4AKH
 
 | | Dynein Motor Domain - AMPPNP complex | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GLUTATHIONE S-TRANSFERASE CLASS-MU 26 KDA ISOZYME, DYNEIN HEAVY CHAIN CYTOPLASMIC, ... | | 著者 | Schmidt, H, Gleave, E.S, Carter, A.P. | | 登録日 | 2012-02-22 | | 公開日 | 2012-03-14 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Insights Into Dynein Motor Domain Function from a 3.3 Angstrom Crystal Structure
Nat.Struct.Mol.Biol., 19, 2012
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4AI6
 | | Dynein Motor Domain - ADP complex | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, GLUTATHIONE S-TRANSFERASE CLASS-MU 26 KDA ISOZYME, ... | | 著者 | Schmidt, H, Gleave, E.S, Carter, A.P. | | 登録日 | 2012-02-08 | | 公開日 | 2012-03-14 | | 最終更新日 | 2017-03-15 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Insights Into Dynein Motor Domain Function from a 3.3 Angstrom Crystal Structure
Nat.Struct.Mol.Biol., 19, 2012
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4AKI
 | | Dynein Motor Domain - LuAc derivative | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GLUTATHIONE S-TRANSFERASE CLASS-MU 26 KDA ISOZYME, DYNEIN HEAVY CHAIN CYTOPLASMIC, ... | | 著者 | Schmidt, H, Gleave, E.S, Carter, A.P. | | 登録日 | 2012-02-22 | | 公開日 | 2012-03-14 | | 最終更新日 | 2017-03-15 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Insights Into Dynein Motor Domain Function from a 3.3 Angstrom Crystal Structure
Nat.Struct.Mol.Biol., 19, 2012
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7MI8
 | | Signal subtracted reconstruction of AAA5 and AAA6 domains of dynein in the presence of a pyrazolo-pyrimidinone-based compound, Model 5 | | 分子名称: | Fusion protein of Dynein and Endolysin | | 著者 | Santarossa, C.C, Coudray, N, Urnavicius, L, Ekiert, D.C, Bhabha, G, Kapoor, T.M. | | 登録日 | 2021-04-16 | | 公開日 | 2021-05-26 | | 最終更新日 | 2021-11-03 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Targeting allostery in the Dynein motor domain with small molecule inhibitors.
Cell Chem Biol, 28, 2021
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7MI3
 | | Signal subtracted reconstruction of AAA2, AAA3, and AAA4 domains of dynein in the presence of a pyrazolo-pyrimidinone-based compound, Model 4 | | 分子名称: | (8S)-6-(3-bromophenoxy)-2-[1-(4-chlorophenyl)cyclopropyl]-7-hydroxypyrazolo[1,5-a]pyrimidine-3-carbonitrile, ADENOSINE-5'-TRIPHOSPHATE, Fusion protein of Dynein and Endolysin, ... | | 著者 | Santarossa, C.C, Coudray, N, Urnavicius, L, Ekiert, D.C, Bhabha, G, Kapoor, T.M. | | 登録日 | 2021-04-16 | | 公開日 | 2021-05-26 | | 最終更新日 | 2021-11-03 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Targeting allostery in the Dynein motor domain with small molecule inhibitors.
Cell Chem Biol, 28, 2021
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7MI6
 | | Yeast dynein motor domain in the presence of a pyrazolo-pyrimidinone-based compound, Model 1 | | 分子名称: | (8S)-6-(3-bromophenoxy)-2-[1-(4-chlorophenyl)cyclopropyl]-7-hydroxypyrazolo[1,5-a]pyrimidine-3-carbonitrile, ADENOSINE-5'-TRIPHOSPHATE, Fusion protein of Dynein and Endolysin, ... | | 著者 | Santarossa, C.C, Urnavicius, L, Coudray, N, Ekeirt, D.C, Bhabha, G, Kapoor, T.M. | | 登録日 | 2021-04-16 | | 公開日 | 2021-05-26 | | 最終更新日 | 2021-11-03 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Targeting allostery in the Dynein motor domain with small molecule inhibitors.
Cell Chem Biol, 28, 2021
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7MI1
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7MGM
 | | Structure of yeast cytoplasmic dynein with AAA3 Walker B mutation bound to Lis1 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Lahiri, I, Reimer, J.M, Leschziner, A.E. | | 登録日 | 2021-04-12 | | 公開日 | 2022-01-19 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis for cytoplasmic dynein-1 regulation by Lis1.
Elife, 11, 2022
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7K58
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7K5B
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7KEK
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7KZO
 | | Outer dynein arm docking complex bound to doublet microtubules from C. reinhardtii | | 分子名称: | Dynein gamma chain, flagellar outer arm, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Walton, T, Wu, H, Brown, A.B. | | 登録日 | 2020-12-10 | | 公開日 | 2021-01-20 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of a microtubule-bound axonemal dynein.
Nat Commun, 12, 2021
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7KZM
 | | Outer dynein arm bound to doublet microtubules from C. reinhardtii | | 分子名称: | DC1, DC2, Dynein 11 kDa light chain, ... | | 著者 | Walton, T, Wu, H, Brown, A.B. | | 登録日 | 2020-12-10 | | 公開日 | 2021-01-20 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (7.5 Å) | | 主引用文献 | Structure of a microtubule-bound axonemal dynein.
