3HU1
 
 | | Structure of p97 N-D1 R95G mutant in complex with ATPgS | | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | | Authors: | Tang, W.-K. | | Deposit date: | 2009-06-12 | | Release date: | 2010-06-16 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.81 Å) | | Cite: | A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants.
Embo J., 29, 2010
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3J99
 | | Structure of 20S supercomplex determined by single particle cryoelectron microscopy (State IIIb) | | Descriptor: | Alpha-soluble NSF attachment protein, Synaptosomal-associated protein 25, Syntaxin-1A, ... | | Authors: | Zhao, M, Wu, S, Cheng, Y, Brunger, A.T. | | Deposit date: | 2014-12-05 | | Release date: | 2015-01-28 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (8.2 Å) | | Cite: | Mechanistic insights into the recycling machine of the SNARE complex.
Nature, 518, 2015
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3J96
 | | Structure of 20S supercomplex determined by single particle cryoelectron microscopy (State I) | | Descriptor: | Alpha-soluble NSF attachment protein, Synaptosomal-associated protein 25, Syntaxin-1A, ... | | Authors: | Zhao, M, Wu, S, Cheng, Y, Brunger, A.T. | | Deposit date: | 2014-12-05 | | Release date: | 2015-01-28 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (7.6 Å) | | Cite: | Mechanistic insights into the recycling machine of the SNARE complex.
Nature, 518, 2015
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3HU2
 | | Structure of p97 N-D1 R86A mutant in complex with ATPgS | | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | | Authors: | Tang, W.-K. | | Deposit date: | 2009-06-12 | | Release date: | 2010-06-16 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants.
Embo J., 29, 2010
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3J95
 | | Structure of ADP-bound N-ethylmaleimide sensitive factor determined by single particle cryoelectron microscopy | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Vesicle-fusing ATPase | | Authors: | Zhao, M, Wu, S, Cheng, Y, Brunger, A.T. | | Deposit date: | 2014-12-05 | | Release date: | 2015-01-28 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (7.6 Å) | | Cite: | Mechanistic insights into the recycling machine of the SNARE complex.
Nature, 518, 2015
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3J94
 | | Structure of ATP-bound N-ethylmaleimide sensitive factor determined by single particle cryoelectron microscopy | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Vesicle-fusing ATPase | | Authors: | Zhao, M, Wu, S, Cheng, Y, Brunger, A.T. | | Deposit date: | 2014-12-05 | | Release date: | 2015-01-28 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Mechanistic insights into the recycling machine of the SNARE complex.
Nature, 518, 2015
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3HU3
 | | Structure of p97 N-D1 R155H mutant in complex with ATPgS | | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | | Authors: | Tang, W.-K. | | Deposit date: | 2009-06-12 | | Release date: | 2010-06-16 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants.
Embo J., 29, 2010
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3J98
 | | Structure of 20S supercomplex determined by single particle cryoelectron microscopy (State IIIa) | | Descriptor: | Alpha-soluble NSF attachment protein, Synaptosomal-associated protein 25, Syntaxin-1A, ... | | Authors: | Zhao, M, Wu, S, Cheng, Y, Brunger, A.T. | | Deposit date: | 2014-12-05 | | Release date: | 2015-01-28 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (8.4 Å) | | Cite: | Mechanistic insights into the recycling machine of the SNARE complex.
Nature, 518, 2015
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3J97
 | | Structure of 20S supercomplex determined by single particle cryoelectron microscopy (State II) | | Descriptor: | Alpha-soluble NSF attachment protein, Synaptosomal-associated protein 25, Syntaxin-1A, ... | | Authors: | Zhao, M, Wu, S, Cheng, Y, Brunger, A.T. | | Deposit date: | 2014-12-05 | | Release date: | 2015-01-28 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (7.8 Å) | | Cite: | Mechanistic insights into the recycling machine of the SNARE complex.
Nature, 518, 2015
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5DYI
 | | Structure of p97 N-D1 wild-type in complex with ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | | Authors: | Tang, W.K, Xia, D. | | Deposit date: | 2015-09-24 | | Release date: | 2016-02-10 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (3.71 Å) | | Cite: | Role of the D1-D2 Linker of Human VCP/p97 in the Asymmetry and ATPase Activity of the D1-domain.
Sci Rep, 6, 2016
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5FTK
 | | Cryo-EM structure of human p97 bound to ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | | Authors: | Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. | | Deposit date: | 2016-01-14 | | Release date: | 2016-01-27 | | Last modified: | 2018-10-03 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
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5FTL
 | | Cryo-EM structure of human p97 bound to ATPgS (Conformation I) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | | Authors: | Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. | | Deposit date: | 2016-01-14 | | Release date: | 2016-01-27 | | Last modified: | 2018-10-03 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
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5FTJ
 | | Cryo-EM structure of human p97 bound to UPCDC30245 inhibitor | | Descriptor: | 1-(3-(5-FLUORO-1H-INDOL-2-YL)PHENYL)PIPERIDIN-4-YL)(2-(4-ISOPROPYL-PIPERAZIN1-YL)ETHYL)-CARBAMATE, ADENOSINE-5'-DIPHOSPHATE, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | | Authors: | Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. | | Deposit date: | 2016-01-14 | | Release date: | 2016-01-27 | | Last modified: | 2018-10-03 | | Method: | ELECTRON MICROSCOPY (2.3 Å) | | Cite: | 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
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5FTN
 | | Cryo-EM structure of human p97 bound to ATPgS (Conformation III) | | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | | Authors: | Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. | | Deposit date: | 2016-01-14 | | Release date: | 2016-01-27 | | Last modified: | 2018-10-03 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
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5DYG
 | | Structure of p97 N-D1 L198W mutant in complex with ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | | Authors: | Tang, W.K, Xia, D. | | Deposit date: | 2015-09-24 | | Release date: | 2016-02-10 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Role of the D1-D2 Linker of Human VCP/p97 in the Asymmetry and ATPase Activity of the D1-domain.
