, P.
登録日2003-08-05
公開日2003-12-11
最終更新日2017-02-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Insights Into Cyclin Groove Recognition. Complex Crystal Structures and Inhibitor Design Through Ligand Exchange
Structure, 11, 2003
4KLZ
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INHIBITION OF SMALL GTPASES BY STABILIZATION OF THE GDP COMPLEX, A NOVEL APPROACH APPLIED TO RIT1, A TARGET FOR RHEUMATOID ARTHRITIS
分子名称:GTP-binding protein Rit1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Shah, D.M., Kobayashi, M., Keizers, P.H., Tuin, A.W., Ab, E., Manning, L., Rzepiela, A.A., Andrews, M., Hoedemaeker, F.J., Siegal, G.
登録日2013-05-07
公開日2014-09-17
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Inhibition of Small GTPases by Stabilization of the GDP Complex, a Novel Approach applied to Rit1, a Target for Rheumatoid Arthritis
To be Published
1URC
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CYCLIN A BINDING GROOVE INHIBITOR ACE-ARG-LYS-LEU-PHE-GLY
分子名称:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, PEPTIDE INHIBITOR
著者Kontopidis, G., Andrews, M., McInnes, C., Cowan, A., Powers, H., Innes, L., Plater, A., Griffiths, G., Paterson, D., Zheleva, D., Lane, D., Green, S., Walkinshaw, M., Fischer, P.
登録日2003-10-28
公開日2003-10-31
最終更新日2018-03-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Design, synthesis, biological activity and structural analysis of cyclic peptide inhibitors targeting the substrate recruitment site of cyclin-dependent kinase complexes.
Org. Biomol. Chem., 2, 2004
6DKB
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CRYSTAL STRUCTURE OF TRK-A IN COMPLEX WITH THE PAN-TRK KINASE INHIBITOR, COMPOUND 10B.
分子名称:High affinity nerve growth factor receptor, 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide
著者Greasley, S.E., Johnson, E., Kraus, M.L., Cronin, C.N.
登録日2018-05-29
公開日2018-07-11
最終更新日2018-08-15
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain.
J. Med. Chem., 61, 2018
6DKG
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CRYSTAL STRUCTURE OF TRK-A IN COMPLEX WITH THE PAN-TRK KINASE INHIBITOR, COMPOUND 13B.
分子名称:High affinity nerve growth factor receptor, 5-phenylthieno[2,3-d]pyrimidin-4(3H)-one, 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-4-(2-hydroxy-2-methylpropoxy)benzamide
著者Greasley, S.E., Johnson, E., Kraus, M.L., Cronin, C.N.
登録日2018-05-29
公開日2018-07-11
最終更新日2018-08-15
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain.
J. Med. Chem., 61, 2018
6DKI
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CRYSTAL STRUCTURE OF TRK-A IN COMPLEX WITH THE PAN-TRK KINASE INHIBITOR, COMPOUND 19.
分子名称:High affinity nerve growth factor receptor, 5-phenylthieno[2,3-d]pyrimidin-4(3H)-one, 6-amino-5-{[(3S)-4,4-difluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}pyrrolidin-3-yl]oxy}-N-methylpyridine-3-carboxamide
著者Greasley, S.E., Johnson, E., Kraus, M.L., Cronin, C.N.
登録日2018-05-29
公開日2018-07-11
最終更新日2018-08-15
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain.
J. Med. Chem., 61, 2018
6DKW
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CRYSTAL STRUCTURE OF TRK-A IN COMPLEX WITH THE PAN-TRK KINASE INHIBITOR, COMPOUND 3.
分子名称:Tyrosine-protein kinase receptor, 5-(1-methyl-1H-imidazol-4-yl)-2-[(1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl)oxy]benzamide
著者Greasley, S.E., Brown, D.
登録日2018-05-31
公開日2018-07-11
最終更新日2018-08-15
実験手法X-RAY DIFFRACTION (2.91 Å)
主引用文献Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain.
J. Med. Chem., 61, 2018
5JFS
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CRYSTAL STRUCTURE OF TRKA IN COMPLEX WITH PF-00593174
分子名称:High affinity nerve growth factor receptor, N-{4-[4-amino-7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-2-yl}-N'-(2,4-difluorophenyl)urea
著者Jayasankar, J., Brown, D., Skerratt, S., Kurumbail, R.
登録日2016-04-19
公開日2017-03-01
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
J. Med. Chem., 59, 2016
5JFV
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CRYSTAL STRUCTURE OF TRKA IN COMPLEX WITH PF-05206283
分子名称:High affinity nerve growth factor receptor, N-{5-[4-amino-7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}-2-(4-chlorophenyl)acetamide
著者Jayasankar, J., Kurumbail, R., Brown, D., Skerratt, S.
登録日2016-04-19
公開日2017-03-01
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
J. Med. Chem., 59, 2016
5JFW
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CRYSTAL STRUCTURE OF TRKA IN COMPLEX WITH PF-05247452
分子名称:High affinity nerve growth factor receptor, 2-(4-cyanophenyl)-N-{5-[7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}acetamide
著者Jayasankar, J., Kurumbail, R., Skerratt, S., Brown, D.
登録日2016-04-19
公開日2017-03-01
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
J. Med. Chem., 59, 2016
5JFX
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CRYSTAL STRUCTURE OF TRKA IN COMPLEX WITH PF-06273340
分子名称:High affinity nerve growth factor receptor, N-{5-[2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}-2-(5-chloropyridin-2-yl)acetamide
著者Jayasankar, J., Kurumbail, R., Skerratt, S., Brown, D.
登録日2016-04-19
公開日2017-03-01
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
J. Med. Chem., 59, 2016