Nat Commun, 12, 2021
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7KZN
 | | Outer dynein arm core subcomplex from C. reinhardtii | | 分子名称: | DC1, DC2, Dynein 11 kDa light chain, ... | | 著者 | Walton, T, Wu, H, Brown, A.B. | | 登録日 | 2020-12-10 | | 公開日 | 2021-01-20 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structure of a microtubule-bound axonemal dynein.
Nat Commun, 12, 2021
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7MOQ
 | | The structure of the Tetrahymena thermophila outer dynein arm on doublet microtubule | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Docking complex 1 protein, ... | | 著者 | Kubo, S, Yang, S.K, Ichikawa, M, Bui, K.H. | | 登録日 | 2021-05-03 | | 公開日 | 2021-07-14 | | 最終更新日 | 2021-09-15 | | 実験手法 | ELECTRON MICROSCOPY (8 Å) | | 主引用文献 | Remodeling and activation mechanisms of outer arm dyneins revealed by cryo-EM.
Embo Rep., 22, 2021
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7Z8I
 | | The barbed end complex of dynactin bound to BICDR1 and the cytoplasmic dynein tails (A2, B1, B2) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ARP1 actin related protein 1 homolog A, BICD family-like cargo adapter 1, ... | | 著者 | Chaaban, S, Carter, A.P. | | 登録日 | 2022-03-17 | | 公開日 | 2022-08-17 | | 最終更新日 | 2022-10-19 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of dynein-dynactin on microtubules shows tandem adaptor binding.
Nature, 610, 2022
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7Z8K
 | | Cytoplasmic dynein (A1) bound to BICDR1 | | 分子名称: | ARP1 actin related protein 1 homolog A, BICD family-like cargo adapter 1, Cytoplasmic dynein 1 heavy chain 1, ... | | 著者 | Chaaban, S, Carter, A.P. | | 登録日 | 2022-03-17 | | 公開日 | 2022-07-27 | | 最終更新日 | 2022-10-19 | | 実験手法 | ELECTRON MICROSCOPY (4.37 Å) | | 主引用文献 | Structure of dynein-dynactin on microtubules shows tandem adaptor binding.
Nature, 610, 2022
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7Z8J
 | | Cytoplasmic dynein (A2) bound to BICDR1 | | 分子名称: | BICD family-like cargo adapter 1, Cytoplasmic dynein 1 heavy chain 1, Cytoplasmic dynein 1 intermediate chain 2, ... | | 著者 | Chaaban, S, Carter, A.P. | | 登録日 | 2022-03-17 | | 公開日 | 2022-07-27 | | 最終更新日 | 2022-10-19 | | 実験手法 | ELECTRON MICROSCOPY (3.93 Å) | | 主引用文献 | Structure of dynein-dynactin on microtubules shows tandem adaptor binding.
Nature, 610, 2022
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7Z8F
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8DYV
 | | Structure of human cytoplasmic dynein-1 bound to one Lis1 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ... | | 著者 | Reimer, J.M, DeSantis, M, Reck-Peterson, S.L, Leschziner, A.E. | | 登録日 | 2022-08-05 | | 公開日 | 2023-02-01 | | 実験手法 | ELECTRON MICROSCOPY (3.97 Å) | | 主引用文献 | Structures of human dynein in complex with the lissencephaly 1 protein, LIS1.
Elife, 12, 2023
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8DYU
 | | Structure of human cytoplasmic dynein-1 bound to two Lis1 proteins | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ... | | 著者 | Reimer, J.M, DeSantis, M, Reck-Peterson, S.L, Leschziner, A.E. | | 登録日 | 2022-08-05 | | 公開日 | 2023-02-01 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structures of human dynein in complex with the lissencephaly 1 protein, LIS1.
Elife, 12, 2023
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8DZZ
 | | Cryo-EM structure of chi dynein bound to Lis1 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ... | | 著者 | Reimer, J.M, Lahiri, I, Leschziner, A.E. | | 登録日 | 2022-08-08 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-09-27 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge.
Nat.Struct.Mol.Biol., 30, 2023
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8E00
 | | Symmetry expansion of yeast cytoplasmic dynein-1 bound to Lis1 in the chi conformation. | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ... | | 著者 | Reimer, J.M, Lahiri, I, Leschziner, A.E. | | 登録日 | 2022-08-08 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-09-27 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge.
Nat.Struct.Mol.Biol., 30, 2023
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8FDU
 | | Engineered human dynein motor domain in the microtubule-unbound state with LIS1 complex in the buffer containing ATP-Vi (local refined on AAA3-AAA5 and LIS1) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase, Platelet-activating factor acetylhydrolase IB subunit beta,Platelet-activating factor acetylhydrolase IB subunit beta,human LIS1 protein with a SNAP tag | | 著者 | Ton, W, Wang, Y, Chai, P. | | 登録日 | 2022-12-04 | | 公開日 | 2023-06-21 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport.
Nat.Struct.Mol.Biol., 30, 2023
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8FCY
 | | Engineered human dynein motor domain in microtubule-bound state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase | | 著者 | Ton, W, Wang, Y, Chai, P. | | 登録日 | 2022-12-01 | | 公開日 | 2023-06-21 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport.
Nat.Struct.Mol.Biol., 30, 2023
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