Sci Rep, 6, 2016
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5EPP
 | | Structural Insights into the Interaction of p97 N-terminus Domain and VBM Motif in Rhomboid Protease, RHBDL4 | | Descriptor: | Rhomboid-related protein 4, Transitional endoplasmic reticulum ATPase | | Authors: | Lim, J.J, Lee, Y, Ly, T.T, Kang, J.Y, Lee, J.-G, An, J.Y, Youn, H.-S, Park, K.R, Kim, T.G, Yang, J.K, Jun, Y, Eom, S.H. | | Deposit date: | 2015-11-12 | | Release date: | 2016-09-14 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Structural insights into the interaction of p97 N-terminus domain and VBM in rhomboid protease, RHBDL4.
Biochem.J., 473, 2016
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5FTM
 | | Cryo-EM structure of human p97 bound to ATPgS (Conformation II) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | Authors: | Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. | | Deposit date: | 2016-01-14 | | Release date: | 2016-01-27 | | Last modified: | 2018-10-03 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Science, 351, 2016
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5G4F
 | | Structure of the ADP-bound VAT complex | | Descriptor: | VCP-LIKE ATPASE | | Authors: | Huang, R, Ripstein, Z.A, Augustyniak, R, Lazniewski, M, Ginalski, K, Kay, L.E, Rubinstein, J.L. | | Deposit date: | 2016-05-12 | | Release date: | 2016-07-27 | | Last modified: | 2018-10-03 | | Method: | ELECTRON MICROSCOPY (7 Å) | | Cite: | Unfolding the Mechanism of the Aaa+ Unfoldase Vat by a Combined Cryo-Em, Solution NMR Study.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5G4G
 | | Structure of the ATPgS-bound VAT complex | | Descriptor: | VCP-LIKE ATPASE | | Authors: | Huang, R, Ripstein, Z.A, Augustyniak, R, Lazniewski, M, Ginalski, K, Kay, L.E, Rubinstein, J.L. | | Deposit date: | 2016-05-12 | | Release date: | 2016-07-27 | | Last modified: | 2018-10-03 | | Method: | ELECTRON MICROSCOPY (7.8 Å) | | Cite: | Unfolding the Mechanism of the Aaa+ Unfoldase Vat by a Combined Cryo-Em, Solution NMR Study.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5GLF
 | | Structural insights into the interaction of p97 N-terminal domain and SHP motif in Derlin-1 rhomboid pseudoprotease | | Descriptor: | Derlin-1, Transitional endoplasmic reticulum ATPase | | Authors: | Lim, J.J, Lee, Y, Yoon, S.Y, Ly, T.T, Kang, J.Y, Youn, H.-S, An, J.Y, Lee, J.-G, Park, K.R, Kim, T.G, Yang, J.K, Jun, Y, Eom, S.H. | | Deposit date: | 2016-07-11 | | Release date: | 2016-11-09 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structural insights into the interaction of human p97 N-terminal domain and SHP motif in Derlin-1 rhomboid pseudoprotease.
FEBS Lett., 590, 2016
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7R7S
 | | p47-bound p97-R155H mutant with ATPgammaS | | Descriptor: | NSFL1 cofactor p47, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | | Authors: | Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Malyutin, A.G, Poh, Y.-P, Chou, T.-F, Chiu, P.-L. | | Deposit date: | 2021-06-25 | | Release date: | 2021-08-04 | | Last modified: | 2021-08-25 | | Method: | ELECTRON MICROSCOPY (4.23 Å) | | Cite: | Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes.
Int J Mol Sci, 22, 2021
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7R7T
 | | p47-bound p97-R155H mutant with ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, NSFL1 cofactor p47, Transitional endoplasmic reticulum ATPase | | Authors: | Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Malyutin, A.G, Poh, Y.-P, Chou, T.-F, Chiu, P.-L. | | Deposit date: | 2021-06-25 | | Release date: | 2021-08-04 | | Last modified: | 2021-08-25 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes.
Int J Mol Sci, 22, 2021
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7R7U
 | | D1 and D2 domain structure of the p97(R155H)-p47 complex | | Descriptor: | Transitional endoplasmic reticulum ATPase | | Authors: | Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Poh, Y.-P, Chou, T.-F, Chiu, P.-L. | | Deposit date: | 2021-06-25 | | Release date: | 2021-08-04 | | Last modified: | 2021-08-25 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes.
Int J Mol Sci, 22, 2021
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7RLH
 | | Cryo-EM structure of human p97-D592N mutant bound to ATPgS. | | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | | Authors: | Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S. | | Deposit date: | 2021-07-23 | | Release date: | 2021-09-22 | | Last modified: | 2021-11-17 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
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7RLG
 | | Cryo-EM structure of human p97-D592N mutant bound to ADP. | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | | Authors: | Caffrey, B, Zhu, X, Berezuk, A, Tuttle, K, Chittori, S, Subramaniam, S. | | Deposit date: | 2021-07-23 | | Release date: | 2021-09-22 | | Last modified: | 2021-11-17 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.
J.Biol.Chem., 297, 2021
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